CN105213402A - A kind of poultry compound enrofloxacin meloxicam soluble powder - Google Patents

Abstract

A compound enrofloxacin-meroxicam soluble powder for livestock and poultry is prepared from the following components: 2.5-10 grams of enrofloxacin, 0.05-1.0 grams of meloxicam, 2.5-10 grams of solubilizer, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, 1-2 grams of flavoring agent, and 92-72 grams of excipients. The preparation method is as follows: Meloxicam and solubilizer are mixed to obtain mixture A; mixture A is added to enrofloxacin to obtain mixture B; stabilizer, sweetener, and flavoring agent are mixed to obtain mixture C; mixture C is added to the excipients and mixed to obtain mixture D; mixture B and mixture D are mixed to obtain mixture E; mixture E is sieved, packaged, and sealed to obtain the finished product. It significantly improves palatability in livestock, has an appetite-stimulating effect and suppresses bitterness, and can be administered via drinking water or orally. It is convenient to use and has good efficacy.

Description

A kind of livestock and poultry compound enrofloxacin meloxicam soluble powder

technical field

The invention relates to medicines in the technical field of veterinary medicines, in particular to a soluble powder of livestock and poultry compound enrofloxacin and meloxicam.

Background technique

Enrofloxacin belongs to fluoroquinolone chemically synthesized antibacterial agent, which is slightly yellow or light yellow crystalline powder, bitter in taste, insoluble in water, easily soluble in alkaline solution, and is a broad-spectrum antibacterial drug for animals. The third-generation quinolone antibacterial drugs can bind to subunit A of bacterial DNA gyrase, thereby inhibiting the cutting and joining functions of the enzyme, preventing the replication of bacterial DNA, and exhibiting antibacterial effects. Oral absorption is rapid and relatively complete, the blood drug concentration reaches the peak in 0.5--2 hours, the blood drug concentration is high and stable, and can be widely distributed in tissues. Except for the central nervous system, the drug concentration in almost all tissues is higher than that in plasma. This facilitates the treatment of systemic infections and deep tissue infections. This product is eliminated through renal and non-renal means, about 15% - 50% of the original drug is excreted through urine. Its metabolite is ciprofloxacin, which still has strong antibacterial effect. This product has special effects on mycoplasma. It has bactericidal effect on Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolyticus, Staphylococcus aureus, Streptococcus, etc. But this medicine is only to because of therapeutic effect, takes effect relatively slowly, and its taste is extremely bitter in addition, and insoluble in water, and oral administration is very poor to the pig with developed sense of taste, produces anorexia phenomenon, influences feed intake, has limited use of this medicine.

In view of the above reasons, a livestock and poultry compound enrofloxacin meloxicam soluble powder has been developed.

Contents of the invention

The purpose of the present invention is to overcome the deficiencies in the prior art, to provide a kind of livestock and poultry compound enrofloxacin meloxicam soluble powder, which can significantly improve the palatability of livestock, has the effect of attracting food and suppressing bitterness, It can be administered through drinking water or oral administration (administration, mixing), which is convenient to use and has good effect.

In order to achieve the above object, the present invention adopts the following technical solutions:

A livestock and poultry compound enrofloxacin-meloxicam soluble powder, which is prepared from the following components: 2.5-10 grams of enrofloxacin, 0.05-1.0 grams of meloxicam, 2.5-10 grams of co-solvent, stabilizer 0.5-4 grams, 1-2 grams of sweetener, 1-2 grams of flavoring agent, 92-72 grams of auxiliary materials.

The weight ratio of meloxicam to enrofloxacin is 0.2-1.0:10, and the described meloxicam can also use meloxicam solid dispersion or meloxicam base in addition to meloxicam itself sexual salt.

Described meloxicam solid dispersion refers to the meloxicam PEG6000 solid dispersion that meloxicam prepares by melting co-dissolution method, and described meloxicam basic salt is meglumine salt or sodium salt Or potassium or ammonium salt.

Described cosolvent adopts sodium carbonate or potassium carbonate.

The stabilizer is selected from sodium EDTA2, calcium sodium edetate, sodium tripolyphosphate, N-(2-hydroxyethyl)-sodium ethylenediaminetriacetate, N-(2-hydroxyethyl)-glycine , one or a combination of several of them.

The sweetener is selected from stevioside, sorbitol, mannitol, maltitol, xylitol saccharin, cyclamate, aspartame and acesulfame potassium, one or a combination thereof.

The flavoring agent is selected from: ethyl vanillin, natural fragrance extract, ethyl maltol, isoamyl acetate, ethyl butyrate, one or a combination thereof.

The auxiliary material is selected from: glucose, lactose, sucrose, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate, one or more combinations thereof.

The preparation method is as follows: in the first step, meloxicam and the co-solvent are gradually mixed and stirred uniformly to obtain a mixture A, and then the prepared mixture A is added to enrofloxacin to obtain a mixture B, which is set aside;

In the second step, mix and stir the stabilizer, sweetener, and flavoring agent to obtain mixture C, then add the prepared mixture C to the auxiliary materials and stir and mix evenly to obtain mixture D, and finally mix the prepared mixture B with the mixture D is stirred evenly at room temperature to obtain mixture E, which is set aside;

The third step is to directly sieve the prepared mixture E or first crush it and then sieve it. The sieve uses a 60-80 mesh sieve, and packs it into a packaging bag or a packaging bottle according to 50g-1000g, and seals or presses the cap. Get the finished product.

The beneficial effects of the present invention are: meloxicam is a non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects, and its mechanism may be related to inhibiting the synthesis of prostaglandins. Meloxicam and enrofloxacin are compounded and used together to treat fever, pain and inflammation caused by bacterial infectious diseases. And it has a better protective effect in the stomach, and overcomes the problem that the combination of metal ions such as calcium and magnesium in water and digested stomach with enrofloxacin affects the absorption. The addition of flavoring agent and sweetener plays a role in attracting food and suppressing bitterness, improving palatability. The use of co-solvent enables enrofloxacin to dissolve in water, which is convenient for poultry and non-eating animals to drink water.

The present invention is administered through drinking water or oral administration (administration, mixing materials), is convenient to use, has good use effect, and the application of flavoring agent and sweetener can significantly improve the palatability of livestock.

detailed description

Below in conjunction with embodiment and specific implementation mode, the present invention is described in further detail:

Example 1

It is prepared from the following components: 2.5-10 grams of enrofloxacin, 0.05-1.0 grams of meloxicam, 2.5-10 grams of co-solvent, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, and 1 fragrance agent -2 grams, accessories 92-72 grams.

Example 2

The weight ratio of meloxicam to enrofloxacin is 0.2-1.0:10, and the described meloxicam can also use meloxicam solid dispersion or meloxicam base in addition to meloxicam itself sexual salt.

Example 3

Described meloxicam solid dispersion refers to the meloxicam PEG6000 solid dispersion that meloxicam prepares by melting co-dissolution method, and described meloxicam basic salt is meglumine salt or sodium salt Or potassium or ammonium salt.

Example 4

Described cosolvent adopts sodium carbonate or potassium carbonate.

Example 5

The stabilizer is selected from sodium EDTA2, calcium sodium edetate, sodium tripolyphosphate, N-(2-hydroxyethyl)-sodium ethylenediaminetriacetate, N-(2-hydroxyethyl)-glycine , one or a combination of several of them.

Example 6

The sweetener is selected from stevioside, sorbitol, mannitol, maltitol, xylitol saccharin, cyclamate, aspartame and acesulfame potassium, one or a combination thereof.

Example 7

The flavoring agent is selected from: ethyl vanillin, natural fragrance extract, ethyl maltol, isoamyl acetate, ethyl butyrate, one or a combination thereof.

Example 8

The auxiliary material is selected from: glucose, lactose, sucrose, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate, one or more combinations thereof.

Example 9

The preparation method is as follows: in the first step, meloxicam and the co-solvent are gradually mixed and stirred uniformly to obtain a mixture A, and then the prepared mixture A is added to enrofloxacin to obtain a mixture B, which is set aside;

In the second step, mix and stir the stabilizer, sweetener, and flavoring agent to obtain mixture C, then add the prepared mixture C to the auxiliary materials and stir and mix evenly to obtain mixture D, and finally mix the prepared mixture B with the mixture D is stirred evenly at room temperature to obtain mixture E, which is set aside;

The third step is to directly sieve the prepared mixture E or first crush it and then sieve it. The sieve uses a 60-80 mesh sieve, and packs it into a packaging bag or a packaging bottle according to 50g-1000g, and seals or presses the cap. Get the finished product.

Claims (9)

1. A livestock and poultry compound enrofloxacin-meloxicam soluble powder is characterized in that: it is prepared from the following components: 2.5-10 grams of enrofloxacin, 0.05-1.0 grams of meloxicam, and 2.5 grams of cosolvent -10 grams, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, 1-2 grams of fragrance, 92-72 grams of auxiliary materials. 2. A kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 1, characterized in that: the weight ratio of meloxicam to enrofloxacin is 0.2-1.0: 10, and the In addition to meloxicam itself, meloxicam solid dispersion or basic salt of meloxicam can also be used. 3. a kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 2, is characterized in that: described meloxicam solid dispersion means that meloxicam is melted co-dissolving method The prepared meloxicam PEG6000 solid dispersion, the basic salt of meloxicam is meglumine salt or sodium salt or potassium salt or ammonium salt. 4. A livestock and poultry compound enrofloxacin-meloxicam soluble powder according to claim 1, characterized in that sodium carbonate or potassium carbonate is used as the co-solvent. 5. a kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 1, is characterized in that: described stabilizing agent is selected from EDTA2 sodium, edetate calcium sodium, sodium tripolyphosphate , N-(2-hydroxyethyl)-sodium ethylenediaminetriacetate, N-(2-hydroxyethyl)-glycine, one or a combination of them. 6. a kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 1, is characterized in that: described sweetener is selected from, stevioside, sorbitol, mannitol, Maltitol, xylitol saccharin, cyclamate, aspartame and acesulfame potassium, one or a combination of several. 7. a kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 1, is characterized in that: described fragrance agent is selected from: ethyl vanillin, natural flavor extract, ethyl vanillin Maltol, isoamyl acetate, ethyl butyrate, one or a combination of several of them. 8. A kind of livestock and poultry compound enrofloxacin meloxicam soluble powder according to claim 1, characterized in that: the auxiliary material is selected from: glucose, lactose, sucrose, water-soluble starch, anhydrous sulfuric acid Sodium, sodium bicarbonate, one or a combination of several. 9. A livestock and poultry compound enrofloxacin meloxicam soluble powder, characterized in that: the preparation method is as follows: In the first step, meloxicam and co-solvent are gradually mixed and stirred uniformly to obtain mixture A, and then the prepared mixture A is added to enrofloxacin to obtain mixture B, which is set aside; In the second step, mix and stir the stabilizer, sweetener, and flavoring agent to obtain mixture C, then add the prepared mixture C to the auxiliary materials and stir and mix evenly to obtain mixture D, and finally mix the prepared mixture B with the mixture D is stirred evenly at room temperature to obtain mixture E, which is set aside; The third step is to directly sieve the prepared mixture E or first crush it and then sieve it. The sieve uses a 60-80 mesh sieve, and packs it into a packaging bag or a packaging bottle according to 50g-1000g, and seals or presses the cap. Get the finished product.