CN1108694A - 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法 - Google Patents

一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法 Download PDF

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Publication number
CN1108694A
CN1108694A CN 94105525 CN94105525D CN1108694A CN 1108694 A CN1108694 A CN 1108694A CN 94105525 CN94105525 CN 94105525 CN 94105525 D CN94105525 D CN 94105525D CN 1108694 A CN1108694 A CN 1108694A
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CN
China
Prior art keywords
aclacinomycin
streptomycete
dkrs
aglycone
pale purple
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 94105525
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English (en)
Chinese (zh)
Other versions
CN1104682A (zh
Inventor
赵源太
金完燮
金明国
朴真圭
金学烈
李尚基
A·G·道拉谢娃
T·B·帕尼奇纳
L·A·萨布劳巴
L·M·诺比考巴
Y·E·巴托谢维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quan Qifan
Dong Kook Pharmaceutical Co Ltd
Original Assignee
Quan Qifan
Dong Kook Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quan Qifan, Dong Kook Pharmaceutical Co Ltd filed Critical Quan Qifan
Publication of CN1108694A publication Critical patent/CN1108694A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN 94105525 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法 Pending CN1108694A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019930017589A KR970000591B1 (ko) 1993-09-03 1993-09-03 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법
KR17589/93 1993-09-03

Publications (1)

Publication Number Publication Date
CN1108694A true CN1108694A (zh) 1995-07-05

Family

ID=19362801

Family Applications (2)

Application Number Title Priority Date Filing Date
CN 94105525 Pending CN1108694A (zh) 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法
CN94105525A Pending CN1104682A (zh) 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN94105525A Pending CN1104682A (zh) 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法

Country Status (13)

Country Link
US (2) US5468637A (2)
JP (1) JP2718002B2 (2)
KR (1) KR970000591B1 (2)
CN (2) CN1108694A (2)
CA (1) CA2113871C (2)
CH (1) CH688151A5 (2)
DE (1) DE4401546C2 (2)
ES (1) ES2078875B1 (2)
FR (1) FR2709497B1 (2)
GB (1) GB2281563B (2)
IT (1) IT1273049B (2)
NL (1) NL9400096A (2)
TW (1) TW258754B (2)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071411A (en) * 1974-07-27 1978-01-31 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor antibiotics aclacinomycins A and B [RD-9187A]
JPS5134915B2 (2) * 1974-07-27 1976-09-29
US4204038A (en) * 1976-04-07 1980-05-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing antibiotics MA 144-M1 and MA 144-M2
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
NL176004C (nl) * 1976-10-05 1985-02-01 Microbial Chem Res Found Werkwijze ter bereiding van geneesmiddelen met antitumorwerking op basis van anthracycline glycosiden en werkwijze ter bereiding van daartoe dienende anthracycline glycosiden.
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
DE3164574D1 (en) * 1980-10-27 1984-08-09 Hoffmann La Roche Process for aclacinomycins and microorganism used therein
DE3168154D1 (en) * 1980-10-27 1985-02-21 Hoffmann La Roche Process for anthracycline glycosides
US4405713A (en) * 1981-12-28 1983-09-20 Hoffmann-La Roche Inc. Process for the preparation of optically active anthracycline glycosides A and B
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
SU1069433A1 (ru) * 1982-06-29 1984-11-23 Всесоюзный научно-исследовательский институт антибиотиков Штамм @ @ 12/3а-продуцент аклациномицинов @ и @

Also Published As

Publication number Publication date
GB2281563A (en) 1995-03-08
US5468637A (en) 1995-11-21
DE4401546A1 (de) 1995-03-30
JPH0775575A (ja) 1995-03-20
KR950008679A (ko) 1995-04-19
DE4401546C2 (de) 1997-09-25
ITMI940035A1 (it) 1995-07-14
CN1104682A (zh) 1995-07-05
CA2113871A1 (en) 1995-03-04
KR970000591B1 (ko) 1997-01-14
CA2113871C (en) 2000-01-18
ITMI940035A0 (it) 1994-01-14
FR2709497B1 (fr) 1996-11-15
NL9400096A (nl) 1995-04-03
CH688151A5 (fr) 1997-05-30
JP2718002B2 (ja) 1998-02-25
GB2281563B (en) 1998-01-28
ES2078875A1 (es) 1995-12-16
IT1273049B (it) 1997-07-01
FR2709497A1 (fr) 1995-03-10
GB9400513D0 (en) 1994-03-09
ES2078875B1 (es) 1996-08-16
US5484712A (en) 1996-01-16
TW258754B (2) 1995-10-01

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