CN108261563A - A kind of bionical ligament of activeness and quietness - Google Patents
A kind of bionical ligament of activeness and quietness Download PDFInfo
- Publication number
- CN108261563A CN108261563A CN201810160062.7A CN201810160062A CN108261563A CN 108261563 A CN108261563 A CN 108261563A CN 201810160062 A CN201810160062 A CN 201810160062A CN 108261563 A CN108261563 A CN 108261563A
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- CN
- China
- Prior art keywords
- activeness
- quietness
- fibroin
- ligament
- bionical
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003041 ligament Anatomy 0.000 title claims abstract description 43
- 108010022355 Fibroins Proteins 0.000 claims abstract description 54
- 239000000835 fiber Substances 0.000 claims abstract description 33
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 12
- 229910044991 metal oxide Inorganic materials 0.000 claims abstract description 11
- 150000004706 metal oxides Chemical class 0.000 claims abstract description 11
- 239000002105 nanoparticle Substances 0.000 claims abstract description 6
- 235000021197 fiber intake Nutrition 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000009987 spinning Methods 0.000 claims description 6
- 241000255789 Bombyx mori Species 0.000 claims description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 3
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
- 238000009954 braiding Methods 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229910001424 calcium ion Inorganic materials 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 229910052593 corundum Inorganic materials 0.000 claims description 3
- 238000000578 dry spinning Methods 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000004804 winding Methods 0.000 claims description 3
- 229910001845 yogo sapphire Inorganic materials 0.000 claims description 3
- 239000012460 protein solution Substances 0.000 claims 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 abstract description 4
- 238000002513 implantation Methods 0.000 abstract description 4
- 239000000463 material Substances 0.000 description 12
- 210000000988 bone and bone Anatomy 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000005452 bending Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The present invention provides a kind of bionical ligament of activeness and quietness, and the bionical ligament is woven by the fibroin fiber and Biodegradable fibers PCL of activeness and quietness.Fibroin fiber dosage described in bionical ligament accounts for the 60~90% of total amount, and the PCL fiber consumptions account for the 10~40% of total amount.The performances such as graphene oxide and metal oxide nanoparticles are utilized in the fibroin fiber of activeness and quietness intensity is big, modulus is high, activeness and quietness is carried out to fibroin fiber；Fibroin fiber after activeness and quietness has high mechanical strength, can meet the needs of patient is to tough band strength, bionical implantation of ligament provided by the present invention is simple and convenient, securely and reliably, the advantages that patient tolerability is good, and immunogenicity is small, has broad application prospects.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of bionical ligaments of activeness and quietness.
Background technology
Due to being on the increase for the high energy wound such as traffic accident, bone defect caused by wound or secondary infection becomes orthopedist
The a major challenge faced, autologous bone transplanting art is to treat the effective means of bone defect, however itself bone amount is limited, and increases trouble
The risk and pain of person many places operation.Bone renovating material made of organizational engineering material combination multipotential stem cell, can promote to plant
Enter position new bone formation, be expected to reduce the needs to autologous bone, partially or completely substitute self bone tissue.
Material based on metal is initially applied in bone tissue reparation, however the implantation material of metal needs second operation
It takes out, larger pain is brought to patient.A variety of absorbable materials (hand over by such as polylactide (PLA), pla-pcl (PCL) and poly- second
Compound lactide of ester (PLGA) etc.) succeed is substituted by cambium in an experiment, obtain extensive concern.Wherein, gather in oneself
Ester material (PCL) ductility is good, can degrade in vivo, Various Tissues functional material has been made.Using fibroin as representative
Natural degradable material then has relatively low immunogenicity, and fibroin mechanical strength is preferable, and has good biofacies
Capacitive.The process of fibroin degradation in vivo and has certain experiment basis to the supporting function of bone remoulding.It is however, single
Pure fibroin ductility in the application of electrostatic spinning is poor, it is impossible to provide the tension of initial stage ligament needs after operation, easily
Lead to operative failure.
Invention content
In order to solve the above technical problem, the present invention provides a kind of bionical ligaments of activeness and quietness.
The present invention is realized with following technical solution：
A kind of bionical ligament of activeness and quietness, the bionical ligament by activeness and quietness fibroin fiber and Biodegradable fibers
PCL weaves, and fibroin fiber dosage described in bionical ligament accounts for the 60~90% of total amount, and the PCL fiber consumptions account for always
The 10~40% of amount.
Further, the preparation method of the bionical ligament of the activeness and quietness is：
1) Na is used2CO3Then aqueous solution dissolves, and after centrifuging, dialysing, obtain degumming silkworm cocoons with LiBr aqueous solutions
To regenerated silk fibroin water solution, and then the mass percent for being concentrated into fibroin albumen is 10%~20%；
2) regenerated silk fibroin water solution obtained after graphene oxide water solution previous step is concentrated is 1 in mass ratio:100
~10000 are blended, and obtain graphene oxide/fibroin albumen mixed solution；
3) calcium carbonate aqueous solution is added, it is 0.2~0.5mol/L to adjust calcium ion molar concentration in solution, continues to concentrate, until
The percentage that fibroin albumen obtains quality is 50%~70%, has obtained the spinning solution of fibroin albumen/graphene oxide at this time；
4) dry spinning is carried out at room temperature using the solution after concentration as spinning solution, the fibroin for obtaining activeness and quietness is fine
Dimension；
5) it will be immersed in ethanol solution after above-mentioned fibroin fiber and Biodegradable fibers PCL windings braiding, suture, warp
After stretching, fixed length are soaked for a period of time, take out and obtain the bionical ligament of activeness and quietness.
Further, the ethanol solution, the volume fraction of ethyl alcohol is 75%~99%；The multiple of the stretching is 5~8
Times, the time that the fixed length is impregnated is 5~10 hours.
Further, the bionical ligament length be 25~50cm, it is a diameter of to be repaired the 0.9 of ligament diameter~
1.2 again；A diameter of 80~200 μm of the fibroin fiber.
Further, the metal oxide hydrosol, the metal can also be added in the preparation process of the bionical ligament
Metal oxide in the oxide hydrosol can be TiO2、ZnO、Al2O3Or ZrO2One or more of mixing, and the gold
It is 10~100nm to belong to the nano particle diameter in the oxide hydrosol.
The beneficial effects of the invention are as follows：
The raw materials used in the present invention is PCL materials and pure natural fibroin, and PCL materials have well-known biocompatibility,
Ligament has high tractive resistance, bending force and torsion made of PCL.Fibroin also has excellent bio-compatible
Property, it is nontoxic, conducive to cell adherence, growth and differentiation；Thus the bionical ligament prepared has good biocompatibility with that can drop
Xie Xing.
Graphene oxide and metal oxide nanoparticles are utilized in the fibroin fiber of activeness and quietness intensity is big,
The performances such as modulus height carry out activeness and quietness to fibroin fiber.Fibroin fiber after activeness and quietness, fracture strength,
All fibroin fibers before the remote superorder of elongation at break have high mechanical strength, can meet patient to tough band strength
Demand.
Bionical implantation of ligament provided by the present invention is simple and convenient, securely and reliably, patient tolerability is good, and immunogenicity is small etc.
Advantage has broad application prospects.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, the present invention will be made below further detailed
Description.
Embodiment 1：
A kind of bionical ligament of activeness and quietness, the bionical ligament by activeness and quietness fibroin fiber and Biodegradable fibers
PCL weaves.Fibroin fiber dosage described in bionical ligament accounts for the 60~90% of total amount, and the PCL fiber consumptions account for always
The 10~40% of amount.
The preparation method of the bionical ligament of the activeness and quietness is：
1) Na is used2CO3Then aqueous solution dissolves, and after centrifuging, dialysing, obtain degumming silkworm cocoons with LiBr aqueous solutions
To regenerated silk fibroin water solution, and then the mass percent for being concentrated into fibroin albumen is 10%~20%；
2) regenerated silk fibroin water solution obtained after graphene oxide water solution previous step is concentrated is 1 in mass ratio:100
~10000 are blended, and obtain graphene oxide/fibroin albumen mixed solution；
3) calcium carbonate aqueous solution is added, it is 0.2~0.5mol/L to adjust calcium ion molar concentration in solution, continues to concentrate, until
The percentage that fibroin albumen obtains quality is 50%~70%, has obtained the spinning solution of fibroin albumen/graphene oxide at this time；
4) dry spinning is carried out at room temperature using the solution after concentration as spinning solution, the fibroin for obtaining activeness and quietness is fine
Dimension；
5) it will be immersed in ethanol solution after above-mentioned fibroin fiber and Biodegradable fibers PCL windings braiding, suture, warp
After stretching, fixed length are soaked for a period of time, take out and obtain the bionical ligament of activeness and quietness.
The bionical ligament length be 25~50cm, a diameter of to be repaired the 0.9~1.2 of ligament diameter times；It is described
A diameter of 80~200 μm of fibroin fiber.
Further, the metal oxide hydrosol, the metal can also be added in the preparation process of the bionical ligament
Metal oxide in the oxide hydrosol can be TiO2、ZnO、Al2O3Or ZrO2One or more of mixing, and the gold
It is 10~100nm to belong to the nano particle diameter in the oxide hydrosol.
Further, the ethanol solution, the volume fraction of ethyl alcohol is 75%~99%；The multiple of the stretching is 5~8
Times, the time that the fixed length is impregnated is 5~10 hours.
Embodiment 2：
The raw materials used in the present invention is PCL materials and pure natural fibroin, and PCL materials have well-known biocompatibility,
Ligament has high tractive resistance, bending force and torsion made of PCL.Fibroin also has excellent bio-compatible
Property, it is nontoxic, conducive to cell adherence, growth and differentiation；Thus the bionical ligament prepared has good biocompatibility with that can drop
Xie Xing.
Graphene oxide and metal oxide nanoparticles are utilized in the fibroin fiber of activeness and quietness intensity is big,
The performances such as modulus height carry out activeness and quietness to fibroin fiber.Fibroin fiber after activeness and quietness, fracture strength,
All fibroin fibers before the remote superorder of elongation at break have high mechanical strength, can meet patient to tough band strength
Demand.
Bionical implantation of ligament provided by the present invention is simple and convenient, securely and reliably, patient tolerability is good, and immunogenicity is small etc.
Advantage has broad application prospects.
The above disclosure is only the preferred embodiments of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, therefore equivalent variations made according to the claims of the present invention, is still within the scope of the present invention.
Claims (5)
1. a kind of bionical ligament of activeness and quietness, it is characterised in that：The bionical ligament by activeness and quietness fibroin fiber and
Biodegradable fibers PCL weaves, and fibroin fiber dosage described in bionical ligament accounts for the 60~90% of total amount, described
PCL fiber consumptions account for the 10~40% of total amount.
2. the bionical ligament of activeness and quietness according to claim 1, it is characterised in that：The bionical ligament of the activeness and quietness
Preparation method is：
Use Na2CO3Then aqueous solution dissolves, and after centrifuging, dialysing, obtain again degumming silkworm cocoons with LiBr aqueous solutions
Fibroin protein solution, and then the mass percent for being concentrated into fibroin albumen is 10%~20%；
The regenerated silk fibroin water solution obtained after graphene oxide water solution previous step is concentrated is 1 in mass ratio:100~
10000 are blended, and obtain graphene oxide/fibroin albumen mixed solution；
Calcium carbonate aqueous solution is added, it is 0.2~0.5mol/L to adjust calcium ion molar concentration in solution, continues to concentrate, until silk
The percentage that fibroin obtains quality is 50%~70%, has obtained the spinning solution of fibroin albumen/graphene oxide at this time；
Dry spinning is carried out at room temperature using the solution after concentration as spinning solution, obtains the fibroin fiber of activeness and quietness；
It will be immersed in ethanol solution after above-mentioned fibroin fiber and Biodegradable fibers PCL windings braiding, suture, through drawing
It stretches, after fixed length is soaked for a period of time, takes out and obtain the bionical ligament of activeness and quietness.
3. the bionical ligament of activeness and quietness according to claim 1, it is characterised in that：The ethanol solution, the volume of ethyl alcohol
Score is 75%~99%；The multiple of the stretching is 5~8 times, and the time that the fixed length is impregnated is 5~10 hours.
4. the bionical ligament of activeness and quietness according to claim 1, it is characterised in that：The bionical ligament length for 25~
50cm, a diameter of to be repaired the 0.9~1.2 of ligament diameter times；A diameter of 80~200 μm of the fibroin fiber.
5. the bionical ligament of activeness and quietness according to claim 1, it is characterised in that：In the preparation process of the bionical ligament
The metal oxide hydrosol can also be added, the metal oxide in the metal oxide hydrosol can be TiO2、ZnO、
Al2O3Or ZrO2One or more of mixing, and the nano particle diameter in the metal oxide hydrosol is 10~100nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810160062.7A CN108261563A (en) | 2018-02-26 | 2018-02-26 | A kind of bionical ligament of activeness and quietness |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810160062.7A CN108261563A (en) | 2018-02-26 | 2018-02-26 | A kind of bionical ligament of activeness and quietness |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108261563A true CN108261563A (en) | 2018-07-10 |
Family
ID=62774378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810160062.7A Pending CN108261563A (en) | 2018-02-26 | 2018-02-26 | A kind of bionical ligament of activeness and quietness |
Country Status (1)
| Country | Link |
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| CN (1) | CN108261563A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114228279A (en) * | 2021-12-16 | 2022-03-25 | 吉林大学 | Multi-material composite bionic foot pad with adjustable mechanical property |
| CN115679695A (en) * | 2022-04-21 | 2023-02-03 | 复向丝泰医疗科技(苏州)有限公司 | Hybrid fiber for promoting tissue regeneration, preparation method thereof and fiber structure using same |
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| CN101274105A (en) * | 2008-05-19 | 2008-10-01 | 福建师范大学 | Method for preparing tendon tissue artificial substitute by tussah silk |
| CN103157135A (en) * | 2011-12-14 | 2013-06-19 | 西安瑞捷生物科技有限公司 | Reticular tissue engineering scaffold |
| CN103570951A (en) * | 2013-11-14 | 2014-02-12 | 东华大学 | Preparation method of silk fibroin/graphene oxide high-concentration blended aqueous solution |
| CN103572395A (en) * | 2013-11-14 | 2014-02-12 | 东华大学 | Strengthened toughened regenerated silk fibers and preparation method thereof |
| CN104043148A (en) * | 2014-06-17 | 2014-09-17 | 武汉纺织大学 | Ligament support and preparation method thereof |
| EP1558444B1 (en) * | 2002-06-24 | 2016-09-21 | Tufts University | Silk biomaterials and methods of use thereof |
| CN106048765A (en) * | 2016-07-14 | 2016-10-26 | 苏州经贸职业技术学院 | Preparation method of artificial ligament material |
-
2018
- 2018-02-26 CN CN201810160062.7A patent/CN108261563A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1558444B1 (en) * | 2002-06-24 | 2016-09-21 | Tufts University | Silk biomaterials and methods of use thereof |
| CN101274105A (en) * | 2008-05-19 | 2008-10-01 | 福建师范大学 | Method for preparing tendon tissue artificial substitute by tussah silk |
| CN103157135A (en) * | 2011-12-14 | 2013-06-19 | 西安瑞捷生物科技有限公司 | Reticular tissue engineering scaffold |
| CN103570951A (en) * | 2013-11-14 | 2014-02-12 | 东华大学 | Preparation method of silk fibroin/graphene oxide high-concentration blended aqueous solution |
| CN103572395A (en) * | 2013-11-14 | 2014-02-12 | 东华大学 | Strengthened toughened regenerated silk fibers and preparation method thereof |
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| CN106048765A (en) * | 2016-07-14 | 2016-10-26 | 苏州经贸职业技术学院 | Preparation method of artificial ligament material |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114228279A (en) * | 2021-12-16 | 2022-03-25 | 吉林大学 | Multi-material composite bionic foot pad with adjustable mechanical property |
| CN114228279B (en) * | 2021-12-16 | 2023-08-08 | 吉林大学 | Multi-material composite bionic foot pad with adjustable mechanical properties |
| CN115679695A (en) * | 2022-04-21 | 2023-02-03 | 复向丝泰医疗科技(苏州)有限公司 | Hybrid fiber for promoting tissue regeneration, preparation method thereof and fiber structure using same |
| CN115679695B (en) * | 2022-04-21 | 2024-11-12 | 复向丝泰医疗科技(苏州)有限公司 | Hybrid fiber for promoting tissue regeneration, preparation method thereof, and fiber structure using the same |
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