JP2017522046A - 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 - Google Patents
生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 Download PDFInfo
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- JP2017522046A JP2017522046A JP2017516650A JP2017516650A JP2017522046A JP 2017522046 A JP2017522046 A JP 2017522046A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017522046 A JP2017522046 A JP 2017522046A
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- 0 CCc([o]1)c(C)c(*)c1Br Chemical compound CCc([o]1)c(C)c(*)c1Br 0.000 description 14
- BVZFVTJMCZLZTR-UHFFFAOYSA-N CC(C)SSc1c(CCO)cccc1 Chemical compound CC(C)SSc1c(CCO)cccc1 BVZFVTJMCZLZTR-UHFFFAOYSA-N 0.000 description 1
- RWGFKTVRMDUZSP-UHFFFAOYSA-N CC(C)c1ccccc1 Chemical compound CC(C)c1ccccc1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 1
- FLAHSSHSYCYJKU-UHFFFAOYSA-N CC(CCC(NCc1ccccc1)=O)SSCCCCO Chemical compound CC(CCC(NCc1ccccc1)=O)SSCCCCO FLAHSSHSYCYJKU-UHFFFAOYSA-N 0.000 description 1
- LFINOVGTZAMNRH-UHFFFAOYSA-N CC(c1ccccc1)SSCCCCO Chemical compound CC(c1ccccc1)SSCCCCO LFINOVGTZAMNRH-UHFFFAOYSA-N 0.000 description 1
- ALVSEZZLFXRSRZ-UHFFFAOYSA-N CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 Chemical compound CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 ALVSEZZLFXRSRZ-UHFFFAOYSA-N 0.000 description 1
- MFRQAHHMZZKCLP-UHFFFAOYSA-N Cc1c(CCO)c(S)ccc1 Chemical compound Cc1c(CCO)c(S)ccc1 MFRQAHHMZZKCLP-UHFFFAOYSA-N 0.000 description 1
- VSNHUQURADARHR-UHFFFAOYSA-N Cc1cc(OC(C2)=O)c2cc1 Chemical compound Cc1cc(OC(C2)=O)c2cc1 VSNHUQURADARHR-UHFFFAOYSA-N 0.000 description 1
- YABOHRWGTPOWPS-UHFFFAOYSA-N Cc1cccc(SSc2ncccc2)c1CCO Chemical compound Cc1cccc(SSc2ncccc2)c1CCO YABOHRWGTPOWPS-UHFFFAOYSA-N 0.000 description 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N NCc1ccccc1 Chemical compound NCc1ccccc1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 1
- GOUHYARYYWKXHS-UHFFFAOYSA-N OC(c1ccc(C=O)cc1)=O Chemical compound OC(c1ccc(C=O)cc1)=O GOUHYARYYWKXHS-UHFFFAOYSA-N 0.000 description 1
- HAXFWIACAGNFHA-UHFFFAOYSA-N c1cc(SSc2ccccn2)ncc1 Chemical compound c1cc(SSc2ccccn2)ncc1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/09—Recombinant DNA-technology
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009123P | 2014-06-06 | 2014-06-06 | |
| US62/009,123 | 2014-06-06 | ||
| PCT/US2015/034749 WO2015188197A2 (en) | 2014-06-06 | 2015-06-08 | Polynucleotide constructs having bioreversible and non-bioreversible groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522046A true JP2017522046A (ja) | 2017-08-10 |
| JP2017522046A5 JP2017522046A5 (2) | 2018-07-19 |
Family
ID=54767614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516650A Pending JP2017522046A (ja) | 2014-06-06 | 2015-06-08 | 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170114341A1 (2) |
| EP (1) | EP3152308A4 (2) |
| JP (1) | JP2017522046A (2) |
| CN (1) | CN107109405A (2) |
| AU (1) | AU2015269053A1 (2) |
| CA (1) | CA2950960A1 (2) |
| WO (1) | WO2015188197A2 (2) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP2021509402A (ja) * | 2017-12-29 | 2021-03-25 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
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| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法 |
| US20180133327A1 (en) * | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| CA3021580A1 (en) | 2015-06-25 | 2016-12-29 | Barry L. Merriman | Biomolecular sensors and methods |
| WO2017100461A1 (en) * | 2015-12-08 | 2017-06-15 | Solstice Biologics, Ltd. | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate |
| CA3050062A1 (en) | 2016-01-14 | 2017-07-20 | Roswell Biotechnologies, Inc. | Molecular sensors and related methods |
| EP3408219B1 (en) | 2016-01-28 | 2022-08-17 | Roswell Biotechnologies, Inc | Massively parallel dna sequencing apparatus |
| JP7280590B2 (ja) | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
| US10737263B2 (en) | 2016-02-09 | 2020-08-11 | Roswell Biotechnologies, Inc. | Electronic label-free DNA and genome sequencing |
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| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
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| JP7436030B2 (ja) | 2017-12-29 | 2024-02-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP7507495B2 (ja) | 2018-12-28 | 2024-06-28 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107109405A (zh) | 2017-08-29 |
| WO2015188197A2 (en) | 2015-12-10 |
| EP3152308A4 (en) | 2017-12-27 |
| CA2950960A1 (en) | 2015-12-10 |
| US20200392498A1 (en) | 2020-12-17 |
| AU2015269053A1 (en) | 2016-12-22 |
| US20170114341A1 (en) | 2017-04-27 |
| EP3152308A2 (en) | 2017-04-12 |
| WO2015188197A3 (en) | 2016-02-25 |
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