CN1071114C - 可注射咪斯钠溶液 - Google Patents

可注射咪斯钠溶液 Download PDF

Info

Publication number: CN1071114C
Authority: CN; China
Prior art keywords: sodium; solution; miaow; injection; water
Prior art date: 1992-10-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CN93118643A

Other languages

English (en)

Chinese (zh)

Other versions

CN1089137A (zh

Inventor

J·恩格尔

E·沃尔海斯

W·迪格

G·卡穆格利亚

D·索尔比尔

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Asta Pharmaceutical Co ltd

Original Assignee

Asta Pharmaceutical Co ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-08

Filing date

1993-10-05

Publication date

2001-09-19

1993-10-05 Application filed by Asta Pharmaceutical Co ltd filed Critical Asta Pharmaceutical Co ltd

1994-07-13 Publication of CN1089137A publication Critical patent/CN1089137A/zh

2001-09-19 Application granted granted Critical

2001-09-19 Publication of CN1071114C publication Critical patent/CN1071114C/zh

2013-10-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 title claims abstract description 12
229960004635 mesna Drugs 0.000 title claims abstract description 12
239000000243 solution Substances 0.000 claims abstract description 40
238000002347 injection Methods 0.000 claims abstract description 18
239000007924 injection Substances 0.000 claims abstract description 18
238000002360 preparation method Methods 0.000 claims abstract description 6
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims description 7
229960001101 ifosfamide Drugs 0.000 claims description 7
238000000034 method Methods 0.000 claims description 4
ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical compound N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
239000011734 sodium Substances 0.000 description 25
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 24
229910052708 sodium Inorganic materials 0.000 description 23
150000003385 sodium Chemical class 0.000 description 22
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
235000019445 benzyl alcohol Nutrition 0.000 description 8
230000001954 sterilising effect Effects 0.000 description 8
239000011521 glass Substances 0.000 description 7
229910052757 nitrogen Inorganic materials 0.000 description 7
239000008215 water for injection Substances 0.000 description 7
239000003708 ampul Substances 0.000 description 6
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
238000001914 filtration Methods 0.000 description 6
239000001301 oxygen Substances 0.000 description 6
229910052760 oxygen Inorganic materials 0.000 description 6
238000004659 sterilization and disinfection Methods 0.000 description 5
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
238000001035 drying Methods 0.000 description 4
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
239000002738 chelating agent Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000011109 contamination Methods 0.000 description 3
238000005115 demineralization Methods 0.000 description 3
230000002328 demineralizing effect Effects 0.000 description 3
BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 description 3
230000000968 intestinal effect Effects 0.000 description 3
230000003647 oxidation Effects 0.000 description 3
238000007254 oxidation reaction Methods 0.000 description 3
239000003223 protective agent Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000004140 cleaning Methods 0.000 description 2
239000007857 degradation product Substances 0.000 description 2
-1 disodium hydrogen Chemical class 0.000 description 2
238000011049 filling Methods 0.000 description 2
229940102223 injectable solution Drugs 0.000 description 2
239000000463 material Substances 0.000 description 2
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
244000052769 pathogen Species 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
238000003860 storage Methods 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001274216 Naso Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
208000005374 Poisoning Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
ITBPIKUGMIZTJR-UHFFFAOYSA-N [bis(hydroxymethyl)amino]methanol Chemical compound OCN(CO)CO ITBPIKUGMIZTJR-UHFFFAOYSA-N 0.000 description 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
238000007664 blowing Methods 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
230000007547 defect Effects 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
229950009278 dimesna Drugs 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
KQYGMURBTJPBPQ-UHFFFAOYSA-L disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)CCSSCCS([O-])(=O)=O KQYGMURBTJPBPQ-UHFFFAOYSA-L 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940059082 douche Drugs 0.000 description 1
229940093495 ethanethiol Drugs 0.000 description 1
229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
239000003172 expectorant agent Substances 0.000 description 1
239000000835 fiber Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
239000013505 freshwater Substances 0.000 description 1
230000002650 habitual effect Effects 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229940066491 mucolytics Drugs 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
231100000572 poisoning Toxicity 0.000 description 1
230000000607 poisoning effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
238000007789 sealing Methods 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/105—Persulfides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Filling Or Discharging Of Gas Storage Vessels (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Luminescent Compositions (AREA)

CN93118643A 1992-10-08 1993-10-05 可注射咪斯钠溶液 Expired - Lifetime CN1071114C (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4233842A DE4233842A1 (de)	1992-10-08	1992-10-08	Mesna Injektionslösungen
DEP4233842.5		1992-10-08

Publications (2)

Publication Number	Publication Date
CN1089137A CN1089137A (zh)	1994-07-13
CN1071114C true CN1071114C (zh)	2001-09-19

Family

ID=6469925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN93118643A Expired - Lifetime CN1071114C (zh)	1992-10-08	1993-10-05	可注射咪斯钠溶液

Country Status (28)

Country	Link
US (2)	US5728738A (2)
EP (1)	EP0591710B1 (2)
JP (1)	JP3636372B2 (2)
KR (1)	KR100364466B1 (2)
CN (1)	CN1071114C (2)
AT (1)	ATE139693T1 (2)
AU (1)	AU667129B2 (2)
BR (1)	BR9304151A (2)
CA (1)	CA2107961C (2)
CZ (1)	CZ284584B6 (2)
DE (2)	DE4233842A1 (2)
DK (1)	DK0591710T3 (2)
EG (1)	EG20308A (2)
ES (1)	ES2089661T3 (2)
FI (1)	FI111804B (2)
GR (1)	GR3020669T3 (2)
HK (1)	HK7397A (2)
HR (1)	HRP931267B1 (2)
HU (1)	HU217123B (2)
IL (1)	IL107187A (2)
NO (1)	NO303712B1 (2)
NZ (1)	NZ248873A (2)
RU (1)	RU2105550C1 (2)
SI (1)	SI9300525A (2)
SK (1)	SK279609B6 (2)
TW (1)	TW279131B (2)
UA (1)	UA26134C2 (2)
ZA (1)	ZA937458B (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en)	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
IT1284973B1 (it) *	1996-10-11	1998-05-28	A R D O Associazione Ricerca E	Uso del sodio 2-mercaptoetansolfonato (mesna) in chirurgia
US6031006A (en) *	1999-10-21	2000-02-29	Bionumerik Pharmaceuticals, Inc.	Method of treating diabetic nephropathy
TW201036529A (en)	2009-03-25	2010-10-01	Askey Computer Corp	A liquid crystal anti-freeze method and a liquid crystal module using the liquid crystal anti-freeze method
UA74097U (ru) *	2012-07-24	2012-10-10	Николай Иванович Гуменюк	Способ изготовления средства для лечения туберкулеза
ES2762880T3 (es)	2013-05-07	2020-05-26	Auxin Surgery Sa	Dispositivo para disección asistida químicamente
BE1024110B1 (fr) *	2016-10-18	2017-11-16	Auxin Surgery Sa	Dispositif, procédé et formulation pour dissection assistée de manière chimique
EP3429555B1 (en) *	2016-03-14	2020-04-29	AuXin Surgery SA	Mesna formulation and its use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3111770A1 (de) *	1981-03-25	1982-10-07	Heyl Chemisch-pharmazeutische Fabrik GmbH & Co KG, 1000 Berlin	Verwendung von dimercaptopropansulfonsaeure und dimercaptobernsteinsaeure zur herstellung von pharmazeutischen mitteln
IT1185551B (it) *	1985-04-15	1987-11-12	Schering Spa	Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione
EP0334083B1 (de) *	1988-03-19	1991-07-24	ASTA Pharma Aktiengesellschaft	Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung

1992
- 1992-10-08 DE DE4233842A patent/DE4233842A1/de not_active Withdrawn
1993
- 1993-08-24 TW TW082106854A patent/TW279131B/zh not_active IP Right Cessation
- 1993-09-13 DK DK93114670.8T patent/DK0591710T3/da active
- 1993-09-13 ES ES93114670T patent/ES2089661T3/es not_active Expired - Lifetime
- 1993-09-13 EP EP93114670A patent/EP0591710B1/de not_active Expired - Lifetime
- 1993-09-13 AT AT93114670T patent/ATE139693T1/de active
- 1993-09-13 DE DE59303067T patent/DE59303067D1/de not_active Expired - Lifetime
- 1993-10-03 EG EG64293A patent/EG20308A/xx active
- 1993-10-05 SI SI9300525A patent/SI9300525A/sl unknown
- 1993-10-05 CN CN93118643A patent/CN1071114C/zh not_active Expired - Lifetime
- 1993-10-05 IL IL10718793A patent/IL107187A/en not_active IP Right Cessation
- 1993-10-06 NZ NZ248873A patent/NZ248873A/en not_active IP Right Cessation
- 1993-10-06 BR BR9304151A patent/BR9304151A/pt not_active Application Discontinuation
- 1993-10-06 JP JP25042793A patent/JP3636372B2/ja not_active Expired - Lifetime
- 1993-10-06 KR KR1019930020576A patent/KR100364466B1/ko not_active Expired - Lifetime
- 1993-10-06 UA UA93002240A patent/UA26134C2/uk unknown
- 1993-10-07 CZ CZ932097A patent/CZ284584B6/cs not_active IP Right Cessation
- 1993-10-07 ZA ZA937458A patent/ZA937458B/xx unknown
- 1993-10-07 HR HRP4233842.5A patent/HRP931267B1/xx not_active IP Right Cessation
- 1993-10-07 RU RU93048160A patent/RU2105550C1/ru active
- 1993-10-07 HU HU9302837A patent/HU217123B/hu unknown
- 1993-10-07 SK SK1079-93A patent/SK279609B6/sk not_active IP Right Cessation
- 1993-10-07 AU AU48883/93A patent/AU667129B2/en not_active Expired
- 1993-10-07 CA CA002107961A patent/CA2107961C/en not_active Expired - Fee Related
- 1993-10-07 FI FI934410A patent/FI111804B/fi not_active IP Right Cessation
- 1993-10-07 NO NO933590A patent/NO303712B1/no not_active IP Right Cessation
1995
- 1995-06-07 US US08/474,246 patent/US5728738A/en not_active Expired - Lifetime
1996
- 1996-04-23 US US08/636,821 patent/US5696172A/en not_active Expired - Lifetime
- 1996-07-31 GR GR960402027T patent/GR3020669T3/el unknown
1997
- 1997-01-16 HK HK7397A patent/HK7397A/xx not_active IP Right Cessation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE MERCK LNDEX 11版 1989.1.1 Merck co，IN *

Also Published As

Publication number	Publication date
FI934410L (fi)	1994-04-09
DK0591710T3 (da)	1996-09-30
CN1089137A (zh)	1994-07-13
JP3636372B2 (ja)	2005-04-06
HU9302837D0 (en)	1993-12-28
ATE139693T1 (de)	1996-07-15
KR940008678A (ko)	1994-05-16
EG20308A (en)	1998-10-31
DE59303067D1 (de)	1996-08-01
IL107187A0 (en)	1994-01-25
SK279609B6 (sk)	1999-01-11
NZ248873A (en)	1995-10-26
NO303712B1 (no)	1998-08-24
CZ209793A3 (en)	1994-04-13
HK7397A (en)	1997-01-24
ES2089661T3 (es)	1996-10-01
HUT65096A (en)	1994-04-28
JPH06263629A (ja)	1994-09-20
SI9300525A (en)	1994-06-30
CA2107961A1 (en)	1994-04-09
US5696172A (en)	1997-12-09
UA26134C2 (uk)	1999-06-07
KR100364466B1 (ko)	2003-01-29
NO933590D0 (no)	1993-10-07
CZ284584B6 (cs)	1999-01-13
BR9304151A (pt)	1994-06-07
IL107187A (en)	1999-03-12
ZA937458B (en)	1994-04-26
HRP931267A2 (en)	1994-12-31
HRP931267B1 (en)	1997-08-31
DE4233842A1 (de)	1994-04-14
US5728738A (en)	1998-03-17
AU667129B2 (en)	1996-03-07
EP0591710B1 (de)	1996-06-26
AU4888393A (en)	1994-04-21
HU217123B (hu)	1999-11-29
RU2105550C1 (ru)	1998-02-27
SK107993A3 (en)	1994-05-11
CA2107961C (en)	2003-03-25
FI934410A0 (fi)	1993-10-07
GR3020669T3 (en)	1996-10-31
TW279131B (2)	1996-06-21
FI111804B (fi)	2003-09-30
EP0591710A1 (de)	1994-04-13
NO933590L (no)	1994-04-11

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