CN1045291C - 制备被取代的四氢异喹啉化合物的方法 - Google Patents

制备被取代的四氢异喹啉化合物的方法 Download PDF

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Publication number
CN1045291C
CN1045291C CN93109559A CN93109559A CN1045291C CN 1045291 C CN1045291 C CN 1045291C CN 93109559 A CN93109559 A CN 93109559A CN 93109559 A CN93109559 A CN 93109559A CN 1045291 C CN1045291 C CN 1045291C
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CN
China
Prior art keywords
mixture
chlorophenyl
methyl
ome
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93109559A
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English (en)
Chinese (zh)
Other versions
CN1096780A (zh
Inventor
A·科茨力克
B·J·沙根特
P·L·尼达姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB919127306A priority Critical patent/GB9127306D0/en
Priority to NZ246155A priority patent/NZ246155A/en
Priority to ES93900051T priority patent/ES2098721T3/es
Priority to CZ941534A priority patent/CZ282869B6/cs
Priority to AT93900051T priority patent/ATE150015T1/de
Priority to EP93900051A priority patent/EP0618900B1/en
Priority to US08/244,368 priority patent/US5519034A/en
Priority to RO94-01028A priority patent/RO114790B1/ro
Priority to DK93900051.9T priority patent/DK0618900T3/da
Priority to CA002126308A priority patent/CA2126308A1/en
Priority to AU31586/93A priority patent/AU662584B2/en
Priority to SK751-94A priority patent/SK280318B6/sk
Priority to DE69218248T priority patent/DE69218248T2/de
Priority to PCT/EP1992/002900 priority patent/WO1993013073A1/en
Priority to HU9401878A priority patent/HUT70495A/hu
Priority to RU94030499A priority patent/RU2122999C1/ru
Priority to JP5511396A priority patent/JP2642244B2/ja
Priority to PL92304143A priority patent/PL173944B1/pl
Priority to IN757MA1992 priority patent/IN174437B/en
Priority to IL10417092A priority patent/IL104170A/en
Priority to MX9207495A priority patent/MX9207495A/es
Priority to SI9200410A priority patent/SI9200410B/sl
Priority to HR9127306.0A priority patent/HRP921458B1/xx
Priority to CN93109559A priority patent/CN1045291C/zh
Application filed by Boots Co PLC filed Critical Boots Co PLC
Priority to BG98822A priority patent/BG62326B1/bg
Priority to FI943018A priority patent/FI105401B/fi
Priority to NO942375A priority patent/NO301474B1/no
Publication of CN1096780A publication Critical patent/CN1096780A/zh
Priority to HU95P/P00689P priority patent/HU211302A9/hu
Priority to GR970401221T priority patent/GR3023568T3/el
Application granted granted Critical
Publication of CN1045291C publication Critical patent/CN1045291C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN93109559A 1991-12-23 1993-06-26 制备被取代的四氢异喹啉化合物的方法 Expired - Fee Related CN1045291C (zh)

Priority Applications (29)

Application Number Priority Date Filing Date Title
GB919127306A GB9127306D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
CZ941534A CZ282869B6 (cs) 1991-12-23 1992-12-12 Tetrahydroisochinolinové deriváty, způsob jejich přípravy, jejich použití jako léčiva a farmaceutické kompozice tyto deriváty obsahující
AT93900051T ATE150015T1 (de) 1991-12-23 1992-12-12 Substituierte tetrahydroisochinolin-derivate und ihre anwendung in der therapie
EP93900051A EP0618900B1 (en) 1991-12-23 1992-12-12 Substituted tetrahydroisoquinolines and their use as therapeutic agents
US08/244,368 US5519034A (en) 1991-12-23 1992-12-12 Tetraisoquinoline compounds which have useful pharmaceutical utility
RO94-01028A RO114790B1 (ro) 1991-12-23 1992-12-12 Derivati de tetrahidroizochinolina, procedeu de preparare a acestora, compozitii farmaceutice care ii contin si metoda de tratament
DK93900051.9T DK0618900T3 (da) 1991-12-23 1992-12-12 Substituerede tetrahydroisoquinoliner og deres anvendelse som terapeutiske midler
CA002126308A CA2126308A1 (en) 1991-12-23 1992-12-12 Therapeutic agents
AU31586/93A AU662584B2 (en) 1991-12-23 1992-12-12 Substituted tetrahydroisoquinolines and their use as therapeutic agents
JP5511396A JP2642244B2 (ja) 1991-12-23 1992-12-12 治療剤
DE69218248T DE69218248T2 (de) 1991-12-23 1992-12-12 Substituierte tetrahydroisochinolin-derivate und ihre anwendung in der therapie
PCT/EP1992/002900 WO1993013073A1 (en) 1991-12-23 1992-12-12 Substituted tetrahydroisoquinolines and their use as therapeutic agents
HU9401878A HUT70495A (en) 1991-12-23 1992-12-12 Tetrahydroisoquinolines process for productions thereof and pharmaceutical compositions comprising same compounds
RU94030499A RU2122999C1 (ru) 1991-12-23 1992-12-12 Тетрагидроизохинолиновые соединения или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция на их основе и способ связывания допаминовых рецепторов
NZ246155A NZ246155A (en) 1991-12-23 1992-12-12 1-(1-aryl cycloalkyl)-1,2,3,4-tetrahydroisoquinoline derivatives and pharmaceutical compositions
PL92304143A PL173944B1 (pl) 1991-12-23 1992-12-12 Sposób wytwarzania nowych związków tetrahydroizochinolinowych
ES93900051T ES2098721T3 (es) 1991-12-23 1992-12-12 Tetrahidroisoquinoleinas substituidas y su uso como agentes terapeuticos.
SK751-94A SK280318B6 (sk) 1991-12-23 1992-12-12 Tetrahydroizochinolínové zlúčeniny, farmaceutická
IN757MA1992 IN174437B (2) 1991-12-23 1992-12-17
IL10417092A IL104170A (en) 1991-12-23 1992-12-18 Tetrahydroisoquinoline derivatives process for their preparation and pharmaceutical compositions containing them
MX9207495A MX9207495A (es) 1991-12-23 1992-12-22 Compuestos de tetrahidroisoquinolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
SI9200410A SI9200410B (sl) 1991-12-23 1992-12-22 Nove tetrahidroizokinolinove spojine
HR9127306.0A HRP921458B1 (en) 1991-12-23 1992-12-22 Tetrahydroisoquinoline compounds
CN93109559A CN1045291C (zh) 1991-12-23 1993-06-26 制备被取代的四氢异喹啉化合物的方法
BG98822A BG62326B1 (bg) 1991-12-23 1994-05-31 Тетрахидроизохинолинови съединения и употребата им катотерапевтични вещества
FI943018A FI105401B (fi) 1991-12-23 1994-06-22 Menetelmä terapeuttisesti käyttökelpoisten 1-(1-fenyylisykloalkyyli)substituoitujen 7-hydroksi-2-alkyyli-1,2,3,4-tetrahydroisokinoliiniyhdisteiden valmistamiseksi
NO942375A NO301474B1 (no) 1991-12-23 1994-06-22 Tetrahydroisokinolinforbindelser, terapeutiske midler inneholdende dem og anvendelse av forbindelsene
HU95P/P00689P HU211302A9 (en) 1991-12-23 1995-06-30 Novel tetrahydroisoquinoline derivatives
GR970401221T GR3023568T3 (en) 1991-12-23 1997-05-28 Substituted tetrahydroisoquinolines and their use as therapeutic agents.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127306A GB9127306D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
CN93109559A CN1045291C (zh) 1991-12-23 1993-06-26 制备被取代的四氢异喹啉化合物的方法

Publications (2)

Publication Number Publication Date
CN1096780A CN1096780A (zh) 1994-12-28
CN1045291C true CN1045291C (zh) 1999-09-29

Family

ID=36822306

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93109559A Expired - Fee Related CN1045291C (zh) 1991-12-23 1993-06-26 制备被取代的四氢异喹啉化合物的方法

Country Status (28)

Country Link
US (1) US5519034A (2)
EP (1) EP0618900B1 (2)
JP (1) JP2642244B2 (2)
CN (1) CN1045291C (2)
AT (1) ATE150015T1 (2)
AU (1) AU662584B2 (2)
BG (1) BG62326B1 (2)
CA (1) CA2126308A1 (2)
CZ (1) CZ282869B6 (2)
DE (1) DE69218248T2 (2)
DK (1) DK0618900T3 (2)
ES (1) ES2098721T3 (2)
FI (1) FI105401B (2)
GB (1) GB9127306D0 (2)
GR (1) GR3023568T3 (2)
HR (1) HRP921458B1 (2)
HU (2) HUT70495A (2)
IL (1) IL104170A (2)
IN (1) IN174437B (2)
MX (1) MX9207495A (2)
NO (1) NO301474B1 (2)
NZ (1) NZ246155A (2)
PL (1) PL173944B1 (2)
RO (1) RO114790B1 (2)
RU (1) RU2122999C1 (2)
SI (1) SI9200410B (2)
SK (1) SK280318B6 (2)
WO (1) WO1993013073A1 (2)

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Also Published As

Publication number Publication date
EP0618900A1 (en) 1994-10-12
DE69218248D1 (de) 1997-04-17
FI943018A7 (fi) 1994-06-22
JP2642244B2 (ja) 1997-08-20
IN174437B (2) 1994-12-03
WO1993013073A1 (en) 1993-07-08
DE69218248T2 (de) 1997-06-19
CA2126308A1 (en) 1993-07-08
ATE150015T1 (de) 1997-03-15
SI9200410A (en) 1993-09-30
RU94030499A (ru) 1996-04-20
AU3158693A (en) 1993-07-28
NO942375L (no) 1994-06-22
RU2122999C1 (ru) 1998-12-10
NO942375D0 (2) 1994-06-22
BG62326B1 (bg) 1999-08-31
HRP921458B1 (en) 1999-02-28
CZ282869B6 (cs) 1997-11-12
GB9127306D0 (en) 1992-02-19
BG98822A (bg) 1995-05-31
ES2098721T3 (es) 1997-05-01
NO301474B1 (no) 1997-11-03
CZ153494A3 (en) 1995-07-12
US5519034A (en) 1996-05-21
NZ246155A (en) 1996-02-27
HU9401878D0 (en) 1994-09-28
IL104170A0 (en) 1993-05-13
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JPH07502279A (ja) 1995-03-09
CN1096780A (zh) 1994-12-28
SK75194A3 (en) 1995-08-09
HUT70495A (en) 1995-10-30
EP0618900B1 (en) 1997-03-12
IL104170A (en) 1999-04-11
FI105401B (fi) 2000-08-15
DK0618900T3 (da) 1997-04-07
MX9207495A (es) 1993-07-01
AU662584B2 (en) 1995-09-07
SI9200410B (sl) 2002-02-28
SK280318B6 (sk) 1999-11-08
HU211302A9 (en) 1995-11-28
FI943018A0 (fi) 1994-06-22
RO114790B1 (ro) 1999-07-30
HRP921458A2 (en) 1995-06-30
PL173944B1 (pl) 1998-05-29

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