CN105123746A - Compound composition containing dufulin and bromothalonil and bactericide - Google Patents
Compound composition containing dufulin and bromothalonil and bactericide Download PDFInfo
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- CN105123746A CN105123746A CN201510466650.XA CN201510466650A CN105123746A CN 105123746 A CN105123746 A CN 105123746A CN 201510466650 A CN201510466650 A CN 201510466650A CN 105123746 A CN105123746 A CN 105123746A
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- Prior art keywords
- bromothalonil
- bactericide
- fluorine phosphorus
- complex composition
- compound composition
- Prior art date
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- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 35
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 35
- 150000001875 compounds Chemical class 0.000 title abstract 5
- CLASFMUIFVKHQI-UHFFFAOYSA-N n-[diethoxyphosphoryl-(2-fluorophenyl)methyl]-4-methyl-1,3-benzothiazol-2-amine Chemical compound N=1C2=C(C)C=CC=C2SC=1NC(P(=O)(OCC)OCC)C1=CC=CC=C1F CLASFMUIFVKHQI-UHFFFAOYSA-N 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 201000010099 disease Diseases 0.000 claims abstract description 13
- ZHQXROVTUTVPGO-UHFFFAOYSA-N [F].[P] Chemical compound [F].[P] ZHQXROVTUTVPGO-UHFFFAOYSA-N 0.000 claims description 52
- 239000003905 agrochemical Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 6
- 231100000331 toxic Toxicity 0.000 claims description 6
- 230000002588 toxic effect Effects 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 3
- 231100000572 poisoning Toxicity 0.000 claims description 2
- 230000000607 poisoning effect Effects 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 abstract description 10
- 230000002195 synergetic effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 239000000447 pesticide residue Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 25
- 239000002574 poison Substances 0.000 description 22
- 231100000614 poison Toxicity 0.000 description 22
- 231100000419 toxicity Toxicity 0.000 description 14
- 230000001988 toxicity Effects 0.000 description 14
- 230000003449 preventive effect Effects 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 241000700605 Viruses Species 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 240000007594 Oryza sativa Species 0.000 description 7
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000002131 composite material Substances 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 239000012752 auxiliary agent Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000009736 wetting Methods 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 241000227653 Lycopersicon Species 0.000 description 5
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 241000607479 Yersinia pestis Species 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 244000061176 Nicotiana tabacum Species 0.000 description 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 4
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 235000019837 monoammonium phosphate Nutrition 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- FSLGRPCWSUDGGH-UHFFFAOYSA-N 2-methylnaphthalene-1-sulfonic acid;sodium Chemical compound [Na].C1=CC=CC2=C(S(O)(=O)=O)C(C)=CC=C21 FSLGRPCWSUDGGH-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 2
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 229940073769 methyl oleate Drugs 0.000 description 2
- 235000019691 monocalcium phosphate Nutrition 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 description 2
- 235000011151 potassium sulphates Nutrition 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000031968 Cadaver Diseases 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 101710096342 Pathogenesis-related protein Proteins 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 241000626572 Xanthomonas oryzae pv. oryzicola Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- -1 amino phosphonate ester Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002507 anti-phytoviral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- CWFOCCVIPCEQCK-UHFFFAOYSA-N chlorfenapyr Chemical compound BrC1=C(C(F)(F)F)N(COCC)C(C=2C=CC(Cl)=CC=2)=C1C#N CWFOCCVIPCEQCK-UHFFFAOYSA-N 0.000 description 1
- 238000012505 colouration Methods 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 238000007599 discharging Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
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- 238000004848 nephelometry Methods 0.000 description 1
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- 235000020232 peanut Nutrition 0.000 description 1
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- 241000894007 species Species 0.000 description 1
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- 230000003612 virological effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a compound composition containing dufulin and bromothalonil and a bactericide thereof. The compound composition is composed of dufulin and bromothalonil. The weight ratio of dufulin to bromothalonil is 50:1-1:50, and preferably, the weight ratio of dufulin to bromothalonil is 20:1-1:40. The compound composition accounts for 0.1 to 80% of the total weight of the bactericide. The provided compound composition and bactericide thereof have a prominent synergetic effect on controlling crop diseases, improve the bacterium-killing effect, reduce the using amount of pesticide, reduce the environment pollution and pesticide residue, and delay or prevent the generation of drug resistance.
Description
Technical field
The present invention relates to technical field of pesticide, be specifically related to complex composition and the preparation of two fungicide active ingredient mixtures.
Background technology
Chlorfenapyr, No. CAS is 35691-65-7, English name bromothalonil, and it is known in the art and disclosed pesticide species.It is the bactericide of a kind of wide spectrum, efficient, low toxicity, has good control efficiency, have special efficacy to anthracnose to corps diseases.Be widely used in the various crop such as fruit tree, grape, vegetables, cotton, peanut, watermelon, tobacco, tea tree, flowers and prevent and treat multiple diseases.But along with its frequency of utilization improves, pathogen resistance level improves, and preventive effect declines, and alonely prevents and treats crop pest, and the using dosage of agricultural chemicals is large.
And malicious fluorine phosphorus is applicant is transferred the possession of the plant virus resistance product (patent No. ZL200510003041.7) of new generation come by Guizhou University, it is a kind of novel Antiphytoviral medicament of fluorine-containing amino phosphonate ester of novel structure, by activating tobacco bigcatkin willow acid signal conduction path, improve the salicylic content of signaling molecule, thus promote the expression of downstream pathogenesis-related proteins; Anti-virus ability is obtained by evoking tobacco PAL, POD, SOD Defense Enzyme Activities; The invasion of virus to host is reduced by assembling TMV particle.In view of its characteristic such as novel structure, mechanism of action uniqueness, though malicious fluorine phosphorus is remarkably productive for preventing and treating virus disease, control spectrum is narrow.
In this area, utilizing the pesticide active ingredient of the different mechanism of action to carry out composite is the one mode effectively efficiently developed pesticide new product at present and prevent and treat resistance damage by disease and insect.Different pesticide active ingredient carry out composite after, three kinds of type of action can be shown: summation action, synergistic effect and antagonism.Find through test, malicious fluorine phosphorus and bromothalonil mixture prevent and treat crop pest, and synergistic effect is remarkable.
Do not find the relevant report of the complex composition of malicious fluorine phosphorus and bromothalonil at present.
Summary of the invention
By Given this, for the deficiency that prior art exists, the object of the present invention is to provide complex composition and the bactericide thereof of a kind of toxic fluorine phosphorus and bromothalonil.This complex composition and bactericide thereof have obvious synergistic function relative to single dose, improve control efficiency, reduce the usage amount of agricultural chemicals, delay the pesticide resistance of pathogen simultaneously.
To achieve these goals, the technical solution used in the present invention is:
There is provided the complex composition of a kind of toxic fluorine phosphorus and bromothalonil, this complex composition is made up of malicious fluorine phosphorus and bromothalonil, and the weight ratio of its poisoning fluorine phosphorus and bromothalonil is 50:1 to 1:50.
Preferably, the weight ratio of above-described malicious fluorine phosphorus and bromothalonil is 20:1 to 1:30.
Present invention also offers a kind of bactericide containing the above malicious fluorine phosphorus and bromothalonil compounded composition, described complex composition accounts for 0.1% ~ 80% of described bactericide gross weight.Preferably, described complex composition accounts for 5% ~ 60% of the gross weight of described bactericide.
Bactericide provided by the invention, except containing except above-described malicious fluorine phosphorus and bromothalonil compounded composition, also contains acceptable auxiliary element on agricultural chemicals.
In embodiment provided by the invention, on agricultural chemicals, acceptable auxiliary element is the mixture of a kind of and auxiliary agent in carrier, solvent.
Auxiliary agent of the present invention can comprise one or more in emulsifier, wetting dispersing agent, defoamer, thickener and antifreezing agent as required.Other function additives that the industry is conventional can also be comprised as required.
Described carrier is precipitated calcium carbonate, kaolin, white carbon, bentonite, diatomite, potassium sulfate, ammonium dihydrogen phosphate (ADP), urea, calcium dihydrogen phosphate.
Described solvent is water, cyclohexanone, methyl oleate.
Described emulsifier, wetting dispersing agent are sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, neopelex, the formaldehyde condensation products of methyl naphthalene sulfonic acid sodium, alkylphenol-polyethenoxy base phosphate, alkylnaphthalene sulfonate, styrylphenol polyoxyethylene ether, alkyl benzene sulfonate calcium salt, sodium carboxymethylcellulose, lauryl sodium sulfate, alkylaryl polyoxyethylene polyoxypropylene ether, agriculture breast 500#, alkylphenol-polyethenoxy base ether.
Described binding agent is starch, aluminium-magnesium silicate, polyvinyl alcohol.
Described disintegrant is sodium sulphate, sodium bicarbonate.
Described thickener is xanthans.
Described antifreezing agent is ethylene glycol.
Described defoamer is organosilicon.
Described warning colouration is acid red.
The auxiliary agent that the embodiment of the present invention uses is not limited only to this, can also comprise other auxiliary agents that this area is conventional.
The bactericide of the above toxic fluorine phosphorus and bromothalonil compounded composition, the formulation of bactericide is wettable powder, water dispersible granules, suspending agent, seed treatment dry powder doses, ultra low volume liquids or granule, and other formulations that other agricultural chemicals can be prepared.
The application in crop pest prevented and treated by bactericide provided by the invention.
Compared with prior art, tool has the following advantages for complex composition of the present invention and bactericide:
1, malicious fluorine phosphorus and bromothalonil compounded have obvious synergistic function, and the co-toxicity coefficient preventing and treating crop pest in the proportion limited is greater than 120, and both are composite is not simple superposition.The more each single dose of bactericide bactericidal effect containing complex composition is significantly improved.
2, the dosage of bactericide of the present invention is fewer than single dose, but the preventive effect of controlling disease is higher than the preventive effect of single dose by more than 20%.After second time medicine, the field efficacy of 14 days is more than 85%, and the lasting period is long.
3, bactericidal composition of the present invention adopts malicious fluorine phosphorus and bromothalonil compounded, also slows down the pesticide resistance of pathogen to malicious fluorine phosphorus or bromothalonil single dose.
Embodiment
The present invention's the following example is described, but does not limit the scope of the invention.Du Fu Lin Yuanyaoshi Guangxi Tianyuan Biochemical Co., Ltd. used in the present invention provides, and other former medicines used and medicament are commercial.
Embodiment prepared by bactericide:
In the following embodiments, to complex composition further instruction of the present invention, but it is never limit scope of the present invention.
One, the preparation method of wettable powder:
After auxiliary agent, the carrier mixing such as poison fluorine phosphorus former medicine, the former medicine of bromothalonil, wetting dispersing agent, add in cracker and be crushed to granularity and meet the requirements, discharging also stirs, and obtains the wettable powder of bactericide of the present invention.
Embodiment 1:41% poison fluorine phosphorus bromothalonil wettable powder (40:1)
Poison fluorine phosphorus 40%, bromothalonil 1%, sodium lignin sulfonate 2%, sodium metnylene bis-naphthalene sulfonate 5%, precipitated calcium carbonate 5%, kaolin supplies 100%.
Embodiment 2:80% poison fluorine phosphorus bromothalonil wettable powder (4:1)
Poison fluorine phosphorus 64%, bromothalonil 16%, neopelex 3%, the formaldehyde condensation products 4% of methyl naphthalene sulfonic acid sodium, white carbon 2%, bentonite supplies 100%.
Two, the preparation method of water dispersible granules: after the auxiliary agents such as the former medicine of malicious fluorine phosphorus, the former medicine of bromothalonil, wetting dispersing agent, carrier mixing, add in cracker and pulverize, carry out fluidized bed prilling after having pulverized, granulation completes, and carries out drying, the screening i.e. water dispersible granules of obtained bactericide of the present invention.
Embodiment 3:51% poison fluorine phosphorus bromothalonil water dispersible granule (1:50)
Poison fluorine phosphorus 1%, bromothalonil 50%, sodium lignin sulfonate 2%, sodium metnylene bis-naphthalene sulfonate 5%, starch 2%, sodium sulphate 6%, kaolin supplies 100%.
Embodiment 4:60% poison fluorine phosphorus bromothalonil water dispersible granule (1:2)
Poison fluorine phosphorus 20%, bromothalonil 40%, alkylphenol-polyethenoxy base phosphate 3%, alkylnaphthalene sulfonate 5%, aluminium-magnesium silicate 2%, sodium bicarbonate 10%, diatomite supplies 100%.
Three, the preparation method of suspending agent: the former medicine of malicious fluorine phosphorus, the former medicine of bromothalonil, emulsifier and a small amount of water are ground in sand mill, after having ground, by in material suction high-speed shearing machine, add antifreezing agent again, thickener, the water of surplus, defoamer carry out high speed shear, shear the suspending agent of rear obtained bactericide of the present invention.
Embodiment 5:21% poison fluorine phosphorus bromothalonil suspending agent (20:1)
Poison fluorine phosphorus 20%, bromothalonil 1%, styrylphenol polyoxyethylene ether 5%, alkyl benzene sulfonate calcium salt 2.5%, sodium carboxymethylcellulose 2%, xanthans 0.2%, ethylene glycol 2%, silicone defoaming agent 0.1%, water supplies 100%.
Embodiment 6:26% poison fluorine phosphorus bromothalonil suspending agent (1:2.5)
Poison fluorine phosphorus 1%, bromothalonil 25%, styrylphenol polyoxyethylene ether 3%, the formaldehyde condensation products 4% of methyl naphthalene sulfonic acid sodium, sodium carboxymethylcellulose 5%, xanthans 0.2%, ethylene glycol 3%, silicone defoaming agent 0.1%, water supplies 100%.
Embodiment 7:9.3% poison fluorine phosphorus bromothalonil seed treatment dry powder doses (1:30)
Poison fluorine phosphorus 9%, bromothalonil 0.3%, sodium metnylene bis-naphthalene sulfonate 2%, lauryl sodium sulfate 3%, polyvinyl alcohol 2%, azogeramine .5%, kaolin supplies 100%.By above-mentioned formula, premixed is even in proportion, then carries out pulverizing, stirring, i.e. obtained 9.3% malicious fluorine phosphorus bromothalonil seed treatment dry powder doses.
Embodiment 8:6% poison fluorine phosphorus bromothalonil ultra low volume liquids (5:1)
Poison fluorine phosphorus 5%, bromothalonil 1%, cyclohexanone 10%, alkylaryl polyoxyethylene polyoxypropylene ether 6%, agriculture breast 500#2%, methyl oleate supplies 100%.By above-mentioned formula mix and blend 20-30 minute in mixing kettle in proportion, i.e. obtained 6% malicious fluorine phosphorus bromothalonil ultra low volume liquids.
Embodiment 9:0.4% poison fluorine phosphorus bromothalonil granule (1:1)
Poison fluorine phosphorus 0.2%, bromothalonil 0.2%, alkylphenol-polyethenoxy base ether 1%, lauryl sodium sulfate 3%, polyvinyl alcohol 1%, potassium sulfate 5%, ammonium dihydrogen phosphate (ADP) 15%, urea supplies 100%.By above-mentioned formula, premixed is even in proportion, and air-flow crushing, adds suitable quantity of water kneading, granulation, is drying to obtain 0.4% malicious fluorine phosphorus bromothalonil granule.
Embodiment 10:5% poison fluorine phosphorus bromothalonil granule (1:4)
Poison fluorine phosphorus 1%, bromothalonil 4%, sodium carboxymethylcellulose 4%, lauryl sodium sulfate 1%, polyvinyl alcohol 2.5%, urea 20%, calcium dihydrogen phosphate 10%, kaolin supplies 100%.By above-mentioned formula, premixed is even in proportion, and air-flow crushing, then mediates granulation, is drying to obtain 5% malicious fluorine phosphorus bromothalonil granule.
Indoor bioassay is tested:
Bactericidal composition of the present invention, combines between them and has obvious synergistic function to disease, and be not only the simple addition of two kinds of pharmacy effects, is specifically illustrated with following Assays Example.
Below raw test is tested and is adopted Sun Yun abundant method calculating co-toxicity coefficient (CTC) to evaluate mixed effect.
Toxicity index TI (B)=(EC of standard agent A
50the EC of ÷ B agent
50) × 100
Actual toxicity index ATI (AB)=(EC of A
50the EC of ÷ AB
50) × 100
Theoretical toxicity index TTI (AB)=TI (the A) × A percentage+TI (B) in the mixture × percentage of B in mixture
Actual measurement toxicity index (ATI)=(standard agent EC
50÷ reagent agent EC
50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI) ÷ mixture] × 100
Evaluation criterion: (CTC) >=120 show as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Toxicity Determination embodiment one
Test method: adopt in vitro nephelometry to carry out Toxicity Determination, selects bacterial leaf streak of rice to be target target, repeats 4 times, latter 24 hours check results of investigating.Be independent variable x with drug concentration (mg/l) logarithm value, with the probit value of the corrected mortality of its correspondence for dependent variable y, set up virulence regression equation respectively, obtain the co-toxicity coefficient of two single dose different ratio.Experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect.
Concrete grammar: adopt in vitro Nephelometric Determination, design concentration on the basis of preliminary experiment, each medicament is joined respectively in NA liquid nutrient medium, gradient dilution makes pastille medium, Inoculated Rice Xanthomonas campestris PV.oryzicola is placed on 28 DEG C of about shaken cultivation 24h, its turbidity (turbidity and bacterium amount be changing into positive correlation) is measured with transmissometer, the inhibiting rate that each chemicals treatment breeds bacterial growth is calculated according to the turbidity of blank and the turbidity of process, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of serial drug concentration, obtain the EC of each medicament
50value, CTC value.Test result refers to table 1.
The joint toxicity measuring result of bacterial leaf streak of rice prevented and treated by table 1
From the measurement result of table 1, the co-toxicity coefficient of malicious fluorine phosphorus and bromothalonil composite control bacterial leaf streak of rice in the scope of 50:1 to 1:50 is greater than 120, shows that both are composite and has obvious synergistic function.
Toxicity Determination embodiment two
Test method: indoor pot tobacco susceptible variety plant, to the 4-5 leaf phase, with the isopyknic viral juice frictional inoculation of liquid mixing of different ratio variable concentrations, often processes 3 strains, often to select good strains in the field for seed 3 leaves, repeat 4 times, 3-4 days " Invest, Then Investigate " withered spot numbers, calculate inhibiting rate, use EC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient.Measurement result is in table 2.
The joint toxicity measuring result of tomato virus disease prevented and treated by table 2
From the measurement result of table 2, the co-toxicity coefficient of malicious fluorine phosphorus and bromothalonil composite control tomato virus disease in the scope of 50:1 to 1:50 is greater than 120, shows that both are composite and has obvious synergistic function.
Field medicine effect test embodiment:
In order to clear and definite malicious fluorine phosphorus and bromothalonil compounded are to the control efficiency of crop pest, present invention applicant at home different regions has carried out a large amount of field trials.Illustrate with several fields embodiment below.
Contrast medicament 1:30% poison fluorine phosphorus wetting powder, registration card LS20130359, Guangxi Tianyuan Biochemical Co., Ltd. produces.
Contrast medicament 2:25% bromothalonil wetting powder, registration card PD20080673, Jiangsu Tuoqiu Agrochemicals Co., Ltd. produces.
Field trial embodiment 1:
Test method and investigation computational methods: with reference to " GB/T17980.105-2004 pesticide field efficacy medicine test criterion (two) the 105th part: bactericidal agent for preventing and treating bacterial leaf streak of rice " test.Result of the test is in table 3.
The field control effectiveness test result of bacterial leaf streak of rice prevented and treated by table 3
As shown in Table 3, when active ingredient dosage is fewer than single dose dosage, bactericide of the present invention is for preventing and treating bacterial leaf streak of rice, and after second time medicine, the preventive effect of 7d and 14d is all high than the preventive effect of single dose for result of the test.Wherein after second time medicine, the preventive effect of 7d is higher than the preventive effect of single dose by 21.61% ~ 33.72%.And the preventive effect of 14d is still more than 85.58%, the lasting period is long, reduces mu dosage and cost.
Field trial embodiment 2:
Test method: test method and investigation method: with reference to " NY/T1464.8-2007 pesticide field efficacy medicine test criterion the 8th part: bactericidal agent for preventing and treating tomato virus disease ", disease occur before or initial stage of origination first time spray dispenser, after 5d second time spray dispenser.Dispenser twice altogether, each process plot area is 20m
2, number of repetition 4 times.
Investigation method: 7d, 14d investigation before dispenser and after last dispenser, random 5 samplings in every community, get 6 strains at often, investigate total strain number, diseased plant number at different levels.Result of the test is in table 4.
The field control effectiveness test result of tomato virus disease prevented and treated by table 4
As shown in Table 4, when active ingredient dosage is fewer than single dose dosage, after bactericidal agent for preventing and treating tomato virus disease second time medicine of the present invention, the preventive effect of 7d and 14d is all high than the preventive effect of single dose for result of the test.Wherein, after second time medicine, the preventive effect of 7d is higher than the preventive effect of single dose by 20.46% ~ 43.88%, and the preventive effect of 14d is still between 87.16% ~ 94.30%, and the lasting period is long, reduces mu dosage and cost.
Claims (7)
1. a complex composition for toxic fluorine phosphorus and bromothalonil, is characterized in that, described complex composition is made up of malicious fluorine phosphorus and bromothalonil; The weight ratio of its poisoning fluorine phosphorus and bromothalonil is 50:1 to 1:50.
2. the complex composition of toxic fluorine phosphorus according to claim 1 and bromothalonil, is characterized in that, the weight ratio of described malicious fluorine phosphorus and bromothalonil is 20:1 to 1:30.
3. the bactericide containing the arbitrary described complex composition of claim 1-2, it is characterized in that, described complex composition accounts for 0.1% ~ 80% of described bactericide gross weight.
4. bactericide according to claim 3, is characterized in that, described complex composition accounts for 5% ~ 60% of described bactericide gross weight.
5. bactericide according to claim 3, is characterized in that, described bactericide is also containing acceptable auxiliary element on agricultural chemicals.
6. bactericide according to claim 3, is characterized in that, the formulation of described bactericide is wettable powder, water dispersible granules, suspending agent, seed treatment dry powder doses, ultra low volume liquids or granule.
7. according to the arbitrary described application of bactericide in controlling plant diseases of claim 3 ~ 6.
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| CN107711858A (en) * | 2017-10-24 | 2018-02-23 | 邓杵娇 | A kind of complex composition containing gold alloy hydride and bromothalonil |
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|---|---|---|---|---|
| CN1291993C (en) * | 2005-04-04 | 2006-12-27 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-O,O-dialkyl-α-amino phosphonate derivatives, preparation method and use |
| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN104798798A (en) * | 2014-01-26 | 2015-07-29 | 沈阳化工研究院有限公司 | Binary composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291993C (en) * | 2005-04-04 | 2006-12-27 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-O,O-dialkyl-α-amino phosphonate derivatives, preparation method and use |
| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN104798798A (en) * | 2014-01-26 | 2015-07-29 | 沈阳化工研究院有限公司 | Binary composition and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107711858A (en) * | 2017-10-24 | 2018-02-23 | 邓杵娇 | A kind of complex composition containing gold alloy hydride and bromothalonil |
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