CN106414768B - 与癌症相关的基因融合体和基因变异体 - Google Patents

与癌症相关的基因融合体和基因变异体 Download PDF

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CN106414768B
CN106414768B CN201580016472.9A CN201580016472A CN106414768B CN 106414768 B CN106414768 B CN 106414768B CN 201580016472 A CN201580016472 A CN 201580016472A CN 106414768 B CN106414768 B CN 106414768B
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gene
cancer
fusion
data
nucleic acid
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CN106414768A (zh
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D·罗兹
S·萨迪什
P·韦恩加德
N·哈扎诺夫
S·班德尔
M·托米略
S·埃迪
E·鲍登
J·李
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Life Technologies Corp
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
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  • Analytical Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201580016472.9A 2014-03-27 2015-03-27 与癌症相关的基因融合体和基因变异体 Active CN106414768B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201461971455P 2014-03-27 2014-03-27
US61/971,455 2014-03-27
US201461993732P 2014-05-15 2014-05-15
US61/993,732 2014-05-15
US201462004727P 2014-05-29 2014-05-29
US62/004,727 2014-05-29
US201462092898P 2014-12-17 2014-12-17
US62/092,898 2014-12-17
PCT/US2015/023197 WO2015149034A2 (fr) 2014-03-27 2015-03-27 Fusions de gènes et variants de gènes associés au cancer

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CN106414768A CN106414768A (zh) 2017-02-15
CN106414768B true CN106414768B (zh) 2020-05-29

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EP (2) EP3122901B1 (fr)
CN (1) CN106414768B (fr)
WO (1) WO2015149034A2 (fr)

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WO2013059740A1 (fr) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Nouvelles molécules de fusion alk et ntrk1 et leurs utilisations
CN110234773B (zh) * 2016-12-13 2024-07-02 匹兹堡大学联邦系统高等教育 治疗含融合基因的癌症的方法
BR112019014042A2 (pt) * 2017-01-17 2020-02-04 Illumina, Inc. determinação de variante de splice oncogênica
US10964410B2 (en) * 2017-05-25 2021-03-30 Koninklijke Philips N.V. System and method for detecting gene fusion
EP3631011B1 (fr) 2017-05-31 2021-06-23 Roche Diagnostics GmbH Détection par pcr multiplex de fusions d'alk, ret et ros
CN107944223B (zh) * 2017-11-10 2019-12-31 深圳裕策生物科技有限公司 基于二代测序的点突变检测过滤方法、装置和存储介质
CN108707628B (zh) * 2018-05-28 2021-11-23 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108841959B (zh) * 2018-07-12 2022-03-01 吉林大学 一种口腔及头颈部恶性肿瘤易感性预测试剂盒及系统
CN108866189B (zh) * 2018-07-12 2022-03-01 吉林大学 一种喉鳞状细胞癌易感性预测试剂盒及系统
CN111172281B (zh) * 2019-12-31 2023-10-20 广州达安基因股份有限公司 非小细胞肺癌多重基因突变检测试剂盒及方法
CN111269983A (zh) * 2020-02-21 2020-06-12 深圳市众循精准医学研究院 一种膀胱癌基因扩增的fish检测方法、探针及试剂盒
CN111653312B (zh) * 2020-05-28 2021-04-16 上海宝藤生物医药科技股份有限公司 一种利用基因组数据探究疾病亚型亲缘性的方法
CN112599188B (zh) * 2021-03-01 2021-05-11 上海思路迪医学检验所有限公司 一种融合驱动基因单端锚定的dna融合断点注释方法
CN113516653B (zh) * 2021-08-11 2024-03-15 中科(厦门)数据智能研究院 一种多特征融合计算识别胶质瘤复发与坏死的方法
WO2023039539A1 (fr) * 2021-09-10 2023-03-16 Foundation Medicine, Inc. Fusions de gènes dans un sarcome

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CN102533945A (zh) * 2010-12-13 2012-07-04 江苏百帝生物科技有限公司 前列腺癌相关融合基因Fish检测方法和相关检测探针及试剂盒
CN102575287A (zh) * 2009-05-15 2012-07-11 因赛特遗传学公司 用于诊断和治疗癌症的涉及alk融合物的方法和组合物
WO2013006195A1 (fr) * 2011-07-01 2013-01-10 Htg Molecular Diagnostics, Inc. Procédés de détection de fusions de gènes
CN103468813A (zh) * 2013-09-17 2013-12-25 广州达健生物科技有限公司 Eml4-alk融合基因荧光定量pcr检测试剂盒

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CN102575287A (zh) * 2009-05-15 2012-07-11 因赛特遗传学公司 用于诊断和治疗癌症的涉及alk融合物的方法和组合物
CN102533945A (zh) * 2010-12-13 2012-07-04 江苏百帝生物科技有限公司 前列腺癌相关融合基因Fish检测方法和相关检测探针及试剂盒
WO2013006195A1 (fr) * 2011-07-01 2013-01-10 Htg Molecular Diagnostics, Inc. Procédés de détection de fusions de gènes
CN103468813A (zh) * 2013-09-17 2013-12-25 广州达健生物科技有限公司 Eml4-alk融合基因荧光定量pcr检测试剂盒

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Publication number Publication date
EP3438288A1 (fr) 2019-02-06
CN106414768A (zh) 2017-02-15
WO2015149034A3 (fr) 2016-01-28
EP3122901A2 (fr) 2017-02-01
WO2015149034A2 (fr) 2015-10-01
WO2015149034A9 (fr) 2015-12-10
EP3122901B1 (fr) 2018-08-15

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