ATE322480T1 - Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden - Google Patents
Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-ligandenInfo
- Publication number
- ATE322480T1 ATE322480T1 AT97904754T AT97904754T ATE322480T1 AT E322480 T1 ATE322480 T1 AT E322480T1 AT 97904754 T AT97904754 T AT 97904754T AT 97904754 T AT97904754 T AT 97904754T AT E322480 T1 ATE322480 T1 AT E322480T1
- Authority
- AT
- Austria
- Prior art keywords
- gabe
- carboxamides
- pyrrol
- condensed
- new class
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- -1 PYRROL CARBOXAMIDES Chemical class 0.000 title 1
- 210000004556 brain Anatomy 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/588,711 US5804686A (en) | 1996-01-19 | 1996-01-19 | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE322480T1 true ATE322480T1 (de) | 2006-04-15 |
Family
ID=24354983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97904754T ATE322480T1 (de) | 1996-01-19 | 1997-01-14 | Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5804686A (de) |
| EP (1) | EP1019372B1 (de) |
| JP (1) | JP2000503321A (de) |
| KR (1) | KR100490108B1 (de) |
| CN (1) | CN1209805A (de) |
| AP (1) | AP1015A (de) |
| AT (1) | ATE322480T1 (de) |
| AU (1) | AU1746697A (de) |
| BG (1) | BG102634A (de) |
| BR (1) | BR9707051A (de) |
| CA (1) | CA2243317C (de) |
| CZ (1) | CZ215498A3 (de) |
| DE (1) | DE69735647T2 (de) |
| ES (1) | ES2263170T3 (de) |
| HU (1) | HUP9901018A3 (de) |
| IL (1) | IL125391A (de) |
| IS (1) | IS4798A (de) |
| MX (1) | MX9805701A (de) |
| NO (1) | NO312670B1 (de) |
| NZ (1) | NZ330861A (de) |
| OA (1) | OA10811A (de) |
| PL (1) | PL327936A1 (de) |
| RU (1) | RU2167151C2 (de) |
| SK (1) | SK94398A3 (de) |
| UA (1) | UA49001C2 (de) |
| WO (1) | WO1997026243A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750702A (en) * | 1993-10-27 | 1998-05-12 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands |
| US6211365B1 (en) | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| AU2218997A (en) * | 1996-03-22 | 1997-10-10 | Neurogen Corporation | Certain fused pyrrolecarboxamides as gaba brain receptor ligands |
| US5723462A (en) * | 1996-04-26 | 1998-03-03 | Neurogen Corporation | Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands |
| GT199800179A (es) * | 1997-11-13 | 2000-05-02 | Procedimiento de sintesis de pirrol amidas. | |
| BR9814161A (pt) * | 1997-11-13 | 2000-09-26 | Pfizer Prod Inc | Método de sìntese de pirrolamidas |
| AU2881199A (en) * | 1998-02-26 | 1999-09-15 | Neurogen Corporation | Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands |
| GB9812038D0 (en) | 1998-06-04 | 1998-07-29 | Merck Sharp & Dohme | Therapeutic compound |
| WO2000012492A1 (en) * | 1998-09-01 | 2000-03-09 | Nissan Chemical Industries, Ltd. | Benzoxazine derivatives |
| US20050014939A1 (en) * | 1999-08-31 | 2005-01-20 | Neurogen Corporation | Fused pyrrolecarboxamides: GABA brain receptor ligands |
| IL147971A0 (en) * | 1999-08-31 | 2002-09-12 | Neurogen Corp | Fused pyrrolecarboxamides: gaba brain receptor ligands |
| US6723332B2 (en) | 2000-05-26 | 2004-04-20 | Neurogen Corporation | Oxomidazopyridine-carboxamides |
| BR0113697A (pt) | 2000-09-06 | 2003-07-22 | Neurogen Corp | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou sal, embalagem e métodos para, para alterar a atividade transdutora de sinal dos receptores de gabaa, para tratar ansiedade, depressão, um distúrbio do sono, ou demência de alzheimer, para demonstrar a presença dos receptores de gabaa em células ou amostras de tecido e para preparar um composto |
| MXPA03001951A (es) * | 2000-09-06 | 2003-10-15 | Neurogen Corp | Pirroliminas y pirazoliminas fusionadas substituidas. |
| BR0115874A (pt) * | 2000-12-04 | 2003-10-28 | Pfizer Prod Inc | Sìntese de pirrole-amidas |
| JP2005525333A (ja) * | 2002-02-07 | 2005-08-25 | ニューロジェン コーポレイション | 置換縮合ピラゾールカルボン酸アリールアミド及び関連化合物 |
| WO2003097643A1 (en) * | 2002-05-17 | 2003-11-27 | Neurogen Corporation | Substituted ring-fused imidazole derivates: gabaa receptor ligands |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| ES2399071T3 (es) | 2006-10-16 | 2013-03-25 | Bionomics Limited | Nuevos compuestos ansiolíticos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| PL2984930T3 (pl) | 2010-08-31 | 2019-03-29 | Meiji Seika Pharma Co., Ltd. | Środek do zwalczania szkodników |
| JP2014510065A (ja) | 2011-03-02 | 2014-04-24 | バイオノミックス リミテッド | 治療薬としての新規な小分子 |
| JP6055817B2 (ja) | 2011-05-12 | 2016-12-27 | バイオノミックス リミテッド | ナフチリジンの調製方法 |
| CN120081825B (zh) * | 2025-05-07 | 2025-09-16 | 天津匠新致成科技有限公司 | 一种化合物及其制备方法和医药用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455943A (en) * | 1966-10-21 | 1969-07-15 | American Cyanamid Co | Certain 5,8-dihydro-beta-carbolines |
| US4075343A (en) * | 1976-09-13 | 1978-02-21 | Pfizer Inc. | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof |
| DE3029980A1 (de) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indolderivate und verfahren zu ihrer herstellung |
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| DE3147276A1 (de) * | 1981-11-28 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole |
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| DE3335323A1 (de) * | 1983-09-27 | 1985-04-04 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| DE3535927A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| JPH06502147A (ja) * | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| AU3443493A (en) * | 1992-02-19 | 1993-09-13 | Upjohn Company, The | 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity |
| US5266698A (en) * | 1992-04-30 | 1993-11-30 | Neurogen Corporation | Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands |
| AU6098194A (en) * | 1993-01-29 | 1994-08-15 | Ariad Pharmaceuticals, Inc. | Analogs of receptor tyrosine activation motifs and therapeutic uses thereof |
| FR2705095B1 (fr) * | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5484944A (en) * | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
-
1996
- 1996-01-19 US US08/588,711 patent/US5804686A/en not_active Expired - Fee Related
-
1997
- 1997-01-14 KR KR10-1998-0705446A patent/KR100490108B1/ko not_active Expired - Fee Related
- 1997-01-14 WO PCT/US1997/000519 patent/WO1997026243A1/en not_active Ceased
- 1997-01-14 CZ CZ982154A patent/CZ215498A3/cs unknown
- 1997-01-14 SK SK943-98A patent/SK94398A3/sk unknown
- 1997-01-14 AU AU17466/97A patent/AU1746697A/en not_active Abandoned
- 1997-01-14 JP JP9526110A patent/JP2000503321A/ja not_active Ceased
- 1997-01-14 RU RU98115534/04A patent/RU2167151C2/ru not_active IP Right Cessation
- 1997-01-14 ES ES97904754T patent/ES2263170T3/es not_active Expired - Lifetime
- 1997-01-14 BR BR9707051A patent/BR9707051A/pt not_active Application Discontinuation
- 1997-01-14 NZ NZ330861A patent/NZ330861A/xx unknown
- 1997-01-14 CN CN97191759A patent/CN1209805A/zh active Pending
- 1997-01-14 AP APAP/P/1998/001297A patent/AP1015A/en active
- 1997-01-14 EP EP97904754A patent/EP1019372B1/de not_active Expired - Lifetime
- 1997-01-14 UA UA98073904A patent/UA49001C2/uk unknown
- 1997-01-14 PL PL97327936A patent/PL327936A1/xx unknown
- 1997-01-14 AT AT97904754T patent/ATE322480T1/de not_active IP Right Cessation
- 1997-01-14 HU HU9901018A patent/HUP9901018A3/hu unknown
- 1997-01-14 IL IL12539197A patent/IL125391A/en not_active IP Right Cessation
- 1997-01-14 DE DE69735647T patent/DE69735647T2/de not_active Expired - Fee Related
- 1997-01-14 CA CA002243317A patent/CA2243317C/en not_active Expired - Fee Related
-
1998
- 1998-07-15 BG BG102634A patent/BG102634A/xx unknown
- 1998-07-15 OA OA9800115A patent/OA10811A/en unknown
- 1998-07-15 MX MX9805701A patent/MX9805701A/es not_active IP Right Cessation
- 1998-07-16 IS IS4798A patent/IS4798A/is unknown
- 1998-07-17 NO NO19983315A patent/NO312670B1/no not_active IP Right Cessation
- 1998-09-04 US US09/148,247 patent/US6080873A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901018A2 (hu) | 1999-07-28 |
| MX9805701A (es) | 1998-11-30 |
| CN1209805A (zh) | 1999-03-03 |
| NZ330861A (en) | 2000-03-27 |
| IL125391A (en) | 2004-07-25 |
| CA2243317A1 (en) | 1997-07-24 |
| DE69735647D1 (de) | 2006-05-18 |
| US6080873A (en) | 2000-06-27 |
| AP9801297A0 (en) | 1998-09-30 |
| KR100490108B1 (ko) | 2005-11-25 |
| WO1997026243A1 (en) | 1997-07-24 |
| CA2243317C (en) | 2007-09-25 |
| EP1019372A1 (de) | 2000-07-19 |
| US5804686A (en) | 1998-09-08 |
| AP1015A (en) | 2001-09-28 |
| AU1746697A (en) | 1997-08-11 |
| KR19990077300A (ko) | 1999-10-25 |
| UA49001C2 (uk) | 2002-09-16 |
| ES2263170T3 (es) | 2006-12-01 |
| EP1019372B1 (de) | 2006-04-05 |
| PL327936A1 (en) | 1999-01-04 |
| IL125391A0 (en) | 1999-03-12 |
| DE69735647T2 (de) | 2007-05-03 |
| NO983315L (no) | 1998-09-03 |
| IS4798A (is) | 1998-07-16 |
| OA10811A (en) | 2001-07-05 |
| NO312670B1 (no) | 2002-06-17 |
| SK94398A3 (en) | 1999-02-11 |
| NO983315D0 (no) | 1998-07-17 |
| CZ215498A3 (cs) | 1999-09-15 |
| RU2167151C2 (ru) | 2001-05-20 |
| JP2000503321A (ja) | 2000-03-21 |
| BG102634A (en) | 1999-08-31 |
| BR9707051A (pt) | 1999-07-20 |
| HUP9901018A3 (en) | 1999-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |