CN105189453B - 氨磺酰基‑芳基酰胺及其作为用于乙型肝炎治疗的药物的用途 - Google Patents

氨磺酰基‑芳基酰胺及其作为用于乙型肝炎治疗的药物的用途 Download PDF

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CN105189453B
CN105189453B CN201480010919.7A CN201480010919A CN105189453B CN 105189453 B CN105189453 B CN 105189453B CN 201480010919 A CN201480010919 A CN 201480010919A CN 105189453 B CN105189453 B CN 105189453B
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CN105189453A (zh
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K.范德克
S.J.拉斯特
P.J-M.B.拉博伊斯森
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Janssen Sciences Ireland ULC
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

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CN201480010919.7A 2013-02-28 2014-02-27 氨磺酰基‑芳基酰胺及其作为用于乙型肝炎治疗的药物的用途 Expired - Fee Related CN105189453B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13157232 2013-02-28
EP13157232.3 2013-02-28
EP13170069 2013-05-31
EP13170069.2 2013-05-31
PCT/EP2014/053858 WO2014131847A1 (en) 2013-02-28 2014-02-27 Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b

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CN105189453A CN105189453A (zh) 2015-12-23
CN105189453B true CN105189453B (zh) 2018-04-10

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US (2) US10125094B2 (2)
EP (1) EP2961732B1 (2)
JP (1) JP6466348B2 (2)
CN (1) CN105189453B (2)
AU (1) AU2014222641B2 (2)
BR (1) BR112015020242A2 (2)
CA (1) CA2899706C (2)
DK (1) DK2961732T3 (2)
EA (1) EA027194B1 (2)
ES (1) ES2628953T3 (2)
HR (1) HRP20170945T1 (2)
HU (1) HUE034820T2 (2)
IL (1) IL240213A (2)
MX (1) MX366123B (2)
PL (1) PL2961732T3 (2)
PT (1) PT2961732T (2)
SI (1) SI2961732T1 (2)
WO (1) WO2014131847A1 (2)

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