CN109893473A - Deep Ocean Concentrate Skin Care and Maintenance Kit and Its Application - Google Patents
Deep Ocean Concentrate Skin Care and Maintenance Kit and Its Application Download PDFInfo
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- CN109893473A CN109893473A CN201810883066.8A CN201810883066A CN109893473A CN 109893473 A CN109893473 A CN 109893473A CN 201810883066 A CN201810883066 A CN 201810883066A CN 109893473 A CN109893473 A CN 109893473A
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Abstract
本发明是有关于含有海洋深层浓缩物与皮肤用护理保养配方的海洋深层浓缩皮肤护理保养套组。本发明的海洋深层浓缩物皮肤护理保养套组具有：1.立即微粒化皮肤用护理保养配方；2.立即减少海洋深层浓缩物高表面张力、解决皮肤不易吸收的问题；3.海洋深层浓缩物的其一的物质特性成为微粒化后的皮肤用护理保养配方渗透的推动力(Driving Force)，使皮肤(真皮层)更易于吸收。本发明更提供海洋深层浓缩物皮肤护理保养套组产生改善皮肤外观的制备方法。
The invention relates to a deep marine concentrated skin care and maintenance kit containing a deep marine concentrate and a skin care and maintenance formula. The deep ocean concentrate skin care and maintenance kit of the present invention has: 1. Immediately micronized skin care and maintenance formula; 2. Immediately reduce the high surface tension of the deep ocean concentrate and solve the problem of difficulty in skin absorption; 3. The deep ocean concentrate One of the material properties becomes the driving force for the penetration of micronized skin care formulas, making it easier for the skin (dermis) to absorb. The present invention further provides a method for preparing a deep marine concentrate skin care and maintenance kit to improve skin appearance.
Description
[technical field]
The invention relates to the bathypelagic concentrate skins containing bathypelagic concentrate and skin nursing maintenance formula
Skin nursing maintenance set group, and particularly with regard to the composition of the bathypelagic concentrate prepared in real time and skin nursing maintenance formula
Object reduces the high surface tension of bathypelagic concentrate through micronized micel, becomes the high concentration charged ion in it
The driving force of permeability, and then promote absorption of the Skin Cell to skin nursing maintenance formula.
[background technique]
Deep ocean water (deep-sea water, DSW) is taken from lower than 200 meters of sea level low temperature below, cleaning
Free of contamination seawater, deep ocean water rich in the metal ions such as magnesium, calcium, potassium, nutritive salt and have high solubilised state with it is hard-decomposed
Inorganic constituents.Why deep ocean water is rich in minerals, and being primarily due to sunlight cannot penetrate, and photosynthesis can not be sent out
It is raw, so that inorganic nutrient salt is not consumed by phytoplankton and the surface seawater deep sea water that compares up has the inorganic of high level
Nutritive salt.Due to inorganic nutrient salt rich in, deep ocean water is widely applied to health drink, food, medicine at present
Product and aquaculture.
In recent years, deep ocean water be widely used in food processing industry, agricultural, with it is medicinal.There is Research Literature to point out
Bathypelagic water energy reduces blood fat, lipid oxidation, vascular sclerosis and hypertension, while also can be reduced vascular wall hyperplasia；Though
So in the research of Atopic dermatitis, it has been found that sufferer can improve chafing and allergy after drinking or impregnating deep sea water
Symptom, so not large-scale application in cosmetic industry.It is also found to be used to improve in white in addition, drinking deep ocean water
Barrier.
Since deep ocean water can only acquire everywhere in the whole world, successful acquisition and concentrate has been made in TaiWan, China, dense
Contracting liquid can be eaten and as skin care products.Existing document points out that discovery, deep ocean water can stimulate collagen egg in cell experiment
White new life makes skin whitening, inhibits the phenomenon that or treat inflammation, however deep ocean water is not yet used heavily in makeup and protected
In the addition for the product of supporting.General commercially available skin care products is merged due to that need to be stablized grease with emulsifier, therefore micel is larger, is not easy by skin
Skin absorbs, and bathypelagic concentrate has balance and stable ion composition, and the state absorbed, but high table are easy for cell
The characteristic of face tension, makes it not easily penetrate into skin.There is not document announcement to there is bathypelagic concentrate directly to mix guarantor yet at present
The effective product for the product of supporting.In order to provide the skin care products of more effective fruit, while increasing the industrial value of deep ocean water, industry needs
A kind of constituent containing bathypelagic concentration (liquid/powder) and skin nursing maintenance formula is provided.
[summary of the invention]
In view of this, the present invention provide it is a kind of can be by bathypelagic concentrate to the health of skin or the ingredient of appearance investigation
Maintenance set group, its usage mode and preparation method thereof of formula are maintained with skin nursing.And bathypelagic concentrate of the invention
Skin nursing maintenance set group is characterized in that it is formulated with nursing maintenance with micronized skin immediately, reduces bathypelagic immediately
Concentrate high surface tension solves the problems, such as that skin is not easy to absorb and the substance characteristics of bathypelagic concentrate can become particle
The skin motive force (Driving Force) of nursing maintenance formula infiltration after change, more easily absorbs skin (skin corium).
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, including first dose and second dose, described
First dose is bathypelagic concentrate, and described second dose is skin nursing maintenance formula, and the two is independent packaging.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the bathypelagic concentrate
Magnesium density is 6,500~110,000mg/l.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the bathypelagic concentrate
Na concn is 3,800~30,000mg/l, potassium concn is 400~18,000mg/l, calcium concentration is 100~500mg/l.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the deep sea water concentrate
Hardness is 80,000~420,000mg/l, and salinity is 380~430 ‰.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the deep sea water concentrate is every
Calcium, 1,400~2,100mg magnesium, the sodium of 2,000~4,000mg, 1,400~2 in 100g containing 1,000~1,500mg,
The potassium of 100mg, sulfate radical < 6.5wt%, and specific gravity is 1.17~1.32g/cm3Ocean minerals solution.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the deep sea water concentrate is
It is derived from the water source below ocean 200m.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the deep sea water concentrate is
It is derived from the water source below ocean 500m.
The present invention provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein skin nursing maintenance is matched
Side is that whitening articles, moisturizing articles, smoothing wrinkle articles, wound healing devices, medicine or beauty import articles, collagen promoted to increase
All articles with improvement skin appearance such as production product.
The present invention separately provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein the bathypelagic concentrate
For liquid or powder.
The present invention separately provides a kind of bathypelagic concentrate skin nursing maintenance set group, wherein skin nursing maintenance is matched
Side is gel or creams shape.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, and (a) provides skin shield
Reason maintenance formula；(b) skin is mixed with nursing maintenance formula with bathypelagic concentrate using preceding；Make the skin
Formula micronized immediately is maintained with nursing, increases the penetrability of skin nursing maintenance formula, skin nursing maintenance
With that can be rapidly introduced into skin, reach skin corium.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
The magnesium density of contracting object is 6,500~110,000mg/l.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
The na concn of contracting object is 3,800~30,000mg/l, potassium concn is 400~18,000mg/l, calcium concentration is 100~500mg/l.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
The hardness of contracting object is 80,000~420,000mg/l, and salinity is 380~430 ‰.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
Contracting object is liquid or powder.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the skin is nursed
Maintenance formula is gel or creams shape.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
After contracting object is mixed with skin nursing maintenance formula, the effective concentration of the bathypelagic concentrate is at least greater than or equal to
1.25 (v/v) %.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the bathypelagic is dense
Contracting object is nursed after maintenance formula mixes with the skin and is applied on an affected part immediately.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability, wherein the affected part is skin
Skin.
The present invention separately provides a kind of method for nursing skin care, including by above-mentioned bathypelagic concentrate skin
Nursing maintenance set group is given after the completion of preparation immediately to a skin.
The present invention separately provides a kind of method for nursing skin care, wherein the bathypelagic concentrate and the skin are used
After nursing maintenance formula mixing, the effective concentration of the bathypelagic concentrate is at least greater than or equal to 1.25 (v/v) %.
The present invention separately provides a kind of method for nursing skin care, wherein the bathypelagic concentrate skin nursing is maintained
Set group can be rapidly introduced into skin, and reaching skin corium, and achieve the effect that smoothing wrinkle, whitening, consolidation etc. improves skin appearance.
To reach above and other purpose, to the present invention, one or more specific embodiments are illustrated below.Of the invention
Other feature or advantage are described in detail with embodiment and claims.
[Detailed description of the invention]
Figure 1A -1C shows that wound smears the variation before and after " set group is maintained in bathypelagic concentrate skin nursing ", wherein scheming
1A is wound photo before smearing.Figure 1B is the wound photo just smeared the skin nursing of bathypelagic concentrate and maintained set group.Fig. 1 C
To smear the wound after set group a few hours are maintained in the skin nursing of bathypelagic concentrate.
Fig. 2A -2G display is shot with 40 multiples and 200 multiple optical microscopies, observes bathypelagic concentrate (figure respectively
2A), gel (Fig. 2 B), maintenance creams (Fig. 2 C-1,2C-2), in real time mixing bathypelagic concentrate and maintenance gel (sea are maintained
The foreign deep layer volume of the concentrated liquid: maintenance gel volume=1:1) (Fig. 2 D-1,2D-2), in real time mixing bathypelagic concentrate and maintenance
Creams (the bathypelagic volume of the concentrated liquid: maintenance creams volume=1:1) (Fig. 2 E-1,2E-2), the mixing ocean depth for placing 3 hours
Layer concentrate and maintenance gel (the bathypelagic volume of the concentrated liquid: maintenance gel volume=1:1) (Fig. 2 F-1,2F-2) place 3
Mixing bathypelagic concentrate and maintenance creams (the bathypelagic volume of the concentrated liquid: maintenance creams volume=1:1) (figure of hour
2G-1、 2G-2)。
After Fig. 3 A-3C shows that bathypelagic concentrate mixes 10 days with skin nursing maintenance formula, physical characteristic changes
Become.After Fig. 3 A shows that bathypelagic concentrate mixes 10 days with skin care products gel, white chunks precipitate can be generated.Fig. 3 B is shown
After bathypelagic concentrate mixes 10 days with maintenance gel, gel disintegrates, and the viscosity of gel significantly reduces.Fig. 3 C display sea
After foreign deep layer concentrate mixes 10 days with maintenance creams, creams are disintegrated, and the viscosity of creams significantly reduces.
Fig. 4 A-4B, which is shown, imports " set group is maintained in bathypelagic concentrate skin nursing " to patient's face with current iontophoresis instrument
Portion improves face texture and speckle.
Fig. 5 A-5B shows dynamic laser granularmetric analysis figure, and wherein Fig. 5 A is bathypelagic concentrate granularmetric analysis figure；Fig. 5 B
To mix bathypelagic concentrate in real time and maintaining the grain of gel (bathypelagic concentrate weight: maintenance gel weight=1:1)
Diameter analysis chart.
Fig. 6 A shows mixing bathypelagic concentrate in real time and maintenance gel (bathypelagic concentrate weight: maintenance gel
Weight=1:1) different time points afterwards particle size variation diagram.
The micro- sem observation figure of particle size of Fig. 6 B display maintenance gel.
Particle size microscope is seen afterwards for Fig. 6 C display mixing pure water and maintenance gel (pure water: maintenance gel weight=1:1)
Examine figure.
Fig. 6 D display mixing bathypelagic concentrate and maintenance gel (bathypelagic concentrate weight: maintenance gel weight
=1:1) micella particle micro- sem observation figure.
[specific embodiment]
The present invention is to provide a kind of bathypelagic concentrate skin nursing maintenance set group.
Heretofore described " deep ocean water ", which refers to, is derived under sea level 200 to 1500 meters, preferably sea level
Lower 500 to 700 meters of seawater, the calcium containing 1000~1500mg in every 100g molten (liquid/powder), 1400~2100mg magnesium,
The sodium of 2000~4000mg, the potassium of 1400~2100mg, sulfate radical < 6.5wt%, and specific gravity is 1.17-1.32g/cm3Sea
The solution of foreign minerals.
Heretofore described " bathypelagic concentrate " refers to generated liquid after the concentrated program of deep ocean water
Or powder.This bathypelagic is concentrated (liquid/powder) concentration processes and uses fiber filter system, hyperfiltration system, seawater reverse osmosis system
System, cryogenic vacuum evaporation concentration system and/or centrifugation and etc..
The hardness of bathypelagic concentrate is 80,000~420,000mg/l, salinity is 380~430 ‰, magnesium density is
6,500~110,000mg/l and na concn are 3,800~30,000mg/l.Bathypelagic concentrate of the invention is rich in a variety of
Minerals, include, but are not limited to calcium (Ca), potassium (K), iron (Fe), zinc (Zn), molybdenum (Mo), manganese (Mn), lithium (Li), strontium (Sr),
The microelements such as copper (Cu), silicon (Si).In one embodiment, the ingredient of bathypelagic concentrate is as shown in Table 1, but due to inspection
It surveys unit not complete complete Element detection, so bathypelagic concentrate of the invention is without being limited thereto.
The ingredient of table one, bathypelagic concentrate
Heretofore described skin nursing maintenance formula refers to that general skin care products and beauty correlation institutes are used in the course for the treatment of
Formula, can be creams or gel skin care products.For example, whitening articles, moisturizing articles, smoothing wrinkle articles, wound healing devices, speed are cured
The articles of the improvement skin appearance such as course for the treatment of.
Of the invention " mixture of bathypelagic concentrate and skin nursing maintenance formula " or " bathypelagic concentration mixes
Object " refers to the mixing object of mixing bathypelagic concentrate and skin nursing maintenance formula.Since ocean concentrate adds to gel
After shape or the skin care products of creams shape, phase transfer being generated at once, molecule is made to become smaller, skin care products is allowed to be easy and be less readily available for absorption by the skin,
Deep skin is reached, effect is played.
However, bathypelagic concentrate is after being added to skin nursing maintenance and being formulated interior a period of time, bathypelagic is concentrated
Object will lead to skin nursing maintenance and be formulated rotten, unstable and disintegration.Therefore, bathypelagic concentrate of the invention and skin protect
The mixture of reason maintenance formula is preferably Fresh, upon mixing in 10 days, preferably 9 days, 8 days, 7 days, 6 days, 5 days, 4
It, 3 days, 2 days, in 1 day using finishing, in most preferably 12 hours, 6 hours, 3 hours, 2 hours, 1 hour.
After bathypelagic concentrate is mixed with skin nursing maintenance formula, mixture (bathypelagic concentrate can be reduced
With skin nursing maintain be formulated) surface tension, increase skin (skin corium) to maintenance set group absorption.Therefore, mixture holds
Easily be less readily available for absorption by the skin, reach skin corium, play effect.
The present invention separately provides a kind of method of promotion skin nursing maintenance formula penetrability comprising provides skin shield
Reason maintenance formula is mixed the skin with nursing maintenance formula using preceding with bathypelagic concentrate.
Mixed mode has no special limitation, and general method can be used, for example, stirring, shake, test tube concussion, ultrasonic
It swings, as long as the two can be mixed uniformly.The mixed time has no special limitation because mixing after must use as early as possible to avoid
Skin is deteriorated with nursing maintenance prescription quality, so mixed time should not be too long, usually in 15 minutes, preferably 14,13,
12, in 11,10,9,8,7,6,5,4,3 minutes.The mixed time can nurse maintenance formula and mixing according to used skin
Mode carries out adjustment appropriate.
As described above, after bathypelagic concentrate is mixed with skin nursing maintenance formula, it is necessary to it is applied to skin as early as possible,
To avoid the skin mass change of nursing maintenance formula.
Bathypelagic concentrate is after being added to skin nursing maintenance formula, and merely through 10 days, gel and creams were maintained
Product obviously go bad.In addition, bathypelagic concentrate can make gel skin care products generate unknown sediment and floating material, display sea
If foreign deep layer concentrate, which is added directly to a period of time, ion in skin nursing maintenance formula, to generate chemistry with ingredient
Variation reduces original skin nursing maintenance formula to the effect of skin, or even generating may harmful skin derivative.Therefore,
Bathypelagic concentrate must be packed individually with skin care products, using preceding Fresh again, can achieve the effect that mutually addition multiplies.
Bathypelagic concentrate can generate phase transfer at once, make skin care products after being added to skin nursing maintenance formula
Molecule become smaller, allow skin nursing maintenance formula be easy be less readily available for absorption by the skin, arrival skin corium.Therefore, bathypelagic is dense
Contracting object can promote commercially available skin nursing maintenance formula to the penetrability of skin, accelerate to play the skin effect of nursing maintenance formula
Fruit.
The present invention more provides a kind of method of skin care, including preparing bathypelagic concentration mixture of the invention
After the completion, it is given immediately to skin.Mixture is concentrated after smearing or being directed into skin through instrument in bathypelagic of the invention,
It can reach rapidly and be absorbed by the body inside skin, and play effect.
[embodiment]
The preparation method of bathypelagic concentrate:
Bathypelagic concentrate preparation step includes as follows: it is provided first from the deep sea water under the predetermined depth of sea level,
Deep sea water sequentially is filtered using fiber filter system, hyperfiltration system and seawater reverse osmosis system, makes to obtain the first concentrate
And pure water, the first concentrate is concentrated by cryogenic vacuum evaporation concentration system, then can get the second concentrate and calcium sulfate (stone
Cream).Because cryogenic vacuum evaporation concentration system is a circulatory system, therefore the second concentrate can by its systems stay be concentrated.?
In concentration process, the second concentrate can generate crystallization salt, therefore solid particle salt (i.e. deep-sea can be obtained via centrifugation
Salt) and third concentrate.With (90~120 DEG C) heating third concentrates of a predetermined high temperature, during heating, third concentration
Liquid persistently can have crystallization to salt out, and stand the third concentrate heated, so that crystal salt is deposited in lower layer, and draw its supernatant
Liquid obtains the 4th concentrate.Finally, being filtered using the filter membrane with preset aperture (0.5~1.5 μm) dense through cooling the 4th
Contracting liquid, to obtain seawater deep layer concentrate.
The property of substance characteristics collocation nursing maintenance formula according to bathypelagic concentrate different formulations prepares difference
Mixture is concentrated in the bathypelagic of effect, can optimize the whitening of this mixture, moisturizing, smoothing wrinkle, wound healing and other effects.
Various formula bathypelagic concentrations (liquid/powder) is prepared by above-mentioned processing procedure mode, and by choosing in each formula
Reasonable interval, as shown in following table two.
The component content of (liquid/powder) is concentrated in table two, different formulations bathypelagic
Embodiment 1: wound experiment
In injured leg portion, the mixture of " mix bathypelagic concentrate in real time and maintain gel " is smeared, and observes it
Wound variation.
A-1C referring to Fig.1, leg is when morning 10:16 on the 23rd of September in 2017 injury (such as Figure 1A), 3:56 in afternoon by wound
Bathypelagic concentration (liquid/powder) the skin nursing maintenance of " mix bathypelagic concentrate in real time and maintain gel " is smeared after disinfection
Set group (such as Figure 1B), when night 10:45, wound is red and swollen subsides, without incrustation generation (such as Fig. 1 C).
Thus result can accelerate skin to absorb it is found that by gel mixing bathypelagic concentrate is maintained, and wound is promoted to be cured
It closes.
Embodiment 2: influence of the bathypelagic concentrate to maintenance creams and gel penetrability
The equal amount of mixture of bathypelagic concentrate and creams or gel is drawn using quantitative dropper.Control group is respectively
(a) water, (b) bathypelagic concentrate, (c) gel or (d) creams.Experimental group is that (1 times, 5 times, 10 are concentrated in 1mL bathypelagic
Times, 20 times, 40 times) with 1mL creams or gel, effective concentration in bathypelagic concentrate final mixture: 50 (v/v) %, 10
(v/v) %, 5 (v/v) %, 2.5 (v/v) % and 1.25 (v/v) %.
On the regular cloth AATCC97 of inter-hole testing, 0.5mL mixture is dripped in regular cloth with the height of fixed range 1cm
On AATCC97.After instillation " bathypelagic concentrate and gel " mixture, mixture complete penetration test cloth institute is started counting
It takes time；On the other hand, after the mixture of instillation " bathypelagic concentrate and creams ", start the timing mixing of observation in 2 minutes
Object permeates situation, as a result as shown in Table 3.
Table three, skin care products mixed with bathypelagic concentrate before with mix after, penetration power compares
It is shown by the experimental result of (b) bathypelagic concentrate, the bathypelagic concentrate of ionic condition, although having perhaps
More documents prove that he has the anti-ageing equal effect of whitening to Skin Cell, just as the ingredient of other many maintenances, practical Shanghai
Foreign deep layer concentrate has high surface tension, there is the difficulty for absorbing and penetrating on Skin Cell.
However, micel can be made to become after being mixed by bathypelagic concentrate and maintenance gel or maintenance frost with volume 1:1
It is small, penetration power, the absorbability of skin care products are promoted immediately, and also reduce the high surface tension of bathypelagic concentrate, solution immediately
Certainly skin is not easy the problem of absorbing.To generate excellent permeability while increase the absorptivity of skin and reach better effect
Fruit.
The influence of formula size is maintained skin nursing in the concentration of 3. bathypelagic of embodiment
This experiment commission ITRI material and chemical institute are tested, and are shot with optical microscopy, respectively observation sea
Foreign deep layer concentrate (such as Fig. 2A), maintenance gel (such as Fig. 2 B), maintenance creams (such as Fig. 2 C), the in real time concentration of mixing bathypelagic
It is deep that liquid mixes ocean with maintenance gel (the bathypelagic volume of the concentrated liquid: maintenance gel volume=1:1) (such as Fig. 2 D figure), in real time
Layer concentrate is with maintenance creams (the bathypelagic volume of the concentrated liquid: maintenance creams volume=1:1) (such as Fig. 2 E), placement 3 hours
Mixing bathypelagic concentrate and maintenance gel (the bathypelagic volume of the concentrated liquid: maintenance gel volume=1:1) (such as Fig. 2 F) are put
Set 3 hours mixing bathypelagic concentrates and maintenance creams (the bathypelagic volume of the concentrated liquid: maintenance creams volume=1:1)
(such as Fig. 2 figure).
In the microscopically observation of 40 multiples, maintains gel (such as Fig. 2 B) and maintain the micel of creams (such as Fig. 2 C-1)
Closely, without granular particle.Maintenance creams (such as Fig. 2 C-2) is observed with 200 multiples, is also not apparent from presentation graininess.
In the microscopically observation of 40 and 200 multiples, bathypelagic concentrate and maintenance gel (such as Fig. 2 D- are mixed in real time
1, such as Fig. 2 D-2) and mixing bathypelagic concentration industry and maintenance creams (such as Fig. 2 E-1, such as Fig. 2 E-2) in real time, script micel
Closely maintenance gel and maintenance creams immediately by electrically charged mineral ion micronized to original 1/3rd or smaller and
It is uniformly distributed.To sum up, bathypelagic concentrate and maintenance gel/maintenance creams are mixed in real time, and packet grain understands and grease uniformly mixes
Credit union makes it easier to as skin absorption.
However, placing mixing bathypelagic concentrate and maintenance in 3 hours in the microscopically observation of 40 and 200 multiples
Gel (such as Fig. 2 F-1, such as Fig. 2 F-2) and place 3 hours mixing bathypelagic concentrates and maintenance creams (such as Fig. 2 G-1, such as
Fig. 2 G-2), hence it is evident that micel clustering becomes larger, and is concentrated by the mixing bathypelagic that the microscopically observation of 200 multiples is placed 3 hours
The mixing bathypelagic concentrate and maintenance creams (such as Fig. 2 F-2, such as Fig. 2 G-2) of liquid and maintenance gel and placement 3 hours,
More it can be found that the phenomenon that its micel clustering, it is more difficult to by percutaneous absorption.
By being tested above it is recognised that there is the bathypelagic concentrate of this case the maintenance of micronized skin nursing immediately to match
Effect of side.Gel is maintained existing for individually and maintenance creams are macromolecular and micel is close, is not easy to be inhaled by skin
It receives.The phenomenon that mixing bathypelagic concentrate and maintenance gel/maintenance creams after placing a period of time have micel clustering,
It can be made to be more difficult to be absorbed.Respective molecule can be allowed by having mixing bathypelagic concentrate in real time and maintenance gel/maintenance creams only
Micronized simultaneously uniformly mixes, and skin can be made to be easier to absorb.
Influence of the 4. bathypelagic concentrate of embodiment to maintenance creams and gel density and stability
1mL creams and gel are filled into microcentrifugal tube respectively, it is super using sterilizing with 2000rpm centrifugation 5 minutes
Bathypelagic concentrate is cooked 1 times, 5 times, 10 times, 20 times and 40 times of serial dilution by pure water.Take the sea of 1mL difference extension rate
Foreign deep layer concentrate, is separately added into the microcentrifugal tube for having been loaded with 1mL creams or gel and mixes.Control group is respectively (a) 1mL
Ultrapure water+1mL gel, (b) 0.5mL ultrapure water+0.5mL creams；Experimental group is respectively 1mL bathypelagic concentrate (1 times, 5
Times, 10 times, 20 times and 40 times)+1mL creams or gel.Effective concentration is 50 (v/ in bathypelagic concentrate final mixture
V) %, 10 (v/v) %, 5 (v/v) %, 2.5 (v/v) % and 1.25 (v/v) %.Mixture is acutely mixed using test tube oscillator
It closes uniformly, is placed on rack for test tube to put and is stored at room temperature 10 days, utilize capillary glass tube measurement mixture viscosity (viscosity).
Microcentrifugal tube equipped with mixture is fixed on desktop, a capillary glass tube is taken to go deep into simultaneously timing 1 in microcentrifugal tube
Minute, capillary is taken out, height of the fluid in pipe is measured.
Referring to Fig. 3 A, the stickiness of 10 days gels is substantially change after bathypelagic concentrate is mixed with maintenance gel, is represented
It has been denaturalized in physical characteristic, and the precipitation of white chunks object can be clearly visible in the case where visually observing, indicated mixture at 10 days
There is chemical change during standing.
Referring to Fig. 3 B, after bathypelagic concentrate is mixed with maintenance creams, creams viscosity is equal through naked eyes and experiment test
It can find the reduction for having conspicuousness, represent creams stability and be changed.
Referring to Fig. 3 C, bathypelagic concentrate mix with maintenance gel after 10 days, it can be found that gel disintegration, density drop
Low 100%, it is can be found that by Fig. 3 C when there is no bathypelagic concentrate, capillary height 1.5cm, represents it as glue phase；
And when the either high or low bathypelagic concentrate of concentration is added, even dilute 40 times of bathypelagic concentrate
(bathypelagic concentrate concentration 1.25%), capillary height is all 3cm, and representative has been changed to water phase.
It can be seen from the above, bathypelagic concentration (liquid/powder) can cause skin nursing maintenance formula water-oil separating that shakiness is presented
Determining state or even long-term preservation, there may be the qualitative changes of chemicrystallization, can not confirm advantageous skin health, therefore bathypelagic is concentrated
Liquid mixed with maintenance creams or gel after can not long-term preservation, optimal use mode suggests as using being applied to after preceding mixed in equal amounts
Skin.
Embodiment 5: mixing ocean concentrate in real time and maintenance gel non-intrusion type water laser accunputure imports test
On October 15th, 2017, using medical grade current iontophoresis instrument, in right face import mix in real time ocean concentrate and
Maintain the mixture of gel.October 26 imported right face again.After October 15 imported right face, right face is general red, this skin appearance
On phenomenon indicate that the high concentration ion in bathypelagic concentrate permeate after importing up to skin corium even basal layer, initiation
The capillary blood internal circulating load of deep skin part increases and skin temperature improves slightly, effectively facilitates skin metabolism rate, general red
Phenomenon disappears within a few hours, and compact smooth skin pattern (such as Fig. 4 A) is presented.October 26 imported right face again,
Forward and backward obvious right face lifting is imported, eyebrow height changes (such as Fig. 4 B).Analysis imports forward and backward face texture, surface layer spot, sclererythrin and palm fibre
The ratio of color spot, as shown in Table 4.
Table four, the comparison for importing forward and backward facial skin
| October 15 | October 26 | Change | |
| Texture | 51% | 61% | 10% |
| Surface layer spot | 88% | 91% | 3% |
| Sclererythrin (deep layer spot) | 89% | 92% | 3% |
| Brown spot (substrate) | 47% | 67% | 20% |
The experimental result of upper table can influence to start after 24 hours it is found that be directed into cell deep layer using ion introducing apparatus
Improve skin consolidation, microgroove is reduced, the effect of skin gloss.The substance characteristics of this case bathypelagic concentrate can become micronized
The skin motive force (Driving Force) of nursing maintenance formula infiltration afterwards, more easily absorbs skin (skin corium), really
Reach basal layer and carry out quick maintenance, and reaches quickly reparation, increase cuticula water holding capacity immediately, be obviously improved unity and coherence in writing
Effect.
It can be seen from the above, maintaining gel compared to being used alone, the maintenance gel of mixing ocean concentrate can accelerate skin
It absorbs, quickly reaches skin corium even basal layer, generate therapeutic effect.
Influence of the 6. bathypelagic concentrate of embodiment to maintenance gel particles size
This experiment commission ITRI material and chemical institute are tested, and measure grain with dynamic light scattering granularmetric analysis instrument
Sub- size examines bathypelagic concentrate (such as Fig. 5 A), in real time mixing bathypelagic concentrate and maintenance gel (ocean respectively
Deep layer concentrate weight: maintenance gel weight=1:1) (such as Fig. 5 B).
Dynamic light scattering granularmetric analysis instrument injects the solution containing particle using laser light, after laser light strikes particle
Scattering light can be generated, the particle diameter distribution that scattering light changed with time and calculated particle is measured.
It is learnt with dynamic laser granularmetric analysis figure, bathypelagic concentrate (such as Fig. 5 A) partial size is mainly distributed as 0.89nm
The particle signal highest of size, ensemble average partial size are 19.2nm (Z average=19.2nm), show that this specimen is without obvious
The liquid of particle.
It is learnt with dynamic laser granularmetric analysis figure, mixing bathypelagic concentrate in real time, (bathypelagic is dense with maintenance gel
Contracting liquid weight: maintenance gel weight=1:1) after (such as Fig. 5 B), begins with micella particle and formed, Dominant particle is distributed basis
5082nm has highest signal value as the result is shown for analysis, and ensemble average partial size is 5.2 μm (Z average=5.2 μm).By Fig. 5 B
In it can be seen that, this specimen signal Distribution value it is single and concentrate, indicate in real time mixing bathypelagic concentrate and maintenance gel (ocean
Deep layer concentrate weight: maintenance gel weight=1:1) after, evenly sized micella particle can be formed immediately.
Table five, bathypelagic concentrate and the dynamic laser partial size point for mixing bathypelagic concentrate and maintenance gel in real time
Analysis ratio distribution table
Mixing bathypelagic concentrate and the influence in the short time after maintenance gel to particle size in real time of embodiment 7.
This experiment commission ITRI material and chemical institute are tested, and optical microscopy and dynamic light scattering are utilized
Particle size analyzer observes the particle size of sample, this examines mixing bathypelagic concentrate in real time and maintenance gel (bathypelagic
Concentrate weight: maintenance gel weight=1:1) afterwards different time points particle size change (such as Fig. 6 A).
Under the optical microscopy of 200 multiples, with field of excursion observation bathypelagic concentrate and maintenance gel, (ocean is deep
Layer concentrate weight: maintenance gel weight=1:1) in real time mixing after the 0th second, 10 seconds, 20 seconds, 30 seconds, 1 minute, 2 minutes, 3
Minute, learn within 5 minutes, with field of excursion observation sample discovery, from bathypelagic concentrate with maintain gel mix in real time after the 0th
In second to the 5th minute, bathypelagic concentrate and maintenance gel mixture can maintain stable size in a short time, and in mixed
Bathypelagic concentrate is completed within the 0th second after conjunction and maintains the process of gel micella particle, particle size is in short time (5 minutes)
It is interior to substantially change, after indicating that this Real-Time Ocean deep layer concentrate is mixed with maintenance gel suitable for mixing immediately
It is applied to human skin.
The dynamic laser granularmetric analysis table of different time points after table six, bathypelagic concentrate mix in real time with maintenance gel
It can be summarized and be learnt by the above optical microscopy and the experiment of laser particle size, bathypelagic concentrate and maintenance gel
The effect of micella is completed after mixing in real time, and stable size, table is all presented in the average grain diameter of micella after mixing in 5 minutes
Showing in bathypelagic concentrate and maintenance gel after evenly mixing short time not will receive the increase of time and changes the big of particle
It is small, it is applied to human skin immediately after being suitble to mixing.
In addition, observing the maintenance gel (such as Fig. 6 B) of single dose under the optical microscopy of 200 multiples, mixing pure water in real time
With maintenance gel (pure water: maintenance gel weight=1:1) (such as Fig. 6 C) and mix bathypelagic concentrate in real time and maintain gel
The difference of (bathypelagic concentrate weight: maintenance gel weight=1:1) (such as Fig. 6 D) micella particle.
By optical microphotograph sem observation it is found that the maintenance gel (such as Fig. 6 B) of single dose, in real time mixing pure water and maintenance gel are (pure
Water: maintenance gel weight=1:1) (such as Fig. 6 C) maintenance gel white body can not be evenly dispersed, effectively occur particle micella work
With so significantly building up phenomenon.Conversely, mixing bathypelagic concentrate and maintenance gel (bathypelagic concentrate weight in real time
Amount: maintenance gel weight=1:1) (such as Fig. 6 D) can be observed maintain gelatin white constitution immediately occur phase transfer (Phase
Transfer) and the particle of micella is formed, average grain diameter is about 5.03 μm.Compare the big of general skin care products micel partial size
Small is 15-50 μm, can reduce one third to 1/10th, help to improve skin care products micel and more effectively enter deep skin
Probability.
The motive force (Driving Force) of mixing bathypelagic concentrate and maintenance gel measures embodiment 8. in real time
This experiment commission ITRI material and chemical institute are tested, and are measured, are examined using electrical conductivity analyzer
It tests mixing bathypelagic concentrate in real time and maintains leading for gel (bathypelagic concentrate weight: maintenance gel weight=1:1)
Electrically, it and then explains this bathypelagic concentrate and maintains the propulsive force of the real-time mixture of gel.
Using the electric conductivity of electrical conductivity analyzer measurement mixture, respectively control group (a) pure water and experimental group (b) is real
When mixing pure water mix bathypelagic concentrate in real time with maintenance gel (pure water: maintenance gel weight=1:1) and (c) and maintain
Gel (bathypelagic concentrate weight: maintenance gel weight=1:1), after sample mixes in real time, is directly carried out using analyzer
It measures.
The electric conductivity of table seven, bathypelagic concentrate and different mixtures is tested
It is learnt by electric conductivity test, (bathypelagic is dense with maintenance gel for mixing bathypelagic concentrate in real time for experimental group (c)
Contracting liquid weight: maintenance gel weight=1:1) electrical conductivity be more than experimental group (b) in real time mixing pure water and maintenance gel (pure water:
Maintain gel weight=1:1) 20 times of electrical conductivity or more.Even up to 12,250 times compared with control group (a) pure water, this electrical conductivity
Notable difference show, in real time mix bathypelagic concentrate and maintenance gel (bathypelagic concentrate weight: maintenance gel weight
Amount=1:1) the good propulsive force of mixture (Driving Force) is provided, promote human body effectively to absorb guarantor through this propulsive force
The effect of feeding product enter deep skin, improve skin nursing maintenance formula.
The disclosed all features of invention should can be realized with any combination.Disclosed herein each feature should can
Replaced the substituent of identical, impartial or similar purpose.Therefore, it is specified unless there are specific, otherwise each disclosed
Feature is only merely an embodiment of a type of equipollent or similar features.
Claims (22)
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