CN115299534A - A kind of NADH composition for pet energy quick supplement and fatigue alleviation and preparation method thereof - Google Patents

Abstract

The invention discloses a NADH composition for quick energy supplementation and fatigue relief for pets. The composition includes a first homogeneous liquid, the first homogeneous liquid includes NADH and stearyl alcohol, and uses twenty Octanol wraps NADH, wherein: the weight ratio of NADH to octacosanol is 10:(4-10). The preparation method of the composition comprises: homogenizing NADH and octacosanol to obtain a first homogeneous solution; homogenizing fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil and phospholipid , obtain the second homogeneous solution; Homogenize the wolfberry polysaccharide syrup, 1,6-diphosphate fructose trisodium salt, water and glycerol monostearate to obtain the third homogeneous solution; The liposome liquid is mixed with the third homogeneous liquid to prepare the liposome liquid; the first homogeneous liquid is dispersed into the liposome liquid to prepare the NADH-containing composition.

Description

A kind of NADH composition and its preparation for rapid energy supplementation and fatigue relief of pets method

technical field

The invention relates to the technical field of pet food, in particular to a composition containing NADH and a preparation method thereof.

Background technique

According to the physical characteristics of dogs and cats in sports and old age, infirmity, postoperative, and disease recovery, especially after a lot of exercise, racing dogs rely on glycolysis to supply energy when the body is in a state of high hypoxia. Lactic acid is the anaerobic glycolysis of sugar. Long-term strenuous exercise will cause excessive accumulation of lactic acid in the body, which will affect the relative stability of the internal environment and the normal metabolic process in the body. Blood lactic acid level can reflect aerobic metabolism capacity, fatigue generation and elimination speed.

At this stage, the global pet industry is in a period of rapid development, and the development of pet food and pet nutrition products is in full bloom. However, there are currently no nutrition products specifically for pet sports in the market.

Contents of the invention

The object of the present invention is to provide a composition containing NADH and its preparation method, which can solve one or more of the above-mentioned problems in the prior art.

In one aspect, the present invention provides a composition containing NADH, the composition includes a first homogeneous liquid, the first homogeneous liquid includes NADH and octacosanol, and uses octacosanol to wrap NADH ,

Wherein: the weight ratio of NADH and octacosanol is 10:(4-10).

Among them: the present invention uses the company's existing stable raw material NADH (nicotinamide adenine dinucleotide) as the core product of the nutritional formula through the characteristics of changes in body functions during the exercise of dogs and cats, and uses corresponding functional raw materials to achieve synergistic effect Play together to quickly improve physical strength, restore physical function, improve fatigue ability and exercise ability, and slow down sports injuries. NADH in the formula is the reduced state of nicotinamide adenine dinucleotide, which releases energy through the transfer of electrons and is utilized by the process of oxidative phosphorylation to produce adenosine triphosphate, which quickly replenishes the body's energy for pets during exercise. While covering and protecting NADH with octacosanol, the synergistically reduced nicotinamide adenine dinucleotide protects the cells of sports dogs and cats, reduces the oxidative damage of pet dogs and cats during exercise, and improves the health of dogs and cats. The body's ability to repair movement.

In certain embodiments, the composition further includes a second homogeneous solution comprising fat-soluble raw material coenzyme Q10, vitamin E, chicken fat, Antarctic krill oil and phospholipids.

In certain embodiments, the composition further includes a third homogeneous liquid comprising Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, water and glyceryl monostearate.

In certain embodiments, the weight of NADH, octacosanol, and trisodium fructose 1,6-diphosphate is: 10:(4-10):(3.3-10).

Among them: the present invention adopts the digestion characteristics of dogs and cats: its gastric acid concentration is high, the intestinal tract is relatively short, and it can quickly digest and absorb meat. Compared with humans, it has higher protein requirements. Dogs and cats, especially cats, can produce gluconeogenesis in the liver Function Metabolizes proteins from the glucose they need. Through the creative material screening and ratio matching of NADH, 1,6-diphosphate fructose trisodium salt and octacosanol, the best formula for NADH enteric-coated encapsulation and energy supplementation is found.

In certain embodiments, the NADH-containing composition includes the following components in parts by weight:

The first homogenate:

NADH 10 parts,

Octacosanol 4-10 parts;

The second homogenate:

The third homogeneous liquid:

Wherein: the present invention provides scientific and reasonable nutritional formula, specifically as follows:

Reasonable combination of antioxidant coenzyme Q10 and vitamin E can remove free radicals during exercise, activate the nutrition of dog and cat cells and cell energy, and reduce the fatigue caused by the reduction of mitochondrial membrane phospholipids caused by long-term exercise. At the same time, it has the antioxidant of the whole liquid preparation and stabilizes the product quality.

1,6-diphosphate fructose trisodium salt, phospholipids, and Antarctic krill oil are nutrients that participate in and maintain body metabolism, maintain muscle function, and help maintain optimal exercise performance during long-term high-intensity exercise;

Astaxanthin contained in Antarctic krill oil is a red carotenoid and a powerful antioxidant that can ensure the body repair during exercise, effectively slow down and reduce the oxidative damage of the exercise body of dogs and cats, and improve exercise endurance. Polysaccharides can effectively remove the metabolites of the body during exercise, and increase the storage of glycogen, so as to delay the occurrence of fatigue and accelerate the elimination of fatigue. At the same time, phospholipids and Antarctic krill oil are used as emulsifiers and stabilizers for liquid preparation.

Chicken oil can increase the palatability of the product. It is a nutritional supplement that is very popular with various pets. After adding chicken oil, it can increase the aroma of liquid preparations. Adding a certain proportion makes the nutritional supplements emit the taste that dogs and cats like, so as to actively attract food. Effect. But it’s not that the more food-inducing effects, the better the effect. It is necessary to find the best addition amount between taste coordination and system stability;

Chicken fat and water, and the nutrients in the formula cannot be dissolved together to form a coordinated, stable and uniform liquid system. Through the screening, matching and ratio adjustment of emulsifiers, a liquid preparation that can maintain stability for 18 months is finally made.

Glyceryl monostearate: a nonionic surfactant with both hydrophilic and lipophilic groups, and has multiple functions such as wetting and emulsification. It is a fungicide with strong antibacterial activity and wide antibacterial spectrum, which can be used for antiseptic preservation;

Phospholipids are commonly used charged amphoteric surfactants;

As emulsifiers, both can form a stable interface between oil and water, so that oil and water can combine to form a stable dispersion system.

Antarctic krill oil: It is rich in phospholipids. As a nutritional supplement, it also has a synergistic emulsifying effect. According to the characteristics of the three emulsifiers, the formula materials can be used after testing. Homogeneously disperse with a suitable solvent, and then formulate glyceryl monostearate, phospholipids, and Antarctic krill oil to achieve the best emulsifier, which is a pet liquid emulsifier with long-lasting stability and good uniform dispersion.

In certain embodiments, the NADH-containing composition includes the following components in parts by weight:

The first homogenate:

NADH 10 parts,

Octacosanol 4-10 parts;

The second homogenate:

The third homogeneous liquid:

On the other hand, the preparation method of a composition containing NADH provided by the present invention comprises the following steps:

S1, get each component by weight parts of raw materials;

S2. Homogenize NADH and octacosanol to obtain a first homogeneous liquid;

S3. Homogenize the fat-soluble raw materials coenzyme Q10, vitamin E, chicken fat, Antarctic krill oil and phospholipids to obtain a second homogenized liquid;

S4. Homogenizing Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, water and glyceryl monostearate to obtain a third homogenized liquid;

S5. Mixing the second homogeneous liquid and the third homogeneous liquid to obtain a liposome liquid;

S6. Dispersing the first homogeneous liquid into the liposome liquid to prepare the NADH-containing composition.

In some embodiments, step S2 includes:

Heating octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now Ready to use.

In some embodiments, step S3 includes:

The fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil, and phospholipids are added to the high-pressure homogenization equipment, and nitrogen gas is introduced to homogeneously emulsify to obtain the second homogeneous liquid.

In some embodiments, step S4 includes:

Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water were added to high-pressure homogenization equipment, and nitrogen gas was passed through for homogenization and emulsification. During the homogenization process, glycerol monostearate was gradually added to obtain the first Three homogeneous liquids.

In some embodiments, step S5 includes:

The second homogeneous liquid and the third homogeneous liquid are placed in a high-pressure micro-fluidic device, and nitrogen gas is passed through to obtain a homogeneous liposome liquid;

Step S6 includes:

The first homogeneous liquid is uniformly dispersed into the liposome liquid through an emulsification tank to obtain the NADH-containing composition.

Beneficial effects: the NADH-containing composition of the present invention uses NADH as the main functional raw material, and is matched with the nutrient requirements in the process of body function metabolism, compatibility and matching, and anti-oxidant components to eliminate the generation of free radicals in the process of exercise, and reuse Lycium barbarum polysaccharide delays the occurrence of sports fatigue and sports injuries, can greatly improve the sensitivity, endurance and energy of dogs and cats, relieve the damage of free radicals during exercise, relieve physical fatigue, and restore physical strength with quick-acting supplements. Using preparation technology to prepare enteric-coated NADH, 18-month stable liposome solution, doubled nutrient absorption, concentrated liquid efficiently, reduced feeding dosage, and improved palatability and pet food compliance.

Detailed ways

The present invention will be further described in detail through embodiments below.

Example 1

An NADH-containing composition comprising components by weight of:

Its preparation method comprises the following steps:

S1, get each component by weight parts of raw materials;

S2. Heating the octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now ready to use;

S3. Add fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil, and phospholipids to the high-pressure homogenization equipment, and inject nitrogen gas for homogeneous emulsification to obtain a second homogeneous liquid;

S4. Add Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water into high-pressure homogenization equipment, pass nitrogen gas for homogenization and emulsification, and gradually add glyceryl monostearate during the homogenization process to obtain the first Three homogeneous liquids;

S5, placing the second homogeneous liquid and the third homogeneous liquid in a high-pressure micro-fluidic device, and injecting nitrogen gas to obtain a homogeneous liposome liquid;

S6. Uniformly disperse the first homogeneous liquid into the liposome liquid through an emulsification tank to obtain a composition containing NADH.

Among them: NADH is produced in the citric acid cycle in glycolysis and cellular respiration. The NADH molecule is a control marker in the chain of energy production in the mitochondria. NADH is a coenzyme necessary for cellular energy metabolism, participates in glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, releases protons and electrons, and provides energy to synthesize ATP;

All kinds of activities and cell renewal of life phenomena, and the maintenance and balance of the structure of the whole life require energy to proceed, and NADH plays the role of electron transfer in biological processes;

NADH activates the multi-enzyme system, promotes the synthesis and metabolism of nucleic acid, protein, and polysaccharides, increases material movement and regulation control, and improves metabolic functions. Therefore, it has a material basis for cell regeneration, repair, and protection. NADH plays an important role in maintaining cell growth, differentiation and energy metabolism.

Octacosanol: (1) Enhances stamina, energy and physical strength. (2) Improve muscle strength (muscle function); improve muscle pain and reduce muscle friction. (3) Shorten the muscle nerve reaction time and improve the reaction sensitivity. (4) Strengthen heart function. (5) Increase the basal metabolic rate. (6) Enhance the resistance to reactions such as high mountains. (7) Lower systolic blood pressure. (8) Improve oxygen transport capacity and reduce oxygen demand. Increase physical strength, endurance and energy; improve muscle endurance; improve reaction acuity and shorten reaction time; increase climbing power, increase energy metabolism rate, eliminate muscle spasm; enhance muscle function including cardiac muscle, reduce systolic blood pressure, and improve basal metabolism rate, stimulate sex hormones, and promote fat breakdown.

Coenzyme Q10 is a fat-soluble antioxidant, which can activate the nutrition of human cells and cell energy, and has a significant anti-fatigue effect.

Vitamin E can inhibit the oxidative damage of membrane lipoproteins mediated by free radicals, remove free radicals, and reduce the fatigue caused by the reduction of mitochondrial membrane phospholipids caused by long-term exercise.

Lycium barbarum polysaccharide: It can significantly increase the activity of plasma, muscle tissue SOD and liver tissue GSH-Px in exercising mice, thereby benefiting the removal of active oxygen, delaying the occurrence of exercise-induced fatigue and sports injuries, and significantly increasing the activity of LDH in mice, effectively Clear the metabolites of the body during exercise, increase the glycogen reserve, provide more energy for the body, delay the occurrence of fatigue and accelerate the elimination of fatigue.

1,6-Diphosphate fructose trisodium salt is an important intermediate product in the process of glucose metabolism, which can regulate various metabolic enzymes. It can activate the rate-limiting enzymes in glycolysis—phosphofructokinase and pyruvate kinase, accelerate the conversion of phosphoenonepyruvate to pyruvate, and increase intracellular energy. It can directly enter the cells as an energy substrate to supply energy, promote the utilization of sugar by activating glycolysis while inhibiting gluconeogenesis, inhibit glycogen decomposition, and promote glycogen synthesis. It can also inhibit the utilization of glycerol and promote the synthesis of fatty acid triglycerides and phospholipids. Interact with the cell membrane to change the ion permeability of the membrane, which can effectively prevent the "calcium overload" of smooth muscle cells, neurons, platelets, increase the activity of activating Na ⁺ -K ⁺ ATPase, and prevent cells.

Antarctic krill oil, as a new source of marine Omega-3 polyunsaturated fatty acids, is a natural source rich in EPA and DHA. Phospholipid-type omega-3 fatty acids have better tissue absorption rate and bioavailability. Can improve pain in patients with mild knee osteoarthritis. The phospholipids it contains (phosphatidylcholine, phosphatidylserine, and phosphatidic acid) have anabolic properties and can be involved in maintaining muscle function, helping to maintain optimal sports performance during prolonged high-intensity exercise. Astaxanthin, a red carotenoid and powerful antioxidant contained in Antarctic Krill Oil, can inhibit oxidative stress after intense exercise. Phospholipid-type DHA and EPA can increase the expression of skeletal muscle glucose metabolism-related proteins glucose transporter 4, glucose-6-phosphate dehydrogenase genes, key enzymes carnitine palmitoyltransferase I and acyl-CoA oxidase genes in fat oxidation and decomposition; It can also increase the rate of skeletal muscle energy production by promoting the mRNA expression of mitochondrial respiratory chain complexes I, II, III, IV and tricarboxylic acid cycle-related enzymes, thereby improving running performance. Supplementing Antarctic krill oil can improve the blood viscosity of long-distance runners, which is an important manifestation of improving the metabolic capacity of endurance athletes. Taking Omega-3 polyunsaturated fatty acids can improve blood lipid metabolism and reduce circulating lipid concentration, improve blood viscosity and regulate blood rheology; Omega-3 polyunsaturated fatty acids can also improve red blood cell function by changing the phospholipid composition of red blood cell membrane, including improving red blood cell morphology and red blood cell deformability.

Phospholipids can play an important role in activating cells, maintaining metabolism, basal metabolism and balanced secretion of hormones, enhancing the body's immunity and regeneration. In addition, phospholipids can also promote fat metabolism, prevent fatty liver, lower serum cholesterol, improve blood circulation, and prevent cardiovascular diseases.

Chicken oil can improve the palatability. The ingredients in chicken oil are more likely to react with oxygen in the air and cause deterioration. After eating, it is easy to have adverse effects on human health. It is required to use freshly boiled chicken fat within ten days.

Glyceryl monostearate was used as an emulsifier.

Example 2

An NADH-containing composition comprising components by weight of:

raw material Dosage (mg) NADH 200 Octacosyl Alcohol (Encapsulated NADH Enteric Coated) 80 Coenzyme Q10 60 Vitamin E 20 Lycium barbarum polysaccharide 200 1,6-Diphosphate fructose trisodium salt 66 Antarctic Krill Oil 200 Phospholipids 60 chicken fat 80 Glyceryl monostearate 40 water 400

Its preparation method comprises the following steps:

S1, get each component by weight parts of raw materials;

S2. Heating the octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now ready to use;

S3. Add fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil, and phospholipids to the high-pressure homogenization equipment, and inject nitrogen gas for homogeneous emulsification to obtain a second homogeneous liquid;

S4. Add Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water into high-pressure homogenization equipment, pass nitrogen gas for homogenization and emulsification, and gradually add glyceryl monostearate during the homogenization process to obtain the first Three homogeneous liquids;

S5. Place the second homogeneous liquid and the third homogeneous liquid in a high-pressure micro-fluidic device, and inject nitrogen gas to obtain a homogeneous liposome liquid;

S6. Uniformly disperse the first homogeneous liquid into the liposome liquid through an emulsification tank to obtain a composition containing NADH.

Example 3

An NADH-containing composition comprising components by weight of:

raw material Dosage (mg) NADH 200 Octacosyl Alcohol (Encapsulated NADH Enteric Coated) 200 Coenzyme Q10 100 Vitamin E 40 Lycium barbarum polysaccharide 360 1,6-Diphosphate fructose trisodium salt 200 Antarctic Krill Oil 360 Phospholipids 160 chicken fat 120 Glyceryl monostearate 60 water 500

Its preparation method comprises the following steps:

S1, get each component by weight parts of raw materials;

S2. Heating the octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now ready to use;

S3. Add fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil, and phospholipids to the high-pressure homogenization equipment, and inject nitrogen gas for homogeneous emulsification to obtain a second homogeneous liquid;

S4. Add Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water into high-pressure homogenization equipment, pass nitrogen gas for homogenization and emulsification, and gradually add glyceryl monostearate during the homogenization process to obtain the first Three homogeneous liquids;

S5, placing the second homogeneous liquid and the third homogeneous liquid in a high-pressure micro-fluidic device, and injecting nitrogen gas to obtain a homogeneous liposome liquid;

S6. Uniformly disperse the first homogeneous liquid into the liposome liquid through an emulsification tank to obtain a composition containing NADH.

Comparative example 1

On the basis of the formula of Example 1, chicken fat is removed, and other conditions remain unchanged. Specifically:

An NADH-containing composition comprising components by weight of:

raw material Dosage (mg) NADH 200 Octacosyl Alcohol (Encapsulated NADH Enteric Coated) 200 Coenzyme Q10 80 Vitamin E 30 Lycium barbarum polysaccharide 300 1,6-Diphosphate fructose trisodium salt 200 Antarctic Krill Oil 300 Phospholipids 100 Glyceryl monostearate 50 water 440

Its preparation method comprises the following steps:

S1, get each component by weight parts of raw materials;

S2. Heating the octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now ready to use;

S3. Add fat-soluble raw materials coenzyme Q10, vitamin E, Antarctic krill oil, and phospholipids to the high-pressure homogenization equipment, and inject nitrogen gas for homogeneous emulsification to obtain a second homogeneous liquid;

S4. Add Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water into high-pressure homogenization equipment, pass nitrogen gas for homogenization and emulsification, and gradually add glyceryl monostearate during the homogenization process to obtain the first Three homogeneous liquids;

S5, placing the second homogeneous liquid and the third homogeneous liquid in a high-pressure micro-fluidic device, and injecting nitrogen gas to obtain a homogeneous liposome liquid;

S6. Uniformly disperse the first homogeneous liquid into the liposome liquid through an emulsification tank to obtain a composition containing NADH.

Performance Testing

1, carry out stability investigation to the liposome liquid of embodiment 1

A. Stability investigation at 4°C, the results are shown in Table 1:

Table 1

B. 60°C destruction test, the results are shown in Table 2:

Table 2

C, accelerated test, the results are as shown in table 3:

table 3

2. Palatability inspection

A, carry out single bowl test to the composition containing NADH of embodiment 1, the result is as shown in table 4:

Table 4

B. The NADH-containing compositions of Example 1 and Comparative Example 1 were carried out for the first preference of the double-bowl test, and the results are shown in Table 5:

table 5

3. Efficacy

Select 40 golden retrievers aged 10-12, weighing 25-30 kg, half male and half female, and randomly divide them into 2 groups, with 10 males and 10 females in each group. Nutritional group and blank control group, respectively.

The nutrition group was fed the NADH-containing composition (nutrient solution) of Example 1 5 days in advance, and 10 mg of the nutrient solution per 10 kg of body weight. The control group was fed the same food as the nutrition group except the nutrient solution.

After feeding the nutrient solution for 5 days and finishing the nutrient feeding on the last day, let 40 dogs (red in the nutrient solution group and green in the control group) run continuously for 10 kilometers, and record the time it took for the dogs to run 10 kilometers. Test their heart rate before running and within 3 minutes after running. Observe the dog's physical condition. The results are shown in Table 6:

Table 6

In summary: the NADH-containing composition of the present invention has the following advantages:

1. Through experimental design and verification, the present invention rationally mixes a stable suspension homogeneous solution emulsifier formula and preparation process where oil, water, and particles coexist, and successfully establishes a stable suspension liquid system for 18 months;

2. The present invention solves the inherent problem of poor palatability of raw materials and liquids, and the final product has better palatability for pet dogs and cats;

3. The product of the present invention can allow pets to achieve the purpose of quick-acting energy replenishment, can effectively stimulate the endurance, energy and responsiveness of pets during exercise and competition, relieve free radical damage during exercise, relieve physical fatigue, and reduce exercise Inflammation occurs.

The above statement is only the preferred mode of the present invention. It should be pointed out that those skilled in the art can make some modifications and improvements without departing from the inventive concept of the present invention, and these should also be regarded as the protection of the invention. within range.

Claims (10)

1. A NADH composition for quick energy supplementation and fatigue relief for pets, characterized in that the composition comprises a first homogeneous liquid, which comprises NADH and octacosanol, and uses Octacosanol encapsulates NADH, Wherein: the weight ratio of NADH and octacosanol is 10:(4-10). 2. NADH composition according to claim 1, is characterized in that, this composition also comprises the second homogeneous liquid, and described second homogeneous liquid comprises fat-soluble raw material coenzyme Q10, vitamin E, chicken oil, Antarctic phosphorus Shrimp oil and phospholipids. 3. NADH composition according to claim 2, is characterized in that, this composition also comprises the 3rd homogeneous liquid, and described 3rd homogeneous liquid comprises Lycium barbarum polysaccharide syrup, 1,6-diphosphate trisodium fructose , Water and Glyceryl Monostearate. 4. NADH composition according to claim 3, is characterized in that, the weight ratio of NADH, octacosanol and 1,6-diphosphate fructose trisodium salt is: 10:(4-10):(3.3- 10). 5. The NADH composition according to any one of claims 1 to 4, characterized in that it comprises the following components in parts by weight: The first homogenate: NADH 10 parts, Octacosanol 4-10 parts; The second homogenate:

The third homogeneous liquid:

6. A method for preparing the NADH composition according to any one of claims 1 to 5, comprising the following steps: S1, get each component by weight parts of raw materials; S2. Homogenize NADH and octacosanol to obtain a first homogeneous liquid; S3. Homogenize the fat-soluble raw materials coenzyme Q10, vitamin E, chicken fat, Antarctic krill oil and phospholipids to obtain a second homogenized liquid; S4. Homogenizing Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, water and glyceryl monostearate to obtain a third homogenized liquid; S5. Mixing the second homogeneous liquid and the third homogeneous liquid to obtain a liposome liquid; S6. Dispersing the first homogeneous liquid into the liposome liquid to prepare the NADH composition. 7. The preparation method of NADH composition according to claim 6, is characterized in that, step S2 comprises: Heating octacosanol until completely melted, adding NADH to the melted octacosanol, performing high-speed emulsification and homogenization at a speed of 4000r/min to obtain the first homogeneous liquid, ready for use, now Ready to use. 8. The preparation method of NADH composition according to claim 6, is characterized in that, step S3 comprises: The fat-soluble raw materials coenzyme Q10, vitamin E, chicken oil, Antarctic krill oil, and phospholipids are added to the high-pressure homogenization equipment, and nitrogen gas is passed through for homogeneous emulsification to obtain the second homogeneous liquid. 9. The preparation method of NADH composition according to claim 6, is characterized in that, step S4 comprises: Lycium barbarum polysaccharide syrup, fructose 1,6-diphosphate trisodium salt, and water were added to high-pressure homogenization equipment, and nitrogen gas was passed through for homogenization and emulsification. During the homogenization process, glycerol monostearate was gradually added to obtain the first Three homogeneous liquids. 10. The preparation method of NADH composition according to claim 6, is characterized in that, step S5 comprises: The second homogeneous liquid and the third homogeneous liquid are placed in a high-pressure micro-fluidic device, and nitrogen gas is passed through to obtain a homogeneous liposome liquid; Step S6 includes: The first homogeneous liquid is uniformly dispersed into the liposome liquid through an emulsification tank to obtain the NADH-containing composition.