CN115201190A - A vacuum negative pressure real-time monitoring platform for the steady state of pathological slices - Google Patents

Abstract

The invention belongs to the technical field of medical detection equipment, and particularly relates to a vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time. The invention provides a vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time, which comprises a vacuum platform, wherein the vacuum platform is of a' 21274; the alignment structure is arranged to be a V-shaped structure; the alignment structure and the vacuum platform are arranged at the same height; and the position detection mechanism is arranged inside the vacuum platform. The invention adopts a special vacuum structure as a mode of fixing the slide, takes the roller with torque control as an alignment mechanism and is assisted by the detection sensor, thereby fully ensuring the integrity, stability and smoothness of the slide and monitoring the slide state in real time in the scanning process and ensuring the definition of an image to the maximum extent.

Description

A vacuum negative pressure real-time monitoring platform for the steady state of pathological slices

technical field

The invention belongs to the technical field of medical testing equipment, in particular to a vacuum negative pressure real-time monitoring platform for the steady state of pathological slices.

Background technique

The digital pathological slide scanner is a high-precision digital image acquisition system. The objects captured are extremely small cells or tissues (micron size). In order to achieve a clear and complete slice picture with a full field of view, the camera is often required in the vertical and horizontal directions. Continuously shoot multiple times, and finally fuse and stitch through algorithms. During the scanning process, since the slide is placed on the scanning platform, it needs to move with the platform at high speed and accuracy, so there are higher requirements on the movement accuracy, levelness and stability of the slide, otherwise it may cause Partial or overall scanning of pathological sections is unclear.

The Chinese patent with publication number CN208350608U discloses a platform installation mechanism in a digital pathological slice scanner. Taking the above-mentioned patent as an example, the current digital pathological slice scanning platforms all have the following problems that can be improved: (1) The traditional scanning platform has no One exception is a purely mechanical glass fixing structure, and a device such as a cylinder or a motor is often used to drive the fixing device, and the glass slide is squeezed and fixed by horizontal or vertical downward force. When the plate and the glass slide are not parallel, pushing the glass slide to move makes the edge of the glass slide easily collide with another fixed plate, and the distance between the push plate driven by the cylinder is constant, so that the non-parallel glass slide The actual running distance of the slide is far less than the actual distance that the push plate can run, so that the non-parallel glass slides are squeezed between the push plate and the fixed plate, which is very easy to cause the slide glass to break and affect the positioning. and subsequent identification process. (2) The pathological slide is fixed on the stage and moves with the stage at high speed. At this time, it is required that there is no relative displacement between the stage and the pathological slide. The traditional clamping structure by mechanical pressure will In the process of repeated pushing and clamping, there will be wear, deformation, loosening, etc., so that when the platform is running at high speed, there will be relative displacement, and the relative displacement during the shooting process will have a fatal impact on the image quality. Shadow, misalignment, blur. (3) The traditional scanning platform is scanned after the initial one-time fixation. The state of the glass slide on the platform during the entire scanning process is unknown. Implement effective monitoring and alerting.

SUMMARY OF THE INVENTION

In view of the above problems, the present invention provides a vacuum negative pressure real-time monitoring platform for the steady state of pathological slices, comprising:

a vacuum platform, the vacuum platform is set to a "scratch" type structure;

an alignment structure, the alignment structure is set as a "V" type structure; the alignment structure and the vacuum platform are arranged at the same height;

A position detection mechanism is provided inside the vacuum platform.

As a preferred technical solution, a carrier plane is arranged in the vacuum platform, the height of the carrier plane is lower than the highest plane of the vacuum platform, and the carrier plane is arranged on the vacuum platform "嚚" type structure on the two protruding arm structure.

As a preferred technical solution, a hollow groove is arranged in the vacuum platform, and the hollow groove is arranged to be recessed downward from the carrier plane.

As a preferred technical solution, the position detection mechanism is arranged in the hollow groove.

As a preferred technical solution, the vacuum platform is provided with a plurality of vacuum holes on the carrier plane, and the plurality of vacuum holes communicate with each other inside the vacuum platform.

As a preferred technical solution, a vacuum generator is connected to the vacuum platform, and the vacuum generator is connected to a plurality of the vacuum holes; a vacuum pressure is set at the connection port of the vacuum generator and the vacuum platform surface,

As a preferred technical solution, the number of the vacuum holes is four, and the four vacuum holes are arranged at four corners of the carrier plane.

As a preferred technical solution, the vacuum platform is provided with an alarm device, and the alarm device is connected to the vacuum pressure gauge.

As a preferred technical solution, the alignment structure includes a torsion motor and two rollers, the torsion motor is arranged at the connection of the two arms of the "V"-shaped structure, and the two rollers are arranged at the "V" The end positions of the two arms of the type structure.

As a preferred technical solution, the position detection structure is configured as a position detection sensor.

As a preferred technical solution, the vacuum platform is used to carry the pathological slice, the alignment structure is used to push the pathological slice to the target position, and the position detection mechanism is used to detect the position of the pathological slice.

Beneficial effects:

(1) The present invention provides a vacuum negative pressure real-time monitoring platform for the stable state of pathological slices, which is used in the scanning of digital pathological slices. As the alignment mechanism and the aid of the detection sensor, the integrity, stability and flatness of the glass slide can be fully guaranteed during the scanning process, and the state of the glass slide can be monitored in real time, which maximizes the clarity of the image.

(2) In the present invention, the vacuum negative pressure adsorption method is adopted, the size of the vacuum negative pressure can be adjusted by a pressure gauge, and the threshold value of the vacuum pressure is monitored in real time. As long as the vacuum is less than the set threshold value, the machine will issue an alarm to remind the user The vacuum is abnormal, and the stable state of the slide on the platform needs to be checked.

(3) In the present invention, the vacuum adsorption method is adopted, in addition to making the slices very firmly fixed on the stage, the more important thing is to make the slices very flat, that is, the levelness of the glass slides is very high, and each part of the glass slides is very flat. The level error of the position is very small, which greatly improves the clarity of the scan. For example: if one of the four corners of the slide has a raised piece of dirt, the height of this corner will be higher than the other corners, which will affect the scanning clarity. If a vacuum platform is used, due to the raised particles, the vacuum in this corner will cause air leakage, and the pressure sensor will alarm when the threshold value is not reached.

Description of drawings

Fig. 1 is the top-view structure schematic diagram of the vacuum platform in a kind of vacuum negative pressure type real-time monitoring pathological section stable state platform provided by the present invention;

Fig. 2 is the front view structure schematic diagram of vacuum platform;

Fig. 3 is the top view structure schematic diagram of the vacuum platform with pathological section;

Fig. 4 is the front view structure schematic diagram of the vacuum platform with pathological section;

5 is a schematic structural diagram of a platform for real-time monitoring of the stable state of pathological slices by vacuum negative pressure type provided by the present invention;

Figure 6 is a schematic diagram of the working principle;

Among them, 1-vacuum platform, 11-object plane, 12-empty groove, 13-vacuum hole, 2-alignment structure, 21-torque motor, 22-roller, 3-position detection mechanism.

Detailed ways

A vacuum negative pressure real-time monitoring platform for the steady state of pathological slices, including

The vacuum platform 1, the vacuum platform 1 is set to a "scratch" type structure;

Alignment structure 2, the alignment structure 2 is set to a "V" type structure; the alignment structure 2 and the vacuum platform 1 are set at the same height;

A position detection mechanism 3 is provided inside the vacuum platform 1 .

The vacuum platform 1 is used to carry the pathological slice, the alignment structure 2 is used to push the pathological slice to the target position, and the position detection mechanism 3 is used to detect the position of the pathological slice.

In some preferred embodiments, the vacuum platform 1 is provided with a carrier plane 11, the height of the carrier plane 11 is lower than the highest plane of the vacuum platform 1, and the carrier plane 11 is arranged on the On the two protruding arms of the vacuum platform 1 "crown" type structure.

In some preferred embodiments, the vacuum platform 1 is provided with a hollow groove 12 , and the hollow groove 12 is arranged to be recessed downward from the carrier plane 11 .

The empty groove is set to reduce the contact area between the pathological slice and the object plane, so as to reduce the influence of foreign objects on the object platform on scanning.

In some preferred embodiments, the position detection mechanism 3 is arranged in the hollow groove 12 .

In some preferred embodiments, the vacuum platform 1 is provided with a plurality of vacuum holes 13 on the carrier plane 11 , and the vacuum holes 13 communicate with each other inside the vacuum platform 1 .

In some preferred embodiments, a vacuum generator is connected to the vacuum platform 1, and the vacuum generator communicates with a plurality of the vacuum holes 13; a connection port between the vacuum generator and the vacuum platform 1 is provided There is a vacuum pressure gauge,

In some preferred embodiments, the number of the vacuum holes 13 is four, and the four vacuum holes 13 are arranged at four corners of the carrier plane 11.

In some preferred embodiments, the vacuum platform 1 is provided with an alarm device, and the alarm device is connected to the vacuum pressure gauge.

If one of the four corners of the slide has a raised piece of dirt, the height of this corner will be higher than the other corners, which will affect the scanning clarity. If a vacuum platform is used, due to the raised particles, the vacuum in this corner will cause air leakage, and the pressure sensor will alarm when the threshold value is not reached.

In some preferred embodiments, the alignment structure 2 includes a torque motor 21 and two rollers 22, the torque motor 21 is arranged at the connection of two arms of the "V"-shaped structure, and the two rollers 22 Set at the end positions of the two arms of the "V"-shaped structure. The movement of the motor drives the movement of the rollers, and then pushes the glass slide forward 45 degrees. When the glass slide is about to touch the edge of the chamfered platform, the motor stops moving forward. At this time, the vacuum is turned on and the glass slide is sucked. If the vacuum value meets the set value, the motor Immediately return, if not satisfied, do it again.

Preferably, when the motor pushes the roller forward, there will be no extrusion between the motor and the edge of the platform on the right side, and there will be a slight gap, so as to avoid collision and lead to debris.

The motor is protected by the safety setting of the torque value. If there is an error due to the difference in the width of the glass slide itself, it will stop moving after being stressed.

In some preferred embodiments, the position detection mechanism 3 is configured as a position detection sensor.

Working principle: The invention provides a vacuum negative pressure real-time monitoring platform for the stable state of pathological slices, which is used in the scanning of digital pathological slices to effectively avoid the problem of the slide being squeezed and broken by force, and prevent debris from affecting the pathological scanning. Through the assistance of the pathological scanning camera, the scanning of the pathology on a single slide can be completed quickly, and the scanning efficiency is improved. In the present invention, the vacuum adsorption method is adopted, in addition to making the slices very firmly fixed on the stage, the more important thing is to make the slices very flat, that is, the levelness of the glass slides is very high, and the level of each position of the glass slides is very high. The degree of error is very small, which greatly improves the clarity of the scan. For example: if one of the four corners of the slide has a raised piece of dirt, the height of this corner will be higher than the other corners, which will affect the scanning clarity. If a vacuum platform is used, due to the raised particles, the vacuum in this corner will cause air leakage, and the pressure sensor will alarm when the threshold value is not reached.

Claims (10)

1. A vacuum negative pressure type platform for real-time monitoring of pathological section stable state comprises

The vacuum platform (1), the vacuum platform (1) is arranged into a structure of '21274';

the alignment structure (2), the alignment structure (2) is set to be a V-shaped structure; the alignment structure (2) and the vacuum platform (1) are arranged at the same height;

a position detection mechanism (3) disposed inside the vacuum platform (1).

2. Vacuum negative pressure type platform for real-time monitoring of the stable state of pathological sections according to claim 1, characterized in that a loading plane (11) is arranged in the vacuum platform (1), the height of the loading plane (11) is lower than the highest plane of the vacuum platform (1), the loading plane (11) is arranged on two protruding arm structures of the "21274" type structure of the vacuum platform (1).

3. The vacuum negative pressure type real-time monitoring platform for the stable state of pathological sections according to claim 2, characterized in that the vacuum platform (1) is provided with a vacant slot (12), and the vacant slot (12) is arranged to be downwards sunken from the loading plane (11).

4. Vacuum negative pressure type real-time monitoring pathological section steady state platform according to claim 3, characterized in that, the position detection mechanism (3) is arranged in the vacant slot (12).

5. The vacuum negative pressure type platform for real-time monitoring of the stable state of pathological sections according to claim 2, wherein the vacuum platform (1) is provided with a plurality of vacuum holes (13) on the object carrying plane (11), and the plurality of vacuum holes (13) are communicated with each other inside the vacuum platform (1).

6. The vacuum negative-pressure type platform for monitoring the stable state of the pathological section in real time according to claim 5, wherein a vacuum generator is connected to the vacuum platform (1), and the vacuum generator is communicated with a plurality of vacuum holes (13); and a vacuum pressure gauge is arranged at the connecting port of the vacuum generator and the vacuum platform (1).

7. The vacuum negative pressure type real-time monitoring platform for pathological section steady state according to claim 6, characterized in that the number of vacuum holes (13) is 4, and 4 vacuum holes (13) are arranged at 4 corners of the object plane (11).

8. The vacuum negative pressure type platform for monitoring the stable state of pathological sections in real time according to claim 6, wherein the vacuum platform (1) is provided with an alarm device, and the alarm device is connected with the vacuum pressure gauge.

9. The vacuum negative pressure type real-time pathological section steady state monitoring platform according to claim 1, wherein the alignment structure (2) comprises a torque motor (21) and two rollers (22), the torque motor (21) is arranged at the connection of the two arms of the "V" structure, and the two rollers (22) are arranged at the end positions of the two arms of the "V" structure.

10. The vacuum negative pressure type real-time monitoring platform for the stable state of pathological section according to claim 1, wherein the position detection mechanism (3) is configured as a position detection sensor.

Images