CN110483501B - 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 - Google Patents

作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 Download PDF

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CN110483501B
CN110483501B CN201910626474.XA CN201910626474A CN110483501B CN 110483501 B CN110483501 B CN 110483501B CN 201910626474 A CN201910626474 A CN 201910626474A CN 110483501 B CN110483501 B CN 110483501B
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compound
compounds
cancer
bcl
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CN110483501A (zh
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S·王
J·陈
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University of Michigan Ann Arbor
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
CN201910626474.XA 2016-08-05 2017-08-04 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 Active CN110483501B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
CN201780035965.6A CN109311871B (zh) 2016-08-05 2017-08-04 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

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CN110483501B true CN110483501B (zh) 2022-07-01

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CN201780035965.6A Active CN109311871B (zh) 2016-08-05 2017-08-04 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物

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US (3) US10829488B2 (2)
EP (3) EP4129999A1 (2)
JP (2) JP6651180B2 (2)
KR (2) KR102429704B1 (2)
CN (2) CN110483501B (2)
AU (2) AU2017305508B2 (2)
CA (1) CA3031419C (2)
CY (1) CY1123859T1 (2)
DK (1) DK3494115T3 (2)
ES (1) ES2849959T3 (2)
HR (1) HRP20202073T1 (2)
HU (1) HUE053414T2 (2)
IL (2) IL264059B (2)
LT (1) LT3494115T (2)
MX (2) MX381588B (2)
MY (1) MY199409A (2)
PE (1) PE20190711A1 (2)
PH (1) PH12019500231A1 (2)
PT (1) PT3494115T (2)
RS (1) RS61821B1 (2)
RU (2) RU2744358C2 (2)
SA (1) SA519401020B1 (2)
SG (2) SG11201900135YA (2)
SI (1) SI3494115T1 (2)
SM (1) SMT202100025T1 (2)
WO (1) WO2018027097A1 (2)
ZA (2) ZA201900240B (2)

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US10829488B2 (en) * 2016-08-05 2020-11-10 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
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BR112020018978A2 (pt) * 2018-07-31 2021-03-02 Ascentage Pharma (Suzhou) Co., Ltd. produto de combinação que compreende um inibidor de bcl-2 e um inibidor de mdm2 e uso dos ditos inibidores na prevenção e/ou tratamento de câncer
CA3095699A1 (en) * 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
US11554127B2 (en) * 2018-07-31 2023-01-17 Ascentage Pharma (Suzhou) Co., Ltd. Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP
WO2020103921A1 (en) * 2018-11-23 2020-05-28 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition and use thereof
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CN112168830B (zh) * 2019-07-02 2022-01-25 苏州亚盛药业有限公司 一种含有mTOR抑制剂的药物组合及其应用
US12370197B2 (en) * 2019-07-31 2025-07-29 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
WO2021083135A1 (en) 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
US12287338B2 (en) 2019-11-27 2025-04-29 Ascentage Pharma (Suzhou) Co., Ltd. Method and compositions for predicting anti-cancer efficacy of compounds targeting apoptosis pathway
CN119097631A (zh) * 2019-12-03 2024-12-10 苏州亚盛药业有限公司 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
TWI777321B (zh) * 2019-12-04 2022-09-11 大陸商蘇州亞盛藥業有限公司 藥物組合及其用途
JP7142173B2 (ja) 2019-12-06 2022-09-26 ロクソ オンコロジー， インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の投薬
WO2021175321A1 (en) 2020-03-06 2021-09-10 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline forms or amorphous forms of n- (phenyl sulfonyl) benzamide compounds or its salts or solvates
US20230128137A1 (en) * 2020-03-12 2023-04-27 Medshine Discovery Inc. Benzo five-membered cyclic compound
IL296582A (en) 2020-04-15 2022-11-01 Beigene Ltd bcl-2 inhibitor
WO2021227763A1 (en) * 2020-05-14 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Hplc analysis method for n- (phenylsulfonyl) benzamide compound
WO2022002178A1 (en) * 2020-07-01 2022-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
BR112023000320A2 (pt) * 2020-07-10 2023-01-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de sulfonilbenzamida e seu cojugado, método de preparação do mesmo e seu uso
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230301989A1 (en) * 2020-08-21 2023-09-28 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating systemic lupus erythematosus
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
CN114533677A (zh) * 2020-11-25 2022-05-27 苏州亚盛药业有限公司 固体分散体、制剂、其制备方法及其应用
US20240316069A1 (en) * 2020-12-28 2024-09-26 Ascentage Pharma (Suzhou) Co., Ltd. Methods of treating multiple sclerosis
WO2022161496A1 (en) * 2021-02-01 2022-08-04 Ascentage Pharma (Suzhou) Co., Ltd. Sulfonyl benzamide derivatives as bcl-2 inhibitors
WO2022216942A1 (en) 2021-04-07 2022-10-13 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of cancer
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CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
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RU2744358C2 (ru) 2021-03-05
KR102376764B1 (ko) 2022-03-18
ZA201908466B (en) 2020-05-27
CN110483501A (zh) 2019-11-22
EP3494115B1 (en) 2020-10-21
JP6651180B2 (ja) 2020-02-19
EP4129999A1 (en) 2023-02-08
IL264059B (en) 2021-05-31
SG10201913643YA (en) 2020-03-30
WO2018027097A1 (en) 2018-02-08
US11718613B2 (en) 2023-08-08
PE20190711A1 (es) 2019-05-17
DK3494115T3 (da) 2021-01-18
RU2020114660A3 (2) 2020-09-15
EP3494115A1 (en) 2019-06-12
CY1123859T1 (el) 2022-05-27
PT3494115T (pt) 2021-01-15
MY199409A (en) 2023-10-25
HRP20202073T1 (hr) 2021-02-19
ZA201900240B (en) 2020-05-27
SG11201900135YA (en) 2019-02-27
IL282099A (en) 2021-05-31
SI3494115T1 (sl) 2021-02-26
NZ750100A (en) 2021-01-29
MX2020013014A (es) 2021-02-22
US10829488B2 (en) 2020-11-10
US20180354950A1 (en) 2018-12-13
PH12019500231A1 (en) 2019-07-29
RS61821B1 (sr) 2021-06-30
SMT202100025T1 (it) 2021-03-15
CN109311871B (zh) 2020-02-28
IL264059A (en) 2019-01-31
AU2017305508B2 (en) 2021-01-07
CA3031419C (en) 2021-08-24
EP3569601B1 (en) 2022-06-22
MX381588B (es) 2025-03-12
BR112019001666A2 (pt) 2019-05-28
ES2849959T3 (es) 2021-08-24
US10221174B2 (en) 2019-03-05
IL282099B (en) 2022-03-01
JP7205903B2 (ja) 2023-01-17
RU2020114660A (ru) 2020-06-19
RU2020134802A (ru) 2022-04-25
HUE053414T2 (hu) 2021-06-28
KR20190035710A (ko) 2019-04-03
US20190315739A1 (en) 2019-10-17
AU2021202113A1 (en) 2021-05-06
CA3031419A1 (en) 2018-02-08
US20210002277A1 (en) 2021-01-07
JP2019527705A (ja) 2019-10-03
SA519401020B1 (ar) 2022-03-16
EP3569601A3 (en) 2019-11-27
AU2021202113B2 (en) 2022-08-18
JP2020007311A (ja) 2020-01-16
KR20210107170A (ko) 2021-08-31
LT3494115T (lt) 2021-01-25
RU2722560C1 (ru) 2020-06-01
MX2019001391A (es) 2019-06-06
KR102429704B1 (ko) 2022-08-04
CN109311871A (zh) 2019-02-05
AU2017305508A1 (en) 2019-02-07
EP3569601A2 (en) 2019-11-20

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