CN1145067A - 唑酮的抗螺旋杆菌酯和氨基甲酸酯衍生物 - Google Patents

唑酮的抗螺旋杆菌酯和氨基甲酸酯衍生物 Download PDF

Info

Publication number
CN1145067A
CN1145067A CN95192436A CN95192436A CN1145067A CN 1145067 A CN1145067 A CN 1145067A CN 95192436 A CN95192436 A CN 95192436A CN 95192436 A CN95192436 A CN 95192436A CN 1145067 A CN1145067 A CN 1145067A
Authority
CN
China
Prior art keywords
compound
formula
alkyl
phenyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN95192436A
Other languages
English (en)
Chinese (zh)
Inventor
J·希尔斯
J·H·莫斯特曼斯
R·J·M·亨德里克斯
L·J·E·范德韦肯
R·A·施托布罗斯
M·J·M·范德阿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN1145067A publication Critical patent/CN1145067A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN95192436A 1994-04-06 1995-03-29 唑酮的抗螺旋杆菌酯和氨基甲酸酯衍生物 Pending CN1145067A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94200938 1994-04-06
EP94200938.2 1994-04-06

Publications (1)

Publication Number Publication Date
CN1145067A true CN1145067A (zh) 1997-03-12

Family

ID=8216773

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95192436A Pending CN1145067A (zh) 1994-04-06 1995-03-29 唑酮的抗螺旋杆菌酯和氨基甲酸酯衍生物

Country Status (20)

Country Link
US (1) US5710156A (de)
EP (1) EP0754180B1 (de)
JP (1) JPH09511513A (de)
CN (1) CN1145067A (de)
AT (1) ATE207910T1 (de)
AU (1) AU685935B2 (de)
BR (1) BR9507289A (de)
CA (1) CA2185552A1 (de)
CZ (1) CZ287596A3 (de)
DE (1) DE69523581T2 (de)
EE (1) EE9600142A (de)
FI (1) FI963995L (de)
HU (1) HUT76287A (de)
IL (1) IL113254A (de)
NO (1) NO964216L (de)
NZ (1) NZ283346A (de)
PL (1) PL316655A1 (de)
SK (1) SK127196A3 (de)
WO (1) WO1995027704A1 (de)
ZA (1) ZA952810B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5250528A (en) * 1989-08-02 1993-10-05 Fujisawa Pharmaceutical Co., Ltd. New aminopiperazine derivatives
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
US5202346A (en) * 1992-02-25 1993-04-13 American Home Products Corporation Piperidinyl and piperazinyl derivatives
TW279864B (de) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv

Also Published As

Publication number Publication date
NZ283346A (en) 1997-05-26
FI963995A0 (fi) 1996-10-04
FI963995A7 (fi) 1996-10-04
CZ287596A3 (en) 1997-01-15
SK127196A3 (en) 1997-05-07
US5710156A (en) 1998-01-20
DE69523581T2 (de) 2002-07-11
WO1995027704A1 (en) 1995-10-19
EP0754180A1 (de) 1997-01-22
BR9507289A (pt) 1997-09-23
FI963995L (fi) 1996-10-04
ATE207910T1 (de) 2001-11-15
DE69523581D1 (de) 2001-12-06
AU685935B2 (en) 1998-01-29
MX9604610A (es) 1997-11-29
NO964216D0 (no) 1996-10-04
NO964216L (no) 1996-10-04
AU2137195A (en) 1995-10-30
ZA952810B (en) 1996-10-07
PL316655A1 (en) 1997-02-03
CA2185552A1 (en) 1995-10-19
EE9600142A (et) 1997-04-15
JPH09511513A (ja) 1997-11-18
HUT76287A (en) 1997-07-28
IL113254A (en) 1999-03-12
IL113254A0 (en) 1995-07-31
EP0754180B1 (de) 2001-10-31
HU9602725D0 (en) 1996-11-28

Similar Documents

Publication Publication Date Title
CN1071330C (zh) 抗螺杆菌的唑酮类脲和硫脲衍生物
RU2152392C1 (ru) Ацильные производные азолонов, способ их получения, фармацевтическая композиция на их основе и способ ее получения
CN1068878C (zh) 唑酮类氨磺酰衍生物抗螺杆菌剂
EP0581552A2 (de) Triazolylthiomethylthiocephalosporin-Hydrochlorid, sein kristallines Hydrat und seine Herstellung
RU2128659C1 (ru) Замещенные производные азолона, способ их получения, фармацевтическая композиция и способ ее получения
CN101232884A (zh) 作为抗菌剂的喹啉衍生物
CA2044700A1 (fr) Cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium guaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaire obtenus
DK163514B (da) Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre
Singh et al. The development of thymol–isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity
CN1152310A (zh) 抗螺杆菌的唑酮类杂环衍生物
DE69523581T2 (de) Anti-helicobacter ester- oder carbamatderivate von azolonen
JPWO2002094829A1 (ja) カルバペネム化合物
WO1998034936A1 (en) Carbapenem compounds, use thereof, and intermediate compounds of the same
CN114591255A (zh) 一种含1,2,4-三氮唑丙烯酰胺侧链的截短侧耳素衍生物及其制备方法与应用
CN119119027B (zh) 一种氮杂环丁烷衍生物及其制备方法、应用
JP3148235B2 (ja) 抗菌性ペネム化合物
DD149528A5 (de) Verfahren zur herstellung von neuen beta-lactam-verbindungen
CA2425314C (en) Pharmaceutical compositions containing oxapenem-3-carboxylic acids
CN101245077B (zh) 头孢菌素衍生物
JP2798094B2 (ja) 抗菌剤としてのジクロロ置換イミダゾール誘導体
CA2536910A1 (en) Oral neurotherapeutic cefazolin compositions
CN104774155B (zh) 一种1，3-茚满二酮衍生物及其晶型
JPS6178790A (ja) ２‐（ｎ‐ヘテロサイクリル）ペネム
CN104610191B (zh) 罗丹宁手性环己烷螺环化合物的晶型及其制备方法与用途
JP3274856B2 (ja) ペネム化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication