CN107308024A - Salvia japonica essential oil oral care gels and preparation method - Google Patents
Salvia japonica essential oil oral care gels and preparation method Download PDFInfo
- Publication number
- CN107308024A CN107308024A CN201710484199.3A CN201710484199A CN107308024A CN 107308024 A CN107308024 A CN 107308024A CN 201710484199 A CN201710484199 A CN 201710484199A CN 107308024 A CN107308024 A CN 107308024A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- essential oil
- oral care
- salvia japonica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 40
- 239000000499 gel Substances 0.000 title claims abstract description 24
- 244000143590 Salvia chinensis Species 0.000 title claims abstract description 21
- 235000007154 Salvia chinensis Nutrition 0.000 title claims abstract description 21
- 235000005794 Salvia japonica Nutrition 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 9
- 229960001631 carbomer Drugs 0.000 claims abstract description 9
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 8
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 8
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 8
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 7
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 7
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 5
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 5
- 239000008367 deionised water Substances 0.000 claims abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 5
- 235000011187 glycerol Nutrition 0.000 claims abstract description 5
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- -1 polyoxyethylene Polymers 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 4
- 239000001301 oxygen Substances 0.000 claims abstract description 4
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims abstract description 4
- 239000003921 oil Substances 0.000 claims description 7
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 241000220324 Pyrus Species 0.000 claims 1
- 235000021017 pears Nutrition 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 14
- 244000005700 microbiome Species 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 238000009395 breeding Methods 0.000 abstract description 4
- 230000001488 breeding effect Effects 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000033228 biological regulation Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000036651 mood Effects 0.000 abstract description 3
- 230000000474 nursing effect Effects 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract description 2
- 230000001680 brushing effect Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 229940034610 toothpaste Drugs 0.000 abstract description 2
- 239000000606 toothpaste Substances 0.000 abstract description 2
- 230000001580 bacterial effect Effects 0.000 description 7
- 230000036541 health Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229920002444 Exopolysaccharide Polymers 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000020670 canker sore Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000003433 Gingival Pocket Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003074 dental pulp Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000005548 health behavior Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to oral care gels, Salvia japonica essential oil oral care gels and preparation method thereof.Prior art carries out oral care when brushing teeth using toothpaste, has the disadvantage：Action time is short, and nursing efficacy is undesirable.The present invention is made up of following materials in part by weight:The parts by weight of chlorhexidine gluconate 0.01~0.012, the parts by weight of Salvia japonica essential oil 0.85~0.9, the parts by weight of myrrh essential oil 0.1~0.15, the parts by weight of Peppermint essential oil 0.1~0.15, the parts by weight of imidazoline 1~3, the parts by weight of glycerine 4~7, the parts by weight of polyoxyethylene poly-oxygen propylene aether 1~3, the parts by weight of sorbierite 1~2, the parts by weight of carbomer 0.5~0.8, deionized water adds to 100 parts by weight.The method have the advantages that:The oral care time is long, suppresses oral cavity harmful microorganism effect good；Suppress oral microorganism breeding, reduce mouth infection；Analgesia, regulation patient's mood；It is widely used.
Description
Technical field
The invention belongs to oral care gels, more particularly to a kind of Salvia japonica essential oil oral care gels and its preparation side
Method.
Background technology
The incidence of oral health epidemiological clinical investigation result China adult's bleeding gums is 77.3%, dental calculus inspection
Extracting rate 97.3%, carious tooth incidence 88.1%, periodontal health rate is only 14.5%.Oral health issue is generally serious, depends alone general
It is logical to brush teeth to protect the health of one's mouth, prevent mouth disease, it is far from enough.Oral microorganism is present in bacterial plaque, mucous membrane of mouth, tooth
In calculus, gingival pocket, saliva, postoperative dental pulp, particularly bacterial plaque has unique " biomembrane " structure, is to cause oral cavity serious
The secret worry of illness.Plants essential oil is that many kinds of substance contained in the peculiar aromatic substance extracted from plant, essential oil has and promoted
Mucomembranous cell metabolism, promotes salivary gland secretion, excites autoimmune function, suppresses the work of oral cavity harmful microorganism breeding
With.Chlorohexidene is a kind of broad-spectrum antibiotic, and it can be combined with saliva glycoprotein, reduces facing adhesion protein, disturbs bacterial plaque shape
Into.Chlorohexidene can also be combined with bacterial cell exo polysaccharides, make bacterium be difficult to be adsorbed onto on acquisition film, reached prevention and reduced periodontal
The purpose of disease and dental caries.Prior art carries out oral care when brushing teeth using toothpaste, has the disadvantage：Action time is short, and effect is not
It is preferable.
Gel refers to mixture of the granular size between 1 angstrom to 10 angstroms.Polymer Solution under suitable condition, entirely
System can be transformed into a kind of stiff material of elastic semi-solid state, lose flowability, the product formed is called gel.This
Oral care gels are made in carbomer and chlorohexidene, Salvia japonica essential oil, myrrh essential oil etc. by invention, are harmful to suppression oral cavity micro-
Biology, improves immunity of organism, promotes the function of mucous membrane healing, changes the thinking mould that original traditional oral medical treatment is simply sterilized
Formula, chlorohexidene can kill pathogenic microorganisms, and essential oil can promote the metabolism of human body probiotics, allow probiotics to produce bacteriolyze everyday
Enzyme, biotin are gone to resist harmful bacteria, and oral cavity benign cycle is formed so that Each performs its own functions, common to create oral health Tiny ecosystem.Make
Oral care is carried out with gel, with long action time, suppresses the good advantage of oral cavity harmful microorganism effect.User of the present invention
Just, cost is low, oral cavity prevention nursing efficacy is good, be widely used.
The content of the invention
Suppress the breeding of oral cavity harmful microorganism it is an object of the invention to provide one kind, adjustment micro-ecological environment, raising are immune
Function, the Salvia japonica essential oil oral care gels for promoting oral mucosa healing.
It is a further object of the present invention to provide the preparation method of the Salvia japonica essential oil oral care gels.
The object of the present invention is achieved like this：
A kind of Salvia japonica essential oil oral care gels, are made up of following materials in part by weight:
A kind of preparation method of Salvia japonica essential oil oral care gels, step is as follows:
(1) prepared by mixed essential oil:Parts by weight as described in claim 1 accurately claim Salvia japonica, myrrh essential oil, peppermint essence
Oil, inserts same container, adds the parts by weight of imidazoline emulsifying agent 1~3, is thoroughly mixed, emulsified refined oil is made standby；
(2) parts by weight as described in claim 1 weigh chlorhexidine gluconate, glycerine, polyoxyethylene polyoxypropylene respectively
Ether, sorbierite, carbomer insert same container, are thoroughly mixed；
(3) step (1) product is added in step (2) product；
(4) deionized water is added to step (3) product, to 100 parts by weight；
(5) step (4) product is thoroughly mixed, uses homogenizer second homogenate；
(6) step (5) product is vacuumized, packed.
The method is characterized in that：
Carbomer and Salvia japonica, myrrh, peppermint mixed essential oil, chlorohexidene etc. are combined, oral care gels are prepared.This hair
Bright utilization chlorohexidene is combined with saliva glycoprotein, reduces the albumen that facing is adsorbed；Combined, done with bacterial cell exo polysaccharides simultaneously
The formation of bacterial plaque and the permeability barrier of adsorbable bacterial cytoplasm film are disturbed, cellular content is spilt, is in bacteriostasis during low concentration,
It is in then bactericidal action during high concentration.The glucoside material contained in Salvia japonica essential oil promotes the metabolism of human body mucomembranous cell, excites
Mucomembranous cell improves autoimmunization, effectively nurses oral cavity；The bitter taste of Salvia japonica essential oil can be neutralized using myrrh essential oil, is reached
Gel mouthfeel is adjusted, mitigates pain, the mood of regulation people.Using Peppermint essential oil throat-clearing throat-moistening, eliminate halitosis.
Raw material carbomer in the present invention, Chinese:Acrylic resin, molecular formula:(C3H4O2) n, molecular weight:
72.06.Acrylic resin color is shallow, water-white transparent；Film performance is excellent, fast light, heat-resisting, chemical-resistant and the performance such as corrosion-resistant
It is all fabulous.Carbomer plays coagulation in the present invention, and consumption is extremely low, to ensure using safety.
Other raw materials in the present invention, are existing known technology, market public offering and the raw material used.
It is an advantage of the invention that:
1. the nursing time is longer for gel effect, effect more preferably, chlorohexidene suppresses oral cavity harmful microorganism.
2. many kinds of natural essential oil formulas, make full use of essential oil small molecule high osmosis, give Stomatocyte nutrition, moist, foster
Shield, improves immunity of human body itself, so as to adjust Oral health behaviours, suppresses oral microorganism breeding, reduces mouth infection.
3. the effect with analgesia, regulation patient's mood.
4. being widely used, in addition to being in hospital and operation crowd is applicable, long-term bed crowd can be used.
Embodiment
Below by embodiment, the present invention will be further described.
Embodiment 1：
(1) prepared by mixed essential oil:It is accurate to claim 0.9 kilogram of Salvia japonica essential oil, 0.12 kilogram of myrrh essential oil, Peppermint essential oil 0.12
Kilogram, same container is inserted, 1.2 kilograms of imidazoline emulsifying agent is added, is thoroughly mixed, emulsified refined oil is made standby；
(2) it is public that 0.01 kilogram of chlorhexidine gluconate, 4 kilograms of glycerine, polyoxyethylene poly-oxygen propylene aether 1.2 are weighed respectively
Jin, 1 kilogram of sorbierite, 0.5 kilogram of carbomer insert same container, are thoroughly mixed；
(3) emulsified refined oil is added in step (2) product；
(4) deionized water is added to step (3) product, to 100 kilograms；
(5) step (4) product is thoroughly mixed, uses homogenizer second homogenate；
(6) step (5) product is vacuumized, be filled into bag.
Salvia japonica essential oil oral care gels of the present invention are made.
Embodiment 2：
(1) prepared by mixed essential oil:It is accurate to claim 0.9 kilogram of Salvia japonica essential oil, 0.15 kilogram of myrrh essential oil, Peppermint essential oil 0.15
Kilogram, same container is inserted, 2 kilograms of imidazoline emulsifying agent is added, is thoroughly mixed, emulsified refined oil is made standby；
(2) weigh respectively 0.01 kilogram of chlorhexidine gluconate, 5 kilograms of glycerine, 2 kilograms of polyoxyethylene poly-oxygen propylene aether,
1 kilogram of sorbierite, 0.8 kilogram of carbomer insert same container, are thoroughly mixed；
(3) emulsified refined oil is added in step (2) product；
(4) deionized water is added to step (3) product, to 100 kilograms；
(5) step (4) product is thoroughly mixed, uses homogenizer second homogenate；
(6) step (5) product is vacuumized, be filled into bag.
Salvia japonica essential oil oral care gels of the present invention are made.
Embodiment 3：
Canker sore patient, 2 grams of the gel that Example 1 is made, is put at canker sore, three times a day, continuous seven days,
Oral bacteria is killed, ulcer rehabilitation.
Embodiment 4：
Patient with toothache, 2 grams of the gel that Example 2 is made, is put into root of the tooth, after 1 minute, and toothache mitigates.After 3 minutes, tooth
Tooth is not bitterly.
Embodiment 5：
Bleeding gums patient, 2 grams of the gel that Example 2 is made, is put into bleeding affected part, after 1 minute, pain relief.Often
It is secondary, continuous three days, and gum recovers normal.
Above-described embodiment is only the preference of the present invention, is not intended to limit the present invention, all within the principle of the present invention,
Any modifications and variations done, within protection scope of the present invention.
Claims (2)
1. a kind of Salvia japonica essential oil oral care gels, are made up of following materials in part by weight:
2. a kind of preparation method of Salvia japonica essential oil oral care gels, step is as follows:
(1) prepared by mixed essential oil:Parts by weight as described in claim 1 accurately claim Salvia japonica, myrrh essential oil, Peppermint essential oil, put
Enter same container, add the parts by weight of imidazoline emulsifying agent 1~3, be thoroughly mixed, emulsified refined oil be made standby；
(2) parts by weight as described in claim 1 weigh chlorhexidine gluconate, glycerine, polyoxyethylene poly-oxygen propylene aether, mountain respectively
Pears alcohol, carbomer insert same container, are thoroughly mixed；
(3) step (1) product is added in step (2) product；
(4) deionized water is added to step (3) product, to 100 parts by weight；
(5) step (4) product is thoroughly mixed, uses homogenizer second homogenate；
(6) step (5) product is vacuumized, packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710484199.3A CN107308024A (en) | 2017-06-23 | 2017-06-23 | Salvia japonica essential oil oral care gels and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710484199.3A CN107308024A (en) | 2017-06-23 | 2017-06-23 | Salvia japonica essential oil oral care gels and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107308024A true CN107308024A (en) | 2017-11-03 |
Family
ID=60179451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710484199.3A Pending CN107308024A (en) | 2017-06-23 | 2017-06-23 | Salvia japonica essential oil oral care gels and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107308024A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110856702A (en) * | 2018-08-23 | 2020-03-03 | 上海利康消毒高科技有限公司 | Dental implant oral care gel and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130190341A1 (en) * | 2004-06-04 | 2013-07-25 | Camurus Ab | High bioavailability opioid formulations |
| CN106361612A (en) * | 2016-11-11 | 2017-02-01 | 上海利康消毒高科技有限公司 | Compound essential oil oral cavity cleaning and caring liquid containing salvia officinalis and preparation method of oral cavity cleaning and caring liquid |
-
2017
- 2017-06-23 CN CN201710484199.3A patent/CN107308024A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130190341A1 (en) * | 2004-06-04 | 2013-07-25 | Camurus Ab | High bioavailability opioid formulations |
| CN106361612A (en) * | 2016-11-11 | 2017-02-01 | 上海利康消毒高科技有限公司 | Compound essential oil oral cavity cleaning and caring liquid containing salvia officinalis and preparation method of oral cavity cleaning and caring liquid |
Non-Patent Citations (1)
| Title |
|---|
| 卢锦华等: "葡萄糖酸氯己定温敏凝胶的制备及处方研究", 《今日药学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110856702A (en) * | 2018-08-23 | 2020-03-03 | 上海利康消毒高科技有限公司 | Dental implant oral care gel and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9339455B2 (en) | Natural anti-bacterial toothpaste composition containing improvement in tooth pain, antibacterial mouth and nerve stability | |
| CN106562923B (en) | Oral care composition containing profitable probliotics and its application in toothpaste | |
| CN102940595A (en) | Mouthwash with functions of antibiosis, antiphlogosis and deodorization, and preparation method and use thereof | |
| CN112426376A (en) | Mouthwash and preparation method thereof | |
| CN110946804B (en) | Mouthwash for preventing dental caries and oral ulcer and preparation method thereof | |
| CN103908423B (en) | Anti-oral helicobacter pylori Chinese medicinal toothpaste | |
| TWI355945B (en) | ||
| CN102764219A (en) | Sterilizing mouthwash for oral cavities | |
| CN105902407A (en) | Lysozyme hydrochloride toothpaste and preparation method thereof | |
| CN101972215A (en) | Chitosan oligosaccharide oral cavity cleaning tablet | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| CN109394554A (en) | A kind of probiotics toothpaste and preparation method thereof | |
| CN113318057A (en) | Old people nursing toothpaste and preparation method and application thereof | |
| CN107308024A (en) | Salvia japonica essential oil oral care gels and preparation method | |
| CN105213216B (en) | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof | |
| CN108420768A (en) | A kind of shield gum toothpaste of anti-inflammation hemostasia and preparation method thereof | |
| CN107242993A (en) | A kind of spearmint ferment mouthwash and preparation method thereof | |
| CN1173323A (en) | Composition for enhancing oral hygiene | |
| CN106309740A (en) | Drug for cleaning oral cavities | |
| CN115645335A (en) | Toothpaste for treating tooth loosening and preparation method thereof | |
| CN103431143B (en) | Fulvic acid containing chewing gum and preparation method thereof | |
| CN107320401A (en) | A kind of mouthwash of pre- anti-caries and preparation method thereof | |
| CN119113044B (en) | A Traditional Chinese Medicine Oral Care Solution, Its Preparation Method and Application | |
| CN111166711A (en) | Sterilizing mouthwash | |
| Jibu et al. | Healozone: A New Way to Treat Dental Caries-A Review |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171103 |