CN105213402B - A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder - Google Patents
A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder Download PDFInfo
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- CN105213402B CN105213402B CN201510658306.0A CN201510658306A CN105213402B CN 105213402 B CN105213402 B CN 105213402B CN 201510658306 A CN201510658306 A CN 201510658306A CN 105213402 B CN105213402 B CN 105213402B
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Abstract
一种畜禽复方恩诺沙星美洛昔康可溶性粉，由以下组分制备构成：恩诺沙星2.5‑10克，美洛昔康0.05‑1.0克，助溶剂2.5‑10克，稳定剂0.5‑4克，甜味剂1‑2克，香味剂1‑2克，辅料92‑72克；制备方法为：将美洛昔康与助溶剂混合搅拌得到混合物A，混合物A加到恩诺沙星中得到混合物B，将稳定剂、甜味剂、香味剂混合得到混合物C，混合物C加到辅料中混合制得混合物D，混合物B与混合物D混合制得混合物E，混合物E过筛包装后封口制得成品；对家畜的适口性有显著改善，具有诱食作用和压制苦味的作用，可通过饮水或者内服给药，使用方便，使用效果好。A livestock and poultry compound enrofloxacin-meloxicam soluble powder is prepared from the following components: 2.5-10 grams of enrofloxacin, 0.05-1.0 grams of meloxicam, 2.5-10 grams of co-solvent, stabilizer 0.5-4 grams, 1-2 grams of sweetener, 1-2 grams of flavoring agent, 92-72 grams of excipients; the preparation method is: mix and stir meloxicam and co-solvent to obtain mixture A, and add mixture A to Enno Mixture B is obtained from floxacin, mixture C is obtained by mixing stabilizers, sweeteners, and flavoring agents, mixture C is added to auxiliary materials and mixed to obtain mixture D, mixture B is mixed with mixture D to obtain mixture E, mixture E is sieved and packaged The finished product is made after sealing; the palatability of livestock is significantly improved, and it has the effect of attracting food and suppressing bitterness. It can be administered through drinking water or taken internally, and it is convenient to use and has good effect.
Description
Technical field
The present invention relates to the drug of veterinary drug technical field, especially a kind of livestock and poultry compound enrofloxacin Meloxicam is soluble
Powder.
Background technique
Enrofloxacin belongs to fluoroquinolones chemical synthesis bacteriostatic agent, be yellowish or light yellow crystalline powder, bitter,
It is not soluble in water, it is soluble in alkaline solution, is animal specific broad-spectrum sterilization medicine, this product is third generation carbostyril family antibacterial drugs, energy
In conjunction with Bacterial DNA gyrase subunit A, to inhibit the cutting and linkage function of enzyme, the duplication of DNA of bacteria is prevented, and
Antibacterial action is presented.Oral absorption is rapidly and relatively complete, and 0.5--2 hours blood medicine degree reach peak, and blood concentration is high and stablizes, energy
It is distributed widely in tissue, other than central nervous system, the drug concentration of almost all of tissue is all higher than blood plasma, this is advantageous
In the treatment of general infection and deep tissue infection.This product is eliminated by kidney and non-kidney mode, the medicine of about 15%--50%
Object original shape passes through homaluria.Its metabolite is Ciprofloxacin, still there is powerful antibacterial action.This product has special efficacy to mycoplasma.It is right
Escherichia coli, Klebsiella, salmonella, proteus, Pseudomonas aeruginosa, haemophilus, pasteurella multocida, hemolytic
Pasteurella, S. aureus L-forms, streptococcus etc. have sterilization effectiveness.But the medicine only has etiological treatment effect, takes effect relatively slow, furthermore its
Taste is extremely bitter, does not dissolve in water, and oral administration palatability for the pig of sense of taste prosperity is very poor, generates anorexia phenomenon, influences to adopt
Appetite limits the use of the medicine.
In view of the foregoing, a kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder is now developed.
Summary of the invention
Purpose of the invention is to overcome the shortcomings in the prior art, provides a kind of livestock and poultry compound enrofloxacin U.S. Lip river former times
Health soluble powder is significantly improved to the palatability of domestic animal, have the function of attractant effect and compacting bitter taste, can by drinking-water or
Person's (throwing clothes, spice) administration for oral administration, easy to use, using effect is good,
The present invention to achieve the goals above, adopts the following technical scheme that
A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder is made of: Enrofloxacin 2.5- following components preparation
10 grams, 0.05-1.0 grams of Meloxicam, 2.5-10 grams of cosolvent, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, 1-2 grams of flavouring agent,
92-72 grams of auxiliary material.
Meloxicam and Enrofloxacin weight ratio are 0.2-1.0: 10, and the Meloxicam, which removes, uses Meloxicam itself
Outside, Meloxicam solid dispersions or Meloxicam basic salt also can be used.
The Meloxicam solid dispersions refer to the Meloxicam melting Meloxicam PEG6000 that altogether prepared by molten method
Solid dispersions, the Meloxicam basic salt are meglumine salt or sodium salt or sylvite or ammonium salt.
The cosolvent uses sodium carbonate or potassium carbonate.
The stabilizer is selected from EDTA2 sodium, mosatil, sodium tripolyphosphate, N- (2- ethoxy)-ethylenediamine three
Sodium acetate, N- (2- ethoxy)-glycine, one of or several combination.
The sweetener is to be selected from, stevioside, D-sorbite, mannitol, maltitol, xylitol saccharin, sweetness
Element, Aspartame and acesulfame potassium, one of or several combination.
The flavouring agent is to be selected from: Ethyl vanillin, natural perfume material extract, ethylmaltol, isoamyl acetate, fourth
Acetoacetic ester, one of or several combination.
The auxiliary material is to be selected from: glucose, lactose, sucrose, water soluble starch, anhydrous sodium sulfate, sodium bicarbonate, wherein
One or more of combinations.
The preparation method is as follows: the first step, Meloxicam is incremented by step by step with cosolvent and is mixed evenly, mixture is obtained
A, then mixture A obtained is added in Enrofloxacin, mixture B is obtained, it is spare；
Stabilizer, sweetener, flavouring agent are mixed evenly to obtain mixture C for second step, then mixture obtained
C is added in auxiliary material and is uniformly mixed, and mixture D is made, finally mixture B obtained is stirred at room temperature with mixture D
Uniformly, mixture E is made, it is spare；
Third step, re-sieving after mixture E obtained is directly sieved or is first crushed, sieve use 60~80 meshes, press
50g~1000g is sub-packed in packaging bag or Packaging Bottle, finished product after sealing or gland.
The beneficial effects of the present invention are: Meloxicam is non-steroidal anti-inflammatory drugs, there is analgesia, anti-inflammatory, refrigeration function, machine
Reason may be related with the synthesis of prostaglandin is inhibited.Meloxicam shares after being made into compound with Enrofloxacin, to bacterial infection
Fever, pain and inflammation caused by disease play the role for the treatment of both manifestation and root cause of disease, and this product increases after stabilizer to Enrofloxacin in difference
It dissolves in water quality and has preferable protective effect under one's belt, overcome the metal ions such as the calcium and magnesium in water and after gastric digestion and grace
Promise sand star, which combines, influences the problem of absorbing.Attractant effect and compacting bitter taste are played the role of in the addition of flavouring agent and sweetener, change
Kind palatability.The use of cosolvent enables Enrofloxacin to be dissolved in water, facilitate fowl with and do not eat affected animal drinking-water application.
The present invention is by drinking-water or (throwing clothes, spice) administration for oral administration, and easy to use, using effect is good, flavouring agent and sweet tea
The application of taste agent is significantly improved to the palatability of domestic animal.
Specific embodiment
Below with reference to embodiment, invention is further described in detail with specific embodiment:
Embodiment 1
It is made of following components preparation: 2.5-10 grams of Enrofloxacin, 0.05-1.0 grams of Meloxicam, cosolvent 2.5-10
Gram, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, 1-2 grams of flavouring agent, 92-72 grams of auxiliary material.
Embodiment 2
Meloxicam and Enrofloxacin weight ratio are 0.2-1.0: 10, and the Meloxicam, which removes, uses Meloxicam itself
Outside, Meloxicam solid dispersions or Meloxicam basic salt also can be used.
Embodiment 3
The Meloxicam solid dispersions refer to the Meloxicam melting Meloxicam PEG6000 that altogether prepared by molten method
Solid dispersions, the Meloxicam basic salt are meglumine salt or sodium salt or sylvite or ammonium salt.
Embodiment 4
The cosolvent uses sodium carbonate or potassium carbonate.
Embodiment 5
The stabilizer is selected from EDTA2 sodium, mosatil, sodium tripolyphosphate, N- (2- ethoxy)-ethylenediamine three
Sodium acetate, N- (2- ethoxy)-glycine, one of or several combination.
Embodiment 6
The sweetener is to be selected from, stevioside, D-sorbite, mannitol, maltitol, xylitol saccharin, sweetness
Element, Aspartame and acesulfame potassium, one of or several combination.
Embodiment 7
The flavouring agent is to be selected from: Ethyl vanillin, natural perfume material extract, ethylmaltol, isoamyl acetate, fourth
Acetoacetic ester, one of or several combination.
Embodiment 8
The auxiliary material is to be selected from: glucose, lactose, sucrose, water soluble starch, anhydrous sodium sulfate, sodium bicarbonate, wherein
One or more of combinations.
Embodiment 9
The preparation method is as follows: the first step, Meloxicam is incremented by step by step with cosolvent and is mixed evenly, mixture is obtained
A, then mixture A obtained is added in Enrofloxacin, mixture B is obtained, it is spare；
Stabilizer, sweetener, flavouring agent are mixed evenly to obtain mixture C for second step, then mixture obtained
C is added in auxiliary material and is uniformly mixed, and mixture D is made, finally mixture B obtained is stirred at room temperature with mixture D
Uniformly, mixture E is made, it is spare；
Third step, re-sieving after mixture E obtained is directly sieved or is first crushed, sieve use 60~80 meshes, press
50g~1000g is sub-packed in packaging bag or Packaging Bottle, finished product after sealing or gland.
Claims (1)
1. a kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder, it is characterised in that: be made of following components preparation: En Nuo
2.5-10 grams of husky star, 0.05-1.0 grams of Meloxicam, 2.5-10 grams of cosolvent, 0.5-4 grams of stabilizer, 1-2 grams of sweetener, fragrance
1-2 grams of agent, 92-72 grams of auxiliary material；
A kind of preparation method of livestock and poultry compound enrofloxacin Meloxicam soluble powder, the specific steps are as follows:
Meloxicam is incremented by step by step with cosolvent and is mixed evenly, obtains mixture A, then mixing obtained by the first step
Object A is added in Enrofloxacin, obtains mixture B, spare；
Stabilizer, sweetener, flavouring agent are mixed evenly to obtain mixture C, then mixture C obtained are added by second step
It is uniformly mixed into auxiliary material, mixture D is made, finally mixture B obtained and mixture D are stirred at room temperature
It is even, mixture E is made, it is spare；
Third step, re-sieving after mixture E obtained is directly sieved or is first crushed, sieve use 60~80 meshes, by 50g~
1000g is sub-packed in packaging bag or Packaging Bottle, finished product after sealing or gland；
Meloxicam and Enrofloxacin weight ratio are 0.2-1.0: 10, the Meloxicam in addition to using Meloxicam itself,
Meloxicam solid dispersions or Meloxicam basic salt also can be used；
The Meloxicam solid dispersions refer to the Meloxicam melting Meloxicam PEG6000 solid that altogether prepared by molten method
Dispersion, the Meloxicam basic salt are meglumine salt or sodium salt or sylvite or ammonium salt；
The cosolvent uses sodium carbonate or potassium carbonate；
The stabilizer is selected from EDTA2 sodium, mosatil, sodium tripolyphosphate, N- (2- ethoxy)-ethylenediamine triacetic acid
Sodium, N- (2- ethoxy)-glycine, one of or several combination；
The sweetener is to be selected from, stevioside, D-sorbite, mannitol, maltitol, xylitol saccharin, honey element, Ah
This Ba Tian and acesulfame potassium, one of or several combination；
The flavouring agent is to be selected from: Ethyl vanillin, natural perfume material extract, ethylmaltol, isoamyl acetate, butyric acid second
Ester, one of or several combination；
The auxiliary material is to be selected from: glucose, lactose, sucrose, water soluble starch, anhydrous sodium sulfate, sodium bicarbonate, one of
Or several combination.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510658306.0A CN105213402B (en) | 2015-09-30 | 2015-09-30 | A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder |
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| CN201510658306.0A CN105213402B (en) | 2015-09-30 | 2015-09-30 | A kind of livestock and poultry compound enrofloxacin Meloxicam soluble powder |
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| CN105213402A CN105213402A (en) | 2016-01-06 |
| CN105213402B true CN105213402B (en) | 2018-12-18 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998036B (en) * | 2016-05-19 | 2018-07-27 | 洛阳市兽药厂 | One boar fowl compound sulfonamide Nitazoxanide soluble powder |
| CN110327348A (en) * | 2019-07-19 | 2019-10-15 | 余祖功 | Compound long-acting injection and preparation method thereof containing Enrofloxacin and Meloxicam |
| CN115998674A (en) * | 2021-10-22 | 2023-04-25 | 洛阳瑞华动物保健品有限公司 | A kind of preparation method of enrofloxacin solution |
| CN116172960A (en) * | 2022-12-01 | 2023-05-30 | 浙江大飞龙动物保健品股份有限公司 | A kind of ciprofloxacin lactate soluble powder and preparation method thereof |
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|---|---|---|---|---|
| CN1273092A (en) * | 2000-04-04 | 2000-11-15 | 华南农业大学 | Water-soluble powdered quinolone medicines |
| CN1437472A (en) * | 2000-06-20 | 2003-08-20 | 贝林格尔·英格海姆维特梅迪卡有限公司 | Highly concentrated stable meloxicam solutions |
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102038643A (en) * | 2010-12-10 | 2011-05-04 | 青岛康地恩药业有限公司 | Enrofloxacin soluble powder and preparation method and application thereof |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones and preparation method and application thereof |
| CN104367553A (en) * | 2014-11-26 | 2015-02-25 | 上海同仁药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
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2015
- 2015-09-30 CN CN201510658306.0A patent/CN105213402B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273092A (en) * | 2000-04-04 | 2000-11-15 | 华南农业大学 | Water-soluble powdered quinolone medicines |
| CN1437472A (en) * | 2000-06-20 | 2003-08-20 | 贝林格尔·英格海姆维特梅迪卡有限公司 | Highly concentrated stable meloxicam solutions |
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones and preparation method and application thereof |
| CN102038643A (en) * | 2010-12-10 | 2011-05-04 | 青岛康地恩药业有限公司 | Enrofloxacin soluble powder and preparation method and application thereof |
| CN104367553A (en) * | 2014-11-26 | 2015-02-25 | 上海同仁药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
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| CN105213402A (en) | 2016-01-06 |
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Address after: No. 6 Fuzuo Road, Shouyangshan Street, Yanshi District, Luoyang City, Henan Province, 471000 Patentee after: Luoyang Luoshen Pharmaceutical Co.,Ltd. Country or region after: China Address before: No. 11 Chezhan Road, Yanshi City, Henan Province 471000 Patentee before: LUOYANG VETERINARY MEDICINES FACTORY Country or region before: China |