CN1118464C - 新颖嘧啶衍生物及其制法 - Google Patents

新颖嘧啶衍生物及其制法 Download PDF

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Publication number
CN1118464C
CN1118464C CN98803765A CN98803765A CN1118464C CN 1118464 C CN1118464 C CN 1118464C CN 98803765 A CN98803765 A CN 98803765A CN 98803765 A CN98803765 A CN 98803765A CN 1118464 C CN1118464 C CN 1118464C
Authority
CN
China
Prior art keywords
methyl
pyrimidine
fluoroanilino
dimethyl
tetrahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN98803765A
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English (en)
Chinese (zh)
Other versions
CN1251586A (zh
Inventor
李钟郁
李峰用
金昌燮
李胜圭
宋根石
李松珍
沈愚田
黄晚淳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ryuhan International Co ltd
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Ryuhan International Co ltd
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Filing date
Publication date
Application filed by Ryuhan International Co ltd filed Critical Ryuhan International Co ltd
Publication of CN1251586A publication Critical patent/CN1251586A/zh
Application granted granted Critical
Publication of CN1118464C publication Critical patent/CN1118464C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN98803765A 1997-03-27 1998-03-24 新颖嘧啶衍生物及其制法 Expired - Fee Related CN1118464C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10863/1997 1997-03-27
KR10862/1997 1997-03-27
KR19970010862 1997-03-27
KR19970010863 1997-03-27

Publications (2)

Publication Number Publication Date
CN1251586A CN1251586A (zh) 2000-04-26
CN1118464C true CN1118464C (zh) 2003-08-20

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98803765A Expired - Fee Related CN1118464C (zh) 1997-03-27 1998-03-24 新颖嘧啶衍生物及其制法

Country Status (21)

Country Link
US (1) US6352993B1 (2)
EP (1) EP1015444B1 (2)
JP (1) JP3176379B2 (2)
KR (1) KR100278857B1 (2)
CN (1) CN1118464C (2)
AR (1) AR012181A1 (2)
AT (1) ATE241613T1 (2)
AU (1) AU720385B2 (2)
BR (1) BR9808070A (2)
CA (1) CA2284795C (2)
DE (1) DE69815126T2 (2)
DK (1) DK1015444T3 (2)
ES (1) ES2200324T3 (2)
HU (1) HUP0000851A3 (2)
IN (1) IN188411B (2)
PT (1) PT1015444E (2)
RU (1) RU2203894C2 (2)
TR (1) TR199902383T2 (2)
TW (1) TW542831B (2)
UY (1) UY24938A1 (2)
WO (1) WO1998043968A1 (2)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
AU2004259346A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
WO2007042571A1 (en) * 2005-10-14 2007-04-19 Neurosearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
NZ590688A (en) 2008-08-05 2012-09-28 Daiichi Sankyo Co Ltd imidazo[4,5-b]pyridin-2-one derivatives
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
PL2678332T3 (pl) * 2011-02-25 2016-12-30 Pochodne diaminopirymidyny i sposoby ich wytwarzania
ES2655177T3 (es) * 2012-02-17 2018-02-19 Abbvie Inc. Diaminopirimidinas útiles como inhibidores del virus respiratorio sincitial (VRS) humano
JP6316282B2 (ja) 2012-05-29 2018-04-25 モメンティブ パフォーマンス マテリアルズ ゲーエムベーハー イソシアナートシランの作製
KR20220143164A (ko) 2012-11-21 2022-10-24 피티씨 테라퓨틱스, 인크. 치환된 리버스 피리미딘 ｂｍｉ-1 저해제
WO2014139326A1 (en) 2013-03-13 2014-09-18 Genentech, Inc. Pyrazolo compounds and uses thereof
AR093580A1 (es) * 2013-08-30 2015-06-10 Ptc Therapeutics Inc Inhibidores bmi-1 de pirimidina sustituidos
EP3055301B1 (en) * 2013-10-07 2019-11-20 Kadmon Corporation, LLC (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
EP3209299A4 (en) * 2014-10-22 2018-04-04 The Board of Regents of The University of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
JP6933322B2 (ja) * 2016-01-04 2021-09-08 メルク セローノ エス．エー． ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形
WO2018184978A1 (de) * 2017-04-05 2018-10-11 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
CN113164479A (zh) 2018-08-17 2021-07-23 Ptc医疗公司 用于治疗胰腺癌的方法
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259174A1 (en) * 1986-09-05 1988-03-09 Smith Kline & French Laboratories Limited Derivatives of 4-aminoquinoline and their use as medicaments
EP0322133A1 (en) * 1987-12-03 1989-06-28 SmithKline Beecham Intercredit B.V. Quinazoline derivatives
EP0379806A2 (en) * 1988-12-29 1990-08-01 Mitsui Petrochemical Industries, Ltd. Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
EP0404322A1 (en) * 1989-05-10 1990-12-27 Smithkline Beecham Intercredit B.V. Quinazoline derivatives
WO1992018498A1 (en) * 1991-04-17 1992-10-29 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
WO1994014795A1 (en) * 1992-12-29 1994-07-07 Yuhan Corporation Quinazoline derivatives
WO1996005177A1 (en) * 1994-08-13 1996-02-22 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof

Family Cites Families (18)

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GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
EP0388838B1 (de) 1989-03-22 1996-01-10 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
CZ400992A3 (en) 1990-11-06 1993-12-15 Pfizer Quinazoline derivatives for enhancing anti-tumor activity
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
WO1995005363A1 (en) * 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
EP0640599B1 (en) 1993-08-26 1998-03-04 Ono Pharmaceutical Co., Ltd. 4-Aminopyrimidine derivatives
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
US5990311A (en) * 1996-05-04 1999-11-23 Uhan Corporation Process for preparation of pyrimidine derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259174A1 (en) * 1986-09-05 1988-03-09 Smith Kline & French Laboratories Limited Derivatives of 4-aminoquinoline and their use as medicaments
EP0322133A1 (en) * 1987-12-03 1989-06-28 SmithKline Beecham Intercredit B.V. Quinazoline derivatives
EP0379806A2 (en) * 1988-12-29 1990-08-01 Mitsui Petrochemical Industries, Ltd. Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
EP0404322A1 (en) * 1989-05-10 1990-12-27 Smithkline Beecham Intercredit B.V. Quinazoline derivatives
WO1992018498A1 (en) * 1991-04-17 1992-10-29 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
WO1994014795A1 (en) * 1992-12-29 1994-07-07 Yuhan Corporation Quinazoline derivatives
WO1996005177A1 (en) * 1994-08-13 1996-02-22 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
TW542831B (en) 2003-07-21
CA2284795C (en) 2004-01-20
RU2203894C2 (ru) 2003-05-10
HUP0000851A1 (hu) 2001-04-28
AU720385B2 (en) 2000-06-01
KR100278857B1 (ko) 2001-01-15
ATE241613T1 (de) 2003-06-15
TR199902383T2 (xx) 2000-06-21
PT1015444E (pt) 2003-10-31
JP2000513014A (ja) 2000-10-03
ES2200324T3 (es) 2004-03-01
EP1015444B1 (en) 2003-05-28
DE69815126D1 (de) 2003-07-03
AU6523998A (en) 1998-10-22
IN188411B (2) 2002-09-21
HUP0000851A3 (en) 2002-04-29
HK1026418A1 (en) 2000-12-15
US6352993B1 (en) 2002-03-05
UY24938A1 (es) 2001-01-31
CN1251586A (zh) 2000-04-26
EP1015444A1 (en) 2000-07-05
BR9808070A (pt) 2000-03-08
CA2284795A1 (en) 1998-10-08
DE69815126T2 (de) 2004-04-08
AR012181A1 (es) 2000-09-27
JP3176379B2 (ja) 2001-06-18
WO1998043968A1 (en) 1998-10-08
KR19980080789A (ko) 1998-11-25
DK1015444T3 (da) 2003-08-18

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee