CN1068588C - 磷脂酶a2抑制剂1h－吲哚－3－乙酰胺类化合物 - Google Patents

磷脂酶a2抑制剂1h－吲哚－3－乙酰胺类化合物 Download PDF

Info

Publication number: CN1068588C
Authority: CN; China
Prior art keywords: methyl; indole; phenmethyl; amino; indoles
Prior art date: 1993-04-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CN94104434A

Other languages

English (en)

Chinese (zh)

Other versions

CN1098715A (zh

Inventor

N·J·巴哈

R·D·迪拉德

S·E·德拉海姆

R·B·赫尔曼

R·W·谢维茨

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-16

Filing date

1994-04-15

Publication date

2001-07-18

1994-04-15 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1995-02-15 Publication of CN1098715A publication Critical patent/CN1098715A/zh

2001-07-18 Application granted granted Critical

2001-07-18 Publication of CN1068588C publication Critical patent/CN1068588C/zh

2014-04-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CN94104434A 1993-04-16 1994-04-15 磷脂酶a2抑制剂1h－吲哚－3－乙酰胺类化合物 Expired - Fee Related CN1068588C (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US4862993A	1993-04-16	1993-04-16
US048,629		1993-04-16
US20872194A	1994-03-15	1994-03-15
US208,721		1994-03-15

Publications (2)

Publication Number	Publication Date
CN1098715A CN1098715A (zh)	1995-02-15
CN1068588C true CN1068588C (zh)	2001-07-18

Family

ID=26726342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN94104434A Expired - Fee Related CN1068588C (zh)	1993-04-16	1994-04-15	磷脂酶a2抑制剂1h－吲哚－3－乙酰胺类化合物

Country Status (25)

Country	Link
US (1)	US5684034A (2)
EP (1)	EP0620215B1 (2)
JP (1)	JPH0725850A (2)
KR (1)	KR100317755B1 (2)
CN (1)	CN1068588C (2)
AT (1)	ATE183503T1 (2)
AU (1)	AU676884B2 (2)
BR (1)	BR9401482A (2)
CA (1)	CA2121323A1 (2)
CO (1)	CO4230092A1 (2)
CZ (1)	CZ289750B6 (2)
DE (1)	DE69420068T2 (2)
DK (1)	DK0620215T3 (2)
ES (1)	ES2138648T3 (2)
FI (1)	FI941767A7 (2)
GR (1)	GR3031783T3 (2)
HU (1)	HUT70836A (2)
IL (1)	IL109311A0 (2)
NO (1)	NO300732B1 (2)
NZ (1)	NZ260298A (2)
PL (1)	PL181319B1 (2)
RU (1)	RU2162463C2 (2)
TW (1)	TW268942B (2)
UA (1)	UA44218C2 (2)
YU (1)	YU20194A (2)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL109309A (en) *	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
US6252084B1 (en)	1994-03-15	2001-06-26	Eli Lilly And Company	1H-indole-3-acetamide sPLA2 inhibitors
JP3109974B2 (ja) *	1994-04-01	2000-11-20	イーライ・リリー・アンド・カンパニー	１Ｈ−インドール−３−グリオキシルアミドｓＰＬＡ２阻害剤
US6214876B1 (en)	1994-07-21	2001-04-10	Eli Lilly And Company	Indene-1-acetamide sPLA2 inhibitors
US5641800A (en) *	1994-07-21	1997-06-24	Eli Lilly And Company	1H-indole-1-functional sPLA2 inhibitors
US6630496B1 (en)	1996-08-26	2003-10-07	Genetics Institute Llc	Inhibitors of phospholipase enzymes
EP0922028A1 (en) *	1996-08-26	1999-06-16	Genetics Institute, Inc.	Inhibitors of phospholipase enzymes
KR20000049210A (ko) *	1996-10-30	2000-07-25	피터 지. 스트링거	치환된 트리시클릭류
US6569539B2 (en)	1996-10-30	2003-05-27	Tetra Level Holdings & Finance S.A.	Gas barrier packaging laminate method for production thereof and packaging containers
US6713645B1 (en) *	1996-10-30	2004-03-30	Eli Lilly And Company	Substituted tricyclics
US5919774A (en) *	1996-12-10	1999-07-06	Eli Lilly And Company	Pyrroles as sPLA2 inhibitors
WO1998037069A1 (en) *	1997-02-20	1998-08-27	Shionogi & Co., Ltd.	Indole dicarboxylic acid derivatives
PL343007A1 (en) *	1998-02-25	2001-07-30	Genetics Inst	Inhibitors of phospholipase enzymes
US6916841B2 (en)	1998-02-25	2005-07-12	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
CA2322163A1 (en) *	1998-02-25	1999-09-02	John Mckew	Inhibitors of phospholipase a2
SK12742000A3 (sk) *	1998-02-25	2001-05-10	Genetics Institute, Inc.	Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
US6828344B1 (en)	1998-02-25	2004-12-07	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
US6500853B1 (en)	1998-02-28	2002-12-31	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
HUP0102981A3 (en)	1998-03-31	2002-10-28	Shionogi & Co	Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
IL129484A0 (en) *	1998-04-17	2000-02-29	Lilly Co Eli	Substituted tricyclics
KR20010034881A (ko)	1998-05-21	2001-04-25	시오노 요시히코	ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
US6608099B1 (en)	1998-08-03	2003-08-19	Eli Lilly And Company	Indole sPLA2 inhibitors
JP2002522385A (ja)	1998-08-03	2002-07-23	イーライ・リリー・アンド・カンパニー	インドールｓＰＬＡ２インヒビター
AU6240099A (en)	1998-08-24	2000-03-14	Susan E Draheim	Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
ATE329619T1 (de)	1998-10-14	2006-07-15	Shionogi & Co	Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden
US6448284B1 (en)	1998-12-22	2002-09-10	Eli Lilly And Company	Substituted tricyclics
AU6015600A (en)	1999-07-19	2001-02-05	Shionogi & Co., Ltd.	Tricyclic compounds having spla2-inhibitory activities
CA2379208A1 (en) *	1999-07-19	2001-01-25	Eli Lilly & Company	Spla2 inhibitors
US6706752B1 (en)	1999-07-19	2004-03-16	Eli Lilly And Company	sPLA2 inhibitors
US6673781B1 (en)	1999-08-02	2004-01-06	Shionogi & Co., Ltd.	Tricyclic compounds having sPLA2-inhibitory activities
US6787545B1 (en)	1999-08-23	2004-09-07	Shiongi & Co., Ltd.	Pyrrolotriazine derivatives having spla2-inhibitory activities
WO2001021587A2 (en) *	1999-09-20	2001-03-29	Eli Lilly And Company	Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors
US6831095B1 (en)	1999-09-20	2004-12-14	Eli Lilly And Company	Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors
AU7559600A (en) *	1999-10-15	2001-04-23	Shionogi & Co., Ltd.	V type and/or x type spla2 inhibitors
US6756376B1 (en)	1999-11-15	2004-06-29	Shionogi & Co., Ltd.	Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities
DE19962300A1 (de) *	1999-12-23	2001-06-28	Asta Medica Ag	Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
WO2002000646A1 (en) *	2000-06-27	2002-01-03	Smithkline Beecham Corporation	Fatty acid synthase inhibitors
WO2002000256A1 (fr)	2000-06-29	2002-01-03	Shionogi & Co., Ltd.	Remedes contre la cirrhose
JPWO2002000621A1 (ja) *	2000-06-29	2004-04-22	塩野義製薬株式会社	Ｘ型ｓＰＬＡ２阻害作用を有する化合物
US20050203166A1 (en) *	2000-06-30	2005-09-15	Cancer Research Technology Limited	Indole-3-acetic acid derivatives
GB0016162D0 (en) *	2000-06-30	2000-08-23	Cancer Res Campaign Tech	Indole-3-acetic acid derivatives
EP1303262A2 (en) *	2000-07-14	2003-04-23	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
WO2002020478A1 (en) *	2000-08-24	2002-03-14	Dublin City University	N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer
ATE354567T1 (de)	2000-12-18	2007-03-15	Lilly Co Eli	Benz(g)indole und deren verwendung als spla2 inhibitoren
JP2004518658A (ja) *	2000-12-18	2004-06-24	イーライ・リリー・アンド・カンパニー	新規なｓＰＬＡ２インヒビター
TWI314457B (2)	2001-03-19	2009-09-11	Shionogi & Co
US6984735B2 (en)	2001-12-03	2006-01-10	Wyeth	Process for making an aldehyde
US6635771B2 (en)	2001-12-03	2003-10-21	Wyeth	N-benzhydryl indole compounds
US6797708B2 (en)	2001-12-03	2004-09-28	Wyeth	Inhibitors of cytosolic phospholipase A2
US7605156B2 (en)	2001-12-03	2009-10-20	Wyeth	Methods for the use of inhibitors of cytosolic phospholipase A2
US7101875B2 (en)	2001-12-03	2006-09-05	Wyeth	Methods for treating arthritic disorders
US7713964B2 (en)	2001-12-03	2010-05-11	Wyeth Llc	Methods for treating asthmatic conditions
US7129264B2 (en) *	2003-04-16	2006-10-31	Bristol-Myers Squibb Company	Biarylmethyl indolines and indoles as antithromboembolic agents
US20070161698A1 (en) *	2003-05-30	2007-07-12	Microbia, Inc.	Modulators of CRTH2 Activity
JP2007527397A (ja) *	2003-07-01	2007-09-27	マイクロバイアインコーポレイテッド	Ｃｏｘ−２及びｆａａｈ阻害剤
WO2005037227A2 (en) *	2003-10-16	2005-04-28	Microbia, Inc.	Selective cox-2 inhibitors
US7417063B2 (en) *	2004-04-13	2008-08-26	Bristol-Myers Squibb Company	Bicyclic heterocycles useful as serine protease inhibitors
US20050234244A1 (en) *	2004-04-20	2005-10-20	Wilmin Bartolini	Synthesis of COX-2 and FAAH inhibitors
US20050234030A1 (en) *	2004-04-20	2005-10-20	Wilmin Bartolini	Modulators of CRTH2, COX-2 and FAAH
TW200718687A (en)	2005-05-27	2007-05-16	Wyeth Corp	Inhibitors of cytosolic phospholipase A2
US20070203209A1 (en) *	2005-08-18	2007-08-30	Wilmin Bartolini	Useful indole compounds
US7666898B2 (en)	2005-11-03	2010-02-23	Ilypsa, Inc.	Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
CA2627352A1 (en) *	2005-11-03	2007-05-18	Ilypsa, Inc.	Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors
GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US8048880B2 (en) *	2007-05-03	2011-11-01	Anthera Pharmaceuticals, Inc.	Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
NZ720946A (en)	2009-04-29	2017-09-29	Amarin Pharmaceuticals Ie Ltd	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
CN105384619B (zh) *	2014-08-22	2020-05-29	四川海思科制药有限公司	一种异丙基苯酚衍生物及其制备方法

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1994
- 1994-04-12 IL IL10931194A patent/IL109311A0/xx unknown
- 1994-04-13 TW TW083103301A patent/TW268942B/zh active
- 1994-04-13 NZ NZ260298A patent/NZ260298A/en unknown
- 1994-04-13 HU HU9401060A patent/HUT70836A/hu unknown
- 1994-04-14 EP EP94302666A patent/EP0620215B1/en not_active Expired - Lifetime
- 1994-04-14 CO CO94014981A patent/CO4230092A1/es unknown
- 1994-04-14 DK DK94302666T patent/DK0620215T3/da active
- 1994-04-14 BR BR9401482A patent/BR9401482A/pt not_active Application Discontinuation
- 1994-04-14 AT AT94302666T patent/ATE183503T1/de not_active IP Right Cessation
- 1994-04-14 CA CA002121323A patent/CA2121323A1/en not_active Abandoned
- 1994-04-14 CZ CZ1994893A patent/CZ289750B6/cs not_active IP Right Cessation
- 1994-04-14 DE DE69420068T patent/DE69420068T2/de not_active Expired - Fee Related
- 1994-04-14 ES ES94302666T patent/ES2138648T3/es not_active Expired - Lifetime
- 1994-04-15 CN CN94104434A patent/CN1068588C/zh not_active Expired - Fee Related
- 1994-04-15 KR KR1019940007935A patent/KR100317755B1/ko not_active Expired - Fee Related
- 1994-04-15 AU AU59492/94A patent/AU676884B2/en not_active Ceased
- 1994-04-15 PL PL94303028A patent/PL181319B1/pl unknown
- 1994-04-15 JP JP6077650A patent/JPH0725850A/ja active Pending
- 1994-04-15 NO NO941361A patent/NO300732B1/no not_active IP Right Cessation
- 1994-04-15 YU YU20194A patent/YU20194A/sh unknown
- 1994-04-15 UA UA94005180A patent/UA44218C2/uk unknown
- 1994-04-15 RU RU94012930/04A patent/RU2162463C2/ru active
- 1994-04-15 FI FI941767A patent/FI941767A7/fi unknown
1995
- 1995-05-05 US US08/435,256 patent/US5684034A/en not_active Expired - Lifetime
1999
- 1999-11-08 GR GR990402875T patent/GR3031783T3/el unknown

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ATE183503T1 (de)	1999-09-15
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HU9401060D0 (en)	1994-07-28
HUT70836A (en)	1995-11-28
PL181319B1 (pl)	2001-07-31
CZ289750B6 (cs)	2002-03-13
BR9401482A (pt)	1994-10-18
TW268942B (2)	1996-01-21
DK0620215T3 (da)	1999-12-06
YU20194A (sh)	1997-09-30
IL109311A0 (en)	1994-07-31
JPH0725850A (ja)	1995-01-27
AU676884B2 (en)	1997-03-27
US5684034A (en)	1997-11-04
EP0620215B1 (en)	1999-08-18
UA44218C2 (uk)	2002-02-15
NO941361L (no)	1994-10-17
NZ260298A (en)	1996-05-28
AU5949294A (en)	1994-10-20
DE69420068D1 (de)	1999-09-23
FI941767L (fi)	1994-10-17
GR3031783T3 (en)	2000-02-29
CZ89394A3 (en)	1994-12-15
FI941767A0 (fi)	1994-04-15
EP0620215A1 (en)	1994-10-19
DE69420068T2 (de)	1999-12-23
NO300732B1 (no)	1997-07-14
CA2121323A1 (en)	1994-10-17
FI941767A7 (fi)	1994-10-17
NO941361D0 (no)	1994-04-15
CO4230092A1 (es)	1995-10-19
KR100317755B1 (ko)	2002-08-09
CN1098715A (zh)	1995-02-15

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