ATE478090T1 - SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN - Google Patents

SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN

Info

Publication number
ATE478090T1
ATE478090T1 AT98957388T AT98957388T ATE478090T1 AT E478090 T1 ATE478090 T1 AT E478090T1 AT 98957388 T AT98957388 T AT 98957388T AT 98957388 T AT98957388 T AT 98957388T AT E478090 T1 ATE478090 T1 AT E478090T1
Authority
AT
Austria
Prior art keywords
methods
probe
target sequence
molecular beacons
ßpna
Prior art date
Application number
AT98957388T
Other languages
English (en)
Inventor
James Coull
Brian Gildea
Jens Hyldig-Nielsen
Original Assignee
Boston Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Probes Inc filed Critical Boston Probes Inc
Application granted granted Critical
Publication of ATE478090T1 publication Critical patent/ATE478090T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Ceramic Products (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT98957388T 1997-10-27 1998-10-27 SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN ATE478090T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95853297A 1997-10-27 1997-10-27
PCT/US1998/022785 WO1999022018A2 (en) 1997-10-27 1998-10-27 Methods, kits and compositions pertaining to pna molecular beacons

Publications (1)

Publication Number Publication Date
ATE478090T1 true ATE478090T1 (de) 2010-09-15

Family

ID=25501029

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98957388T ATE478090T1 (de) 1997-10-27 1998-10-27 SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN

Country Status (6)

Country Link
US (3) US6355421B1 (de)
EP (1) EP1025120B1 (de)
AT (1) ATE478090T1 (de)
AU (1) AU1366299A (de)
DE (1) DE69841849D1 (de)
WO (1) WO1999022018A2 (de)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6355421B1 (en) * 1997-10-27 2002-03-12 Boston Probes, Inc. Methods, kits and compositions pertaining to PNA molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
AU3775099A (en) 1998-04-29 1999-11-16 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
JP4646404B2 (ja) 1998-07-02 2011-03-09 ジェン−プローブ・インコーポレーテッド 分子トーチ（ｔｏｒｃｈ）
US6441152B1 (en) 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
AUPP844899A0 (en) * 1999-02-01 1999-02-25 University Of Western Australia, The A method for detecting methylated nucleic acids
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
DE60030145T2 (de) * 1999-10-22 2008-01-10 PHRI Properties, Inc., Newark Nachweisverfahren für kurze sequenzvarianten
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
US7998673B2 (en) * 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
DK1715063T3 (da) * 2000-03-29 2011-05-16 Lgc Ltd Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion
CA2409512A1 (en) * 2000-05-08 2001-11-15 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6451588B1 (en) * 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
US7270954B1 (en) * 2000-06-30 2007-09-18 Iris Biotechnologies, Inc. Hybridization of target DNA with immobilized nucleic acid analogs
US6596490B2 (en) * 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
DE60138916D1 (de) 2000-09-26 2009-07-16 Boston Probes Inc Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
US6773885B1 (en) * 2000-09-29 2004-08-10 Integrated Dna Technologies, Inc. Compositions and methods for visual ribonuclease detection assays
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US20040229382A1 (en) * 2000-10-23 2004-11-18 Ronald Breaker Characterized arrangements of mixtures (CAM) using polymers
AU2002246676A1 (en) 2000-12-15 2002-07-30 Boston Probes, Inc. Methods for determining organisms
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US20030077609A1 (en) * 2001-03-25 2003-04-24 Jakobsen Mogens Havsteen Modified oligonucleotides and uses thereof
EP1417333B1 (de) 2001-05-18 2011-10-05 Boston Probes, Inc. Pna-sonden, sondensätze, verfahren und kits im zusammenhang mit dem nachweis von candida
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US20030105320A1 (en) * 2001-08-31 2003-06-05 Becker Michael M. Affinity-shifted probes for quantifying analyte polynucleotides
US7070933B2 (en) * 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
US20040106109A1 (en) * 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
WO2003040397A2 (en) * 2001-10-25 2003-05-15 Gorilla Genomics, Inc. Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
JP2005520554A (ja) * 2002-03-21 2005-07-14 ボストン プローブス，インコーポレイテッド ＢａｃｉｌｌｕｓＡｎｔｈｒａｃｉｓの検出に関するＰＮＡオリゴマー、オリゴマーセット、方法およびキット
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
WO2003100076A2 (en) * 2002-05-17 2003-12-04 Applera Corporation Pna probes, probe sets, method and kits pertaining to the determination of listeria
US6713262B2 (en) * 2002-06-25 2004-03-30 Agilent Technologies, Inc. Methods and compositions for high throughput identification of protein/nucleic acid binding pairs
EP1575990B1 (de) 2002-09-08 2009-11-18 Applera Corporation Festphasengebundene PNA-Dimere und deren Synthese
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP3000899A1 (de) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplexverstärkung von polynucleotiden
US7291459B2 (en) * 2002-12-10 2007-11-06 University Of Alabama At Huntsville Nucleic acid detector and method of detecting targets within a sample
US20040115336A1 (en) * 2002-12-12 2004-06-17 Industrial Technology Research Institute Method of fabricating a grating-based optical biosensor
GB2422196B (en) * 2003-05-20 2008-05-07 Investigen Inc System for detecting polynucleotides
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
US20050069895A1 (en) * 2003-08-29 2005-03-31 Applera Corporation Compositions, methods, and kits for fabricating coded molecular tags
US20050048498A1 (en) * 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
WO2005043114A2 (en) * 2003-10-22 2005-05-12 Ron Broide Oligonucleotide probe sets and uses thereof
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
EP2208797A3 (de) 2004-03-01 2010-11-24 Applied Biosystems, LLC Verfahren, Zusammensetzungen und Kits für Polynukleotidamplifikation
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
EP2290073A3 (de) * 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
DK1778867T3 (da) 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
CN1304598C (zh) * 2004-08-13 2007-03-14 湖南大学 一种atp、nad及相关酶和底物的分析方法
EP1791982B1 (de) 2004-09-21 2011-01-05 Life Technologies Corporation Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
US20060252081A1 (en) * 2005-05-06 2006-11-09 Applera Corporation PNA probes, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes
US20090209508A1 (en) * 2005-05-16 2009-08-20 Universite De Geneve Compounds for Photochemotherapy
WO2006130872A2 (en) 2005-06-02 2006-12-07 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
WO2006137786A1 (en) 2005-06-20 2006-12-28 Avaris Ab Hybridization-stabilizing construct
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
US20080032282A1 (en) * 2005-12-23 2008-02-07 Al Vitae Pharmaceuticals Methods and applications of molecular beacon imaging for infectious disease and cancer detection
EP2010677A4 (de) * 2006-02-24 2010-04-14 Investigen Inc Verfahren und zusammensetzungen zum nachweis von polynukleotiden
US9677123B2 (en) 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
DK2004847T3 (en) * 2006-03-16 2017-08-21 Pentabase Aps Oligonucleotides comprising signaling pairs and hydrophobic nucleotides, "stemless beacons", for detection of nucleic acids, methylation status and mutants of nucleic acids
US7947441B2 (en) * 2006-04-14 2011-05-24 University Of South Florida Molecular detection and quantification of Enterococci
EP2484781B1 (de) 2006-08-01 2017-08-23 Applied Biosystems, LLC Nachweis von Analyten und Nukleinsäuren
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
WO2008073919A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
WO2008073920A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
DE102007017051A1 (de) * 2007-04-11 2008-10-16 Humboldt-Universität Zu Berlin Dual-markierte Fluoreszenzsonden zur Detektion von Proteinen
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
CA2689974A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
US7811764B2 (en) * 2007-08-14 2010-10-12 University Of Rochester Hybridization-based biosensor containing hairpin probes and use thereof
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
US8304245B2 (en) * 2007-11-02 2012-11-06 Children's Hospital And Research Center At Oakland Microfluidic flow lysometer device, system and method
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
WO2009140374A2 (en) 2008-05-13 2009-11-19 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
WO2010028014A1 (en) * 2008-09-03 2010-03-11 Abbott Laboratories Assays and kits for determining hiv-1 tropism
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
WO2010068473A1 (en) * 2008-11-25 2010-06-17 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
EP2376659B1 (de) * 2008-12-17 2015-12-02 Life Technologies Corporation Verfahren, zusammensetzungen und kits für den nachweis von allelen varianten
EP3249053A1 (de) 2009-03-27 2017-11-29 Life Technologies Corporation Verfahren, zusammensetzungen und kits für den nachweis von allelen varianten
WO2010135692A2 (en) 2009-05-22 2010-11-25 Asuragen, Inc. Mirna biomarkers of prostate disease
CN101899499B (zh) * 2009-05-26 2016-07-27 厦门大学 一种检测人β-珠蛋白基因突变的方法
EP3330385A1 (de) 2009-07-21 2018-06-06 Gen-Probe Incorporated Verfahren und zusammensetzungen für den quantitativen nachweis von nukleinsäuresequenzen in einem erweiterten dynamischen bereich
US8614062B1 (en) 2009-07-24 2013-12-24 University Of South Florida RNA-based system and method to differentiate seafood
EP2462515A4 (de) * 2009-08-05 2015-08-12 Life Technologies Corp Verfahren zur analyse von näherungsbindenden assay-daten
CN102725632A (zh) 2009-08-28 2012-10-10 奥斯瑞根公司 肺病的miRNA生物标志物
WO2011027218A1 (en) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. High throughput detection of genomic copy number variations
WO2011027219A1 (en) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. High throughput detection of small genomic deletions and insertions
WO2011087789A2 (en) 2009-12-22 2011-07-21 Becton, Dickinson And Company Methods for the detection of microorganisms
WO2011130184A2 (en) 2010-04-11 2011-10-20 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
US9410194B2 (en) 2010-06-21 2016-08-09 Life Technologies Corporation Compositions, kits and methods for synthesis and/or detection of nucleic acids
ES2908415T3 (es) 2010-06-21 2022-04-29 Life Technologies Corp Composición y método para la síntesis y amplificación de ácidos nucleicos mediante el uso de RT
US12043866B2 (en) * 2010-08-13 2024-07-23 Envirologix Inc. Compositions and methods for quantifying a nucleic acid sequence in a sample
EP2641201B1 (de) 2010-11-16 2018-12-26 Life Technologies Corporation Systeme und verfahren zur analyse von näherungsbindenden testdaten
CN107326073A (zh) 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
ES2632768T3 (es) 2011-01-17 2017-09-15 Life Technologies Corporation Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos
WO2012142003A2 (en) 2011-04-15 2012-10-18 Life Technologies Corporation Chemical ligation
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
DK2718260T3 (en) 2011-06-08 2018-11-19 Life Technologies Corp DESIGN AND DEVELOPMENT OF NEW DETERGENTS FOR USE IN PCR SYSTEMS
JP6154809B2 (ja) 2011-06-27 2017-06-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 アルツハイマー病を示すマイクロｒｎａバイオマーカー
KR20130008283A (ko) * 2011-07-12 2013-01-22 주식회사 파나진 평행결합 구조의 이중 혼성화 ｐｎａ 프로브 시스템을 포함하는 실시간 다중 중합효소 연쇄반응에 의한 결핵균 및 비결핵 항산균의 동시 검출용 조성물 및 이를 이용한 검출 방법
WO2013009070A2 (ko) * 2011-07-12 2013-01-17 주식회사 파나진 평행 결합 구조의 이중 혼성화 pna 프로브 시스템
KR20140057343A (ko) 2011-08-18 2014-05-12 네스텍 소시에테아노님 대립형질 변이 검출을 위한 조성물 및 방법
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130179086A1 (en) 2011-11-29 2013-07-11 Life Technologies Corporation Systems and methods for the determination of a copy number of a genomic sequence
EP2812344A4 (de) 2012-02-07 2015-10-28 Vibrant Holdings Llc Substrate, peptidarrays und verfahren
KR102362649B1 (ko) 2012-04-09 2022-02-14 엔바이로로직스 인크. 시료 내 핵산 서열을 정량화하기 위한 조성물 및 방법
KR20210072137A (ko) 2012-06-14 2021-06-16 라이프 테크놀로지스 코포레이션 폴리머라제 연쇄 반응 (pcr)을 위한 신규 조성물, 방법 및 키트
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US20140178875A1 (en) 2012-10-09 2014-06-26 Advandx, Inc. Devices, Compositions and Methods Pertaining To Microscopic Analysis Of Microorganisms and Other Analytes of Interest
PL3260558T3 (pl) 2012-11-02 2020-08-10 Life Technologies Corporation Nowe kompozycje i sposoby poprawy specyficzności pcr
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
US11254977B2 (en) 2013-03-12 2022-02-22 Life Technologies Corporation Universal reporter-based genotyping methods and materials
AU2014227883B9 (en) 2013-03-15 2020-09-10 Life Technologies Corporation Classification and actionability indices for lung cancer
EP2981621B1 (de) 2013-04-05 2019-05-22 Life Technologies Corporation Genfusionen
CN105722996A (zh) 2013-09-13 2016-06-29 生命科技公司 癌症的分类和可行性指数
CN106458885B (zh) 2013-10-25 2019-12-10 生命技术公司 用于聚合酶链式反应系统的新颖化合物及其应用
CN122038564A (zh) 2014-01-05 2026-05-15 G·索兹 使用mirna比率确定肺癌
US10619210B2 (en) 2014-02-07 2020-04-14 The Johns Hopkins University Predicting response to epigenetic drug therapy
EP3122901B1 (de) 2014-03-27 2018-08-15 Life Technologies Corporation Mit krebs assoziierte genfusionen und genvarianten
CN106414766B (zh) * 2014-04-04 2019-10-08 帕纳金股份有限公司 使用pna探针的熔解曲线分析核苷酸多态性的方法和试剂盒
MX386087B (es) 2014-04-22 2025-03-18 Envirologix Inc Composiciones y metodos para mejorar y/o predecir la amplificacion de adn.
ES2832748T3 (es) 2014-08-19 2021-06-11 Hoffmann La Roche Procedimientos y composiciones para la detección de ácidos nucleicos
US10793922B2 (en) 2014-10-20 2020-10-06 Envirologix Inc. Compositions and methods for detecting an RNA virus
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
WO2016092045A1 (en) 2014-12-11 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting medically refractory acute severe colitis
EP3292214A1 (de) 2015-05-04 2018-03-14 Academisch Medisch Centrum Verfahren zur quantifizierung von mirnas mittels normalisierung
EP3440221B1 (de) 2016-04-06 2025-08-27 Life Technologies Corporation Verfahren zur synthese und zum nachweis von nukleinsäuren
US20170362640A1 (en) 2016-06-16 2017-12-21 Life Technologies Corporation Novel compositions, methods and kits for microorganism detection
CN118207299A (zh) 2016-08-26 2024-06-18 生命技术公司 核酸提取和扩增对照及其使用方法
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
WO2018218250A2 (en) 2017-05-26 2018-11-29 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
CN107385016A (zh) * 2017-06-14 2017-11-24 苏州承美生物科技有限公司 一种检测kras基因突变的分子信标探针及试剂盒
JP2021502825A (ja) 2017-11-13 2021-02-04 ライフ テクノロジーズ コーポレイション 尿路微生物検出のための組成物、方法、およびキット
CA3099046A1 (en) 2018-05-09 2019-11-14 Vibrant Holdings, Llc Methods of synthesizing a polynucleotide array using photoactivated agents________________________________________________________
CN112602153A (zh) 2018-08-30 2021-04-02 生命科技股份有限公司 用于对pcr测定进行基因分型的机器学习系统
US11836614B2 (en) 2018-08-31 2023-12-05 Life Technologies Corporation Image driven quality control for array-based PCR
KR20200045212A (ko) * 2018-10-22 2020-05-04 (주)바이오니아 옥타민 또는 옥타민 유도체가 결합된 프로브 및 이의 용도
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
US20220267857A1 (en) 2019-07-19 2022-08-25 Fundación Para La Investigación Biomédikca Del Hospital Universitario La Paz (Fibhulp) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
CA3186955A1 (en) 2020-07-23 2022-01-27 Scott Benson Energy transfer dye conjugates for use in biological assays
US20230304932A1 (en) 2020-07-23 2023-09-28 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
US11649441B2 (en) 2020-10-07 2023-05-16 Abclonal Science, Inc. Taq DNA polymerase mutants for probe qPCR
WO2022178216A2 (en) 2021-02-22 2022-08-25 Cotropia Joseph Corona virus antigens and epitopes and proteins that bind thereto
WO2022197882A1 (en) 2021-03-18 2022-09-22 Cotropia Joseph Human immunodeficiency virus (hiv) antigens and epitopes and proteins that bind thereto
US20250084250A1 (en) 2021-07-21 2025-03-13 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation
WO2023004400A1 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Dibenzoxanthene quenchers, uses, and methods of preparation
IL311066A (en) 2021-08-30 2024-04-01 Galderma Holding SA Treatments for atopic dermatitis
US20240376534A1 (en) 2021-09-10 2024-11-14 Life Technologies Corporation Master mix compositions, kits, and methods
US20250019752A1 (en) 2021-11-02 2025-01-16 Life Technologies Corporation Compositions and methods for reducing master mix contamination
WO2025007089A1 (en) 2023-06-30 2025-01-02 Life Technologies Corporation Compositions, methods and kits for nucleic acids synthesis and amplification
WO2025151807A1 (en) 2024-01-11 2025-07-17 Life Technologies Corporation Crude lysate sample extraction for digital pcr
WO2025175243A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Amplification and data collection protocol for rapid genotyping
WO2025175212A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Methods for rapid extraction-free genotyping
WO2025188713A1 (en) 2024-03-05 2025-09-12 Cotropia Joseph Feline leukemia virus antigens and epitopes and proteins that bind thereto

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
IT8052826V0 (it) * 1980-01-11 1980-01-11 Robaldo Aldo Michele Apparecchio per la polimerizzazione della resina adesiva applicata agli incroci delle corde delle racchette da tennis
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5567587A (en) 1983-01-10 1996-10-22 Gen-Probe Incorporated Method for detecting, the presence and amount of prokaryotic organisms using specific rRNA subsequences as probes
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4666862A (en) 1984-08-14 1987-05-19 Ortho Diagnostic Systems Inc. Fluorescent energy transfer with phycobiliproteins
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4822733A (en) 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4725537A (en) 1985-09-19 1988-02-16 Allied Corporation Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
DK0537270T3 (da) 1990-07-02 1999-06-07 Univ California Påvisning af analytter ved overføring af fluorescensenergi
US5439793A (en) 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5237515A (en) 1991-04-10 1993-08-17 University Of Utah Research Foundation Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
CA2073630C (en) 1991-08-30 2007-12-11 Atsushi Ohshima Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
ATE244259T1 (de) 1992-02-12 2003-07-15 Chromagen Inc Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
DK0566751T3 (da) 1992-03-23 1996-03-04 Hoffmann La Roche DNA-påvisningsmetode
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
EP0601889A2 (de) 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
CA2105364A1 (en) 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
EP2423322A1 (de) 1993-11-12 2012-02-29 PHRI Properties, Inc. Hybridisierungsprobe zur Nukleinsäuredetektion, universelle Stammstrukturen, Methoden und Reagentiensätze
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
AU2522095A (en) 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5675517A (en) 1995-04-25 1997-10-07 Systemix Fluorescence spectral overlap compensation for high speed flow cytometry systems
EP0826066B1 (de) 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
WO1996040709A1 (en) 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
US5879885A (en) 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
US5623019A (en) 1995-07-13 1997-04-22 Bayer Corporation Compatibilized thermoplastic molding composition
US5770365A (en) 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
EP0870055B1 (de) 1995-10-12 2007-05-16 LANSDORP, Peter, M. Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
ES2289753T3 (es) 1995-11-16 2008-02-01 Dako Denmark A/S Hibridacion in situ para detectar secuencias de acidos nucleicos especificas en muestras eucarioticas.
US5723294A (en) 1996-03-05 1998-03-03 Gull Laboratories Methods for detection and discrimination of multiple analytes using fluorescent technology
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
AU2735797A (en) 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
ATE428801T1 (de) 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US5780233A (en) 1996-06-06 1998-07-14 Wisconsin Alumni Research Foundation Artificial mismatch hybridization
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5827660A (en) 1996-08-09 1998-10-27 University Of Massachusetts Caged fluorochrome-labeled probes and subtraction of autoflourescence background
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5853992A (en) 1996-10-04 1998-12-29 The Regents Of The University Of California Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
GB2333597B (en) 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
WO1998026093A2 (en) 1996-12-13 1998-06-18 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fluorescent nucleotide analog hairpin formation for detection of nucleic acid hybridization
US5837466A (en) 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
US6025133A (en) 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US5804386A (en) 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
AU6822598A (en) 1997-02-24 1998-09-09 Georgia Tech Research Corporation Method for determining a nucleic acid
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US5846729A (en) 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
US5786571A (en) 1997-05-09 1998-07-28 Lexmark International, Inc. Wrapped temperature sensing assembly
US6355421B1 (en) * 1997-10-27 2002-03-12 Boston Probes, Inc. Methods, kits and compositions pertaining to PNA molecular beacons
US6328397B1 (en) 1998-09-07 2001-12-11 Hitachi Koki Co., Ltd. Drive voltage adjusting method for an on-demand multi-nozzle ink jet head
US9721845B1 (en) 2016-04-26 2017-08-01 International Business Machines Corporation Vertical field effect transistors with bottom contact metal directly beneath fins

Also Published As

Publication number Publication date
AU1366299A (en) 1999-05-17
WO1999022018A3 (en) 1999-10-21
WO1999022018A2 (en) 1999-05-06
EP1025120B1 (de) 2010-08-18
EP1025120A2 (de) 2000-08-09
US6355421B1 (en) 2002-03-12
US6949343B2 (en) 2005-09-27
US6528267B1 (en) 2003-03-04
DE69841849D1 (de) 2010-09-30
US20030036059A1 (en) 2003-02-20
US20030232327A1 (en) 2003-12-18

Similar Documents

Publication Publication Date Title
DE69841849D1 (de) Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen
ATE286066T1 (de) Verfahren, kits und zusammenfassungen mit beziehung zu linearen baken
ATE233826T1 (de) Verbesserte erkennung von spezifischen nukleinsäuren
CA2256545A1 (en) Probe for analysis of nucleic acids
DE60233477D1 (de) Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung
ATE354588T1 (de) Verfahren und zusammestellungen zum nachweis und behandlung von brustkrebs, beruhend auf brustkrebs-assoziierten polypeptiden
MXPA05008519A (es) Forma de algodon mon 88913 y composiciones y metodos para detectarla.
DE60334524D1 (de) E2-verdrängungs-assay zur identifizierung von hpv-inhibitoren
ATE412066T1 (de) Markierte zwei-konformations oligonukleotid sonden, verfahren und testsätze
ATE200694T1 (de) Verfahren, reagenzien und kits zur untersuchung von neisseria gonorrhoeae und chlamydia trachomatis
ATE360092T1 (de) Nukleinsäureprimer und -sonden zur detektion onkogener humaner papillomaviren
DE60120460D1 (de) Teststab
ATE495434T1 (de) Nukleinsäuresequenzidentifikation
FI971802A0 (fi) Mycobacterium avium-kompleksilajien monistus ja ilmaisu
DE60027045D1 (de) Oligonukleotide und diese enthaltende komplexe zur detektion der anwesenheit oder abwesenheit einer zielnukleinsäure in einer probe
ES8801385A1 (es) Un equipo de diagnostico para discriminar entre dos secuencias nucleotidicas complementarias.
DE69709804D1 (de) Nachweis von nukleotidsequenzen durch signalamplifizierung
ATE235560T1 (de) Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna
ATE449868T1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
ATE495268T1 (de) Nukleinsäureamplifizierung und detektion von mykobacterium-spezies
ATE174634T1 (de) Verfahren und proben zum nachweis von mit dem locus der infantilen spinalamyotrophien verbundenen markern
DE60324395D1 (de) Interne positive kontrolle für auf sonden basierende nukleinsäuremolekül-assays und verfahren zur herstellung und verwendung davon
ATE354670T1 (de) Nucleinsäuresonden und amplifizierungsoligonukleotide für neisseria spezies
BR0115689A (pt) Análise de expressão de inibidor de diferenciação de ácidos nucléicos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata
DE60012723D1 (de) Verfahren zur bestimmung von disaccharidasen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties