CN115201190A - Vacuum negative pressure type platform for monitoring stable state of pathological section in real time - Google Patents
Vacuum negative pressure type platform for monitoring stable state of pathological section in real time Download PDFInfo
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- CN115201190A CN115201190A CN202111096544.9A CN202111096544A CN115201190A CN 115201190 A CN115201190 A CN 115201190A CN 202111096544 A CN202111096544 A CN 202111096544A CN 115201190 A CN115201190 A CN 115201190A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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Abstract
本发明属于医疗检测设备技术领域，具体涉及一种真空负压式实时监控病理切片稳定状态的平台。本发明提供了一种真空负压式实时监控病理切片稳定状态的平台，包括真空平台，所述真空平台设置为“匚”型结构；对位结构，所述对位结构设置为“V”型结构；所述对位结构与所述真空平台设置在同一高度；位置检测机构，所述位置检测结构设置在所述真空平台内部。本发明采用特殊的真空结构作为固定玻片的方式，带扭力控制的滚轮作为对位机构再加上侦测传感器的辅助，在扫描过程中充分保证玻片的完整性、稳定性、平整性、实时监控玻片状态，最大限度保证了图像的清晰度。
The invention belongs to the technical field of medical detection equipment, and in particular relates to a vacuum negative pressure real-time monitoring platform for the steady state of pathological slices. The invention provides a vacuum negative pressure type real-time monitoring platform for the stable state of pathological slices, including a vacuum platform, and the vacuum platform is set to be in a "crawl" type structure; the alignment structure is set to a "V" type structure; the alignment structure and the vacuum platform are arranged at the same height; a position detection mechanism, the position detection structure is arranged inside the vacuum platform. The invention adopts a special vacuum structure as the way to fix the glass slide, the roller with torsion control is used as the alignment mechanism and the assistance of the detection sensor, so as to fully guarantee the integrity, stability, flatness, smoothness, etc. of the glass slide during the scanning process. Monitor the slide status in real time to maximize the clarity of the image.
Description
Technical Field
The invention belongs to the technical field of medical detection equipment, and particularly relates to a vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time.
Background
The digital pathological section scanner is a high-precision digital image acquisition system, the shot object is extremely tiny cells or tissues (micron size), in order to realize a clear and complete section picture with a full field of view, a camera is often required to continuously shoot for a plurality of times in the vertical and horizontal directions, and finally fusion and splicing are carried out through an algorithm. During the scanning process, since the slide is placed on the scanning platform and needs to move along with the platform at high speed and accurately, high requirements are placed on the moving accuracy and levelness of the platform and the stability of the slide, otherwise, the partial or whole scanning of the pathological section is possibly unclear.
Chinese patent publication No. CN208350608U discloses a platform mounting mechanism in a digital pathological section scanner, and for example, the following problems can be improved in the existing digital pathological section scanning platform: (1) Traditional scanning platform all adopts pure mechanical type slide fixed knot to construct without exception, it drives fixing device to use devices such as cylinder or motor more, it is fixed to extrude the power of slide through level or perpendicular downward direction, because the slide is more fragile, when nonparallel between push pedal and the slide, it makes the corner of slide produce the collision between easy and another fixed plate to promote the slide removal, and because the cylinder drives the distance of push pedal invariably, the distance that makes the reality of nonparallel slide can move is less than the actual distance that the push pedal can move far away, make the nonparallel slide receive the extrusion between push pedal and fixed plate, very easily cause the condition that the slide bursts apart, influence location and subsequent identification process. (2) Pathological slide fixes on the objective table to along with objective table high-speed motion, require to take place relative displacement between objective table and the pathological section this moment, the tradition leans on mechanical pressure to carry out the structure of centre gripping, can produce wearing and tearing, deformation, the condition such as not hard up at the in-process that promotes repeatedly and centre gripping, like this under the high-speed moving condition of platform, relative displacement will appear, shoot the relative displacement of in-process, there is fatal influence to image quality, ghost image can appear, the dislocation, fuzzy problem. (3) The traditional scanning platform scans after the initial one-time fixation is completed, the state of the slide on the platform is unknown in the whole scanning process, if the conditions of tilting, unevenness, fragments and the like occur, the scanning is still performed, and effective monitoring and prompting are not implemented.
Disclosure of Invention
Aiming at the problems, the invention provides a vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time, which comprises
A vacuum platform configured in a "21274" type configuration;
the alignment structure is arranged to be a V-shaped structure; the alignment structure and the vacuum platform are arranged at the same height;
and the position detection mechanism is arranged inside the vacuum platform.
As a preferable technical solution, a carrying plane is arranged in the vacuum platform, the height of the carrying plane is lower than the highest plane of the vacuum platform, and the carrying plane is arranged on two extending arm structures of the vacuum platform '21274'.
As a preferred technical scheme, a hollow groove is arranged in the vacuum platform, and the hollow groove is arranged to be downwards sunken from the carrying plane.
As a preferable technical solution, the position detecting mechanism is disposed in the vacant slot.
As a preferable technical solution, the vacuum platform is provided with a plurality of vacuum holes on the carrying plane, and the plurality of vacuum holes are communicated with each other inside the vacuum platform.
As a preferred technical scheme, a vacuum generator is connected to the vacuum platform and is communicated with the plurality of vacuum holes; a vacuum pressure gauge is arranged at the connecting port of the vacuum generator and the vacuum platform,
as a preferable technical solution, the number of the vacuum holes is 4, and 4 of the vacuum holes are arranged at 4 corners of the carrier plane.
As a preferred technical scheme, the vacuum platform is provided with an alarm device, and the alarm device is connected with the vacuum pressure gauge.
As a preferable technical solution, the alignment structure includes a torsion motor and two rollers, the torsion motor is disposed at a connection position of two arms of the "V" shaped structure, and the two rollers are disposed at end positions of the two arms of the "V" shaped structure.
As a preferable technical solution, the position detection structure is provided as a position detection sensor.
As a preferred technical solution, the vacuum platform is configured to carry a pathological section, the alignment structure is configured to push the pathological section to a target position, and the position detection mechanism is configured to detect a position of the pathological section.
Has the advantages that:
(1) The invention provides a vacuum negative pressure type platform for monitoring the stable state of a pathological section in real time, which is used for scanning a digital pathological section.
(2) In the invention, a vacuum negative pressure adsorption mode is adopted, the size of the vacuum negative pressure can be adjusted through a pressure gauge, the threshold value of the vacuum pressure is monitored in real time, and as long as the vacuum is less than the set threshold value, the machine can give an alarm to prompt a user that the vacuum is abnormal and the slide needs to be checked in the stable state of the platform.
(3) The invention adopts a vacuum adsorption mode, can firmly fix the slide on the objective table, and more importantly, can place the slide flatly, namely, the levelness of the slide is very high, and the error of the levelness of each position of the slide is very small, thereby greatly improving the scanning definition. For example: if one corner of the four corners of the slide has a convex dirt, the height of the corner is higher than that of the other corners, which affects the scanning definition. If a vacuum platform is used, the vacuum at this corner can create an air leak due to particulate matter protrusion, and the pressure sensor will alarm if it fails to reach a threshold value.
Drawings
FIG. 1 is a schematic top view of a vacuum platform for real-time monitoring of the stable state of a pathological section according to the present invention;
FIG. 2 is a schematic front view of the vacuum platform;
FIG. 3 is a schematic top view of the vacuum platform with pathological section;
FIG. 4 is a schematic front view of a vacuum platform with pathological section;
FIG. 5 is a schematic structural diagram of a vacuum negative pressure type platform for real-time monitoring of a stable state of a pathological section, provided by the invention;
FIG. 6 is a schematic diagram of the working principle;
the device comprises a vacuum platform 1, a loading plane 11, a vacant slot 12, a vacuum hole 13, a 2-alignment structure, a torsion motor 21, a roller 22 and a position detection mechanism 3.
Detailed Description
A vacuum negative pressure type platform for real-time monitoring of pathological section stable state comprises
The vacuum platform 1 is arranged into a structure of '21274';
the alignment structure 2 is arranged in a V-shaped structure; the alignment structure 2 and the vacuum platform 1 are arranged at the same height;
a position detection mechanism 3, which is arranged inside the vacuum platform 1.
The vacuum platform 1 is used for bearing pathological sections, the contraposition structure 2 is used for pushing the pathological sections to a target position, and the position detection mechanism 3 is used for detecting the positions of the pathological sections.
In some preferred embodiments, a carrier plane 11 is provided within the vacuum platform 1, the height of the carrier plane 11 being lower than the uppermost plane of the vacuum platform 1, the carrier plane 11 being provided on two projecting arm structures of the vacuum platform 1 "21274" -type structure.
In some preferred embodiments, a vacant slot 12 is arranged in the vacuum platform 1, and the vacant slot 12 is arranged to be concave downwards from the carrying plane 11.
Set up the dead slot to reduce pathological section and year planar area of contact, thereby reduce the influence of the foreign matter appearing on the year thing platform to the scanning.
In some preferred embodiments, the position detection mechanism 3 is disposed within the vacant slot 12.
In some preferred embodiments, the vacuum platform 1 is provided with a plurality of vacuum holes 13 on the carrier plane 11, and the plurality of vacuum holes 13 are communicated with each other inside the vacuum platform 1.
In some preferred embodiments, a vacuum generator is connected to the vacuum platform 1, and the vacuum generator is communicated with a plurality of vacuum holes 13; a vacuum pressure gauge is arranged at the connecting port of the vacuum generator and the vacuum platform 1,
in some preferred embodiments, the number of the vacuum holes 13 is 4, and 4 vacuum holes 13 are arranged at 4 corners of the carrier plane 11.
In some preferred embodiments, the vacuum platform 1 is provided with an alarm device, and the alarm device is connected with the vacuum pressure gauge.
If one corner of the four corners of the slide has a convex dirt, the height of the corner is higher than that of the other corners, which affects the scanning definition. If a vacuum platform is used, the vacuum at this corner can create an air leak due to particulate matter protrusion, and the pressure sensor will alarm if it fails to reach a threshold value.
In some preferred embodiments, the alignment structure 2 includes a torsion motor 21 and two rollers 22, the torsion motor 21 is disposed at the connection point of the two arms of the "V" structure, and the two rollers 22 are disposed at the end points of the two arms of the "V" structure. The movement of the motor drives the roller to move, so that the slide is pushed to advance by 45 degrees, when the slide is about to contact with the chamfer edge of the platform, the motor stops advancing, the vacuum is opened at the moment, the slide is sucked, if the vacuum value meets the set value, the motor returns immediately, and if the vacuum value does not meet the set value, the operation is performed again.
Preferably, the motor does not extrude the edge of the right platform when pushing the roller to advance, and a small gap is reserved, so that the collision can be avoided to cause fragments.
The motor is protected by safely setting the torque value, and if errors are caused by the width difference of the slide glass and the like, the motor can stop advancing after being stressed.
In some preferred embodiments, the position detection mechanism 3 is provided as a position detection sensor.
The working principle is as follows: the invention provides a vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time, which is used for effectively avoiding the problem that a glass slide is extruded and cracked under stress in the scanning of digital pathological sections and preventing the chips from interfering the pathological scanning; by the aid of the pathological scanning camera, pathological scanning on a single glass slide is completed quickly, and scanning efficiency is improved. In the invention, a vacuum adsorption mode is adopted, so that the section can be firmly fixed on the objective table, and more importantly, the section is placed flatly, namely the levelness of the slide is very high, and the levelness error of each position of the slide is very small, thereby greatly improving the scanning definition. For example: if one corner of the four corners of the slide has a convex dirt, the height of the corner is higher than that of the other corners, which affects the scanning definition. If a vacuum platform is used, the vacuum at this corner can create an air leak due to particulate matter protrusion, and the pressure sensor will alarm if it fails to reach a threshold value.
Claims (10)
1. A vacuum negative pressure type platform for real-time monitoring of pathological section stable state comprises
The vacuum platform (1), the vacuum platform (1) is arranged into a structure of '21274';
the alignment structure (2), the alignment structure (2) is set to be a V-shaped structure; the alignment structure (2) and the vacuum platform (1) are arranged at the same height;
a position detection mechanism (3) disposed inside the vacuum platform (1).
2. Vacuum negative pressure type platform for real-time monitoring of the stable state of pathological sections according to claim 1, characterized in that a loading plane (11) is arranged in the vacuum platform (1), the height of the loading plane (11) is lower than the highest plane of the vacuum platform (1), the loading plane (11) is arranged on two protruding arm structures of the "21274" type structure of the vacuum platform (1).
3. The vacuum negative pressure type real-time monitoring platform for the stable state of pathological sections according to claim 2, characterized in that the vacuum platform (1) is provided with a vacant slot (12), and the vacant slot (12) is arranged to be downwards sunken from the loading plane (11).
4. Vacuum negative pressure type real-time monitoring pathological section steady state platform according to claim 3, characterized in that, the position detection mechanism (3) is arranged in the vacant slot (12).
5. The vacuum negative pressure type platform for real-time monitoring of the stable state of pathological sections according to claim 2, wherein the vacuum platform (1) is provided with a plurality of vacuum holes (13) on the object carrying plane (11), and the plurality of vacuum holes (13) are communicated with each other inside the vacuum platform (1).
6. The vacuum negative-pressure type platform for monitoring the stable state of the pathological section in real time according to claim 5, wherein a vacuum generator is connected to the vacuum platform (1), and the vacuum generator is communicated with a plurality of vacuum holes (13); and a vacuum pressure gauge is arranged at the connecting port of the vacuum generator and the vacuum platform (1).
7. The vacuum negative pressure type real-time monitoring platform for pathological section steady state according to claim 6, characterized in that the number of vacuum holes (13) is 4, and 4 vacuum holes (13) are arranged at 4 corners of the object plane (11).
8. The vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time according to claim 6, wherein the vacuum platform (1) is provided with an alarm device, and the alarm device is connected with the vacuum pressure gauge.
9. The vacuum negative pressure type real-time pathological section steady state monitoring platform according to claim 1, wherein the alignment structure (2) comprises a torque motor (21) and two rollers (22), the torque motor (21) is arranged at the connection of the two arms of the "V" structure, and the two rollers (22) are arranged at the end positions of the two arms of the "V" structure.
10. The vacuum negative pressure type real-time monitoring platform for the stable state of pathological section according to claim 1, wherein the position detection mechanism (3) is configured as a position detection sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111096544.9A CN115201190A (en) | 2021-09-16 | 2021-09-16 | Vacuum negative pressure type platform for monitoring stable state of pathological section in real time |
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| CN202111096544.9A CN115201190A (en) | 2021-09-16 | 2021-09-16 | Vacuum negative pressure type platform for monitoring stable state of pathological section in real time |
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| CN115201190A true CN115201190A (en) | 2022-10-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119880804A (en) * | 2025-03-28 | 2025-04-25 | 复旦大学附属华山医院 | AI auxiliary diagnosis equipment of nerve pathology |
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| KR20060061096A (en) * | 2004-12-01 | 2006-06-07 | 삼성전자주식회사 | Wafer alignment device |
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| CN213325239U (en) * | 2020-09-27 | 2021-06-01 | 深圳艾维迪泰生物科技有限公司 | Biological slide fixing device |
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2021
- 2021-09-16 CN CN202111096544.9A patent/CN115201190A/en active Pending
Patent Citations (10)
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|---|---|---|---|---|
| US4508435A (en) * | 1982-06-18 | 1985-04-02 | Coulter Electronics, Inc. | Air vacuum chuck for a microscope |
| US4807984A (en) * | 1986-02-18 | 1989-02-28 | Hitachi, Ltd. | Apparatus and method for specimen inspection |
| US4946266A (en) * | 1987-09-16 | 1990-08-07 | Ernst Leitz Wetzlar Gmbh | Universal object holder for microscopes |
| KR20060061096A (en) * | 2004-12-01 | 2006-06-07 | 삼성전자주식회사 | Wafer alignment device |
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| CN205708856U (en) * | 2016-06-14 | 2016-11-23 | 昆山国显光电有限公司 | Glass substrate containing device |
| CN209014455U (en) * | 2018-10-22 | 2019-06-21 | 南昌西尔戴尔医疗科技有限公司 | Clamp system and cervical cytology slide scan-image analysis system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN119880804A (en) * | 2025-03-28 | 2025-04-25 | 复旦大学附属华山医院 | AI auxiliary diagnosis equipment of nerve pathology |
| CN119880804B (en) * | 2025-03-28 | 2025-07-11 | 复旦大学附属华山医院 | AI auxiliary diagnosis equipment of nerve pathology |
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Application publication date: 20221018 |