CU23432B6 - Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras - Google Patents

Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras

Info

Publication number
CU23432B6
CU23432B6 CU20050213A CU20050213A CU23432B6 CU 23432 B6 CU23432 B6 CU 23432B6 CU 20050213 A CU20050213 A CU 20050213A CU 20050213 A CU20050213 A CU 20050213A CU 23432 B6 CU23432 B6 CU 23432B6
Authority
CU
Cuba
Prior art keywords
proportions
potential
formulations containing
containing gamma
stabilized formulations
Prior art date
Application number
CU20050213A
Other languages
English (en)
Inventor
Angulo Lorenzo Anasagasti
Meireles Rolando Paez
Vega Yanelda Garcia
Milian Hector Santana
Barreto Ana Aguilera
Rivero Iraldo Bello
Saura Pedro Antonio Lopez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20050213A priority Critical patent/CU23432B6/es
Priority to EP06805254.7A priority patent/EP1958643B1/en
Priority to ARP060104701A priority patent/AR056586A1/es
Priority to BRPI0618197-0A priority patent/BRPI0618197B1/pt
Priority to ES06805254.7T priority patent/ES2619632T3/es
Priority to CNA2006800502425A priority patent/CN101351219A/zh
Priority to RU2008121874/15A priority patent/RU2403057C2/ru
Priority to JP2008538252A priority patent/JP5366551B2/ja
Priority to KR1020087013121A priority patent/KR101363237B1/ko
Priority to AU2006310918A priority patent/AU2006310918B2/en
Priority to CA2629895A priority patent/CA2629895C/en
Priority to PT68052547T priority patent/PT1958643T/pt
Priority to PCT/CU2006/000011 priority patent/WO2007051431A2/es
Priority to CN201510078548.2A priority patent/CN104826094A/zh
Priority to US12/092,440 priority patent/US8535657B2/en
Priority to ZA200804256A priority patent/ZA200804256B/xx
Publication of CU23432B6 publication Critical patent/CU23432B6/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención está relacionada con formulaciones farmacéuticas estables para ser aplicadas por vía parenteral [líquidas o liofilizadas], o tópica [gel, ungüento o crema] que comprenden diferentes cantidades de los interferones recombinantes gamma y alfa en proporciones potenciadoras para el tratamiento de eventos patológicos que contemplan el crecimiento celular no fisiológico benigno o maligno de tejidos u órganos.
CU20050213A 2005-11-02 2005-11-02 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras CU23432B6 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CU20050213A CU23432B6 (es) 2005-11-02 2005-11-02 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
EP06805254.7A EP1958643B1 (en) 2005-11-02 2006-10-27 Stable formulations containing enhancing proportions of gamma- and alpha-interferons
ARP060104701A AR056586A1 (es) 2005-11-02 2006-10-27 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
BRPI0618197-0A BRPI0618197B1 (pt) 2005-11-02 2006-10-27 Formulações farmacêuticas estáveis
ES06805254.7T ES2619632T3 (es) 2005-11-02 2006-10-27 Formulaciones estables que contienen interferones gamma y alfa en proporciones potenciadoras
CNA2006800502425A CN101351219A (zh) 2005-11-02 2006-10-27 包含增效比例的干扰素γ和α的稳定的制剂
RU2008121874/15A RU2403057C2 (ru) 2005-11-02 2006-10-27 Стабильные фармацевтические составы, которые содержат интерфероны гамма и альфа в синергичных соотношениях
JP2008538252A JP5366551B2 (ja) 2005-11-02 2006-10-27 相乗的効果を奏する割合でγ−及びα−インターフェロンを含有する安定化製剤
KR1020087013121A KR101363237B1 (ko) 2005-11-02 2006-10-27 증강된 비율의 감마 인터페론 및 알파 인터페론을 포함하는안정화된 제형
AU2006310918A AU2006310918B2 (en) 2005-11-02 2006-10-27 Stable formulations containing enhancing proportions of gamma- and alpha-interferons
CA2629895A CA2629895C (en) 2005-11-02 2006-10-27 Stable formulations containing enhancing proportions of gamma- and alpha-interferons
PT68052547T PT1958643T (pt) 2005-11-02 2006-10-27 Formulações estáveis que contêm proporções de aprimoramento de interferões-gama e -alfa
PCT/CU2006/000011 WO2007051431A2 (es) 2005-11-02 2006-10-27 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
CN201510078548.2A CN104826094A (zh) 2005-11-02 2006-10-27 包含增效比例的干扰素γ和α的稳定的制剂
US12/092,440 US8535657B2 (en) 2005-11-02 2006-10-27 Stabilized pharmaceutical formulations that contain the interferons gammas and alpha in synergistic proportions
ZA200804256A ZA200804256B (en) 2005-11-02 2008-05-16 Stable formulations containing enhancing proportions of gamma- and alpha-interferons

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050213A CU23432B6 (es) 2005-11-02 2005-11-02 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras

Publications (1)

Publication Number Publication Date
CU23432B6 true CU23432B6 (es) 2009-10-16

Family

ID=40269648

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20050213A CU23432B6 (es) 2005-11-02 2005-11-02 Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras

Country Status (15)

Country Link
US (1) US8535657B2 (es)
EP (1) EP1958643B1 (es)
JP (1) JP5366551B2 (es)
KR (1) KR101363237B1 (es)
CN (2) CN101351219A (es)
AR (1) AR056586A1 (es)
AU (1) AU2006310918B2 (es)
BR (1) BRPI0618197B1 (es)
CA (1) CA2629895C (es)
CU (1) CU23432B6 (es)
ES (1) ES2619632T3 (es)
PT (1) PT1958643T (es)
RU (1) RU2403057C2 (es)
WO (1) WO2007051431A2 (es)
ZA (1) ZA200804256B (es)

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JP2011001273A (ja) * 2009-06-16 2011-01-06 Eci Inc ｅＭＩＰを有効成分とする水溶性製剤
EP2377516B1 (en) * 2010-04-14 2012-06-20 B. Braun Melsungen AG Acetaminophen composition
RU2482871C2 (ru) * 2010-06-07 2013-05-27 Общество с ограниченной ответственностью "Центр Инновационных Технологий "БиоФарм" (ООО "ЦИТ "БиоФарм") Композиция для лечения вирусных заболеваний животных
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JP2014513103A (ja) * 2011-04-27 2014-05-29 ノースショア・ユニバーシティー・ヘルス・システム 組成物及び方法
RU2524651C1 (ru) * 2013-06-20 2014-07-27 Общество С Ограниченной Ответственностью "Валента-Интеллект" Фармацевтическая композиция в форме раствора для инъекций и способ ее получения
CN104043110B (zh) * 2014-03-28 2016-05-04 上海交通大学 干扰素温敏水凝胶及其制备方法和应用
CN109819650A (zh) * 2017-09-25 2019-05-28 春布里泽·格奥尔基·格奥尔基耶维奇 具有抗病毒和抗细菌活性的热稳定组合物及其用途
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EA202290027A1 (ru) * 2019-06-12 2022-03-29 РИВЕН АйПи ХОЛДКО ЭлЭлСи Способы и композиции для улучшения результатов лечения пациентов с раком
CU20200029A7 (es) * 2020-05-20 2022-01-13 Ct Ingenieria Genetica Biotecnologia Composición farmacéutica para el tratamiento de enfermedades respiratorias de origen viral
CN114015758B (zh) * 2021-10-15 2022-06-24 无锡百泰克生物技术有限公司 一种冻干保护剂、荧光pcr检测试剂盒及冻干工艺
EP4423251A4 (en) * 2021-10-26 2026-01-07 Univ Georgia State Res Found Macrophages deficient in alpha syrup to treat cancer
CN115068592A (zh) * 2022-06-27 2022-09-20 长春生物制品研究所有限责任公司 开封后常温稳定的重组人干扰素α1b滴眼液及制备方法
CN115105584B (zh) * 2022-06-28 2023-03-31 长春生物制品研究所有限责任公司 一种卡式瓶多剂量笔式注射组合包装的干扰素注射液

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Also Published As

Publication number Publication date
BRPI0618197A2 (pt) 2013-01-08
WO2007051431A3 (es) 2007-06-28
CN104826094A (zh) 2015-08-12
JP2009513682A (ja) 2009-04-02
AU2006310918A1 (en) 2007-05-10
US8535657B2 (en) 2013-09-17
CA2629895C (en) 2016-08-30
ES2619632T3 (es) 2017-06-26
EP1958643B1 (en) 2016-12-28
PT1958643T (pt) 2017-03-23
JP5366551B2 (ja) 2013-12-11
ZA200804256B (en) 2009-05-27
BRPI0618197B1 (pt) 2021-06-29
AR056586A1 (es) 2007-10-10
RU2008121874A (ru) 2009-12-10
AU2006310918B2 (en) 2012-09-27
CN101351219A (zh) 2009-01-21
EP1958643A2 (en) 2008-08-20
US20090304628A1 (en) 2009-12-10
RU2403057C2 (ru) 2010-11-10
KR20080065684A (ko) 2008-07-14
WO2007051431A2 (es) 2007-05-10
CA2629895A1 (en) 2007-05-10
KR101363237B1 (ko) 2014-02-12

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