CN1209805A - 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 - Google Patents

新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 Download PDF

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Publication number
CN1209805A
CN1209805A CN97191759A CN97191759A CN1209805A CN 1209805 A CN1209805 A CN 1209805A CN 97191759 A CN97191759 A CN 97191759A CN 97191759 A CN97191759 A CN 97191759A CN 1209805 A CN1209805 A CN 1209805A
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CN
China
Prior art keywords
compound
oxygen
carboxamide
indoles
tetrahydrochysene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97191759A
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English (en)
Chinese (zh)
Inventor
帕梅拉·阿尔鲍格
刘刚
肯尼斯·肖
阿兰·哈奇森
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Neurogen Corp
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Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of CN1209805A publication Critical patent/CN1209805A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
CN97191759A 1996-01-19 1997-01-14 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 Pending CN1209805A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/588,711 1996-01-19
US08/588,711 US5804686A (en) 1996-01-19 1996-01-19 fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Publications (1)

Publication Number Publication Date
CN1209805A true CN1209805A (zh) 1999-03-03

Family

ID=24354983

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97191759A Pending CN1209805A (zh) 1996-01-19 1997-01-14 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体

Country Status (26)

Country Link
US (2) US5804686A (2)
EP (1) EP1019372B1 (2)
JP (1) JP2000503321A (2)
KR (1) KR100490108B1 (2)
CN (1) CN1209805A (2)
AP (1) AP1015A (2)
AT (1) ATE322480T1 (2)
AU (1) AU1746697A (2)
BG (1) BG102634A (2)
BR (1) BR9707051A (2)
CA (1) CA2243317C (2)
CZ (1) CZ215498A3 (2)
DE (1) DE69735647T2 (2)
ES (1) ES2263170T3 (2)
HU (1) HUP9901018A3 (2)
IL (1) IL125391A (2)
IS (1) IS4798A (2)
MX (1) MX9805701A (2)
NO (1) NO312670B1 (2)
NZ (1) NZ330861A (2)
OA (1) OA10811A (2)
PL (1) PL327936A1 (2)
RU (1) RU2167151C2 (2)
SK (1) SK94398A3 (2)
UA (1) UA49001C2 (2)
WO (1) WO1997026243A1 (2)

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US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en) 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
IL135710A0 (en) 1997-11-13 2001-05-20 Pfizer Prod Inc Method of synthesis of pyrrole amides
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
AU2881199A (en) * 1998-02-26 1999-09-15 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
AU5444499A (en) * 1998-09-01 2000-03-21 Nissan Chemical Industries Ltd. Benzoxazine derivatives
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
OA12015A (en) * 1999-08-31 2006-04-19 Neurogen Corp Fused pyrrolecarboxamides: gaba brain receptor ligands.
AU2001264932A1 (en) * 2000-05-26 2001-12-11 Neurogen Corporation Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands
CA2419958A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
BR0113697A (pt) * 2000-09-06 2003-07-22 Neurogen Corp Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou sal, embalagem e métodos para, para alterar a atividade transdutora de sinal dos receptores de gabaa, para tratar ansiedade, depressão, um distúrbio do sono, ou demência de alzheimer, para demonstrar a presença dos receptores de gabaa em células ou amostras de tecido e para preparar um composto
EP1339681A1 (en) * 2000-12-04 2003-09-03 Pfizer Products Inc. Synthesis of fused pyrrolecarboxamides
BR0307504A (pt) * 2002-02-07 2004-12-07 Neurogen Corp Composto ou sal farmaceuticamente aceitável, composição farmacêutica, métodos tratar doenças, para potencializar um efeito terapêutico de um agente para o snc, para melhorar a memória de curto prazo em um paciente, para determinar a presença ou ausência de receptores gabaa em uma amostra, e para alterar a atividade transdutora de sinal do receptor gabaa, embalagem, e, uso de um composto ou sal
DE60306918T2 (de) * 2002-05-17 2007-03-01 Neurogen Corp., Branford Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
JP5373613B2 (ja) 2006-10-16 2013-12-18 バイオノミクス リミテッド 新規な抗不安薬化合物
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AU2011297160B2 (en) 2010-08-31 2014-11-20 Mitsui Chemicals Crop & Life Solutions, Inc. Noxious organism control agent
CA2828780A1 (en) 2011-03-02 2012-09-07 Bionomics Limited Novel small-molecules as therapeutics
EP2707367B1 (en) 2011-05-12 2019-10-09 Bionomics Limited Methods for preparing naphthyridines
CN120081825B (zh) * 2025-05-07 2025-09-16 天津匠新致成科技有限公司 一种化合物及其制备方法和医药用途

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Also Published As

Publication number Publication date
ES2263170T3 (es) 2006-12-01
DE69735647T2 (de) 2007-05-03
CZ215498A3 (cs) 1999-09-15
ATE322480T1 (de) 2006-04-15
AU1746697A (en) 1997-08-11
KR19990077300A (ko) 1999-10-25
CA2243317C (en) 2007-09-25
IL125391A0 (en) 1999-03-12
IS4798A (is) 1998-07-16
HUP9901018A3 (en) 1999-11-29
DE69735647D1 (de) 2006-05-18
PL327936A1 (en) 1999-01-04
KR100490108B1 (ko) 2005-11-25
OA10811A (en) 2001-07-05
SK94398A3 (en) 1999-02-11
US6080873A (en) 2000-06-27
HUP9901018A2 (hu) 1999-07-28
NO983315D0 (no) 1998-07-17
BG102634A (en) 1999-08-31
BR9707051A (pt) 1999-07-20
NO983315L (no) 1998-09-03
EP1019372A1 (en) 2000-07-19
JP2000503321A (ja) 2000-03-21
UA49001C2 (uk) 2002-09-16
US5804686A (en) 1998-09-08
RU2167151C2 (ru) 2001-05-20
IL125391A (en) 2004-07-25
AP9801297A0 (en) 1998-09-30
AP1015A (en) 2001-09-28
NZ330861A (en) 2000-03-27
CA2243317A1 (en) 1997-07-24
MX9805701A (es) 1998-11-30
WO1997026243A1 (en) 1997-07-24
NO312670B1 (no) 2002-06-17
EP1019372B1 (en) 2006-04-05

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