CN104540503A - 包括二倍半萜的组合物及其作为抗生素佐剂和抗真菌剂佐剂的用途 - Google Patents

包括二倍半萜的组合物及其作为抗生素佐剂和抗真菌剂佐剂的用途 Download PDF

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Publication number: CN104540503A
Authority: CN; China
Prior art keywords: sesterterpene; salt; derivatives; indenes; decahydro
Prior art date: 2012-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN201380042898.2A

Other languages

English (en)

Chinese (zh)

Inventor

路易吉·阿梅罗蒂

洛伦佐·赛肯迪尼

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

RODE PHARMA Srl

Original Assignee

RODE PHARMA Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-25

Filing date

2013-06-25

Publication date

2015-04-22

2013-06-25 Application filed by RODE PHARMA Srl filed Critical RODE PHARMA Srl

2015-04-22 Publication of CN104540503A publication Critical patent/CN104540503A/zh

Status Pending legal-status Critical Current

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ORVLUIMCZUPAPB-LBTQIPEASA-M sodium (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide dioxido(oxo)phosphanium phosphenic acid Chemical compound [Na+].O[P+]([O-])=O.O[P+]([O-])=O.O[P+]([O-])=O.O[P+]([O-])=O.O[P+]([O-])=O.[O-][P+]([O-])=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(O)=C(C(N)=O)C1=O ORVLUIMCZUPAPB-LBTQIPEASA-M 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
ICXJVZHDZFXYQC-UHFFFAOYSA-N spongistatin 1 Natural products OC1C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC2(O2)CC(OC)CC2CC(=O)C(C)C(OC(C)=O)C(C)C(=C)CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC2C(O)C(CC(=C)CC(O)C=CC(Cl)=C)OC1C2C ICXJVZHDZFXYQC-UHFFFAOYSA-N 0.000 description 1
229940031000 streptococcus pneumoniae Drugs 0.000 description 1
229940035786 sulfatrim Drugs 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
229940072226 suprax Drugs 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
235000007954 swamp oak Nutrition 0.000 description 1
150000003505 terpenes Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
229940035275 tobrex Drugs 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
238000012546 transfer Methods 0.000 description 1
239000006150 trypticase soy agar Substances 0.000 description 1
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
229940063678 vibramycin Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing carboxylic groups or thio analogues thereof, directly attached by the carbon atom to a cycloaliphatic ring; Derivatives thereof
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Dentistry (AREA)
Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Agronomy & Crop Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pest Control & Pesticides (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CN201380042898.2A 2012-06-25 2013-06-25 包括二倍半萜的组合物及其作为抗生素佐剂和抗真菌剂佐剂的用途 Pending CN104540503A (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI2012A001109		2012-06-25
IT001109A ITMI20121109A1 (it)	2012-06-25	2012-06-25	Composizione comprendente acido gascardico o un suo derivato e relativo uso come coadiuvante per antibiotici
PCT/IB2013/001360 WO2014001882A1 (en)	2012-06-25	2013-06-25	Composition comprising a sesterterpene and use thereof as antibiotic and antifungal adjuvant

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Publication Number	Publication Date
CN104540503A true CN104540503A (zh)	2015-04-22

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CN201380042898.2A Pending CN104540503A (zh)	2012-06-25	2013-06-25	包括二倍半萜的组合物及其作为抗生素佐剂和抗真菌剂佐剂的用途

Country Status (6)

Country	Link
US (1)	US9775348B2 (2)
EP (1)	EP2863904B1 (2)
CN (1)	CN104540503A (2)
IN (1)	IN2014MN02484A (2)
IT (1)	ITMI20121109A1 (2)
WO (1)	WO2014001882A1 (2)

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CN108516923A (zh) *	2018-05-22	2018-09-11	天津汉荣生物技术有限公司	一系列烯萜类化合物及其制备方法和应用
CN109662967A (zh) *	2019-02-19	2019-04-23	孙益虎	一种抗抑郁药物及其用途
CN110507660A (zh) *	2019-09-24	2019-11-29	吉林大学	五环三萜类化合物在制备细菌性溶血素抑制剂中的用途
CN111658683A (zh) *	2020-05-15	2020-09-15	广东药科大学	诃子提取物在制备马拉色菌抑制剂中的应用

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- 2012-06-25 IT IT001109A patent/ITMI20121109A1/it unknown
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- 2013-06-25 EP EP13744788.4A patent/EP2863904B1/en not_active Not-in-force
- 2013-06-25 WO PCT/IB2013/001360 patent/WO2014001882A1/en not_active Ceased
- 2013-06-25 CN CN201380042898.2A patent/CN104540503A/zh active Pending
- 2013-06-25 IN IN2484MUN2014 patent/IN2014MN02484A/en unknown
- 2013-06-25 US US14/408,553 patent/US9775348B2/en not_active Expired - Fee Related

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104940211A (zh) *	2015-06-08	2015-09-30	曹晓宏	白桦脂酸在制备抗真菌生物被膜药物中的应用
CN108516923A (zh) *	2018-05-22	2018-09-11	天津汉荣生物技术有限公司	一系列烯萜类化合物及其制备方法和应用
CN109662967A (zh) *	2019-02-19	2019-04-23	孙益虎	一种抗抑郁药物及其用途
CN109662967B (zh) *	2019-02-19	2021-02-12	孙益虎	一种抗抑郁药物及其用途
CN110507660A (zh) *	2019-09-24	2019-11-29	吉林大学	五环三萜类化合物在制备细菌性溶血素抑制剂中的用途
CN111658683A (zh) *	2020-05-15	2020-09-15	广东药科大学	诃子提取物在制备马拉色菌抑制剂中的应用

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IN2014MN02484A (2)	2015-07-10
US9775348B2 (en)	2017-10-03
WO2014001882A1 (en)	2014-01-03
US20150196029A1 (en)	2015-07-16
EP2863904A1 (en)	2015-04-29
ITMI20121109A1 (it)	2013-12-26
EP2863904B1 (en)	2018-02-21

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