CN1105724C - 棒酸的萃取方法 - Google Patents

棒酸的萃取方法 Download PDF

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Publication number
CN1105724C
CN1105724C CN96192663A CN96192663A CN1105724C CN 1105724 C CN1105724 C CN 1105724C CN 96192663 A CN96192663 A CN 96192663A CN 96192663 A CN96192663 A CN 96192663A CN 1105724 C CN1105724 C CN 1105724C
Authority
CN
China
Prior art keywords
organic solvent
clavulanic acid
mixing
mixing zone
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96192663A
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English (en)
Chinese (zh)
Other versions
CN1179161A (zh
Inventor
S·鲁迪克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1179161A publication Critical patent/CN1179161A/zh
Application granted granted Critical
Publication of CN1105724C publication Critical patent/CN1105724C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN96192663A 1995-01-19 1996-01-17 棒酸的萃取方法 Expired - Lifetime CN1105724C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9500977.5 1995-01-19
GBGB9500977.5A GB9500977D0 (en) 1995-01-19 1995-01-19 Novel process

Publications (2)

Publication Number Publication Date
CN1179161A CN1179161A (zh) 1998-04-15
CN1105724C true CN1105724C (zh) 2003-04-16

Family

ID=10768206

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96192663A Expired - Lifetime CN1105724C (zh) 1995-01-19 1996-01-17 棒酸的萃取方法

Country Status (30)

Country Link
US (1) US6172221B1 (da)
EP (1) EP0804441B1 (da)
JP (1) JP4111998B2 (da)
KR (1) KR100446199B1 (da)
CN (1) CN1105724C (da)
AP (1) AP672A (da)
AT (1) ATE261976T1 (da)
BG (1) BG63308B1 (da)
BR (1) BR9606919A (da)
CA (1) CA2210748C (da)
CZ (1) CZ294581B6 (da)
DE (1) DE69631878T2 (da)
DK (1) DK0804441T3 (da)
EA (1) EA000277B1 (da)
ES (1) ES2217302T3 (da)
FI (1) FI113776B (da)
GB (1) GB9500977D0 (da)
HU (1) HU228768B1 (da)
MX (1) MX9705498A (da)
NO (1) NO317281B1 (da)
NZ (1) NZ300604A (da)
OA (1) OA10501A (da)
PL (1) PL184468B1 (da)
PT (1) PT804441E (da)
RO (1) RO115956B1 (da)
SK (1) SK284484B6 (da)
TR (1) TR199700665T1 (da)
UA (1) UA45380C2 (da)
WO (1) WO1996022296A1 (da)
ZA (1) ZA96392B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
AU2017295866A1 (en) 2016-07-14 2019-01-17 Achaogen, Inc. Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
WO2020176806A1 (en) * 2019-02-27 2020-09-03 3-Delta, Inc. Compositions that contain lipophilic plant material and surfactant, and related methods
US12264296B2 (en) 2020-09-02 2025-04-01 Michael V. Zumpano Compositions that contain lipophilic plant material and surfactant, and related methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0153843A2 (en) * 1984-02-23 1985-09-04 United Kingdom Atomic Energy Authority Improvements in and relating to fluidic contactors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0153843A2 (en) * 1984-02-23 1985-09-04 United Kingdom Atomic Energy Authority Improvements in and relating to fluidic contactors

Also Published As

Publication number Publication date
FI113776B (fi) 2004-06-15
OA10501A (en) 2002-04-24
EA000277B1 (ru) 1999-02-25
CA2210748A1 (en) 1996-07-25
CA2210748C (en) 2008-04-01
EA199700121A1 (ru) 1997-12-30
CZ294581B6 (cs) 2005-02-16
EP0804441A1 (en) 1997-11-05
PT804441E (pt) 2004-07-30
HUP9801699A3 (en) 1999-03-01
FI973057L (fi) 1997-07-18
NZ300604A (en) 2000-06-23
CZ225297A3 (en) 1997-12-17
CN1179161A (zh) 1998-04-15
JPH10512557A (ja) 1998-12-02
DK0804441T3 (da) 2004-07-12
UA45380C2 (uk) 2002-04-15
SK284484B6 (sk) 2005-04-01
ES2217302T3 (es) 2004-11-01
HU228768B1 (en) 2013-05-28
DE69631878D1 (de) 2004-04-22
NO973328L (no) 1997-09-18
BG101768A (en) 1998-10-30
AU706196B2 (en) 1999-06-10
EP0804441B1 (en) 2004-03-17
DE69631878T2 (de) 2005-02-03
KR19980701485A (ko) 1998-05-15
BG63308B1 (bg) 2001-09-28
AP672A (en) 1998-09-09
HUP9801699A2 (hu) 1998-11-30
MX9705498A (es) 1997-10-31
RO115956B1 (ro) 2000-08-30
TR199700665T1 (xx) 1998-01-21
FI973057A0 (fi) 1997-07-18
SK96397A3 (en) 1998-02-04
PL321381A1 (en) 1997-12-08
PL184468B1 (pl) 2002-11-29
KR100446199B1 (ko) 2005-08-04
JP4111998B2 (ja) 2008-07-02
NO317281B1 (no) 2004-10-04
WO1996022296A1 (en) 1996-07-25
ZA96392B (en) 1996-08-29
AP9701022A0 (en) 1997-07-31
NO973328D0 (no) 1997-07-18
US6172221B1 (en) 2001-01-09
ATE261976T1 (de) 2004-04-15
BR9606919A (pt) 1997-11-11
AU4539096A (en) 1996-08-07
GB9500977D0 (en) 1995-03-08
HK1004134A1 (en) 1998-11-20

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AP610A (en) Process for the preparation of a salt of clavulanic acid.
CN1105724C (zh) 棒酸的萃取方法
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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20030416

EXPY Termination of patent right or utility model