CN105123700A - Insecticidal and bactericidal agent with thymol and arecoline and preparation method of insecticidal and bactericidal agent - Google Patents
Insecticidal and bactericidal agent with thymol and arecoline and preparation method of insecticidal and bactericidal agent Download PDFInfo
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- CN105123700A CN105123700A CN201510699914.6A CN201510699914A CN105123700A CN 105123700 A CN105123700 A CN 105123700A CN 201510699914 A CN201510699914 A CN 201510699914A CN 105123700 A CN105123700 A CN 105123700A
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- Prior art keywords
- thymol
- arecaline
- weight percentage
- pesticide
- water
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 title claims abstract description 182
- 239000005844 Thymol Substances 0.000 title claims abstract description 91
- 229960000790 thymol Drugs 0.000 title claims abstract description 91
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 21
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000002917 insecticide Substances 0.000 title abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 241000238631 Hexapoda Species 0.000 claims abstract description 15
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000002270 dispersing agent Substances 0.000 claims description 21
- 239000000080 wetting agent Substances 0.000 claims description 21
- 239000005995 Aluminium silicate Substances 0.000 claims description 17
- 235000012211 aluminium silicate Nutrition 0.000 claims description 17
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 17
- 239000003995 emulsifying agent Substances 0.000 claims description 16
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical group [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000004530 micro-emulsion Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 238000009736 wetting Methods 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 241000221785 Erysiphales Species 0.000 claims description 8
- 239000013530 defoamer Substances 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 8
- 239000007884 disintegrant Substances 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 230000000740 bleeding effect Effects 0.000 claims description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical group OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 210000000481 breast Anatomy 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000002480 mineral oil Substances 0.000 claims description 4
- 235000010446 mineral oil Nutrition 0.000 claims description 4
- 235000010297 nisin Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims description 3
- 108010053775 Nisin Proteins 0.000 claims description 3
- 241000233679 Peronosporaceae Species 0.000 claims description 3
- 241000985245 Spodoptera litura Species 0.000 claims description 3
- 241001414989 Thysanoptera Species 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
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- 238000009472 formulation Methods 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000004309 nisin Substances 0.000 claims description 3
- 241001124076 Aphididae Species 0.000 claims description 2
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 claims description 2
- 241001465977 Coccoidea Species 0.000 claims description 2
- 239000012752 auxiliary agent Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 9
- 239000000575 pesticide Substances 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000002075 main ingredient Substances 0.000 abstract 1
- 230000009044 synergistic interaction Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 20
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 240000008067 Cucumis sativus Species 0.000 description 8
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 8
- 241000500437 Plutella xylostella Species 0.000 description 8
- 238000011835 investigation Methods 0.000 description 7
- 235000006008 Brassica napus var napus Nutrition 0.000 description 6
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 6
- 241001674939 Caulanthus Species 0.000 description 6
- 231100000572 poisoning Toxicity 0.000 description 6
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- 230000002195 synergetic effect Effects 0.000 description 6
- 244000080767 Areca catechu Species 0.000 description 5
- 235000006226 Areca catechu Nutrition 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
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- 230000003449 preventive effect Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000242722 Cestoda Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241000498255 Enterobius vermicularis Species 0.000 description 2
- 241001126309 Fasciolopsis Species 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 230000000507 anthelmentic effect Effects 0.000 description 2
- 239000002026 chloroform extract Substances 0.000 description 2
- 238000000205 computational method Methods 0.000 description 2
- 229960004132 diethyl ether Drugs 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 206010014881 enterobiasis Diseases 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 125000003639 thymyl group Chemical group C1(=CC(C)=CC=C1C(C)C)* 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- LWEAHXKXKDCSIE-UHFFFAOYSA-M 2,3-di(propan-2-yl)naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S([O-])(=O)=O)=C(C(C)C)C(C(C)C)=CC2=C1 LWEAHXKXKDCSIE-UHFFFAOYSA-M 0.000 description 1
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- IOAISUCAQCEHTA-UHFFFAOYSA-N 5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(C)C=C1O.CC(C)C1=CC=C(C)C=C1O IOAISUCAQCEHTA-UHFFFAOYSA-N 0.000 description 1
- OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- 241000050051 Chelone glabra Species 0.000 description 1
- -1 DBSA Chemical compound 0.000 description 1
- 206010013029 Diphyllobothriasis Diseases 0.000 description 1
- 241001137876 Diphyllobothrium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000500441 Plutellidae Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
- 241001442514 Schistosomatidae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000244157 Taenia solium Species 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000000853 biopesticidal effect Effects 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
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- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
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- 235000008216 herbs Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000004476 plant protection product Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 238000012797 qualification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
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- 238000005070 sampling Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
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- 235000013599 spices Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- PRZSXZWFJHEZBJ-UHFFFAOYSA-N thymol blue Chemical compound C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(O)=C(C(C)C)C=2)C)=C1C PRZSXZWFJHEZBJ-UHFFFAOYSA-N 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an insecticidal and bactericidal agent with thymol and arecoline, in particular to a formula of the insecticidal and bactericidal agent with thymol and arecoline and a preparation method of the insecticidal and bactericidal agent. The insecticidal and bactericidal agent is prepared from, by weight, 1-45% of thymol, 1-25% of arecoline and the balance additives. Because few insecticidal and bactericidal pesticides exist on the market, the insecticidal and bactericidal agent will save lots of cost for vast farmers once being produced and used, and the main ingredients, namely, thymol and arecoline, used by the insecticidal and bactericidal agent are plant source ingredients extracted from the nature, can be decomposed in the natural environment, cause no pollution to crops or the environment, and belong to green pesticide. Due to the two active ingredients, namely, thymol and arecoline, the synergistic interaction effect is achieved, and it is avoided that diseases and insects resist to the agent and the control object is simplex in the use process.
Description
Technical field
The present invention relates to a kind of insecticidal bactericide, specifically the formula of a kind of Thymol and arecaline insecticidal bactericide, and the preparation method of several formulation of this insecticidal bactericide.
Background technology
Thymol (Thymol) is the amphyl of cymene, is slightly soluble in water.Its molecular formula is C
10h
14o, chemical name is 2-isopropyl-5-methylphenol, and structural formula is:
Thymol because of initial from thyme extraction and isolation out gain the name, it is a kind of semi-transparent clear crystallization, is very easily dissolved in ethanol, ether, acetic acid, chloroform and benzene, has certain fragrance and has very strong bactericidal action.On June 19th, 2013, EU Committee has ratified Thymol to put on market as plant protection products, and the safety of apparent Thymol is very high, toxicity is also lower.Thymol also has very wide application such as owing to having antimycotic and parasite function in other side at present, can be used to process wound, makes preservative, medical bactericide, store dissec etc.; Because it has phenols smell, be also usually used in pest repellant and spices etc.In addition, Thymol also can be used as antioxidant, the qualification special reagent of titanium nitride, the contrast benchmark of thymol blue.Thymol is a kind of active skull cap components, and safety is high, is easy to obtain, and stable chemical nature, toxicity is low, easily degrades in the environment, the demand for development of these characteristic conforms biopesticides.
Betel nut decocting liquid has anthelmintic action, all has effect to tapeworm, roundworm, pinworm, fasciolopsis, blood fluke etc.Cutting to boil water drinking open can ascarifuge, and its insect-repellent also obtains research clinically and confirms.Especially have stronger anthelmintic action to tapeworm, this effect may be relevant with arecaline similar nicotine sample character, and the nervous system of polypide can be made to benumb.It is generally acknowledged that betel nut is the strongest to the effect of pork tapeworm, to dwarf tapeworm, fish tapeworm and fasciolopsis also have effect.In vitro test also has paralysis effect to mouse pinworm.Also there is broad-spectrum antibacterial action, be anti-inflammation, pain relieving, the Chinese traditional herbs of bringing down a fever.Infusion has inhibitory action to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphoid A bacillus, dysentery (will Hayes, Fu Shi) bacillus, bacillus enteritidis etc.
In view of the pesticide variety taking into account pesticide-germicide effect on market is few, the present invention is once put into production use, many costs will be saved for wide farmers, and the present invention's main component used is all the vegetable-derived components Thymol and arecaline that extract from the Nature, can decompose under natural environment, to crop and environmental nonpollution, belong to environment friendly agricultural.The present invention has synergistic function containing Thymol and arecaline two kinds of active components, this just avoid disease in use procedure to produce resistance and controlling object single.And about the insecticidal bactericide of Thymol and arecaline, there is not yet relevant report at home and abroad at present.
A kind of insecticidal bactericide containing Thymol and arecaline provided by the present invention, it all has excellent control efficiency to the harmful mite insect of thin dish, fruit tree, particularly has good control efficiency to aphid, coccid, tetranychid, thrips, prodenia litura, downy mildew, epidemic disease, powdery mildew, anthracnose, leaf spot etc.
Summary of the invention
The invention provides one there is synergistic function, use cost is low, effective, the insecticidal bactericide containing Thymol and arecaline of green non-pollution.
The insecticidal bactericide that the invention provides a kind of Thymol and arecaline comprises microemulsion, wetting powder, suspending agent, water dispersible granules, adds auxiliary agent and excipient, and the production technology all known according to those skilled in the art can be made into required formulation.
The pesticide-germicide microemulsion of Thymol provided by the present invention and arecaline, is made up of the component of following weight percent:
Thymol 1% ~ 30%,
Arecaline 1% ~ 30%,
Solvent 5% ~ 30%,
Emulsifier 1% ~ 8%,
Preservative 1% ~ 8%,
Surplus is water;
Wherein water is the one in running water, distilled water or deionized water.Described solvent is preferably the one in ethanol or dimethyl sulfoxide (DMSO).The preferred agriculture breast 602 of described emulsifier.Described preservative is preferably the one in nisin or 2-bromo-2-nitro-1,3-propane diol.The weight percentage of described Thymol is preferably 10% ~ 20%.The weight percentage of described arecaline is preferably 5% ~ 20%.The weight percentage of described solvent is preferably 10% ~ 25%.The weight percentage of described emulsifier is preferably 2% ~ 7%.The weight percentage of described preservative is preferably 1% ~ 5%.
The preparation method of the pesticide-germicide microemulsion of Thymol provided by the present invention and arecaline, that former for Thymol medicine, arecaline solvent are dissolved completely, add emulsifier, preservative successively, stir, water is added in gained preparation in room temperature high-speed stirred situation, constant temperature stirs evenly, and makes it to form free dispersion, homogeneous, transparent, stable liquid, is the pesticide-germicide microemulsion of Thymol and arecaline.
A kind of pesticide-germicide suspension emulsion containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 30%,
Arecaline 2% ~ 19%,
Carrier 10% ~ 70%,
Emulsifier 2% ~ 8%,
Dispersant 0.5% ~ 5%,
Wetting agent 0.1% ~ 5%
Thickener 0.5% ~ 6%,
Defoamer 0.1% ~ 0.5%,
Surplus is water.
Wherein water is the one in running water, distilled water or deionized water.Described carrier is preferably in kaolin, white carbon, sour calcium.Emulsifier is preferably Tripolyglycerol monostearates.Described dispersant is preferably sodium lignin sulfonate.Described wetting agent is preferably lauryl sodium sulfate.Described thickener is preferably xanthans.Described defoamer is preferably mineral oil.The weight percentage of described Thymol is preferably 10% ~ 20%.The weight percentage of described arecaline is preferably 5% ~ 10%.The weight percentage of described solvent is preferably 10% ~ 30%.The weight percentage of described emulsifier is preferably 3% ~ 6%.The weight percentage of described dispersant is preferably 1% ~ 3%.The weight percentage of described wetting agent is preferably 0.5% ~ 2%.The weight percentage of described thickener is preferably 1% ~ 3%.The weight percentage of described defoamer is preferably 0.15% ~ 0.25%.
Its preparation method is that Thymol, arecaline are added dispersant, wetting agent, emulsifier, thickener, defoamer successively, and surplus adds water, and stirs to dissolving completely, mixes and obtain the pesticide-germicide suspension emulsion of Thymol and arecaline.
A kind of pesticide-germicide water dispersible granules containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 40%,
Arecaline 2% ~ 19%,
Carrier 40% ~ 85%,
Dispersant 0.2% ~ 5%,
Wetting agent 1% ~ 12%,
Disintegrant 0.3% ~ 13%.
It is characterized in that described carrier is kaolin, one or more in diatomite, bentonite, white carbon, sour calcium mix arbitrarily.Dispersant is sodium lignin sulfonate, one or more in calcium lignosulfonate, alkylphenol-polyethenoxy base phosphate, sodium phosphate trimer mix arbitrarily.Wetting agent is that one or more in lauryl sodium sulfate, DBSA, nekal, dioctyl sodium sulfosuccinate mix arbitrarily.Disintegrant is that one or more in dried starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, Ac-Di-Sol mix arbitrarily.Described carrier is preferably kaolin, white carbon, and described dispersant is preferably sodium lignin sulfonate, and described wetting agent is preferably DBSA, and described disintegrant is preferably dried starch.The weight percentage of described Thymol is preferably 10% ~ 30%.The weight percentage of described carrier is preferably 50% ~ 80%.The weight percentage of described dispersant is preferably 0.5% ~ 2%.The weight percentage of described wetting agent is preferably 2% ~ 6%.The weight percentage of described disintegrant is preferably 1% ~ 5%.
Former for Thymol medicine adds in arecaline, kaolin, sodium lignin sulfonate input screw mixer to stir by a kind of pesticide-germicide suspension emulsion preparation method containing Thymol and arecaline provided by the present invention successively, carry out air-flow crushing again, carry out mixed at high speed granulation after pulverizing, be the pesticide-germicide water dispersible granules of Thymol and arecaline.
A kind of pesticide-germicide wetting powder containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 40%,
Arecaline 2% ~ 19%,
Carrier 10% ~ 60%,
Dispersant 0.2% ~ 5%,
Wetting agent 1% ~ 10%,
Bleeding agent 1% ~ 9%.
Wherein said carrier is preferably kaolin, white carbon, and described dispersant is preferably sodium lignin sulfonate, and described wetting agent is preferably DBSA, and described bleeding agent is preferably fatty alcohol-polyoxyethylene ether.The weight percentage of described Thymol is preferably 20% ~ 45%.Described carrier is preferably the weight percentage of dispersant described in 30% ~ 60%. and is preferably 0.5% ~ 2%.The weight percentage of described wetting agent is preferably 1% ~ 5%.The weight percentage of described bleeding agent is preferably 2% ~ 6%.
Former for Thymol medicine, arecaline, kaolin, sodium lignin sulfonate and fatty alcohol-polyoxyethylene ether drop in screw mixer to stir by a kind of pesticide-germicide wetting powder preparation method containing Thymol and arecaline provided by the present invention, then put into cracker and pulverize.Be the pesticide-germicide wetting powder of Thymol and arecaline.
The invention provides a kind of insecticidal bactericide containing Thymol and arecaline, wherein in formula, the extracting method of arecaline, for taking betel nut, first adds ammoniacal liquor moistening, with ether lixiviate, sucking-off ether extracted liquid obtains filtrate, and residue separately uses washed with diethylether 3 times, merge ether solution, volatilize under normal temperature.With chloroform recovery dry extract, sucking-off, filters, then with chloroform 3 times, combined chloroform extract, namely vacuum drying obtain betel nut active component.
Feature and the beneficial effect of the present composition are:
1. synergistic effect is obvious.Thymol and arecaline mixture all have notable synergistic and summation action to tetranychid, thrips, prodenia litura, downy mildew, epidemic disease, powdery mildew etc. by weight percentage.In two kinds of active component ratio of weight and number model a side gate of an imperial palaces, all meet synergism value (SR50) and be greater than l.50, have synergistic effect, wherein Thymol and arecaline active ingredient ratio of weight and number 20:l, synergy is maximum, is obviously greater than 1.50, and synergy is remarkable.
2. this Pesticidal combination can produce higher synergistic function, overcomes and has delayed insect germ pesticide resistance, and expanding prevention is composed, and pesticide-germicide speed is fast, and two kinds of different mechanism of action insecticide sterilization components combine thus insect is not easily developed immunity to drugs.
3. Thymol and arecaline are the active ingredient extracted from Maki thing, can decompose under natural environment, without chemical residual, and plantation crop green health out, and the present invention has pesticide-germicide two kinds of effects, greatly reduces the use cost of peasant household.
Embodiment
Embodiment one: take betel nut 10kg, first adds the moistening 10min of ammoniacal liquor 8L, and with 120L ether lixiviate 1 hour, separate out ether extracted liquid, residue separately used washed with diethylether 3 times, each 20L, merged ether solution, volatilized under normal temperature.Extract dry extract with chloroform 20L, separate out, filter, then with chloroform 3 times, each 8L, combined chloroform extract, namely vacuum drying obtain arecaline.
Embodiment two: the pesticide-germicide microemulsion of Thymol provided by the present invention and arecaline, is made up of the component of following weight percent:
Thymol 10%,
Arecaline 10%,
Ethanol 20%,
Agriculture breast 6025%,
Nisin 3%,
Surplus is water;
Add 1 kilogram of former medicine of Thymol in a kettle., 1 kilogram of arecaline, 2 kilograms of ethanol are stirred to and dissolve completely, after add 500 grams of agriculture breasts, 602,300 grams of nisins successively, water is added in gained preparation to gross weight 10 kilograms in room temperature high-speed stirred situation, constant temperature stirs evenly, and takes out the pesticide-germicide microemulsion that namely reactant is Thymol and arecaline after 1 hour.
Embodiment three: a kind of pesticide-germicide suspension emulsion containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 15%,
Arecaline 10%,
Kaolin 20%,
Tripolyglycerol monostearates 5%,
Sodium lignin sulfonate 2%,
Lauryl sodium sulfate 1%
Xanthans 1.5%,
Mineral oil 0.3%,
Surplus is water;
1.5 kilograms of former medicines of Thymol, 1 kilogram of arecaline, 2 kilograms of kaolin, 200 grams of sodium lignin sulfonates, 500 grams of Tripolyglycerol monostearates, 100 grams of lauryl sodium sulfate, 150 grams of xanthans, 30 grams of mineral oil are added in 5 kg water, add water to gross weight 10 kilograms, stir, porphyrize in sand mill, namely gains are the pesticide-germicide suspension emulsions of Thymol and arecaline.
Embodiment four: a kind of pesticide-germicide water dispersible granules containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 20%,
Arecaline 12%,
Sodium lignin sulfonate 2%,
DBSA 2%,
Dried starch 1%,
Surplus kaolin is filled up to 100%;
Add 2 kilograms of former medicines of Thymol, 1.2 kilograms of arecalines, 6.3 kilograms of kaolin, 200 grams of sodium lignin sulfonates, 200 grams of DBSA and 100 grams of dried starch in a kettle., after high-speed stirred is even, carry out air-flow crushing again, granulation again, obtains the pesticide-germicide water dispersible granules of Thymol and arecaline.
Embodiment five: a kind of pesticide-germicide wetting powder containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent
Thymol 30%,
Arecaline 16%,
Sodium lignin sulfonate 1.5%,
DBSA 2%,
Fatty alcohol-polyoxyethylene ether 3%,
Surplus adds kaolin to 100%;
Add in a kettle. 3 kilograms of former medicines of Thymol, 4950 grams of kaolin, 150 grams of sodium lignin sulfonates, 200 grams of DBSA and 300 grams of fatty alcohol-polyoxyethylene ether high-speed stirred are even, take out reactant after 30 minutes to put into cracker and pulverize, sieve.Namely gains are the pesticide-germicide wetting powders of Thymol and arecaline.
Embodiment six: by above embodiment two---five medicaments prepared carry out field diamond-back moth control
(1) test method: to be tested on June 12nd, 2015 to June 22 the growing vegetables base, the large pool in Chengmai, Hainan Province and carry out.Test is carried out routine when diamond-back moth is 1 ~ 2 instar larvae peak period by each process design concentration and is watered spraying, and the every mu of amount of being watered is 30kg, makes every effort to evenly thoughtful during spray medicine.Investigation method, diagonal 5 sampling is pressed in dispenser Qian Mei community, often some wild cabbage 10 ~ 11 strain (depending on insect density) choosing Eggs of Diamondback Moth and larva, diamondback moth larvae head number in probability demarcation strain, in this, as insect population radix before dispenser, after dispenser the 3rd, 7, lOd investigates the diamondback moth larvae number determining residual survival in strain, respectively to correct Revision insect recluced rate as control efficiency.
(2) drug effect computational methods
Revision insect recluced rate (%)=(larva number of surviving after medicine prelarva radix-medicine)/medicine prelarva radix * 100
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-blank district Revision insect recluced rate)/(100-blank district Revision insect recluced rate) * 100
(3) poisoning investigation method
Duration of test observes each process community wild cabbage well-grown, all finds no poisoning phenomenon and occurs.
(4) field control effectiveness test result of the test is as follows
Table 1 treatment agent control wild cabbage diamond-back moth field control effectiveness test result
As can be seen from Table 1, the Mixed Pharmacy of different proportion, carries out field experiment by different consumptions, and after medicine, it is all better than the former medicine of contrast medicament 20% Thymol to the control efficiency of wild cabbage diamond-back moth, and control diamond-back moth quick-acting is fast, and efficiency time is long, and control efficiency is good.Insecticidal effect increases progressively along with the increase of consumption.According to experimental observation, each medication process to wild cabbage all without poisoning, simultaneously also find that it also has good control efficiency to insects such as diamond-back moths, the wild cabbage of the former medicine process of other 20% Thymol occurs that disease is more, than with the much about lO%-l5% of the disease plant of complex preparation.
Embodiment seven field trial: to the preventive effect of powdery mildew of cucumber
(1) experimental field basic condition:
Experimental field be located at Hainan, the cucumber field selecting occurring degree medium is that experimental field soil fertility is medium, and irrigation and drainage are convenient.Dispenser weather on the same day is clear to cloudy, mean temperature of air 30 DEG C, relative moisture 80%, southerly 2 ~ 3 grades; Fine day, mean temperature of air 30 DEG C, relative moisture 75%, southerly 2-3 level.
(2) spraying time and method
At powdery mildew of cucumber their early stage (August 7) spray the 1st medicine, after 7d, (August 14) spray second time medicine, sprays 2 times altogether.Carry out foliar spray.
(3) pilot survey and data processing
Investigation state of an illness radix before medicine, test is investigated 3 times altogether, i.e. disease index investigation before medicine, preventive effect investigation in 3 days after the 1st medicine, 7 days and preventive effect investigation in 10 days after 2 medicines.
(4) drug effect computational methods
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 1OO
Control efficiency (%)=[1-(before 8.62 blank district medicines after disease index × treatment region medicine disease index)/(after 9.16 blank district medicines before disease index × treatment region medicine disease index)] × 100
(5) poisoning investigation method
Whether after dispenser, continuous 7d estimates medicament has poisoning to crop.
(6) experimental result and analysis
The test effect of powdery mildew of cucumber prevented and treated by table 2 respectively group test medicine process
Interpretation of result: as shown in Table 2, it is remarkable that the mixture combination of Thymol and arecaline prevents and treats the effectiveness comparison of powdery mildew of cucumber, bactericidal effect increases progressively along with the increase of consumption, several test medicine contrast, 46% pesticide-germicide wetting powder bactericidal effect is more outstanding, first time medicine after 3 days, 7 days and 10 days preventive effects 93.98%, 95.81% and 97.20% the highest after second time medicine, the Be very effective of complex preparation is better than the former prescription agent of 20% Thymol, not only significantly improve the effect to powdery mildew of cucumber, and extend its lasting period further.According to experimental observation, with the cucumber of the former medicine process of 20% Thymol, each medication process all without poisoning, occurs that insect pest is comparatively serious to cucumber simultaneously, than with the much about lO%-15% of the insect pest plant of complex preparation.
Claims (10)
1. the insecticidal bactericide that the invention provides a kind of Thymol and arecaline comprises microemulsion, wetting powder, suspending agent, water dispersible granules, adds auxiliary agent and excipient, and the production technology all known according to those skilled in the art can be made into required formulation.
2. the pesticide-germicide microemulsion of Thymol provided by the present invention and arecaline, is made up of the component of following weight percent:
Thymol 1% ~ 30%,
Arecaline 1% ~ 30%,
Solvent 5% ~ 30%,
Emulsifier 1% ~ 8%,
Preservative 1% ~ 8%,
Surplus is water;
It is characterized in that water is the one in running water, distilled water or deionized water, described solvent is preferably the one in ethanol or dimethyl sulfoxide (DMSO), the preferred agriculture breast 602 of described emulsifier, described preservative is preferably the one in nisin or 2-bromo-2-nitro-1,3-propane diol.
3. according to claim 2, it is characterized in that the weight percentage of described Thymol is preferably 10% ~ 20%, the weight percentage of described arecaline is preferably 5% ~ 20%, the weight percentage of described solvent is preferably 10% ~ 25%, the weight percentage of described emulsifier is preferably 2% ~ 7%, and the weight percentage of described preservative is preferably 1% ~ 5%; The preparation method of the pesticide-germicide microemulsion of Thymol provided by the present invention and arecaline, that former for Thymol medicine, arecaline solvent are dissolved completely, add emulsifier, preservative successively, stir, water is added in gained preparation in room temperature high-speed stirred situation, constant temperature stirs evenly, and makes it to form free dispersion, homogeneous, transparent, stable liquid, is the pesticide-germicide microemulsion of Thymol and arecaline.
4. a kind of pesticide-germicide suspension emulsion containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 30%,
Arecaline 2% ~ 19%,
Carrier 10% ~ 70%,
Emulsifier 2% ~ 8%,
Dispersant 0.5% ~ 5%,
Wetting agent 0.1% ~ 5%,
Thickener 0.5% ~ 6%,
Defoamer 0.1% ~ 0.5%,
Surplus is water;
It is characterized in that described water is the one in running water, distilled water or deionized water, described carrier is preferably in kaolin, white carbon, sour calcium, emulsifier is preferably Tripolyglycerol monostearates, described dispersant is preferably sodium lignin sulfonate, described wetting agent is preferably lauryl sodium sulfate, described thickener is preferably xanthans, and described defoamer is preferably mineral oil.
5. according to claim 4, it is characterized in that the weight percentage of described Thymol is preferably 10% ~ 20%, the weight percentage of described arecaline is preferably 5% ~ 10%, the weight percentage of described solvent is preferably 10% ~ 30%, the weight percentage of described emulsifier is preferably 3% ~ 6%, the weight percentage of described dispersant is preferably 1% ~ 3%, the weight percentage of described wetting agent is preferably 0.5% ~ 2%, the weight percentage of described thickener is preferably 1% ~ 3%, the weight percentage of described defoamer is preferably 0.15% ~ 0.25%, its preparation method is that Thymol, arecaline are added dispersant, wetting agent, emulsifier, thickener, defoamer successively, and surplus adds water, and stirs to dissolving completely, mixes and obtain the pesticide-germicide suspension emulsion of Thymol and arecaline.
6. a kind of pesticide-germicide water dispersible granules containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 40%,
Arecaline 2% ~ 19%,
Carrier 40% ~ 85%
Dispersant 0.2% ~ 5%,
Wetting agent 1% ~ 12%,
Disintegrant 0.3% ~ 13%;
It is characterized in that described carrier is preferably kaolin, white carbon, described dispersant is preferably sodium lignin sulfonate, and described wetting agent is preferably DBSA, and described disintegrant is preferably dried starch.
7. according to claim 6, it is characterized in that the weight percentage of described Thymol is preferably 10% ~ 30%, the weight percentage of described carrier is preferably 50% ~ 80%, the weight percentage of described dispersant is preferably 0.5% ~ 2%, the weight percentage of described wetting agent is preferably 2% ~ 6%, and the weight percentage of described disintegrant is preferably 1% ~ 5%; Its preparation method is added successively by former for Thymol medicine in arecaline, kaolin, sodium lignin sulfonate input screw mixer to stir, carry out air-flow crushing again, carry out mixed at high speed granulation after pulverizing, be the pesticide-germicide water dispersible granules of Thymol and arecaline.
8. a kind of pesticide-germicide wetting powder containing Thymol and arecaline provided by the present invention, is made up of the component of following weight percent:
Thymol 1% ~ 40%,
Arecaline 2% ~ 19%,
Carrier 10% ~ 60%,
Dispersant 0.2% ~ 5%,
Wetting agent 1% ~ 10%,
Bleeding agent 1% ~ 9%;
It is characterized in that described carrier is preferably kaolin, white carbon, described dispersant is preferably sodium lignin sulfonate, and described wetting agent is preferably DBSA, and described bleeding agent is preferably fatty alcohol-polyoxyethylene ether.
9. according to Claim 8, it is characterized in that the weight percentage of described Thymol is preferably 20% ~ 45%, described carrier is preferably 30% ~ 60%, the weight percentage of described dispersant is preferably 0.5% ~ 2%, the weight percentage of described wetting agent is preferably 1% ~ 5%, and the weight percentage of described bleeding agent is preferably 2% ~ 6%; Its preparation method former for Thymol medicine, arecaline, kaolin, sodium lignin sulfonate and fatty alcohol-polyoxyethylene ether is dropped in screw mixer to stir, put into cracker again to pulverize, be the pesticide-germicide wetting powder of Thymol and arecaline.
10. a kind of insecticidal bactericide containing Thymol and arecaline provided by the present invention, it all has excellent control efficiency to the harmful mite insect of thin dish, fruit tree, particularly has good control efficiency to aphid, coccid, tetranychid, thrips, prodenia litura, downy mildew, epidemic disease, powdery mildew, anthracnose, leaf spot etc.
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