CN1184221C - 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法 - Google Patents

有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法 Download PDF

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Publication number
CN1184221C
CN1184221C CNB011236094A CN01123609A CN1184221C CN 1184221 C CN1184221 C CN 1184221C CN B011236094 A CNB011236094 A CN B011236094A CN 01123609 A CN01123609 A CN 01123609A CN 1184221 C CN1184221 C CN 1184221C
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CN
China
Prior art keywords
azaspiro
heptane
compound
dihydro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB011236094A
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English (en)
Chinese (zh)
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CN1400209A (zh
Inventor
郭慧元
戚建军
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Institute of Medicinal Biotechnology of CAMS and PUMC
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Institute of Medicinal Biotechnology of CAMS and PUMC
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Application filed by Institute of Medicinal Biotechnology of CAMS and PUMC filed Critical Institute of Medicinal Biotechnology of CAMS and PUMC
Priority to CNB011236094A priority Critical patent/CN1184221C/zh
Priority to PCT/CN2002/000249 priority patent/WO2003014108A1/fr
Publication of CN1400209A publication Critical patent/CN1400209A/zh
Application granted granted Critical
Publication of CN1184221C publication Critical patent/CN1184221C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB011236094A 2001-08-08 2001-08-08 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法 Expired - Fee Related CN1184221C (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNB011236094A CN1184221C (zh) 2001-08-08 2001-08-08 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法
PCT/CN2002/000249 WO2003014108A1 (fr) 2001-08-08 2002-04-10 Nouveaux derives d'acide carboxylique et de quinoline substitues par 7-(aminomethyl-5-azospiro[2,4]heptane) et leur procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB011236094A CN1184221C (zh) 2001-08-08 2001-08-08 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法

Publications (2)

Publication Number Publication Date
CN1400209A CN1400209A (zh) 2003-03-05
CN1184221C true CN1184221C (zh) 2005-01-12

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CNB011236094A Expired - Fee Related CN1184221C (zh) 2001-08-08 2001-08-08 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法

Country Status (2)

Country Link
CN (1) CN1184221C (fr)
WO (1) WO2003014108A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103102341A (zh) * 2012-12-14 2013-05-15 浙江普洛康裕制药有限公司 一种巴洛沙星二水合物的制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861599A (zh) * 2005-05-11 2006-11-15 孙飘扬 喹诺酮羧酸类衍生物及其制备方法和药物用途
JP5073497B2 (ja) * 2005-09-28 2012-11-14 第一三共株式会社 テトラ置換−５−アザスピロ［２．４］へプタン誘導体の製法およびその光学活性中間体
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
JP2010509305A (ja) * 2006-11-13 2010-03-25 シプラ・リミテッド モキシフロキサシン塩酸塩の合成方法
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
JPH0770110A (ja) * 1993-08-27 1995-03-14 Hokuriku Seiyaku Co Ltd ５，８−ジメチルキノリン−３−カルボン酸誘導体
DE69509442T2 (de) * 1994-06-16 1999-09-02 Lg Chemical Ltd. Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung
DE69622862T2 (de) * 1995-05-26 2003-03-27 Daiichi Pharmaceutical Co., Ltd. Verfahren zur herstellung von zyklischen verbindungen
JP4302205B2 (ja) * 1998-07-14 2009-07-22 第一三共株式会社 感染症治療薬
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
JP2001002676A (ja) * 1999-06-24 2001-01-09 Dai Ichi Seiyaku Co Ltd キノロンカルボン酸誘導体の製法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103102341A (zh) * 2012-12-14 2013-05-15 浙江普洛康裕制药有限公司 一种巴洛沙星二水合物的制备方法

Also Published As

Publication number Publication date
WO2003014108A1 (fr) 2003-02-20
CN1400209A (zh) 2003-03-05

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