CN107109405A - 具有生物可逆性和非生物可逆性基团的多核苷酸构建体 - Google Patents
具有生物可逆性和非生物可逆性基团的多核苷酸构建体 Download PDFInfo
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- CN107109405A CN107109405A CN201580041889.0A CN201580041889A CN107109405A CN 107109405 A CN107109405 A CN 107109405A CN 201580041889 A CN201580041889 A CN 201580041889A CN 107109405 A CN107109405 A CN 107109405A
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- optionally substituted
- alkyl
- polynucleotide construct
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- 0 CCCCN1*(C)CN*C1SS* Chemical compound CCCCN1*(C)CN*C1SS* 0.000 description 17
- KVSMFHFCEDYGEY-UHFFFAOYSA-N CC(C)(C)CC(C)=C1CCCCC1 Chemical compound CC(C)(C)CC(C)=C1CCCCC1 KVSMFHFCEDYGEY-UHFFFAOYSA-N 0.000 description 1
- UNXBOBALIDITOY-LWCMGDNJSA-N CC(C)SSc1[n+](C)(C)c(CC2[C@@H](CC(C)SSC(C)CCCO)C2)ccc1 Chemical compound CC(C)SSc1[n+](C)(C)c(CC2[C@@H](CC(C)SSC(C)CCCO)C2)ccc1 UNXBOBALIDITOY-LWCMGDNJSA-N 0.000 description 1
- QWAVNXZAQASOML-UHFFFAOYSA-N CC(COc1ccccc1)=O Chemical compound CC(COc1ccccc1)=O QWAVNXZAQASOML-UHFFFAOYSA-N 0.000 description 1
- ACQJOCJSOJAWMM-VXLYETTFSA-N CC/C=C/OCC(C(C1F)OP(N(C(C)C)C(C)C)OCCCCSSC(C)(C)CCC2OC2NCCOCCOCCOCCCOCCOCCOCCOCCOC)OC1N(C=CC(N1)=O)C1=O Chemical compound CC/C=C/OCC(C(C1F)OP(N(C(C)C)C(C)C)OCCCCSSC(C)(C)CCC2OC2NCCOCCOCCOCCCOCCOCCOCCOCCOC)OC1N(C=CC(N1)=O)C1=O ACQJOCJSOJAWMM-VXLYETTFSA-N 0.000 description 1
- ULIHJHSSPXPDIR-UHFFFAOYSA-N CCC(OCC(C(C1OC)OP(N(C(C)C)C(C)C)OCCc(cccc2)c2SSC(C)(C)C)OC1N(C1N=C(NC(COc2ccc(C(C)C)cc2)=O)N2)C=NC1C2=O)=C Chemical compound CCC(OCC(C(C1OC)OP(N(C(C)C)C(C)C)OCCc(cccc2)c2SSC(C)(C)C)OC1N(C1N=C(NC(COc2ccc(C(C)C)cc2)=O)N2)C=NC1C2=O)=C ULIHJHSSPXPDIR-UHFFFAOYSA-N 0.000 description 1
- GDDUGVPURCLITP-UHFFFAOYSA-N CCOCCc1c(C)cccc1NNC(C)(C)C Chemical compound CCOCCc1c(C)cccc1NNC(C)(C)C GDDUGVPURCLITP-UHFFFAOYSA-N 0.000 description 1
- KNYDIGUXZIOJAF-UHFFFAOYSA-N OC(c1ccc(C=O)cc1)O Chemical compound OC(c1ccc(C=O)cc1)O KNYDIGUXZIOJAF-UHFFFAOYSA-N 0.000 description 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/32—Chemical structure of the sugar
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
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- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009123P | 2014-06-06 | 2014-06-06 | |
| US62/009123 | 2014-06-06 | ||
| PCT/US2015/034749 WO2015188197A2 (en) | 2014-06-06 | 2015-06-08 | Polynucleotide constructs having bioreversible and non-bioreversible groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107109405A true CN107109405A (zh) | 2017-08-29 |
Family
ID=54767614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580041889.0A Pending CN107109405A (zh) | 2014-06-06 | 2015-06-08 | 具有生物可逆性和非生物可逆性基团的多核苷酸构建体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170114341A1 (2) |
| EP (1) | EP3152308A4 (2) |
| JP (1) | JP2017522046A (2) |
| CN (1) | CN107109405A (2) |
| AU (1) | AU2015269053A1 (2) |
| CA (1) | CA2950960A1 (2) |
| WO (1) | WO2015188197A2 (2) |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110959011A (zh) * | 2017-12-29 | 2020-04-03 | 苏州瑞博生物技术有限公司 | 缀合物及其制备方法和用途 |
| WO2020135673A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020135581A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020238763A1 (zh) * | 2019-05-24 | 2020-12-03 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN112390835A (zh) * | 2019-08-14 | 2021-02-23 | 苏州瑞博生物技术股份有限公司 | 肝靶向化合物及缀合物 |
| WO2021037205A1 (zh) * | 2019-08-29 | 2021-03-04 | 苏州瑞博生物技术股份有限公司 | 化合物和药物缀合物及其制备方法和用途 |
| WO2022161452A1 (zh) * | 2021-01-28 | 2022-08-04 | 南京桦冠生物技术有限公司 | 缀合物及其用途 |
| US11492620B2 (en) | 2017-12-01 | 2022-11-08 | Suzhou Ribo Life Science Co., Ltd. | Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method thereof and use thereof |
| CN115925586A (zh) * | 2022-11-01 | 2023-04-07 | 青岛蓝谷多肽生物医药科技有限公司 | 一种靶向psma的母体及其衍生物的制备方法 |
| US11660347B2 (en) | 2017-12-01 | 2023-05-30 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing same, preparation method, and use thereof |
| CN116925160A (zh) * | 2023-09-15 | 2023-10-24 | 天津全和诚科技有限责任公司 | 一种GalNAc含糖环中间体及其制备方法 |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| WO2024093947A1 (zh) * | 2022-10-31 | 2024-05-10 | 大睿生物医药科技(上海)有限公司 | 向细胞内递送siRNA的前药 |
| US12083142B2 (en) | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| US12084661B2 (en) | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| WO2024222384A1 (zh) | 2023-04-26 | 2024-10-31 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
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| US12497622B2 (en) | 2019-05-22 | 2025-12-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法 |
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| JP7280590B2 (ja) | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
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| US20230287425A1 (en) | 2020-03-18 | 2023-09-14 | Dicerna Pharmacuticals Inc. | Compositions and methods for inhibiting angptl3 expression |
| TW202221120A (zh) | 2020-08-04 | 2022-06-01 | 美商黛瑟納製藥公司 | 用於治療代謝症候群之組成物及方法 |
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| US12435336B2 (en) | 2020-08-05 | 2025-10-07 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting LPA expression |
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| US20230390403A1 (en) * | 2020-10-14 | 2023-12-07 | North Carolina State University | Compositions and methods for drug delivery |
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| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
| US11879125B2 (en) | 2022-03-16 | 2024-01-23 | Empirico Inc. | GalNAc compositions for improving siRNA bioavailability |
| US20230374522A1 (en) | 2022-04-15 | 2023-11-23 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating scap activity |
| WO2024097310A2 (en) * | 2022-11-01 | 2024-05-10 | Impilo Therapeutics, Inc. | Targeted non-charged-nucleic acid (ncna) delivery and related tumor penetrating nanocomplexes |
| TW202430637A (zh) | 2022-11-16 | 2024-08-01 | 美商戴瑟納製藥股份有限公司 | Stat3靶向性寡核苷酸及其用途 |
| WO2025235911A2 (en) * | 2024-05-09 | 2025-11-13 | Wave Life Sciences Ltd. | Inhibin subunit beta e-related double stranded oligonucleotide compositions and methods relating thereto |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101490074A (zh) * | 2006-05-11 | 2009-07-22 | Isis药物公司 | 5’-修饰的双环核酸类似物 |
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| EP3066105A4 (en) * | 2013-11-06 | 2017-10-11 | Solstice Biologics, Ltd. | Polynucleotide constructs having disulfide groups |
-
2015
- 2015-06-08 CA CA2950960A patent/CA2950960A1/en not_active Abandoned
- 2015-06-08 EP EP15803887.7A patent/EP3152308A4/en not_active Withdrawn
- 2015-06-08 JP JP2017516650A patent/JP2017522046A/ja active Pending
- 2015-06-08 WO PCT/US2015/034749 patent/WO2015188197A2/en not_active Ceased
- 2015-06-08 AU AU2015269053A patent/AU2015269053A1/en not_active Abandoned
- 2015-06-08 CN CN201580041889.0A patent/CN107109405A/zh active Pending
- 2015-06-08 US US15/315,608 patent/US20170114341A1/en not_active Abandoned
-
2020
- 2020-02-03 US US16/780,204 patent/US20200392498A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101490074A (zh) * | 2006-05-11 | 2009-07-22 | Isis药物公司 | 5’-修饰的双环核酸类似物 |
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Non-Patent Citations (1)
| Title |
|---|
| AFAF H EL-SAGHEER等: "Synthesis of Alkyne- and Azide-Modified Oligonucleotides and Their Cyclization by the CuAAC (Click) Reaction", 《CURRENT PROTOCOLS IN NUCLEIC ACID CHEMISTRY》 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015188197A2 (en) | 2015-12-10 |
| EP3152308A4 (en) | 2017-12-27 |
| CA2950960A1 (en) | 2015-12-10 |
| US20200392498A1 (en) | 2020-12-17 |
| AU2015269053A1 (en) | 2016-12-22 |
| JP2017522046A (ja) | 2017-08-10 |
| US20170114341A1 (en) | 2017-04-27 |
| EP3152308A2 (en) | 2017-04-12 |
| WO2015188197A3 (en) | 2016-02-25 |
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