CN106172425B - A kind of bactericidal composition and its application containing octyl trichlamide and propiconazole - Google Patents
A kind of bactericidal composition and its application containing octyl trichlamide and propiconazole Download PDFInfo
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- CN106172425B CN106172425B CN201610598645.9A CN201610598645A CN106172425B CN 106172425 B CN106172425 B CN 106172425B CN 201610598645 A CN201610598645 A CN 201610598645A CN 106172425 B CN106172425 B CN 106172425B
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- propiconazole
- octyl
- weight ratio
- bactericidal composition
- preventing
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- 239000005822 Propiconazole Substances 0.000 title claims abstract description 105
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 title claims abstract description 105
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- -1 octyl trichlamide Chemical compound 0.000 title claims abstract description 60
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 56
- 201000010099 disease Diseases 0.000 claims abstract description 47
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 22
- 241000167854 Bourreria succulenta Species 0.000 claims abstract description 18
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- 239000004480 active ingredient Substances 0.000 claims abstract description 15
- 238000009472 formulation Methods 0.000 claims abstract description 13
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- 239000004563 wettable powder Substances 0.000 claims abstract description 12
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 11
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 11
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 11
- 235000021014 blueberries Nutrition 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 11
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- 241000407125 Dothiorella gregaria Species 0.000 claims abstract description 10
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 46
- 241000894006 Bacteria Species 0.000 claims description 42
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- 229940079593 drug Drugs 0.000 description 7
- 239000000417 fungicide Substances 0.000 description 7
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 description 6
- 239000005839 Tebuconazole Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
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- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 6
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- 230000001580 bacterial effect Effects 0.000 description 2
- GAMFEMAXLMWCRG-UHFFFAOYSA-N bis(dimethylcarbamothioylsulfanyl)arsanyl n,n-dimethylcarbamodithioate Chemical compound CN(C)C(=S)S[As](SC(=S)N(C)C)SC(=S)N(C)C GAMFEMAXLMWCRG-UHFFFAOYSA-N 0.000 description 2
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- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 description 1
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- ABUGVBRDFWGJRD-CHOYNLESSA-N [9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]-2-(2,4-dinitrophenyl)sulfanylpurin-6-yl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC(SC=3C(=CC(=CC=3)[N+]([O-])=O)[N+]([O-])=O)=NC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)=C2N=C1 ABUGVBRDFWGJRD-CHOYNLESSA-N 0.000 description 1
- JNVCSEDACVAATK-UHFFFAOYSA-L [Ca+2].[S-]SSS[S-] Chemical compound [Ca+2].[S-]SSS[S-] JNVCSEDACVAATK-UHFFFAOYSA-L 0.000 description 1
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- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
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- 229910052739 hydrogen Inorganic materials 0.000 description 1
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- 230000002085 persistent effect Effects 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G13/00—Protection of plants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G7/00—Botany in general
- A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Forests & Forestry (AREA)
- Ecology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Botany (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing octyl trichlamide and propiconazole, active ingredient is octyl trichlamide and propiconazole, and the weight ratio of propiconazole and octyl trichlamide is 2:1~1:30；Can also contain Pesticide Science in allow use and acceptable auxiliary material, formulation can be wettable powder, suspending agent, missible oil, aqueous emulsion, water dispersible granules or microemulsion.The bactericidal composition of the present invention, the mechanism of action of active ingredient is entirely different, and compounding can act on the more sites of pathogen, synergistic, expands fungicidal spectrum, improves preventive effect, reduces Pesticide use amount, delays drug-fast generation, reduces resistance risk.The bactericidal composition of the present invention, for preventing fruit tree, a variety of trunk diseases on forest, the diseases such as canker of apple fruit, eyespot in apple limb, dry rot of apple, cherry bleeding disease, peach gummosis, blueberry branch-rot, walnut branch-rot, willow branch-rot, dothiorella gregaria are particularly suitable for.It is alternatively arranged as fruit tree, forest grafting, the sealing compound of beta pruning.
Description
Technical field
The present invention relates to a kind of bactericidal composition containing octyl trichlamide and propiconazole, and its in prevention fruit tree, forest limb disease
Applied in evil, belong to pesticide control technical field application.
Background technology
Trunk disease is one of Major Diseases of fruit tree, forest, and its incidence, harmfulness aggravate year by year in recent years, into
To endanger fruit industry, the great disease of production of forestry.Fruit tree, forest trunk disease include rot disease, Trunk canker, bleeding disease,
The diseases such as dry rot, canker, branch-rot, wherein, apple tree Trunk canker is in recent years with the popularization of fruit bagging technology
Promote and occur increasingly severe, most heavy with Fuji, the morbidity of red magnitude seeds, diseased plant rate is up to more than 90%；Apple tree canker
The major branch and side shoot of main harm apple tree, cause apple tree vigo(u)r weak, fruit yield and quality decline, serious orchard of falling ill
A large amount of dead trees even ruin garden；The host range of dothiorella gregaria germ is very extensive, and its parasitics is weak, along with quarantine measures
It is incapable, cause a large amount of germs to be spread with the allocation and transportation of nursery stock, cause dothiorella gregaria occur it is increasingly severe, particularly
To transplanting the nursery stock at initial stage and the harm bigger of treelet, cause the death of a large amount of nursery stocks, cause the failure of whole spring afforestation, according to
Report, in serious area of falling ill, for the incidence of forest up to 96.1%~100%, dothiorella gregaria has become development China
The serious hindrance of Poplar Plantation.
In view of the order of severity of trunk disease harm, recent domestic scholar has carried out substantial amounts of research to it, and carries
Go out many effectively preventing measures, but reach preferable prevention effect in today of wildness outburst, every equal difficulty of control measure.
The preferable medicament asomate category high poison of currently used prevention trunk disease, persistent pesticide, the Ministry of Agriculture are comprehensive in the end of the year 2015
Forbid selling and use, and other medicaments such as lime sulfur, copper humate etc., although playing a role, there are more
Problems and shortcomings, are mainly manifested in that the mode of action is single, and prevention effect is unstable, and the drug effect phase is short etc., causes general control
Effect is undesirable, scab high recurrence rate, and wound healing is poor.Therefore, can be thorough there is an urgent need to invent a kind of efficient, low toxicity, environmental protection
Bottom sterilization can promote the inexpensive prevention fruit tree of wound healing, the therapeutic agent of forest trunk disease again.
Octyl trichlamide, is a kind of environment-friendly type amino acids high molecular polymer fungicide, be high-tech of new generation, environment-friendly type,
High-efficiency broad spectrum, less toxic fungicide.The mechanism of action of octyl trichlamide is to produce ionization in aqueous, and hydrophilic base section contains strongly
Electropositive, absorption usually in negative electricity all kinds of bacteriums, virus so as to inhibit bacterium, virus breeding, solidify germ albumen
Matter, is denatured germ enzyme system, and the film formed plus polymer plugs the ion channel of this part microorganism, makes it immediately
Death by suffocation, so as to reach optimal bactericidal effect.Broad-spectrum, has absorbability and extremely strong permeability, also with two-way
Translocation, at the same have the function of protection, treat, root out, to raise four big.Octyl trichlamide can be used for fruit tree, vegetables, melon, cotton,
The various crops such as rice, wheat, corn and soybean, rape, medicinal material, ginger are by bacterium, virus, fungus-caused multiple diseases
Prevention.
Propiconazole (Propiconazole), chemical name：1- [2-2,4- dichlorophenyls) -4- propyl group -1,3- dioxies penta
Ring -2- methyl] -1 hydrogen -1,2,4- triazoles, chemical formula：C15H17Cl2N3O2.Propiconazole is a kind of with protection and therapeutic effect
Absorbability triazole bactericidal agent, can be absorbed by root, stem, leaf portion, and can soon be conducted upwards in plant body, belong to ergosterol
The inhibitor of biosynthesis.Ergosterol plays an important role in the composition of fungal cell membrane, and propiconazole is by disturbing C14- to go
Methylate and hinder the biosynthesis of ergosterol in fungus body, so as to destroy the growth and breeding of fungi, play protection and treatment
Effect.Have the characteristics that fungicidal spectrum is extensive, activity is high, sterilization speed is fast, the lasting period is long, uptake and translocation is strong, be that triazole type is killed
One of Typical Representative kind of microbial inoculum.Propiconazole is in addition to invalid to oomycetes disease, to Saccharomyces, Basidiomycotina, Dendrochium
Fungi caused multiple diseases on cereal crops, veterinary antibiotics, forest and ornamental plant are effective, especially suitable for prevention
A variety of trunk diseases on fruit tree, forest.
At present, octyl trichlamide and propiconazole are subjected to compounding use and for preventing fruit tree, forest limb disease there is not yet having
Harmful relevant report.
The content of the invention
For the above-mentioned prior art, the present invention provides a kind of bactericidal composition containing octyl trichlamide and propiconazole, and its
Applied in prevention fruit tree, forest trunk disease.
The present invention is achieved by the following technical solutions：
A kind of bactericidal composition containing octyl trichlamide and propiconazole, active ingredient are octyl trichlamide and propiconazole, propiconazole with it is pungent
The weight ratio of bacterium amine is 2:1~1:30, it is preferred that be 1:1~15.
In the bactericidal composition containing octyl trichlamide and propiconazole, can contain allows to use and can receive in Pesticide Science
Auxiliary material.
Further, the bactericidal composition containing octyl trichlamide and propiconazole is made of the component of following parts by weight：
Propiconazole 1%~80%, octyl trichlamide 1%~80%, surplus are to allow to use and acceptable auxiliary material in Pesticide Science.
Allow to use in the Pesticide Science and acceptable auxiliary material is selected from solvent, bleeding agent, dispersant, diffusant, collapses
Solve agent, emulsifying agent, stabilizer, wetting agent, defoamer, antifreezing agent etc. and other stabilizations for contributing to active ingredient drug effect and performance
Allow use auxiliary agent.
The bactericidal composition containing octyl trichlamide and propiconazole, can be prepared into processing method well known in the prior art
Any one formulation that suitable agricultural production uses, preferred dosage form are：Wettable powder, suspending agent, missible oil, aqueous emulsion, moisture
Shot agent, microemulsion.
The present invention the bactericidal composition containing octyl trichlamide and propiconazole, for prevent fruit tree, forest (apple tree, cherry tree,
Pear tree, peach, jujube tree, Chinese chestnut, walnut, Malus spectabilis, willow, willow etc.) on a variety of trunk diseases, be particularly suitable for apple decay
Disease, eyespot in apple limb, dry rot of apple, cherry bleeding disease, peach gummosis, blueberry branch-rot, willow branch-rot, willow
The diseases such as canker, walnut branch-rot.Preferably, when preventing Valsa mali, propiconazole and the weight of both octyl trichlamides
Than with 1:1~15 is preferred, and 1:1~10 more preferably, and 1:5 is optimal.When preventing eyespot in apple limb bacterium, propiconazole and octyl trichlamide two
The weight ratio of person is with 2:1~1:20 are preferred, and 1:5~15 more preferably, and 1:5 is optimal.When preventing cherry gummosis germ, propiconazole with it is pungent
The weight ratio of both bacterium amine is with 2:1~1:20 are preferred, and 1:5~15 more preferably, and 1:5 is optimal.When preventing dothiorella gregaria bacterium, the third ring
The weight ratio of azoles and both octyl trichlamides is with 2:1~1:20 are preferred, and 1:5~15 more preferably, and 1:5 is optimal.In prevention branch of Semen Juglandis blight
During bacterium, the weight ratio of propiconazole and both octyl trichlamides is with 2:1~1:30 are preferred, and 1:1~20 more preferably, and 1:5 is optimal.In prevention blueberry
During branch-rot bacterium, the weight ratio of propiconazole and both octyl trichlamides is with 1:1~25 is preferred, and 1:2~15 more preferably, and 1:5 is optimal.In addition,
The bactericidal composition containing octyl trichlamide and propiconazole of the present invention is alternatively arranged as fruit tree, forest grafting, the sealing compound of beta pruning.
Triazole bactericidal agent is the longer fungicide kind of China's applicating history, plays and focuses in the prevention of crop disease
The effect wanted, although triazole type medicament is still in the use of large area at present, pathogen to the sensitiveness of such medicament
Through there is decline by a relatively large margin, the dosage in field gradually steps up, and the pressure of bigger is generated to environment and resistance, because
This should carry out correlative study to slow down the generation of resistance, and be main direction of studying using the pharmacy mix of different mechanism.
The present inventor is found by experiment that, the different propiconazole of the mechanism of action and octyl trichlamide is bactericide compounded, has obvious
Synergistic function, and medicament osmosis can be improved, extend the lasting period, not only significantly improved to fruit tree, forest limb disease
Harmful treatment, protecting effect, while by the treatment protection plus conditioning to tree body, reach and cure trunk disease and prevent its recurrence
Purpose.
The mechanism of action of the bactericidal composition containing octyl trichlamide and propiconazole of the present invention, active ingredient propiconazole and octyl trichlamide
Entirely different, compounding can act on the more sites of pathogen, synergistic, expand fungicidal spectrum, improve preventive effect, reduce Pesticide use
Amount, delays drug-fast generation, reduces resistance risk.
The bactericidal composition containing octyl trichlamide and propiconazole of the present invention, can be provided in the form of finished product preparation, can also single dose
Form provides, and is directly mixed using preceding, is then watered mixing and is made into required concentration, smeared after striking off limb position disease scar, at the same time
Coordinate whole plant spraying using effect more preferably.
The bactericidal composition containing octyl trichlamide and propiconazole of the present invention, has the following advantages：1st, there is synergistic function,
Improve prevention effect；2nd, fungicidal spectrum is expanded；3rd, two kinds of active ingredient mechanisms of action are different, and mixture use delays the pathogen resistance to the action of a drug
Generation；4th, formulation rate is reduced, reduces access times, reduces use cost.
Embodiment
With reference to embodiment, the present invention is further illustrated.
Involved instrument, reagent, material etc. in following embodiments, are existing in the prior art unless otherwise noted
Conventional instrument, reagent, material etc., can be obtained by regular commercial sources.Involved experimental method in following embodiments, inspection
Survey method etc., is existing normal experiment method, detection method etc. in the prior art unless otherwise noted.
Test propiconazole and (Toxicity Determination) is studied to the preventive and therapeutic effect of disease with octyl trichlamide compounding
First, reagent agent：Propiconazole, octyl trichlamide active compound, and thiophanate-methyl, ambam, Tebuconazole.By the third ring
Azoles, octyl trichlamide active compound acetone solution, and the mother liquor of 10000 μ g/mL is made into, emulsifying agent is added with 0.2% volume fraction
Tween-80, stores spare in refrigerator at 4 DEG C, be diluted to debita spissitudo with sterile water during use.
2nd, for trying pathogen：Valsa mali (Valsa mali), eyespot in apple limb bacterium
(Botryosphaeria dothidea), walnut branch-rot bacterium (Phomopsisjuglandina), cherry gummosis germ
(Botryosphaeria dothidea), dothiorella gregaria bacterium (Botryosphaeria dothidea), blueberry branch-rot bacterium
(Neofusicoccumparvum)。
3rd, assay method：
(1) Toxicity Determination：Virulence is carried out to propiconazole, octyl trichlamide and its mixture preparation using mycelial growth rate method
Measure.
Single dose toxicity test method：
Reagent agent (including propiconazole, octyl trichlamide, thiophanate-methyl, ambam, Tebuconazole) is first configured to 6 concentration
Gradient (propiconazole：0.5th, 1.0,2.0,4.0,8.0,6 concentration gradients such as 16.0mg/kg；Octyl trichlamide：1.0、2.0、4.0、
8.0th, 16.0,6 concentration gradients such as 32.0mg/kg；Thiophanate-methyl：0.5th, 1.0,2.0,4.0,8.0,16.0mg/kg etc. 6
Concentration gradient；Ambam：3.0th, 6.0,12.0,24.0,48.0,6 concentration gradients such as 96.0mg/kg；Tebuconazole：0.5、1.0、
2.0th, 4.0,8.0,6 concentration gradients such as 16.0mg/kg), by pathogen in 26 DEG C of preculture 4d in PDA culture medium, use diameter
The card punch of 7mm is beaten on the same circumference close to colony edge and takes bacteria cake, is inoculated into the culture medium containing different agents concentration
It is a piece of per ware on tablet, culture 4d in 26 DEG C of insulating boxs is placed in, the colony growth diameter of each processing is measured with crossing method,
Using clear water as control, per concentration, processing is repeated 4 times.Bacterium colony radially linear increment is measured, determines suppression of the medicament to colony growth
Rate processed.Probable value and drug concentration are suppressed to the linear regression analysis between numerical value by mycelial growth, obtain each medicament to bacterium
Concentration (EC in effective suppression of strain50Value).
Mixed agent joint toxicity measuring：
On the basis of single dose toxicity test, its EC will be pressed respectively for the propiconazole of mixture, octyl trichlamide50Value dosage presses volume
Ratio sets 10 respectively:1、5:1、2:1、1:1、1:2、1:5、1:10、1:15、1:20、1:25、1:30、1:35、1:40、1:45、
1:50 totally 15 proportionings, by different ratio be configured to final mass concentration (refer to propiconazole, octyl trichlamide gross mass) for 0.25,
0.5th, 1.0,2.0,4.0, the drug containing PDA culture medium of 6 series concentrations of 8.0mg/kg, suppression of the measure medicament to mycelial growth
Rate.Often processing is repeated 4 times (per bacterial strain per concentration level).Probable value and drug concentration are suppressed between numerical value by mycelial growth
Linear regression analysis, obtain Mixed Pharmacy to bacterial strain it is effective suppress in concentration EC50Value and CTC values, with the PDA of not adding medicine
Culture medium is as control.
(2) data statistic analysis
Test data carries out statistical analysis by Microsoft Excel 2013, DPS data processing works platform, calculates
Go out the EC of every kind of medicament50Value, 95% confidence limit.The co-toxicity coefficient of mixed agent is calculated using the abundant methods of Sun Yun (1960), according to common poison
Coefficient magnitude evaluates the synergistic effect of mixed agent.
Each medicament inhibiting rate is calculated according to the following formula：
Suppress growth rate (%)=[(control antibacterial circle diameter-processing antibacterial circle diameter)/(control antibacterial circle diameter -5mm
Punch diameter)] × 100；
Suppress growth rate (%)=[(control colony diameter-processing colony diameter)/(control colony diameter-bacteria cake diameter)]
×100；
Toxicity index TI=(standard agent EC50/ reagent agent EC50)×100；
Actual toxicity index ATI=(the standard agent EC of mixed agent50/ mixture preparation EC50)×100；
(PA and PB are respectively mixed agent to TI × PB of TI × PA+ single doses B of mixed agent theoretical toxicity index TTI=single doses A
The percentage composition of middle active ingredient)；
Theoretical toxicity index TTI × 100 of the actual toxicity index ATI/ mixed agents of co-toxicity coefficient CTC=mixed agents；
Synergistic effect judges：CTC >=120, have synergistic effect；80 ＜ CTC ＜ 120, are summation action；CTC≤80, are
Antagonism.
(3) result and analysis：As shown in 1~table of table 8.
Toxicity test result of the 15 kinds of medicaments of table to Valsa mali
Toxicity test result of 2 propiconazole of table with octyl trichlamide different proportion mixture to Valsa mali
By table 1~2 as it can be seen that propiconazole, octyl trichlamide and its mixture preparation, have Valsa mali and suppress to make well
With wherein the proportioning of propiconazole and octyl trichlamide is 1:1~1:When between 15, to for examination pathogen co-toxicity coefficient 120 with
On, show that both fungicide match down have good synergistic function herein, especially match 1:1~1:Between 10
Synergistic effect is more notable.
35 kinds of medicaments of table to eyespot in apple limb bacterium, cherry gummosis germ, dothiorella gregaria bacterium toxicity test result
4 propiconazole of table bursts eyespot in apple limb bacterium, cherry gummosis germ, willow with octyl trichlamide different proportion mixture
The toxicity test result of ulcer germ
By table 3~4 as it can be seen that propiconazole, octyl trichlamide and its mixture preparation, to eyespot in apple limb bacterium, cherry bleeding disease
Bacterium, dothiorella gregaria bacterium are respectively provided with good inhibiting effect, and wherein the proportioning of propiconazole and octyl trichlamide is 2：1~1：Between 20
When, to the co-toxicity coefficient for examination pathogen more than 120, show that both fungicide match down with collaboration well herein
Synergistic effect, especially matches 1：5~1：Synergistic effect is more notable between 15.
Toxicity test result of the 55 kinds of medicaments of table to walnut branch-rot bacterium
Toxicity test result of 6 propiconazole of table with octyl trichlamide different proportion mixture to walnut branch-rot bacterium
By table 5~6 as it can be seen that propiconazole, octyl trichlamide and its mixture preparation, have walnut branch-rot bacterium and suppress to make well
With wherein the proportioning of propiconazole and octyl trichlamide is 2：1~1：When between 30, to for examination pathogen co-toxicity coefficient 120 with
On, show that both fungicide match down have good synergistic function herein, especially match 1：1~1：Between 20
Synergistic effect is more notable.
Toxicity test result of the 75 kinds of medicaments of table to blueberry branch-rot bacterium
Toxicity test result of 8 propiconazole of table with octyl trichlamide different proportion mixture to blueberry branch-rot bacterium
By table 7~8 as it can be seen that propiconazole, octyl trichlamide and its mixture preparation, have blueberry branch-rot bacterium and suppress to make well
With wherein the proportioning of propiconazole and octyl trichlamide is 1：1~1：When between 25, to for examination pathogen co-toxicity coefficient 120 with
On, show that both fungicide match down have good synergistic function herein, especially match 1：2~1：Between 15
Synergistic effect is more notable.
1 6% propiconazole octyl trichlamide wettable powder of embodiment
Component composition is following (each component is by weight percentage)：
Preparation method is：Above-mentioned each active ingredient, various auxiliary agents and filler are sufficiently mixed uniformly in proportion, mixture warp
Ultra-fine pulverizer disintegrating, is made 6% propiconazole octyl trichlamide wettable powder.
2 20% propiconazole octyl trichlamide suspending agent of embodiment
Component composition is following (each component is by weight percentage)：
Preparation method is：Above-mentioned each active ingredient, various auxiliary agents and water are sufficiently mixed uniformly in proportion, input is sanded
Machine, is ground to 5 μm of particle diameter, 20% propiconazole octyl trichlamide suspending agent.
3 11% propiconazole octyl trichlamide missible oil of embodiment
Component composition is following (each component is by weight percentage)：
Preparation method is：Above-mentioned each active ingredient, various auxiliary agents and water are sufficiently mixed in proportion, added in mixing kettle,
The 11% propiconazole octyl trichlamide missible oil stirred evenly.
Embodiment 4：20% propiconazole octyl trichlamide aqueous emulsion
Component composition is following (each component is by weight percentage)：
Preparation method is：Above-mentioned each active ingredient, various auxiliary agents are sufficiently mixed in proportion, made to be dissolved into and oil phase,
Under high-speed stirred, oil phase is mixed with water, obtains 20% propiconazole octyl trichlamide aqueous emulsion.
Embodiment 5：7% propiconazole octyl trichlamide water dispersible granules
Component composition is following (each component is by weight percentage)：
Preparation method is：By above-mentioned each active ingredient, Negel formaldehyde condensation products, wetting agent, disintegrant, filler
It is sufficiently mixed in proportion, is crushed to 5 μm of particle diameter through airslide disintegrating mill, obtains female powder, female powder and sodium lignin sulfonate are sufficiently mixed
It is granulated, dries afterwards, sieving, so that 7% propiconazole octyl trichlamide water dispersible granules is made.
Embodiment 6：18% propiconazole octyl trichlamide microemulsion
Component composition is following (each component is by weight percentage)：
Preparation method is：Above-mentioned each active ingredient, various auxiliary agents are sufficiently mixed in proportion, made to be dissolved into and oil phase,
Under high-speed stirred, oil phase is mixed with water, obtains 18% propiconazole octyl trichlamide microemulsion.
Application example 1：Field control canker of apple fruit field control effectiveness test
Example 1 (6% propiconazole octyl trichlamide wettable powder) prevention apple is carried out within 2014 in Feicheng, Shandong Province
Fruit tree putrefaction disease field control effectiveness test, verifies the prevention effect, effective dose and the security to apple tree of the medicament.Experiment side
Method reference《GB/T 17980.98-2004 pesticide field efficacy medicine tests criterion (two) bactericidal agent for preventing and treating apple tree cankers drug effect is tried
Test》.Test site gave birth to new Red Star, spacing in the rows × line-spacing=3m × 4m, fertilizer and water management in An Jiazhuan towns Zhang An villages, test tree for 17 years
Horizontal general, extensive management, tree vigo(u)r is weak, and the trunk disease such as rot disease, ring spot occurs heavier.
Test medicine and dosage are：6% 200 times, 400 times, 600 times of propiconazole octyl trichlamide wettable powder；3% methyl
Thiophanate paste；2.12% copper humate aqua；40% 50 times of asomate wettable powder；Blank control, only removes sick scar
Without chemicals treatment.The sick scar that selection tree vigo(u)r is close, sick scar position and sick scar size are close is marked.Per cell into age tree extremely
5 plants few, new sick scar at least eight, is repeated 4 times then.
Test and carried out on March 12nd, 2014.Medication after scab cleaning, is to scrape therapy using production is above common, i.e., first
Rot disease disease portion is shaved with scraper and clear side exceeds disease portion 0.5~1cm of slough, stubble, fusiformis are found in sick scar notch requirement, so
By liquid medicine painting disease portion and exceed 2~3cm of notch with hairbrush again afterwards, all moistened with coating position, liquid slightly flows down as degree.
Scab is only struck off in blank control, clear good side, but does not apply medicament.
A scab recurrence is respectively investigated when early winter on December 3rd, 2014 and the early spring on the 15th March in 2015.Record is multiple
Morbidity scar quantity.With vernier caliper measurement and record the maximum healing width (mm) of disease scar at the same time.And medication after clearing up scab
Statistical comparison is carried out respectively with direct drug injection.
Drug effect statistical analysis technique：Pharmacy control efficacy is calculated by following equation.
a.
b.
The results are shown in Table 9 (notes：In 9~table of table 12, each extension rate, to solids such as wettable powder, water dispersible granules
For formulation, refer to quality multiple, for liquid dosage form, refer to volume multiple).
9 6% propiconazole octyl trichlamide wettable powder of table prevents the pharmacodynamic results of apple tree canker
Field apple tree canker therapeutic test result sees the above table 9.By table as it can be seen that 6% propiconazole octyl trichlamide wettable
The field control effect of each concentration of pulvis processing is best, and cure rate is more than 80.0%, wherein with 200 times of best results, significantly
Better than other each conventional treatments, and wound healing is fast, smooth.
Application example 2：Field apple tree Trunk canker therapeutic test
Example 2 (20% propiconazole octyl trichlamide suspending agent) prevention apple tree is carried out within 2014 in Feicheng, Shandong Province
Trunk canker field control effectiveness test, verifies the prevention effect, effective dose and the security to apple tree of the medicament.Experimental field
For point in Wu villages and small towns Wu Cun, test tree is 19 years raw golden marshall apples, and fertilizer and water management is horizontal general, and tree vigo(u)r is weak, spacing in the rows × line-spacing=3
× 4m, limb disease knurl are more.
Design 5 test process：20% 200 times, 400 times, 600 times of propiconazole octyl trichlamide suspending agent；3% methyl sulfur bacterium
Clever paste；200 times of 430g/L tebuconazole suspension concentrates；Blank control, only removes sick scar and does not have to chemicals treatment.Every 20 plants of trees are one
Cell, is repeated 4 times, and per cell, selection tree vigo(u)r is close, position similar in sick scar is marked.
Test and carried out on November 30th, 2014, strike off on trunk and 2 years sick above branches after knurl, uniformly applied with hairbrush
Liquid is smeared, until trunk base portion, average about 500 milliliters or so of liquid of every plant of painting, after having smeared, carries out full tree spraying.In coating
Before, orientation selects 5 3-4 to give birth to branches per orientation in two plants of every cell trees are by all directions, is demarcated respectively with paint on it
60-100 square centimeters of the trunk or branch section that have certain sick knurl.
Before dispenser and on April 30th, 2015, respectively investigation once, was investigated twice altogether.Each cell is investigated respectively to mark in area
Sick knurl quantity, using sick knurl number before coating as radix, counts sick knurl growth rate, calculates prevention effect.
The results are shown in Table 10.
10 20% propiconazole octyl trichlamide suspending agent of table prevention eyespot in apple limb experiment initial data statistical form
(2015)
20% propiconazole octyl trichlamide suspending agent prevention eyespot in apple limb result of the test sees the above table 10.By table as it can be seen that
20% 200 times of field control effects of propiconazole octyl trichlamide suspending agent are best, and cure rate is significantly better than its elsewhere 85.85%
Reason, uses 20% propiconazole octyl trichlamide suspending agent, bactericidal effect is good, environmental pollution in production in a manner of limb is smeared
It is small, it is the suitable formulation for preventing eyespot in apple limb.
Application example 3：Field cherry tree bleeding disease therapeutic test
Example 4 (20% propiconazole octyl trichlamide aqueous emulsion) prevention cherry tree is carried out within 2014 in Shandong Province Tai'an
Bleeding disease field control effectiveness test, verifies the prevention effect, effective dose and the security to cherry tree of the medicament.
Experiment is carried out in Taishan District Xiyuan village large cherry planting base, and test tree be 16 years raw red lights, selection tree vigo(u)r is suitable,
The plant that the state of an illness is close, management measure is consistent is as examination material.Design 5 test process：20% propiconazole octyl trichlamide aqueous emulsion
200 times, 400 times, 600 times；200 times of 430g/L tebuconazole suspension concentrates；3% thiophanate-methyl paste；5 Baume degrees lime sulfurs；
Blank control, only removes colloid and does not have to chemicals treatment.Every 4 plants of trees are a cell, are repeated 4 times, random alignment.
Disease portion dead skin, breach and blob of viscose are removed on April 25th, 2014 (before rainy season starts), is indulged with scraper at sick cortex
Horizontal cut, then smears test medicine with scrub-brush, and scope exceeds disease portion 3-5cm.Interval applies once for 7 days again.
20 gummosis scabs are applied per cell, often processing amounts to 80.(no longer gummosis) number and stream are cured in observation in 60 days after painting
Healing state (stopping gummosis, the dead tissue of surrounding is substituted by cambium), indicator-specific statistics prevention effect is used as using cure rate at glue.
As a result it is as shown in table 11.
11 cherry tree gummosis therapeutic test result of table
Field cherry tree bleeding disease therapeutic test the results are shown in Table 11.As seen from table, 20% propiconazole octyl trichlamide aqueous emulsion
200 times of field control effects are best, and cure rate is significantly better than other each conventional treatments 87.50%, and wound healing is fast,
It is smooth.
Application example 4：Field branch of Semen Juglandis blight therapeutic test
Example 5 (7% the third is carried out within 2013 in five orchard walnut base of Shandong Province Tai'an Shandong Fruit-tree Inst.
Cycloazoxin bacterium aqueous amine dispersible granule) prevention branch of Semen Juglandis blight field control effectiveness test, verify the medicament prevention effect, effectively
Dosage and the security to walnut.
Test and carried out in five orchard walnut base of Shandong Fruit-tree Inst., test tree is the fragrant tinkling of pieces of jade, and selection tree vigo(u)r is suitable, disease
The plant that feelings are close, management measure is consistent is as examination material.Design 5 test process：7% propiconazole octyl trichlamide water dispersible granules
1000 times, 1500 times, 2000 times；2500 times of 430g/L tebuconazole suspension concentrates；70% 700 times of thiophanate-methyl wettable powder；
Blank control.Every 4 plants of trees are a cell, are repeated 4 times, cell random alignment, and listed sign.
Disease investigation calculates the 15d and 40d after last 1 dispenser respectively with preventive effect, and investigation, calculates strain disease branch rate and deadwood
Rate, while calculate effect of chemical control.
Starting the 1st dispenser in early stage, power driven sprayer carries out complete stool spraying treatment, each dispenser interval 10~
15d.The incidence and disease index of each processing cell of 20d investigation after last time dispenser and its medicine, every plant of tree east during investigation,
South, west, 4, north direction totally 80 shoots (per 20, direction), are calculated Investigate incidence and disease index, are counted using DMRT methods
Result of the test is analyzed, while investigates whether walnut is influenced by institute's dispenser agent and produce poisoning, and the symptom type of poisoning
And extent of injury.
6 grades of the field severity Scaling of walnut branch-rot point, it is specific as follows：
0 grade, complete stool is disease-free；1 grade, for walnut branch scab around the 50% of branch girth, less than 10% blade is wilting；3
Level, for walnut branch scab around the 51%~100% of branch girth, 11%~30% blade is wilting；5 grades, walnut branch
Scab surround branch 1 week, and 31%~50% blade is wilting, and branch is slightly withered；7 grades, walnut branch scab is around branch 1
In week, 51%~70% blade is wilting, fallen leaves, and branch moderate is withered；9 grades, branch of Semen Juglandis branch scab surround branch 1 week, and 70%
With blade is wilting, fallen leaves, branch is withered.The method of the reference such as disease index, preventive effect Huang Guoyang, data statistics are soft using DPS
Part is completed.
a.
b.
It the results are shown in Table 12.
12 field branch of Semen Juglandis blight prevention result of table
Field walnut branch-rot therapeutic test the results are shown in Table 12.7% 1000 times of propiconazole octyl trichlamide water dispersible granules,
1500 times of field control effects are best, and cure rate is significantly better than other each processing, and walnut is pacified more than 90.0%
Entirely.
Claims (12)
- A kind of 1. bactericidal composition containing octyl trichlamide and propiconazole, it is characterised in that：Active ingredient is octyl trichlamide and propiconazole, third The weight ratio of ring azoles and octyl trichlamide is 2:1~1:30.
- 2. the bactericidal composition according to claim 1 containing octyl trichlamide and propiconazole, it is characterised in that：It is described to contain octyl trichlamide It is made of with the bactericidal composition of propiconazole the component of following parts by weight：Propiconazole 1%~80%, octyl trichlamide 1%~ 80%, surplus is to allow to use and acceptable auxiliary material in Pesticide Science；Allow to use in the Pesticide Science and acceptable Auxiliary material is selected from solvent, bleeding agent, dispersant, diffusant, disintegrant, emulsifying agent, stabilizer, wetting agent, defoamer, antifreezing agent, Or other stabilizations for contributing to active ingredient drug effect and performance allow use auxiliary agent.
- 3. the bactericidal composition according to claim 1 containing octyl trichlamide and propiconazole, it is characterised in that：The Bactericidal composite The formulation of thing is wettable powder, suspending agent, missible oil, aqueous emulsion, water dispersible granules or microemulsion.
- 4. according to the bactericidal composition according to any one of claims 1 to 3 containing octyl trichlamide and propiconazole, it is characterised in that： The formulation of the bactericidal composition is wettable powder, is made of the component of following percetage by weight：
- 5. according to the bactericidal composition according to any one of claims 1 to 3 containing octyl trichlamide and propiconazole, it is characterised in that： The formulation of the bactericidal composition is suspending agent, is made of the component of following percetage by weight：
- 6. according to the bactericidal composition according to any one of claims 1 to 3 containing octyl trichlamide and propiconazole, it is characterised in that： The formulation of the bactericidal composition is missible oil, is made of the component of following percetage by weight：
- 7. according to the bactericidal composition according to any one of claims 1 to 3 containing octyl trichlamide and propiconazole, it is characterised in that： The formulation of the bactericidal composition is aqueous emulsion, water dispersible granules or microemulsion,When formulation is aqueous emulsion, it is made of the component of following percetage by weight：When formulation is water dispersible granules, it is made of the component of following percetage by weight：When formulation is microemulsion, it is made of the component of following percetage by weight：
- 8. the bactericidal composition according to any one of claims 1 to 7 containing octyl trichlamide and propiconazole is in prevention fruit tree, forest branch Application in dry disease, or as fruit tree, forest grafting, beta pruning sealing compound in application.
- 9. application according to claim 8, it is characterised in that：The disease is selected from canker of apple fruit, apple limb wheel line Disease, dry rot of apple, cherry bleeding disease, peach gummosis, blueberry branch-rot, willow branch-rot, dothiorella gregaria, Ramulus Juglandis are withered Disease.
- 10. application according to claim 9, it is characterised in that：When preventing Valsa mali, propiconazole and octyl trichlamide The weight ratio of the two is 1:1~15；When preventing eyespot in apple limb bacterium, the weight ratio of propiconazole and both octyl trichlamides is 2: 1~1:20；When preventing cherry gummosis germ, the weight ratio of propiconazole and both octyl trichlamides is 2:1~1:20；In prevention willow During ulcer bacteria, the weight ratio of propiconazole and both octyl trichlamides is 2:1~1:20；When preventing branch of Semen Juglandis blight bacterium, the third ring The weight ratio of azoles and both octyl trichlamides is 2:1~1:30；When preventing blueberry branch-rot bacterium, propiconazole and the weight of both octyl trichlamides Amount is than being 1:1~25.
- 11. application according to claim 9, it is characterised in that：When preventing Valsa mali, propiconazole and octyl trichlamide The weight ratio of the two is 1:1~10；When preventing eyespot in apple limb bacterium, the weight ratio of propiconazole and both octyl trichlamides is 1: 5~15；When preventing cherry gummosis germ, the weight ratio of propiconazole and both octyl trichlamides is 1:5~15；In prevention willow ulcer During germ, the weight ratio of propiconazole and both octyl trichlamides is 1:5~15；When preventing branch of Semen Juglandis blight bacterium, propiconazole with it is pungent The weight ratio of both bacterium amine is 1:1~20；When preventing blueberry branch-rot bacterium, the weight ratio of propiconazole and both octyl trichlamides is 1: 2~15.
- 12. application according to claim 9, it is characterised in that：When preventing Valsa mali, propiconazole and octyl trichlamide The weight ratio of the two is 1:5；When preventing eyespot in apple limb bacterium, the weight ratio of propiconazole and both octyl trichlamides is 1:5； When preventing cherry gummosis germ, the weight ratio of propiconazole and both octyl trichlamides is 1:5；When preventing dothiorella gregaria bacterium, the third ring The weight ratio of azoles and both octyl trichlamides is 1:5；When preventing branch of Semen Juglandis blight bacterium, propiconazole and the weight ratio of both octyl trichlamides For 1:5；When preventing blueberry branch-rot bacterium, the weight ratio of propiconazole and both octyl trichlamides is 1:5.
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| CN107258816A (en) * | 2017-07-20 | 2017-10-20 | 天津市瀚葳园林植物保护技术有限公司 | A kind of composition pesticide for being used to treat and prevent dothiorella gregaria |
| CN107668038A (en) * | 2017-11-07 | 2018-02-09 | 江苏东宝农化股份有限公司 | Using bactericidal composition of the fluorine bacterium azoles with octyl trichlamide as principle active component |
| CN107950646A (en) * | 2017-12-06 | 2018-04-24 | 宁波市农业科学研究院 | A kind of peach method for storing and refreshing |
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| CN103039461A (en) * | 2012-12-17 | 2013-04-17 | 广东中迅农科股份有限公司 | Pesticide composition containing zinc bacteria amine and hexaconazole |
| CN103238611A (en) * | 2013-05-27 | 2013-08-14 | 雷军永 | Medicament for preventing and treating apple tree canker |
| CN104106575A (en) * | 2014-07-31 | 2014-10-22 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Fungicidal composition containing octyl trichlamide and diniconazole |
| CN104770368A (en) * | 2015-04-16 | 2015-07-15 | 山东省果树研究所 | Bactericidal composition containing coumoxystrobin and xinjunan and application thereof |
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| CN103039461A (en) * | 2012-12-17 | 2013-04-17 | 广东中迅农科股份有限公司 | Pesticide composition containing zinc bacteria amine and hexaconazole |
| CN103238611A (en) * | 2013-05-27 | 2013-08-14 | 雷军永 | Medicament for preventing and treating apple tree canker |
| CN104106575A (en) * | 2014-07-31 | 2014-10-22 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Fungicidal composition containing octyl trichlamide and diniconazole |
| CN104770368A (en) * | 2015-04-16 | 2015-07-15 | 山东省果树研究所 | Bactericidal composition containing coumoxystrobin and xinjunan and application thereof |
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