CN105123746B - A kind of complex composition and bactericide containing toxic fluoride phosphate and bromothalonil - Google Patents
A kind of complex composition and bactericide containing toxic fluoride phosphate and bromothalonil Download PDFInfo
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- CN105123746B CN105123746B CN201510466650.XA CN201510466650A CN105123746B CN 105123746 B CN105123746 B CN 105123746B CN 201510466650 A CN201510466650 A CN 201510466650A CN 105123746 B CN105123746 B CN 105123746B
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- Prior art keywords
- bromothalonil
- fluoride phosphate
- bactericide
- toxic fluoride
- complex composition
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- FQKMRXHEIPOETF-UHFFFAOYSA-N F.OP(O)(O)=O Chemical compound F.OP(O)(O)=O FQKMRXHEIPOETF-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 231100000331 toxic Toxicity 0.000 title claims abstract description 58
- 230000002588 toxic effect Effects 0.000 title claims abstract description 58
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 34
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 19
- 201000010099 disease Diseases 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 8
- 239000003905 agrochemical Substances 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 150000002825 nitriles Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 21
- 239000000575 pesticide Substances 0.000 abstract description 8
- 230000009471 action Effects 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 4
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 14
- 231100000419 toxicity Toxicity 0.000 description 14
- 230000001988 toxicity Effects 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 230000003449 preventive effect Effects 0.000 description 12
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 8
- 240000007594 Oryza sativa Species 0.000 description 7
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 241000227653 Lycopersicon Species 0.000 description 5
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- 239000012752 auxiliary agent Substances 0.000 description 5
- 239000013530 defoamer Substances 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 244000061176 Nicotiana tabacum Species 0.000 description 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- 239000004562 water dispersible granule Substances 0.000 description 4
- 238000009736 wetting Methods 0.000 description 4
- FSLGRPCWSUDGGH-UHFFFAOYSA-N 2-methylnaphthalene-1-sulfonic acid;sodium Chemical compound [Na].C1=CC=CC2=C(S(O)(=O)=O)C(C)=CC=C21 FSLGRPCWSUDGGH-UHFFFAOYSA-N 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- -1 amino phosphonate ester Chemical class 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 2
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 2
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 229940073769 methyl oleate Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000019837 monoammonium phosphate Nutrition 0.000 description 2
- 235000019691 monocalcium phosphate Nutrition 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 description 2
- 235000011151 potassium sulphates Nutrition 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 208000031968 Cadaver Diseases 0.000 description 1
- 101100389431 Caenorhabditis elegans enol-1 gene Proteins 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 229910001051 Magnalium Inorganic materials 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 101710096342 Pathogenesis-related protein Proteins 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 241000626572 Xanthomonas oryzae pv. oryzicola Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- ZHQXROVTUTVPGO-UHFFFAOYSA-N [F].[P] Chemical compound [F].[P] ZHQXROVTUTVPGO-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002507 anti-phytoviral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- PANBYUAFMMOFOV-UHFFFAOYSA-N sodium;sulfuric acid Chemical compound [Na].OS(O)(=O)=O PANBYUAFMMOFOV-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention discloses a kind of complex composition and its bactericide containing toxic fluoride phosphate and bromothalonil.The complex composition is made up of toxic fluoride phosphate and bromothalonil；Wherein, toxic fluoride phosphate and the weight of bromothalonil ratio are 50:1 to 1:50, it is preferable that toxic fluoride phosphate and the weight of bromothalonil ratio are 20:1 to 1:40.The complex composition containing toxic fluoride phosphate and bromothalonil accounts for 0.1% the 80% of bactericide gross weight.The complex composition and its bactericidal agent for preventing and treating crop disease of the present invention has significant synergies, and improves bactericidal effect, also reduces dosage, reduces environmental pollution and residues of pesticides；The resistance to the action of a drug for delaying or resisting germ is produced.
Description
Technical field
The present invention relates to technical field of pesticide, and in particular to the complex composition and system of two fungicide active ingredient mixtures
Agent.
Background technology
Bromothalonil, No. CAS is 35691-65-7, English name bromothalonil, and it is known in the art and disclosed
Pesticide species.It is a kind of wide spectrum, the efficient, bactericide of low toxicity, has preferable prevention effect to corps diseases, to anthracnose
There is special efficacy.It is widely used in the anti-Zhiduo County of the various crops such as fruit tree, grape, vegetables, cotton, peanut, watermelon, tobacco, tea tree, flowers
Plant disease.But with it frequency of use improve, pathogen resistance level improve, preventive effect decline, and it is alone prevent and treat crop disease,
The dosage of agricultural chemicals is big.
And toxic fluoride phosphate is the plant virus resistance product (patent No. of new generation that applicant is come by Guizhou University's transfer
ZL200510003041.7), it is a kind of novel new Antiphytoviral medicament of fluorine-containing amino phosphonate ester of structure, can be passed through
Tobacco bigcatkin willow acid signal conduction path is activated, the salicylic content of signaling molecule is improved, so as to promote downstream pathogenesis-related proteins
Expression；Anti-virus ability is obtained by evoking tobacco PAL, POD, SOD Defense Enzyme Activities；Reduced by assembling TMV particles
Invasion of the virus to host.In view of the characteristic such as its structure novelty, mechanism of action uniqueness, though toxic fluoride phosphate is used to prevent and treat virosis effect
Fruit is prominent, but preventing and treating spectrum is narrow.
In this area, using the pesticide active ingredient of the different mechanisms of action carry out compounding be it is current develop pesticide new product and
Prevent and treat a kind of effective quick way of resistance pest and disease damage.After different pesticide active ingredients are compounded, three kinds of works can be shown
Use type：Summation action, synergistic effect and antagonism.Found through experiment, toxic fluoride phosphate and bromothalonil mixture prevent and treat crop disease,
Synergistic effect is notable.
The relevant report of the complex composition of toxic fluoride phosphate and bromothalonil is not found at present.
The content of the invention
By in consideration of it, in view of the deficienciess of the prior art, containing toxic fluoride phosphate and bromine it is an object of the invention to provide one kind
The complex composition and its bactericide of bacterium nitrile.The complex composition and its bactericide have obvious Synergistic relative to single dose
Effect, improves prevention effect, the usage amount of agricultural chemicals is reduced, while delaying the resistance to the action of a drug of pathogen.
To achieve these goals, the technical solution adopted by the present invention is：
A kind of complex composition containing toxic fluoride phosphate and bromothalonil is provided, the complex composition is by toxic fluoride phosphate and bromothalonil group
Into wherein the weight ratio of toxic fluoride phosphate and bromothalonil is 50:1 to 1:50.
Preferably, above-described toxic fluoride phosphate and the weight of bromothalonil ratio are 20:1 to 1:30.
It is described multiple present invention also offers a kind of bactericide containing toxic fluoride phosphate described above and bromothalonil compounded composition
The 0.1%~80% of the bactericide gross weight is accounted for composition.Preferably, the complex composition accounts for the total of the bactericide
The 5%~60% of weight.
The bactericide that the present invention is provided is except containing above-described toxic fluoride phosphate and bromothalonil compounded combination beyond the region of objective existence, also containing
Acceptable auxiliary element on agricultural chemicals.
In the embodiment that the present invention is provided, acceptable auxiliary element is one kind in carrier, solvent with helping on agricultural chemicals
The mixture of agent.
Auxiliary agent of the present invention can include emulsifying agent, wetting dispersing agent, defoamer, thickener and antifreezing agent as needed
In one or more.Other function additives that the industry is commonly used can also be included as needed.
The carrier is precipitated calcium carbonate, kaolin, white carbon, bentonite, diatomite, potassium sulfate, ammonium dihydrogen phosphate, urine
Element, calcium dihydrogen phosphate.
The solvent is water, cyclohexanone, methyl oleate.
The emulsifying agent, wetting dispersing agent are sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, DBSA
Sodium, the formaldehyde condensation products of methyl naphthalene sulfonic acid sodium, alkylphenol-polyethenoxy base phosphate, alkylnaphthalene sulfonate, styrylphenol
APEO, alkyl benzene sulfonate calcium salt, sodium carboxymethylcellulose, lauryl sodium sulfate, alkylaryl polyoxypropylene polyoxy
Vinethene, agriculture breast 500#, alkylphenol-polyethenoxy base ether.
The binding agent is starch, aluminium-magnesium silicate, polyvinyl alcohol.
The disintegrant is sodium sulphate, sodium acid carbonate.
The thickener is xanthans.
The antifreezing agent is ethylene glycol.
The defoamer is organosilicon.
The warning coloration is acid red.
The auxiliary agent that the embodiment of the present invention is used is not limited only to this, can also include other auxiliary agents commonly used in the art.
Bactericide described above containing toxic fluoride phosphate and bromothalonil compounded composition, the formulation of bactericide is wettable powder, water
It can be prepared on dispersible granule, suspending agent, seed treatment dry powder doses, ultra low volume liquids or granule, and other agricultural chemicals
Other formulations.
Application of the bactericide that the present invention is provided in crop disease is prevented and treated.
Complex composition and bactericide of the present invention compared with prior art, have the following advantages that：
1st, toxic fluoride phosphate and bromothalonil compounded have obvious synergistic function, and crop is prevented and treated in the proportion of restriction
The co-toxicity coefficient of disease is more than 120, and both compoundings are not simple superposition.Bactericide bactericidal effect containing complex composition compared with
Each single dose is significantly improved.
2nd, the dosage of bactericide of the present invention is fewer than single dose, but the preventive effect higher than the preventive effect of single dose 20% of controlling disease with
On.The field efficacy of 14 days is more than 85% after second of medicine, and the lasting period is long.
3rd, bactericidal composition of the present invention uses toxic fluoride phosphate and bromothalonil compounded, also slows down pathogen to toxic fluoride phosphate or bromothalonil
The resistance to the action of a drug of single dose.
Embodiment
The present invention is illustrated with the following example, but is not limited the scope of the invention.Toxic fluoride phosphate used in the present invention
Active compound is that Guangxi Tianyuan Biochemical Co., Ltd. provides, and other active compounds used and medicament are purchased in market.
Bactericide prepares embodiment：
In the following embodiments, to the complex composition further instruction of the present invention, but it is definitely not to the present invention
Scope be defined.
First, the preparation method of wettable powder：
After the auxiliary agents such as toxic fluoride phosphate active compound, bromothalonil active compound, wetting dispersing agent, carrier are mixed, add in pulverizer and crush
Met the requirements to granularity, discharge and stir, produce the wettable powder of bactericide of the present invention.
Embodiment 1：41% toxic fluoride phosphate bromothalonil wettable powder (40:1)
Toxic fluoride phosphate 40%, bromothalonil 1%, sodium lignin sulfonate 2%, sodium metnylene bis-naphthalene sulfonate 5%, precipitated calcium carbonate
5%, kaolin supplies 100%.
Embodiment 2：80% toxic fluoride phosphate bromothalonil wettable powder (4:1)
Toxic fluoride phosphate 64%, bromothalonil 16%, neopelex 3%, the formaldehyde condensation products of methyl naphthalene sulfonic acid sodium
4%, white carbon 2%, bentonite supplies 100%.
2nd, the preparation method of water dispersible granules：By auxiliary agent, carriers such as toxic fluoride phosphate active compound, bromothalonil active compound, wetting dispersing agents
After mixing, add in pulverizer and crush, fluidized bed prilling is carried out after having crushed, granulation is completed, be dried, sieve it is i.e. obtained originally
The water dispersible granules of invention bactericide.
Embodiment 3：51% toxic fluoride phosphate bromothalonil water dispersible granule (1:50)
Toxic fluoride phosphate 1%, bromothalonil 50%, sodium lignin sulfonate 2%, sodium metnylene bis-naphthalene sulfonate 5%, starch 2%, sulfuric acid
Sodium 6%, kaolin supplies 100%.
Embodiment 4：60% toxic fluoride phosphate bromothalonil water dispersible granule (1:2)
Toxic fluoride phosphate 20%, bromothalonil 40%, alkylphenol-polyethenoxy base phosphate 3%, alkylnaphthalene sulfonate 5%, silicic acid
Magnalium 2%, sodium acid carbonate 10%, diatomite supplies 100%.
3rd, the preparation method of suspending agent：By toxic fluoride phosphate active compound, bromothalonil active compound, emulsifying agent and a small amount of water in sand mill
Grinding, after the completion of grinding, material is pumped into high-speed shearing machine, antifreezing agent, thickener, the water of surplus, defoamer is added and enters
Row high speed shear, is made the suspending agent of bactericide of the present invention after the completion of shearing.
Embodiment 5：21% toxic fluoride phosphate bromothalonil suspending agent (20:1)
Toxic fluoride phosphate 20%, bromothalonil 1%, styrylphenol polyoxyethylene ether 5%, alkyl benzene sulfonate calcium salt 2.5%, carboxylic
Sodium carboxymethylcellulose pyce 2%, xanthans 0.2%, ethylene glycol 2%, organic silicon defoamer 0.1%, water supplies 100%.
Embodiment 6：26% toxic fluoride phosphate bromothalonil suspending agent (1:2.5)
Toxic fluoride phosphate 1%, bromothalonil 25%, styrylphenol polyoxyethylene ether 3%, the formaldehyde condensation of methyl naphthalene sulfonic acid sodium
Thing 4%, sodium carboxymethylcellulose 5%, xanthans 0.2%, ethylene glycol 3%, organic silicon defoamer 0.1%, water supplies 100%.
Embodiment 7：9.3% toxic fluoride phosphate bromothalonil seed treatment dry powder doses (1:30)
Toxic fluoride phosphate 9%, bromothalonil 0.3%, sodium metnylene bis-naphthalene sulfonate 2%, lauryl sodium sulfate 3%, polyvinyl alcohol
2%, azogeramine .5%, kaolin supplies 100%.Above-mentioned formula is pre-mixed uniformly in proportion, then is crushed, stirred
It is even, that is, 9.3% toxic fluoride phosphate bromothalonil seed treatment dry powder doses are made.
Embodiment 8：6% toxic fluoride phosphate bromothalonil ultra low volume liquids (5:1)
Toxic fluoride phosphate 5%, bromothalonil 1%, cyclohexanone 10%, alkylaryl polyoxyethylene polyoxypropylene ether again 6%, agriculture breast 500#
2%, methyl oleate supplies 100%.Above-mentioned formula is mixed 20-30 minutes in mixing kettle in proportion, that is, 6% poison is made
Fluorine phosphorus bromothalonil ultra low volume liquids.
Embodiment 9：0.4% toxic fluoride phosphate bromothalonil granule (1:1)
Toxic fluoride phosphate 0.2%, bromothalonil 0.2%, alkylphenol-polyethenoxy base ether 1%, lauryl sodium sulfate 3%, poly- second
Enol 1%, potassium sulfate 5%, ammonium dihydrogen phosphate 15%, urea supplies 100%.Above-mentioned formula is pre-mixed uniformly in proportion, gas
Stream is crushed, and is added suitable quantity of water and is mediated, granulates, being drying to obtain 0.4% toxic fluoride phosphate bromothalonil granule.
Embodiment 10：5% toxic fluoride phosphate bromothalonil granule (1:4)
Toxic fluoride phosphate 1%, bromothalonil 4%, sodium carboxymethylcellulose 4%, lauryl sodium sulfate 1%, polyvinyl alcohol
2.5%th, urea 20%, calcium dihydrogen phosphate 10%, kaolin supplies 100%.Above-mentioned formula is pre-mixed uniformly in proportion, air-flow
Crush, then mediate granulation, be drying to obtain 5% toxic fluoride phosphate bromothalonil granule.
Indoor bioassay is tested：
The bactericidal composition of the present invention, combining between them has obvious synergistic function to disease, and not only
It is the simple addition of two kinds of pharmacy effects, is specifically illustrated with following Assays Example.
Following raw test calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Toxicity index TI (B)=(standard agent A EC50The EC of ÷ B agent50)×100
Actual toxicity index ATI (AB)=(A EC50÷ AB EC50)×100
Percentage+TI (B) × B percentages in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture
Number
Survey toxicity index (ATI)=(standard agent EC50÷ reagent agents EC50)×100
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
B percentage composition in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion：(CTC) >=120 synergistic effect is shown as；CTC≤80 show as antagonism；80 ＜ CTC ＜ 120
Show as summation action.
Toxicity Determination embodiment one
Test method：Toxicity Determination is carried out using in vitro nephelometry, selection bacterial leaf streak of rice is target
Mark, is repeated 4 times, 24 hours inspection results after investigating.Using drug concentration (mg/l) logarithm value as independent variable x, with its correspondence
Corrected mortality probit value be dependent variable y, virulence regression equation is set up respectively, obtain two single dose different ratios it is common poison system
Number.Experimental method calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Specific method：Using in vitro Nephelometric Determination, the design concentration on the basis of pilot study adds each medicament respectively
Enter into NA fluid nutrient mediums, gradient dilution, which is made, to be placed in 28 DEG C after pastille culture medium, Inoculated Rice Xanthomonas campestris PV.oryzicola and shake
Culture 24h or so is swung, its turbidity (turbidity and bacterium amount be changing into positive correlation) is determined with transmissometer, according to the turbidity of blank control
The inhibiting rate that each chemicals treatment is bred to bacterial growth is calculated with the turbidity of processing, passes through the probit value and serial medicament of inhibiting rate
Linear regression analysis between the logarithm value of concentration, obtains the EC of each medicament50Value, CTC values.Test result refers to table 1.
Table 1 prevents and treats the joint toxicity measuring result of bacterial leaf streak of rice
From the measurement result of table 1, toxic fluoride phosphate and bromothalonil are 50:1 to 1:Compounding preventing and treating paddy rice is thin in the range of 50
The co-toxicity coefficient of bacterium property cecospora spot is more than 120, shows that both are compounded with obvious synergistic function.
Toxicity Determination embodiment two
Test method：Indoor pot tobacco susceptible variety plant is mixed to the 4-5 leaf phases with the decoction of different ratio various concentrations
Isometric viral juice frictional inoculation is closed, 3 plants are often handled, 3 leaves of often selecting good strains in the field for seed are repeated 4 times, withered spot number is investigated after 3-4 days, meter
Inhibiting rate is calculated, EC is used50Value calculates co-toxicity coefficient by the abundant methods of Sun Yun.Measurement result is shown in Table 2.
Table 2 prevents and treats the joint toxicity measuring result of tomato virus disease
From the measurement result of table 2, toxic fluoride phosphate and bromothalonil are 50:1 to 1:Compounding preventing and treating tomato disease in the range of 50
The co-toxicity coefficient of viral disease is more than 120, shows that both are compounded with obvious synergistic function.
Field medicine effect test embodiment：
For the prevention effect of clear and definite toxic fluoride phosphate and bromothalonil compounded to crop disease, present invention applicant is different at home
Area has carried out substantial amounts of field test.Illustrated below with several field embodiments.
Comparison medicament 1:30% toxic fluoride phosphate wettable powder, registration card LS20130359, Guangxi rural area biochemistry share is limited
Company produces.
Comparison medicament 2:25% bromothalonil wettable powder, registration card PD20080673, Jiangsu Tuoqiu Agrochemicals Co., Ltd.
Production.
Field test embodiment 1：
Test method and investigation computational methods：Reference《GB/T 17980.105-2004 pesticide field efficacy medicine test criterions
(2) the 105th parts：Bactericidal agent for preventing and treating bacterial leaf streak of rice》Experiment.Result of the test is shown in Table 3.
Table 3 prevents and treats the field control effectiveness test result of bacterial leaf streak of rice
Result of the test as shown in Table 3, in the case where active ingredient dosage is fewer than single dose dosage, sterilization of the invention
Agent is high for preventing and treating preventive effect of the preventive effect of 7d and 14d after bacterial leaf streak of rice, second of medicine than single dose.Wherein second
7d preventive effect is higher than the preventive effect of single dose by 21.61%~33.72% after medicine.And 14d preventive effect is held still more than 85.58%
The effect phase is long, reduces mu dosage and cost.
Field test embodiment 2：
Test method：Test method and investigation method：Reference《NY/T1464.8-2007 pesticide field efficacy medicine test criterions
8th part：Bactericidal agent for preventing and treating tomato virus disease》, before disease generation or early period of origination spray dispenser for the first time, second after 5d
Secondary spray dispenser.Twice, each processing plot area is 20m for dispenser altogether2, number of repetition 4 times.
Investigation method：7d, 14d are investigated before dispenser and after last dispenser, random 5 points of samplings per cell, and every takes 6
Strain, investigation total strain number, diseased plant number at different levels.Result of the test is shown in Table 4.
Table 4 prevents and treats the field control effectiveness test result of tomato virus disease
Result of the test as shown in Table 4, in the case where active ingredient dosage is fewer than single dose dosage, sterilization of the invention
Preventive effect of the 7d and 14d preventive effect than single dose is high after agent preventing and treating second of medicine of tomato virus disease.Wherein, after second of medicine 7d it is anti-
Effect it is higher than the preventive effect of single dose by 20.46%~43.88%, and 14d preventive effect still between 87.16%~94.30%, holding effect
Phase is long, reduces mu dosage and cost.
Claims (7)
1. a kind of complex composition containing toxic fluoride phosphate and bromothalonil, it is characterised in that the complex composition is by toxic fluoride phosphate and bromine
Bacterium nitrile is constituted；Wherein the weight ratio of toxic fluoride phosphate and bromothalonil is 50:1 to 1:50.
2. the complex composition according to claim 1 containing toxic fluoride phosphate and bromothalonil, it is characterised in that the toxic fluoride phosphate and
The weight ratio of bromothalonil is 20:1 to 1:30.
3. a kind of bactericide containing any described complex compositions of claim 1-2, it is characterised in that the compounded combination
Thing accounts for the 0.1%~80% of the bactericide gross weight.
4. bactericide according to claim 3, it is characterised in that the complex composition accounts for the bactericide gross weight
5%~60%.
5. bactericide according to claim 3, it is characterised in that the bactericide is also containing acceptable auxiliary on agricultural chemicals
Composition.
6. bactericide according to claim 3, it is characterised in that the formulation of the bactericide is wettable powder, moisture
Shot agent, suspending agent, seed treatment dry powder doses, ultra low volume liquids or granule.
7. application of any described bactericide of claim 3~6 in controlling plant diseases.
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