CN1179948C - Hiv蛋白酶抑制剂 - Google Patents

Hiv蛋白酶抑制剂 Download PDF

Info

Publication number
CN1179948C
CN1179948C CNB988045389A CN98804538A CN1179948C CN 1179948 C CN1179948 C CN 1179948C CN B988045389 A CNB988045389 A CN B988045389A CN 98804538 A CN98804538 A CN 98804538A CN 1179948 C CN1179948 C CN 1179948C
Authority
CN
China
Prior art keywords
compound
alkyl
group
acid
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988045389A
Other languages
English (en)
Chinese (zh)
Other versions
CN1253548A (zh
Inventor
K��F����������
K·F·阿尔比扎提
S·莱西
M·D·瓦尔尼
张侃音
小林卓郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Agouron Pharmaceuticals LLC
Original Assignee
Japan Tobacco Inc
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc, Agouron Pharmaceuticals LLC filed Critical Japan Tobacco Inc
Publication of CN1253548A publication Critical patent/CN1253548A/zh
Application granted granted Critical
Publication of CN1179948C publication Critical patent/CN1179948C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CNB988045389A 1997-03-13 1998-03-12 Hiv蛋白酶抑制剂 Expired - Fee Related CN1179948C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81595197A 1997-03-13 1997-03-13
US08/815,951 1997-03-13

Publications (2)

Publication Number Publication Date
CN1253548A CN1253548A (zh) 2000-05-17
CN1179948C true CN1179948C (zh) 2004-12-15

Family

ID=25219265

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988045389A Expired - Fee Related CN1179948C (zh) 1997-03-13 1998-03-12 Hiv蛋白酶抑制剂

Country Status (35)

Country Link
EP (1) EP0970055A2 (de)
JP (1) JP2001516350A (de)
KR (1) KR100511089B1 (de)
CN (1) CN1179948C (de)
AP (1) AP1358A (de)
AR (1) AR012556A1 (de)
AU (1) AU743078B2 (de)
BG (1) BG63540B1 (de)
BR (1) BR9808867A (de)
CA (1) CA2284163A1 (de)
CO (1) CO4940496A1 (de)
CZ (1) CZ296647B6 (de)
EA (1) EA002378B1 (de)
EE (1) EE04114B1 (de)
GE (1) GEP20022764B (de)
HR (1) HRP980112A2 (de)
HU (1) HUP0001380A3 (de)
IL (2) IL131870A0 (de)
IS (1) IS5176A (de)
MX (1) MXPA99008395A (de)
MY (1) MY117535A (de)
NO (1) NO315555B1 (de)
NZ (1) NZ337706A (de)
OA (1) OA11196A (de)
PA (1) PA8448801A1 (de)
PE (1) PE58799A1 (de)
PL (1) PL192786B1 (de)
SA (1) SA98181116B1 (de)
SK (1) SK283636B6 (de)
SV (1) SV1998000038A (de)
TR (1) TR199902508T2 (de)
TW (1) TW200517112A (de)
UA (1) UA57772C2 (de)
WO (1) WO1998040357A2 (de)
ZA (1) ZA982047B (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
EA002378B1 (ru) 2002-04-25
IS5176A (is) 1999-09-10
CN1253548A (zh) 2000-05-17
PE58799A1 (es) 1999-07-12
CZ296647B6 (cs) 2006-05-17
PL335672A1 (en) 2000-05-08
AP1358A (en) 2004-12-03
PL192786B1 (pl) 2006-12-29
CA2284163A1 (en) 1998-09-17
KR100511089B1 (ko) 2005-08-31
EP0970055A2 (de) 2000-01-12
TW200517112A (en) 2005-06-01
ZA982047B (en) 1998-09-28
SK122299A3 (en) 2000-05-16
WO1998040357A3 (en) 1998-11-26
MY117535A (en) 2004-07-31
AU6457598A (en) 1998-09-29
GEP20022764B (en) 2002-08-26
KR20000076236A (ko) 2000-12-26
AR012556A1 (es) 2000-11-08
EA199900823A1 (ru) 2000-04-24
CZ319199A3 (cs) 2000-06-14
TR199902508T2 (xx) 2000-02-21
NO315555B1 (no) 2003-09-22
EE04114B1 (et) 2003-08-15
MXPA99008395A (es) 2003-08-12
CO4940496A1 (es) 2000-07-24
SA98181116B1 (ar) 2006-10-04
JP2001516350A (ja) 2001-09-25
BG103727A (bg) 2000-04-28
BR9808867A (pt) 2000-07-11
WO1998040357A2 (en) 1998-09-17
EE9900416A (et) 2000-04-17
SV1998000038A (es) 1999-02-15
HUP0001380A2 (hu) 2000-09-28
BG63540B1 (bg) 2002-04-30
UA57772C2 (uk) 2003-07-15
AU743078B2 (en) 2002-01-17
NO994415D0 (no) 1999-09-10
PA8448801A1 (es) 2000-05-24
HUP0001380A3 (en) 2001-12-28
SK283636B6 (sk) 2003-11-04
IL131870A (en) 2006-04-10
AP9901648A0 (en) 1999-09-30
NO994415L (no) 1999-11-10
NZ337706A (en) 2001-04-27
HRP980112A2 (en) 1998-12-31
IL131870A0 (en) 2001-03-19
OA11196A (en) 2003-05-21

Similar Documents

Publication Publication Date Title
CN1071751C (zh) 可逆蛋白酶抑制剂
CN1045204C (zh) 10,11-亚甲基二苯并环庚烷衍生物、制备方法和组合物
US5296604A (en) Proline derivatives and compositions for their use as inhibitors of HIV protease
CN1253474A (zh) 磺酰基二价芳基或杂芳基异羟肟酸化合物
CN1207056C (zh) 含肽的α-酮酰胺半胱氨酸和丝氨酸蛋白酶抑制剂
CN1028992C (zh) 1,4,-苯并硫杂吖庚因衍生物的制备方法
CN1183767A (zh) 磺酰基烷酰氨基羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
CN1036393C (zh) 7-(2-氨乙基)-苯并噻唑酮
CN1422253A (zh) 氨基甲酸酯天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
CN1173174A (zh) 取代的噁唑烷需钙蛋白酶和/或组织蛋白酶b抑制剂
CN1071930A (zh) 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
CN1190424C (zh) 含喹啉的α-酮酰胺半胱氨酸和丝氨酸蛋白酶抑制剂
CN1183102A (zh) 杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
CN1265098A (zh) 抑制因子xa的杂环衍生物
CN1046727C (zh) Hiv蛋白酶抑制剂
CN1098409A (zh) α-哌嗪酮及其应用
CN1208347A (zh) 取代的n-[(氨基亚氨基甲基和氨基甲基)苯基]丙基酰胺
CN1032785A (zh) L-二羟基苯丙氨酸衍生物或其酸加成盐、其生产方法及其用途
CN1198747A (zh) 作为金属蛋白酶和tnf释放抑制剂的硫取代的肽
CN1062729A (zh) 可用作血管紧张肽转化酶抑制剂的含氨基和硝基的三环新化合物
CN1284059A (zh) 联苯基脒衍生物
CN1166825A (zh) 金属蛋白酶抑制剂
CN1218478A (zh) 环状粘着抑制剂
CN1092410A (zh) 用作治疗爱滋病的人免疫缺陷病毒蛋白酶抑制剂
CN1058396A (zh) 二氨基三氟甲基吡啶衍生物及其制备方法和含有它们的磷脂酶a2抑制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041215

Termination date: 20100312