CN1083280C - 用于诊断和治疗的新的靶向组合物 - Google Patents

用于诊断和治疗的新的靶向组合物 Download PDF

Info

Publication number
CN1083280C
CN1083280C CN96194499A CN96194499A CN1083280C CN 1083280 C CN1083280 C CN 1083280C CN 96194499 A CN96194499 A CN 96194499A CN 96194499 A CN96194499 A CN 96194499A CN 1083280 C CN1083280 C CN 1083280C
Authority
CN
China
Prior art keywords
gas
vesicles
lipid
vesicle
targeting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96194499A
Other languages
English (en)
Chinese (zh)
Other versions
CN1187137A (zh
Inventor
埃文·C·翁格尔
沈德康
吴观丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImaRx Pharmaceutical Corp
Original Assignee
ImaRx Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27052585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1083280(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ImaRx Pharmaceutical Corp filed Critical ImaRx Pharmaceutical Corp
Publication of CN1187137A publication Critical patent/CN1187137A/zh
Application granted granted Critical
Publication of CN1083280C publication Critical patent/CN1083280C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN96194499A 1995-06-07 1996-06-06 用于诊断和治疗的新的靶向组合物 Expired - Fee Related CN1083280C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49768495A 1995-06-07 1995-06-07
US08/497,684 1995-06-07
US64046496A 1996-05-01 1996-05-01
US08/640,464 1996-05-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN02105309A Division CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Publications (2)

Publication Number Publication Date
CN1187137A CN1187137A (zh) 1998-07-08
CN1083280C true CN1083280C (zh) 2002-04-24

Family

ID=27052585

Family Applications (2)

Application Number Title Priority Date Filing Date
CN96194499A Expired - Fee Related CN1083280C (zh) 1995-06-07 1996-06-06 用于诊断和治疗的新的靶向组合物
CN02105309A Pending CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN02105309A Pending CN1397348A (zh) 1995-06-07 2002-02-22 用于诊断和治疗的新的靶向组合物

Country Status (8)

Country Link
EP (2) EP1444991A1 (2)
JP (1) JP4215820B2 (2)
CN (2) CN1083280C (2)
AT (1) ATE265863T1 (2)
AU (1) AU709562B2 (2)
CA (1) CA2218541A1 (2)
DE (1) DE69632401T2 (2)
WO (1) WO1996040285A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100402092C (zh) * 2005-06-07 2008-07-16 西安交通大学 血栓诊断和/或治疗用含气干粉活性剂及其制备工艺

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6521211B1 (en) * 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5780010A (en) * 1995-06-08 1998-07-14 Barnes-Jewish Hospital Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
US6548046B1 (en) 1995-06-08 2003-04-15 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
US6821506B2 (en) 1995-06-08 2004-11-23 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
CA2252617A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
BR9712683A (pt) 1996-10-28 1999-10-19 Nyomed Imaging A S Agente de diagnóstico e/ou terapeuticamente ativo alvejável, formulação combinada, processo para preparação e uso do mesmo, formulação combinada, e processos para gerar imagens intensificadas de um corpo animal humano ou não-humano e para investigação in vitro de alvejamento por um agente.
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6493570B1 (en) * 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) * 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
WO1999013918A2 (en) * 1997-09-18 1999-03-25 University Of Pittsburgh Icam-1 selective echogenic microbubbles
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
DE69813853T3 (de) † 1997-09-29 2011-05-12 Novartis Ag Perforierte mikroteilchen und deren verwendung
JP2001520207A (ja) * 1997-10-21 2001-10-30 ニユコメド・イメージング・アクシエセルカペト 微小血管に標的設定された造影剤および血管拡張剤による超音波造影
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
CA2349501A1 (en) * 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Quinolone vitronectin receptor antagonist pharmaceuticals
EP1173600A2 (en) * 1999-04-20 2002-01-23 The University Of British Columbia Cationic peg-lipids and methods of use
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
AU6522400A (en) * 1999-08-10 2001-03-05 Imarx Therapeutics, Inc. Targeted thrombolytic agents
US7220401B2 (en) 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US8263739B2 (en) 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
AU2002214583A1 (en) * 2000-10-11 2002-04-22 Purdue Research Foundation Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US7087212B2 (en) 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
TR200401834T2 (tr) * 2002-01-24 2005-10-21 Barnes-Jewish Hospital İntegrin hedefli görüntüleme etken maddeleri.
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7666979B2 (en) 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2351967T3 (es) * 2002-04-29 2011-02-14 Biotesys Gmbh Lípidos polimerizados modificados con péptidos como sistemas de transporte biológico para micronutrientes.
JP4490290B2 (ja) 2002-12-31 2010-06-23 ネクター セラピューティクス アラバマ，コーポレイション 加水分解安定性マレイミド末端ポリマー
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP2284180B1 (en) 2003-03-03 2015-09-09 Dyax Corp. Uses of peptides that specifically bind HGF receptor (cMET)
CA2529304A1 (en) * 2003-06-13 2005-01-20 Imarx Therapeutics, Inc. Non-invasive intravascular thrombolysis using modified ultrasound techniques
US7358226B2 (en) 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
WO2005027808A1 (en) 2003-09-12 2005-03-31 Z-Medica Corporation Calcium zeolite hemostatic agent
CN1321697C (zh) * 2003-12-23 2007-06-20 中国人民解放军军事医学科学院毒物药物研究所 一种以磷脂类成分为成膜材料的超声造影剂组合物及其制备方法
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
JP2008531498A (ja) 2005-02-15 2008-08-14 バージニア コモンウェルス ユニバーシティ 緊急止血ならびに急性創傷および慢性潰瘍の治療のための鉱物技術（ｍｔ）
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
JP2007001923A (ja) * 2005-06-23 2007-01-11 Shinshu Univ Ｎ−アセチルグルコサミン糖鎖認識タンパク質
CN101374955B (zh) 2005-12-09 2013-03-27 布拉科瑞士有限公司 靶向载体-磷脂缀合物
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US7604819B2 (en) 2006-05-26 2009-10-20 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
WO2008075192A2 (en) 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
US8158746B2 (en) * 2007-03-29 2012-04-17 Canon Kabushiki Kaisha Active energy ray curable liquid composition and liquid cartridge
DE102007041832A1 (de) * 2007-09-03 2009-03-05 Siemens Ag Arzneimittel und Verfahren zur Behandlung von Prostatakrebs
HUE035770T2 (en) * 2008-06-16 2018-05-28 Pfizer Process for the preparation of diblock copolymers functionalized with targeting material for use in the preparation of therapeutic nanoparticles
CN101721719B (zh) * 2008-10-28 2011-09-28 温州医学院 超声造影剂及其制备方法
CN101549161B (zh) * 2009-05-13 2010-12-01 中南大学 一种肝、脾脏特异性阳性核磁共振对比剂及其制备方法
WO2010139003A1 (en) * 2009-06-01 2010-12-09 Commonwealth Scientific And Industrial Research Organisation Chelating amphiphiles
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
WO2013191836A1 (en) 2012-06-22 2013-12-27 Z-Medica, Llc Hemostatic devices
US10035009B2 (en) 2013-04-15 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treating pancreatic cancer
JP2016528259A (ja) * 2013-08-16 2016-09-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア シリコーン系腸管ｃｔ造影材料
KR102031571B1 (ko) * 2014-03-07 2019-10-14 주식회사 퍼시픽시스템 약물 전달을 위해 기포를 포함하는 미셀 및 이를 제조하는 방법
WO2016007091A1 (en) * 2014-07-08 2016-01-14 Agency For Science, Technology And Research Ultrashort peptides as exogenous second harmonic probes for bioimaging applications
CA2965091A1 (en) * 2014-10-20 2016-05-06 Dorian Averbuch Surgical devices and methods of use thereof
AU2015374286B2 (en) 2014-12-31 2021-11-18 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
IL262647B2 (en) 2016-05-04 2023-03-01 Lantheus Medical Imaging Inc Methods and devices for preparing sharpness factors for ultrasound
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
JP7500536B2 (ja) * 2018-03-23 2024-06-17 アデノサイト リミテッド 強化された細胞病理学的細胞採取のための細胞および／または組織片の剥離を誘導する方法
CN110591054B (zh) * 2019-09-17 2021-05-18 江苏泰特尔新材料科技股份有限公司 一种总氯含量低、无重金属残留的环氧化物及其合成工艺
CN112266930B (zh) * 2020-10-14 2023-03-14 中国科学院苏州生物医学工程技术研究所 超声穿孔转染细胞的方法
US20240299653A1 (en) * 2020-12-27 2024-09-12 Solstice Pharmaceuticals B.V. A Cartridge for Mixing a Liquid Intended for Intracorporeal Use
CN113694215B (zh) * 2021-09-09 2023-12-29 南京超维景生物科技有限公司 磁性纳米滴液的组合物，磁性造影剂及其制备方法
WO2026027682A1 (en) * 2024-07-31 2026-02-05 Schrader Juergen Combination comprising a cd63-binding molecule and a drug and/or a tracer and uses thereof
CN121343147A (zh) * 2025-12-18 2026-01-16 广州方中化工有限公司 一种基于蓖麻油衍生物的可降解农药增效剂

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5344930A (en) * 1989-06-22 1994-09-06 Alliance Pharmaceutical Corp. Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5380519A (en) * 1990-04-02 1995-01-10 Bracco International B.V. Stable microbubbles suspensions injectable into living organisms
CN1119831A (zh) * 1993-01-25 1996-04-03 索纳斯药品有限公司 用作超声造影剂的相转变胶体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
DE4232755A1 (de) * 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
EP0727225A3 (en) * 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
US5695760A (en) * 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344930A (en) * 1989-06-22 1994-09-06 Alliance Pharmaceutical Corp. Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5380519A (en) * 1990-04-02 1995-01-10 Bracco International B.V. Stable microbubbles suspensions injectable into living organisms
CN1119831A (zh) * 1993-01-25 1996-04-03 索纳斯药品有限公司 用作超声造影剂的相转变胶体
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100402092C (zh) * 2005-06-07 2008-07-16 西安交通大学 血栓诊断和/或治疗用含气干粉活性剂及其制备工艺

Also Published As

Publication number Publication date
EP0831932A1 (en) 1998-04-01
JP4215820B2 (ja) 2009-01-28
DE69632401T2 (de) 2005-05-19
DE69632401D1 (de) 2004-06-09
EP1444991A1 (en) 2004-08-11
AU709562B2 (en) 1999-09-02
EP0831932B1 (en) 2004-05-06
CA2218541A1 (en) 1996-12-19
ATE265863T1 (de) 2004-05-15
CN1397348A (zh) 2003-02-19
EP0831932A4 (en) 2000-01-12
WO1996040285A1 (en) 1996-12-19
AU6270396A (en) 1996-12-30
CN1187137A (zh) 1998-07-08
JPH11507638A (ja) 1999-07-06

Similar Documents

Publication Publication Date Title
CN1187137A (zh) 用于诊断和治疗的新的靶向组合物
AU777304B2 (en) Novel methods of imaging and treatment with targeted compositions
US7452551B1 (en) Targeted compositions for diagnostic and therapeutic use
US6139819A (en) Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6716412B2 (en) Methods of ultrasound treatment using gas or gaseous precursor-filled compositions
US6090800A (en) Lipid soluble steroid prodrugs
EP1039834B1 (en) Optoacoustic contrast agents and methods for their use
US6403056B1 (en) Method for delivering bioactive agents using cochleates
AU2002213285A1 (en) Novel targeted compositions for diagnostic and therapeutic use
US20100008863A1 (en) Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
WO1998050041A1 (en) Novel prodrugs comprising fluorinated amphiphiles

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1049635

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020424