CN1095592A - 血管紧张素ii拮抗剂的新用途 - Google Patents

血管紧张素ii拮抗剂的新用途 Download PDF

Info

Publication number
CN1095592A
CN1095592A CN93116714A CN93116714A CN1095592A CN 1095592 A CN1095592 A CN 1095592A CN 93116714 A CN93116714 A CN 93116714A CN 93116714 A CN93116714 A CN 93116714A CN 1095592 A CN1095592 A CN 1095592A
Authority
CN
China
Prior art keywords
ester
angiotensin
rudimentary
oxygen base
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93116714A
Other languages
English (en)
Chinese (zh)
Inventor
大实
酒井茂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1095592A publication Critical patent/CN1095592A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN93116714A 1992-08-21 1993-08-20 血管紧张素ii拮抗剂的新用途 Pending CN1095592A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9217820.1 1992-08-21
GB929217820A GB9217820D0 (en) 1992-08-21 1992-08-21 New use

Publications (1)

Publication Number Publication Date
CN1095592A true CN1095592A (zh) 1994-11-30

Family

ID=10720744

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93116714A Pending CN1095592A (zh) 1992-08-21 1993-08-20 血管紧张素ii拮抗剂的新用途

Country Status (9)

Country Link
US (1) US5661158A (2)
EP (1) EP0655915A1 (2)
JP (1) JPH08500587A (2)
CN (1) CN1095592A (2)
AU (1) AU4585993A (2)
GB (1) GB9217820D0 (2)
TW (1) TW226018B (2)
WO (1) WO1994004153A1 (2)
ZA (1) ZA935503B (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3883205B2 (ja) * 1994-03-29 2007-02-21 メルク エンド カンパニー インコーポレーテッド アンギオテンシン▲ｉｉ▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
WO1999012534A1 (en) * 1997-09-10 1999-03-18 Ono Pharmaceutical Co., Ltd. Peroxisome proliferator-activated receptor controllers
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
JP4675586B2 (ja) * 2004-06-23 2011-04-27 壽製薬株式会社 高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
PE20070182A1 (es) 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
US8372862B2 (en) * 2009-06-02 2013-02-12 Korea Research Institute Of Chemical Technology Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96019A0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
US5336677A (en) * 1991-10-24 1994-08-09 American Home Products Corporation Substituted aminopyrimidines as antihypertensives

Also Published As

Publication number Publication date
ZA935503B (en) 1994-06-01
GB9217820D0 (en) 1992-10-07
EP0655915A1 (en) 1995-06-07
JPH08500587A (ja) 1996-01-23
US5661158A (en) 1997-08-26
AU4585993A (en) 1994-03-15
WO1994004153A1 (en) 1994-03-03
TW226018B (2) 1994-07-01

Similar Documents

Publication Publication Date Title
CN1142933C (zh) 抑制胃酸分泌的杂环化合物、其制备方法及其药物组合物
CN1136219C (zh) 用于治疗阳痿的吡唑并嘧啶酮衍生物
CN1195290A (zh) Cgmp磷酸二酯酶抑制剂治疗阳痿的用途
KR101916481B1 (ko) Ｎ-헤테로아릴 화합물
US20070037815A1 (en) Novel pharmaceutical compounds
JP2011520775A (ja) ベンゼン誘導体を含むリポプロテインリパーゼ活性化組成物
CN1168794A (zh) 减少与非心脏局部缺血有关的组织损伤的方法
CN1135485A (zh) 2，9-二取代的嘌呤-6-酮类化合物
CN1344268A (zh) 咪唑[1,5－a]吡啶并[3,2－e]吡嗪酮作为药物的应用
CN1043714A (zh) 治疗活性取代苯并咪唑及其制备方法
EA009558B1 (ru) Соединения с ноотропным действием, их получение, содержащие их фармацевтические композиции и их применение
US5661158A (en) Use of angiotensin II antagonists for the treatment of hyperlipidemia
CN1022754C (zh) 联苯基-1-烷基吡咯-2-羧酸化合物的制备
US11512088B2 (en) Synthetic process and intermediates
JP2003520768A (ja) ＴＮＦα阻害剤として有用なチアゾロピリミジン
US20040176371A1 (en) Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction
JP2003119140A (ja) ピロロピリダジン化合物を含有する医薬
CN1026108C (zh) 制备新的5-苄基取代的苯并咪唑啉-2-硫酮衍生物的方法
CN1689559A (zh) 藜芦胺作为信号转导抑制剂的用途
CN1048382A (zh) 对抗惊厥剂及与抗惊厥剂有关的改进
RU2466725C2 (ru) Композиции для активации липопротеинлипазы, включающие производные бензола
CN118512454B (zh) 纳曲酮在制备治疗高尿酸血症药物中的应用
CN1193029C (zh) 7－氨基吡啶并[2,3－d]嘧啶衍生物，其组合物及用途
CN87108192A (zh) 二唑酮衍生物，其制备方法，及含有该衍生物的除草剂
MC1154A1 (fr) Nouveaux 2,3-alkylene bis(oxy)benzamides substitues,leurs derives et leurs procedes de preparation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication