CN109010090A - A kind of sodium bicarbonate biological complex enzyme toothpaste - Google Patents
A kind of sodium bicarbonate biological complex enzyme toothpaste Download PDFInfo
- Publication number
- CN109010090A CN109010090A CN201811100105.9A CN201811100105A CN109010090A CN 109010090 A CN109010090 A CN 109010090A CN 201811100105 A CN201811100105 A CN 201811100105A CN 109010090 A CN109010090 A CN 109010090A
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- CN
- China
- Prior art keywords
- sodium bicarbonate
- complex enzyme
- biological complex
- toothpaste
- sodium
- Prior art date
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 title claims abstract description 91
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 49
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 49
- 235000017557 sodium bicarbonate Nutrition 0.000 title claims abstract description 39
- 229910000030 sodium bicarbonate Inorganic materials 0.000 title claims abstract description 39
- 239000000606 toothpaste Substances 0.000 title claims abstract description 31
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 31
- 229940088598 enzyme Drugs 0.000 claims abstract description 48
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 102000016943 Muramidase Human genes 0.000 claims abstract description 14
- 108010014251 Muramidase Proteins 0.000 claims abstract description 14
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 14
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 14
- 235000013305 food Nutrition 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 101710130006 Beta-glucanase Proteins 0.000 claims abstract description 11
- 229940051921 muramidase Drugs 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 230000002087 whitening effect Effects 0.000 claims abstract description 6
- 239000004909 Moisturizer Substances 0.000 claims abstract description 5
- 239000000872 buffer Substances 0.000 claims abstract description 5
- 239000003607 modifier Substances 0.000 claims abstract description 5
- 230000001333 moisturizer Effects 0.000 claims abstract description 5
- 239000004094 surface-active agent Substances 0.000 claims abstract description 5
- 239000002562 thickening agent Substances 0.000 claims abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 5
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 4
- 229920013818 hydroxypropyl guar gum Polymers 0.000 claims description 4
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 4
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- 229930182830 galactose Natural products 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 229940083982 sodium phytate Drugs 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 3
- 235000006076 zinc citrate Nutrition 0.000 claims description 3
- 239000011746 zinc citrate Substances 0.000 claims description 3
- 229940068475 zinc citrate Drugs 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 235000019082 Osmanthus Nutrition 0.000 claims 1
- 241000333181 Osmanthus Species 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000000571 coke Substances 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- 235000011008 sodium phosphates Nutrition 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 15
- 241000894006 Bacteria Species 0.000 abstract description 12
- 238000004140 cleaning Methods 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000000845 anti-microbial effect Effects 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 239000000686 essence Substances 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 4
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 229960000274 lysozyme Drugs 0.000 description 4
- 239000004325 lysozyme Substances 0.000 description 4
- 229960004029 silicic acid Drugs 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 108010013639 Peptidoglycan Proteins 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical group [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 3
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 2
- 241001135213 Porphyromonas endodontalis Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of sodium bicarbonate biological complex enzyme toothpaste, efficacy includes food grade saleratus and enzyme preparation, and the enzyme preparation includes muramidase and 1,4 beta-glucanase.The toothpaste be by rubbing agent, moisturizer, surfactant, thickener, acid-base buffer agent, food grade saleratus, enzyme preparation, taste-modifier, except stain whitening agent, essence, water are formulated by certain weight ratio.The sodium bicarbonate biological complex enzyme toothpaste utilizes the characteristics such as sodium bicarbonate particle alkalescent, diffusivity, permeability, strong cleaning force, go deep into teeth crevice, clean each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance the activity of the biological complex enzyme as main antimicrobial component, forms unique bacteriolyze Antibacterial Mechanism, effectively inhibit oral cavity harmful bacteria, bacterium attachment is reduced, dental plaque index is reduced, safeguards oral health jointly.
Description
Technical field
The present invention relates to oral cleaning nursing article technical fields, and in particular to a kind of sodium bicarbonate biological complex enzyme toothpaste.
Background technique
Sodium bicarbonate is a kind of excellent detergent, and itself has no toxic side effect, and sodium bicarbonate is utilized on domestic and international toothpaste market
Natural sex, alkalescent, particle friction the features such as, balance the pH value in oral cavity, inhibit acid plaque in oral cavity, when brushing teeth
Cleaning comprehensively is carried out to oral cavity to achieve the effect that except stain whitening, fresh breath.
Baking soda dentifrice currently on the market substitutes a part of conventional friction agent mainly using sodium bicarbonate as rubbing agent,
Although particle friction energy removes the tartar tooth stain of dental surface accumulation very well, sodium bicarbonate easily reacts production CO with water2, make cream
There are the wild effects such as flatulence, water outlet in body.Foam volume can be reduced by adding a large amount of sodium bicarbonate, and mouthfeel is partially salty, when influence is brushed teeth
Use feeling, while the crowd of mucous membrane of mouth breakage can be had damage.
Lysozyme mainly passes through the β in hydrolytic bacteria cell wall-Isosorbide-5-Nitrae glycosidic bond, destroys peptide glycan bracket, makees in osmotic pressure
Membranolysis is set to cause bacteria lysis dead under.Gram-positive bacteria cell wall outer layer is peptidoglycan layer, therefore lysozyme
There is preferable fungistatic effect to most of gram-positive bacterias, but the peptidoglycan layer of Gram-negative bacteria is located at cell inner wall
Layer, outer layer are covered with a large amount of lipopolysaccharides, and lysozyme is unsatisfactory to the fungistatic effect of most of Gram-negative bacterias.In recent years
That a part of lipopolysaccharides segment of cell surface can be dissolved out the study found that cell membrane agent interfering appropriate is added, promotes phosphatide
The outer layer of outer membrane is moved to, phosphatide replaces the lipopolysaccharides lost, further results in lipid from membrane translocation to supplement phosphatide, cell
Film loss of stability, so that lysozyme be made preferably to act on Gram-negative bacteria.
Summary of the invention
It is an object of the invention to solve the problems, such as it is in the prior art exist, a kind of sodium bicarbonate biological complex enzyme tooth is provided
Cream, the sodium bicarbonate biological complex enzyme toothpaste are deep using characteristics such as sodium bicarbonate particle alkalescent, diffusivity, permeability, cleaning force
Enter teeth crevice, cleans each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance as main antimicrobial component
The activity of biological complex enzyme forms unique bacteriolyze Antibacterial Mechanism, effectively inhibits oral cavity harmful bacteria, reduces bacterium attachment, drop
Low dental plaque index, safeguards oral health jointly.
To achieve the above object, technical solution of the present invention provides a kind of sodium bicarbonate biological complex enzyme toothpaste, the tooth
Cream contains efficacy, and the efficacy includes food grade saleratus and enzyme preparation, and the enzyme preparation includes murein
Enzyme and 1,4 beta-glucanase.
Its weight percent is food grade saleratus 0.1-5%, enzyme preparation 0.0002-0.02%.
The mass parts of the muramidase: the mass parts of 1,4 beta-glucanase are 1:0.4-0.6.
The composition of the sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component are as follows:
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Food grade saleratus 0.1-5%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus.
Wherein the rubbing agent is at least one of hydrated silica, calcium monohydrogen phosphate, aluminium hydroxide.
Wherein the moisturizer is at least one of sorbierite, glycerol, propylene glycol, polyethylene glycol.
Wherein the surfactant is sodium lauroyl sarcosine, sodium lauroyl glutamate, Cocoamidopropyl betaine
At least one of.
Wherein the thickener is at least one of cellulose gum, hydroxypropyl guar gum, xanthan gum.
Wherein the acid-base buffer agent is at least one of sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate.
Wherein the taste-modifier is at least one of saccharin sodium, tri-chloro galactose type sugar, stevioside.
Wherein except stain whitening agent is at least one of sodium phytate, zinc citrate, calcium pyrophosphate.
The beneficial effects of the present invention are: on the basis of traditional baking soda dentifrice formula, the usage amount of sodium bicarbonate is reduced,
Its influence to lotion saline taste, foam volume, stability is reduced, the help of weak base performance adjusts oral cavity acid-base balance, it is right to resist acid
The erosion of tooth.Using biological complex enzyme as main antimicrobial component, the poly- peptide sugar of muramidase selective dissolution bacteria cell wall,
1,4 beta-glucanase decomposes the glucan that dental surface streptococcus mutans generate, and micro sodium bicarbonate can activate the antibacterial of biological enzyme living
Property, during lotion of toothpaste and Buccodental, gum CONTACT WITH FRICTION, promotes biological enzyme deeply to clean each position in oral cavity, have
Effect inhibits oral cavity harmful bacteria, reduces bacterium attachment, reduces dental plaque index, safeguard oral health jointly.
Sodium bicarbonate biological complex enzyme toothpaste of the present invention utilizes sodium bicarbonate particle alkalescent, diffusivity, permeability, strong cleaning force
Etc. characteristics, go deep into teeth crevice, clean each position in oral cavity, help adjusts oral cavity acid-base balance, while can enhance conduct mainly
The activity of the biological complex enzyme of antimicrobial component forms unique bacteriolyze Antibacterial Mechanism.
Specific embodiment
With reference to embodiment, the specific embodiment of the present invention is further described.Once embodiment is only used for more
Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 1 are as follows:
Hydrated silica 20%
Calcium monohydrogen phosphate 10%
Sorbierite 25%
Polyethylene glycol-400 15%
Sodium lauroyl sarcosine 1%
Cocoamidopropyl betaine 1%
Hydroxypropyl guar gum 0.6%
Cellulose gum 0.3%
Tertiary sodium phosphate 0.2%
Food grade saleratus 0.15%
Muramidase 0.001%
1,4 beta-glucanase 0.0006%
Tri-chloro galactose type sugar 0.15%
Zinc citrate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 2
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 2 are as follows:
Hydrated silica 20%
Aluminium hydroxide 10%
Sorbierite 30%
Propylene glycol 10%
Sodium lauroyl glutamate 1%
Cocoamidopropyl betaine 1%
Xanthan gum 0.6%
Cellulose gum 0.3%
Sodium dihydrogen phosphate 0.2%
Food grade saleratus 0.2%
Muramidase 0.005%
1,4 beta-glucanase 0.002%
Saccharin sodium 0.02%
Calcium pyrophosphate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 3
The composition of sodium bicarbonate biological complex enzyme toothpaste and the weight percent of component in embodiment 3 are as follows:
Hydrated silica 25%
Aluminium hydroxide 5%
Sorbierite 25%
Glycerol 10%
Sodium lauroyl glutamate 0.5%
Sodium lauroyl sarcosine 0.5%
Cocoamidopropyl betaine 1%
Hydroxypropyl guar gum 0.6%
Xanthan gum 0.5%
Tetrasodium pyrophosphate 0.5%
Food grade saleratus 0.25%
Muramidase 0.01%
1,4 beta-glucanase 0.05%
Stevioside 0.1%
Sodium phytate 0.3%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Comparative example 1
Comparative example 1 and the difference of embodiment 3 are only that: the additive amount of food grade saleratus is 5%.
Comparative example 2 and the difference of embodiment 3 are only that: being free of food grade saleratus.
Comparative example 3 and the difference of embodiment 3 are only that: being free of muramidase and 1,4 beta-glucanase.
Comparative example 4 and the difference of embodiment 3 are only that: being free of muramidase.
Comparative example 5 and the difference of embodiment 3 are only that: being free of 1,4 beta-glucanase.
Using sodium bicarbonate biological complex enzyme toothpaste performance test methods prepared by the present invention are as follows:
1, physical and chemical index and estimation of stability
Sodium bicarbonate biological complex enzyme toothpaste in embodiment and comparative example is detected by GB/T 8372, evaluates its stability.
2, fungistatic effect is evaluated
Gram-positive bacteria enterococcus faecalis and Gram-negative bacteria Porphyromonas endodontalis in vitro are chosen as experimental strain, observes little Su
It beats and bacteriostasis is cooperateed with to enterococcus faecalis and Porphyromonas endodontalis in vitro with compound biological enzyme.
The above results explanation, the sodium bicarbonate of low content do not influence the stability of lotion of toothpaste, and the sodium bicarbonate of high-content can be broken
The stability of bad lotion of toothpaste；Two kinds of enzyme compoundings are than having more significant fungistatic effect using single enzyme preparation；It adds in right amount small
Soda can rise with compound biological enzyme and cooperate with bacteriostasis, but can inhibit the bacteriostatic activity of biological enzyme when too high levels.
Claims (10)
1. a kind of sodium bicarbonate biological complex enzyme toothpaste, which is characterized in that the toothpaste contains efficacy, effect combination
Object includes food grade saleratus and enzyme preparation, and the enzyme preparation includes muramidase and 1,4 beta-glucanase.
2. sodium bicarbonate biological complex enzyme toothpaste according to claim 1, which is characterized in that the food grade saleratus
0.1-5%, enzyme preparation 0.0002-0.02%.
3. according to claim 1 or sodium bicarbonate biological complex enzyme toothpaste described in 2, which is characterized in that the muramidase
Mass parts: the mass parts of 1,4 beta-glucanase are 1:0.4-0.6.
4. sodium bicarbonate biological complex enzyme toothpaste according to claim 3, which is characterized in that the sodium bicarbonate biological complex enzyme
The composition of toothpaste and the weight percent of component are as follows:
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Food grade saleratus 0.1-5%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus.
5. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the rubbing agent is hydration silicon
At least one of stone, calcium monohydrogen phosphate, aluminium hydroxide.
6. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the moisturizer is sorb
At least one of alcohol, glycerol, propylene glycol, polyethylene glycol.
7. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the surfactant is the moon
At least one of osmanthus acylsarcosine sodium, sodium lauroyl glutamate, Cocoamidopropyl betaine.
8. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the thickener is cellulose
At least one of glue, hydroxypropyl guar gum, xanthan gum.
9. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the acid-base buffer agent is coke
At least one of sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate.
10. sodium bicarbonate biological complex enzyme toothpaste according to claim 4, which is characterized in that the taste-modifier is
At least one of saccharin sodium, tri-chloro galactose type sugar, stevioside；The stain whitening agent that removes is sodium phytate, zinc citrate, calcium pyrophosphate
At least one of.
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| CN110547977A (en) * | 2019-08-30 | 2019-12-10 | 广州悦创实业有限公司 | oral care composition containing baking soda as well as preparation method and application thereof |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | A kind of biological enzyme oral cleaning and nursing toothpaste |
| US11168287B2 (en) | 2016-05-26 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
| WO2022020698A1 (en) * | 2020-07-24 | 2022-01-27 | Colgate-Palmolive Company | Oral care compositions containing sodium lauroyl sarcosinate and betaine |
| US12037497B2 (en) | 2016-01-28 | 2024-07-16 | Kimberly-Clark Worldwide, Inc. | Anti-adherent composition against DNA viruses and method of inhibiting the adherence of DNA viruses to a surface |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12037497B2 (en) | 2016-01-28 | 2024-07-16 | Kimberly-Clark Worldwide, Inc. | Anti-adherent composition against DNA viruses and method of inhibiting the adherence of DNA viruses to a surface |
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| WO2022020698A1 (en) * | 2020-07-24 | 2022-01-27 | Colgate-Palmolive Company | Oral care compositions containing sodium lauroyl sarcosinate and betaine |
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| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | A kind of biological enzyme oral cleaning and nursing toothpaste |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
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