CN106459058B - 作为toll-样受体7激动剂的化合物和组合物 - Google Patents

作为toll-样受体7激动剂的化合物和组合物 Download PDF

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CN106459058B
CN106459058B CN201580021681.2A CN201580021681A CN106459058B CN 106459058 B CN106459058 B CN 106459058B CN 201580021681 A CN201580021681 A CN 201580021681A CN 106459058 B CN106459058 B CN 106459058B
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amino
pyrrolo
methyl
formula
base
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CN106459058A (zh
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A·库尔特茨
T·霍夫曼
Y·李
T·Y-H·吴
X·张
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Novartis AG
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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CN201580021681.2A 2014-05-01 2015-04-29 作为toll-样受体7激动剂的化合物和组合物 Expired - Fee Related CN106459058B (zh)

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US201461987314P 2014-05-01 2014-05-01
US61/987,314 2014-05-01
PCT/US2015/028285 WO2015168279A1 (en) 2014-05-01 2015-04-29 Compounds and compositions as toll-like receptor 7 agonists

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CN106459058A CN106459058A (zh) 2017-02-22
CN106459058B true CN106459058B (zh) 2019-07-05

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US (3) US9944649B2 (2)
EP (1) EP3137468B1 (2)
JP (1) JP6541689B2 (2)
KR (1) KR20160144399A (2)
CN (1) CN106459058B (2)
AU (1) AU2015253225B2 (2)
BR (1) BR112016025048A2 (2)
CA (1) CA2945504A1 (2)
EA (1) EA032487B1 (2)
ES (1) ES2908150T3 (2)
IL (1) IL248311B (2)
MX (1) MX380777B (2)
NZ (1) NZ724878A (2)
SG (1) SG11201608299TA (2)
WO (1) WO2015168279A1 (2)

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