CN108366548B - 具有人源化淋巴细胞活化基因3的非人动物 - Google Patents

具有人源化淋巴细胞活化基因3的非人动物 Download PDF

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CN108366548B
CN108366548B CN201680067496.1A CN201680067496A CN108366548B CN 108366548 B CN108366548 B CN 108366548B CN 201680067496 A CN201680067496 A CN 201680067496A CN 108366548 B CN108366548 B CN 108366548B
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human
lag
gene
polypeptide
rodent
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CN108366548A (zh
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A·O·姆基卡
E·布罗瓦
A·J·莫菲
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
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    • A01K67/0276—Knock-out vertebrates
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/0331—Animal model for proliferative diseases
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2510/00—Genetically modified cells
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    • C12N2517/02—Cells from transgenic animals

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CN201680067496.1A 2015-11-20 2016-11-18 具有人源化淋巴细胞活化基因3的非人动物 Active CN108366548B (zh)

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US201562258181P 2015-11-20 2015-11-20
US62/258,181 2015-11-20
US201662370430P 2016-08-03 2016-08-03
US62/370,430 2016-08-03
PCT/US2016/062733 WO2017087780A1 (en) 2015-11-20 2016-11-18 Non-human animals having a humanized lymphocyte-activation gene 3

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EP (1) EP3376857B1 (2)
JP (1) JP6997708B2 (2)
KR (1) KR102454546B1 (2)
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