CN1102408C - 稳定的α干扰素水溶液制剂 - Google Patents

稳定的α干扰素水溶液制剂 Download PDF

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Publication number
CN1102408C
CN1102408C CN95195600A CN95195600A CN1102408C CN 1102408 C CN1102408 C CN 1102408C CN 95195600 A CN95195600 A CN 95195600A CN 95195600 A CN95195600 A CN 95195600A CN 1102408 C CN1102408 C CN 1102408C
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China
Prior art keywords
interferon
amount
alpha
effective amount
formulation
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Expired - Lifetime
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CN95195600A
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Chinese (zh)
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CN1160355A (zh
Inventor
袁佩豪
D·F·克莱恩
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Merck Sharp and Dohme LLC
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Schering Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN95195600A 1994-10-11 1995-10-10 稳定的α干扰素水溶液制剂 Expired - Lifetime CN1102408C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/329,813 US5766582A (en) 1994-10-11 1994-10-11 Stable, aqueous alfa interferon solution formulations
US08/329,813 1994-10-11

Publications (2)

Publication Number Publication Date
CN1160355A CN1160355A (zh) 1997-09-24
CN1102408C true CN1102408C (zh) 2003-03-05

Family

ID=23287133

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95195600A Expired - Lifetime CN1102408C (zh) 1994-10-11 1995-10-10 稳定的α干扰素水溶液制剂

Country Status (24)

Country Link
US (2) US5766582A (de)
EP (2) EP0777495B1 (de)
JP (2) JP3978228B2 (de)
KR (1) KR100401401B1 (de)
CN (1) CN1102408C (de)
AT (2) ATE194774T1 (de)
AU (1) AU708337B2 (de)
BR (1) BR9509313A (de)
CA (1) CA2201749C (de)
CZ (1) CZ296961B6 (de)
DE (2) DE69531314T2 (de)
DK (1) DK0777495T3 (de)
ES (2) ES2198830T3 (de)
FI (2) FI116558B (de)
GR (1) GR3034619T3 (de)
HU (1) HU225494B1 (de)
NO (1) NO320604B1 (de)
NZ (1) NZ294464A (de)
PL (1) PL183797B1 (de)
PT (1) PT777495E (de)
RU (1) RU2157236C2 (de)
SK (1) SK282949B6 (de)
UA (1) UA42028C2 (de)
WO (1) WO1996011018A1 (de)

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US6180096B1 (en) 1998-03-26 2001-01-30 Schering Corporation Formulations for protection of peg-interferon alpha conjugates
JP3643034B2 (ja) * 1998-03-26 2005-04-27 シェーリング コーポレイション ＰＥＧ−インターフェロンα結合体の保護のための処方物
TWI277424B (en) 1998-05-15 2007-04-01 Schering Corp Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
SK287372B6 (sk) 1998-11-12 2010-08-09 Schering Corporation Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
US7402559B2 (en) * 1999-03-24 2008-07-22 Msh Pharma, Incorporated Composition and method of treatment for urogenital conditions
CN1390132A (zh) 1999-04-08 2003-01-08 先灵公司 聚乙二醇化干扰素α在黑素瘤治疗中的应用
US6362162B1 (en) 1999-04-08 2002-03-26 Schering Corporation CML Therapy
US6923966B2 (en) * 1999-04-08 2005-08-02 Schering Corporation Melanoma therapy
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KR100399156B1 (ko) * 1999-11-19 2003-09-26 주식회사 엘지생명과학 α-인터페론의 용액제형
CN1175901C (zh) * 1999-12-06 2004-11-17 天津华立达生物工程有限公司 一种稳定的干扰素水溶液
KR100771294B1 (ko) * 1999-12-14 2007-10-29 써모 바이오스타, 인크. 폴리펩티드 및 항원 안정화 희석제
JP4536194B2 (ja) * 2000-02-17 2010-09-01 大日本住友製薬株式会社 安定な注射用製剤
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
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KR200492470Y1 (ko) 2020-03-26 2020-10-21 사공탁 빌라 주택용 쓰레기 수거함
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JPS59176216A (ja) * 1983-03-28 1984-10-05 Sumitomo Chem Co Ltd 有用なインタ−フエロン製剤
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
EP0284249A1 (de) * 1987-03-13 1988-09-28 Interferon Sciences, Inc. Gefriergetrocknete Lymphokin-Zusammensetzung

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JPS59176216A (ja) * 1983-03-28 1984-10-05 Sumitomo Chem Co Ltd 有用なインタ−フエロン製剤
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
EP0284249A1 (de) * 1987-03-13 1988-09-28 Interferon Sciences, Inc. Gefriergetrocknete Lymphokin-Zusammensetzung

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Publication number Publication date
NO971633L (no) 1997-04-10
NO320604B1 (no) 2005-12-27
JP2006193536A (ja) 2006-07-27
ATE245033T1 (de) 2003-08-15
FI971486A0 (fi) 1997-04-10
EP0777495A1 (de) 1997-06-11
CA2201749C (en) 1999-06-15
GR3034619T3 (en) 2001-01-31
CZ296961B6 (cs) 2006-08-16
FI20055562L (fi) 2005-10-19
DE69531314D1 (de) 2003-08-21
DE69518084D1 (de) 2000-08-24
RU2157236C2 (ru) 2000-10-10
NO971633D0 (no) 1997-04-10
UA42028C2 (uk) 2001-10-15
US5766582A (en) 1998-06-16
HK1008813A1 (en) 1999-05-21
PT777495E (pt) 2000-12-29
NZ294464A (en) 1999-03-29
CN1160355A (zh) 1997-09-24
FI117377B (fi) 2006-09-29
WO1996011018A1 (en) 1996-04-18
BR9509313A (pt) 1998-01-27
KR970706017A (ko) 1997-11-03
HU225494B1 (en) 2007-01-29
CA2201749A1 (en) 1996-04-18
AU708337B2 (en) 1999-08-05
SK43997A3 (en) 1997-10-08
PL183797B1 (pl) 2002-07-31
FI116558B (fi) 2005-12-30
KR100401401B1 (ko) 2004-02-18
FI971486L (fi) 1997-04-10
ES2148568T3 (es) 2000-10-16
EP0777495B1 (de) 2000-07-19
EP0970703B1 (de) 2003-07-16
DK0777495T3 (da) 2000-11-06
ATE194774T1 (de) 2000-08-15
JP3978228B2 (ja) 2007-09-19
PL319603A1 (en) 1997-08-18
US5935566A (en) 1999-08-10
EP0970703A1 (de) 2000-01-12
JPH10506912A (ja) 1998-07-07
MX9702578A (es) 1997-07-31
AU3727995A (en) 1996-05-02
CZ110497A3 (en) 1997-09-17
HUT77287A (hu) 1998-03-30
DE69531314T2 (de) 2004-05-13
ES2198830T3 (es) 2004-02-01
SK282949B6 (sk) 2003-01-09
DE69518084T2 (de) 2001-03-22

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