CN1216861C - 维生素d衍生物结晶及其制备方法 - Google Patents

维生素d衍生物结晶及其制备方法 Download PDF

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Publication number
CN1216861C
CN1216861C CN971960178A CN97196017A CN1216861C CN 1216861 C CN1216861 C CN 1216861C CN 971960178 A CN971960178 A CN 971960178A CN 97196017 A CN97196017 A CN 97196017A CN 1216861 C CN1216861 C CN 1216861C
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CN
China
Prior art keywords
organic solvent
vitamin
derivative
purified
formula
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Expired - Lifetime
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CN971960178A
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English (en)
Chinese (zh)
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CN1223639A (zh
Inventor
山内刚
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Publication of CN1223639A publication Critical patent/CN1223639A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
CN971960178A 1996-07-01 1997-06-16 维生素d衍生物结晶及其制备方法 Expired - Lifetime CN1216861C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP171321/1996 1996-07-01
JP17132196 1996-07-01
JP171321/96 1996-07-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100926177A Division CN1276927C (zh) 1996-07-01 1997-06-16 维生素d衍生物结晶及其制备方法

Publications (2)

Publication Number Publication Date
CN1223639A CN1223639A (zh) 1999-07-21
CN1216861C true CN1216861C (zh) 2005-08-31

Family

ID=15921084

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2004100926177A Expired - Fee Related CN1276927C (zh) 1996-07-01 1997-06-16 维生素d衍生物结晶及其制备方法
CN971960178A Expired - Lifetime CN1216861C (zh) 1996-07-01 1997-06-16 维生素d衍生物结晶及其制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB2004100926177A Expired - Fee Related CN1276927C (zh) 1996-07-01 1997-06-16 维生素d衍生物结晶及其制备方法

Country Status (12)

Country Link
US (5) US6448421B1 (2)
EP (2) EP1693363A3 (2)
KR (1) KR100487269B1 (2)
CN (2) CN1276927C (2)
AT (1) ATE325788T1 (2)
AU (1) AU717568B2 (2)
CA (1) CA2259339C (2)
DE (1) DE69735845T2 (2)
ES (1) ES2264164T3 (2)
IL (1) IL127861A (2)
TW (2) TWI247001B (2)
WO (1) WO1998000397A1 (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1552837A1 (en) * 2002-08-01 2005-07-13 Chugai Seiyaku Kabushiki Kaisha Antipsoriatic agent
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
US20070129340A1 (en) * 2004-02-06 2007-06-07 Chugai Seiyaku Kabushiki Kaisha Ed-71 preparation
WO2007011951A2 (en) * 2005-07-18 2007-01-25 Teva Pharmaceutical Industries Ltd. Purification of paricalcitol
RU2452488C2 (ru) * 2006-08-29 2012-06-10 Тева Фармасьютикал Индастриес Лтд. Фармацевтические композиции, содержащие витамин группы d и кортикостероид
US9481646B2 (en) * 2007-04-18 2016-11-01 The Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
CA2718238C (en) * 2008-03-12 2018-04-10 Cytochroma Inc. Stabilized 1,25-dihydroxyvitamin d2 and method of making same
US20090275768A1 (en) * 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
CN106336369A (zh) * 2016-08-18 2017-01-18 上海皓元医药股份有限公司 一种艾地骨化醇(Eldecalcitol)晶型及其制备方法
KR102346516B1 (ko) 2016-11-21 2022-01-03 연성정밀화학(주) 엘더칼시톨 결정의 제조방법
CN107540589B (zh) * 2017-09-14 2022-05-03 上海彩迩文生化科技有限公司 一种艾尔骨化醇晶型、药物组合物及制备方法和应用
CN110204470A (zh) * 2019-06-11 2019-09-06 南京海融医药科技股份有限公司 一种艾地骨化醇的新的结晶形式及其制备方法和应用
CN110527700B (zh) * 2019-08-30 2021-07-16 厦门金达威维生素有限公司 一种维生素d3的提纯方法
CN111855851B (zh) * 2020-07-17 2022-04-01 大连美创药业有限公司 一种合成艾地骨化醇中间体的液相色谱检测方法
CN111830158B (zh) * 2020-07-17 2022-04-01 大连美创药业有限公司 一种合成艾地骨化醇中间体的液相色谱检测方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334116A (en) 1964-06-08 1967-08-01 Martin Marietta Corp Phthalocyanine dyestuffs
US3334118A (en) * 1965-07-28 1967-08-01 Nopco Chem Co Process for obtaining purified crystalline vitamin d
JPS5115609A (en) * 1974-07-27 1976-02-07 Eisai Co Ltd 5 66 toransuubitamin d noketsushokaho
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4502991A (en) 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4689180A (en) 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719204A (en) * 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US4666634A (en) 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
US4892821A (en) * 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
EP0536311A4 (en) 1990-06-21 1993-05-19 Trustees Of Boston University Compositions comprising vitamin d precursors, analogs thereof and their use
DK0503630T3 (da) * 1991-03-13 1996-01-29 Kuraray Co Cyclohexantriolderivater
JPH05115609A (ja) * 1991-10-31 1993-05-14 Olympic Co Ltd 遊技場の管理装置
EP0614456B1 (en) 1992-08-28 1999-06-09 Bone Care International, Inc. 1alpha,24(s)-dihydroxy vitamin d2, its formation and use
IL107748A (en) * 1992-11-27 1998-08-16 Chugai Pharmaceutical Co Ltd A method for producing a history of vitamin D.
JP3429341B2 (ja) * 1993-10-14 2003-07-22 株式会社日清製粉グループ本社 活性型ビタミンｄ中間体
JP3589685B2 (ja) * 1993-11-02 2004-11-17 中外製薬株式会社 ステロイド類の２５位水酸化物の生物学的製造法
JP3678446B2 (ja) * 1993-11-02 2005-08-03 中外製薬株式会社 １β−ヒドロキシビタミン▲Ｄ３▼誘導体
CA2122431C (en) * 1994-04-28 2006-10-10 Reinhold W. Vieth Topical administration of vitamin d to mammals and compositions therefor
JP3579094B2 (ja) 1994-07-26 2004-10-20 中外製薬株式会社 ２位に置換基を有するビタミンｄ誘導体
AU710931B2 (en) * 1996-02-28 1999-09-30 Sumitomo Pharmaceuticals Company, Limited Crystalline vitamin D derivative

Also Published As

Publication number Publication date
US20070225513A1 (en) 2007-09-27
AU3107397A (en) 1998-01-21
ATE325788T1 (de) 2006-06-15
US20050009794A1 (en) 2005-01-13
US20020111503A1 (en) 2002-08-15
DE69735845T2 (de) 2006-12-28
HK1018438A1 (en) 1999-12-24
TW584627B (en) 2004-04-21
TWI247001B (en) 2006-01-11
WO1998000397A1 (en) 1998-01-08
TW200502205A (en) 2005-01-16
US20030018206A1 (en) 2003-01-23
US6831183B2 (en) 2004-12-14
AU717568B2 (en) 2000-03-30
KR100487269B1 (ko) 2005-05-03
EP1693363A2 (en) 2006-08-23
US7235679B2 (en) 2007-06-26
EP0924199A4 (2) 1999-07-28
EP0924199B1 (en) 2006-05-10
US7323580B2 (en) 2008-01-29
CA2259339C (en) 2009-04-21
CA2259339A1 (en) 1998-01-08
EP1693363A3 (en) 2012-05-16
US6448421B1 (en) 2002-09-10
DE69735845D1 (de) 2006-06-14
KR20050008861A (ko) 2005-01-21
CN1276927C (zh) 2006-09-27
CN1223639A (zh) 1999-07-21
IL127861A (en) 2004-06-01
US20060217354A1 (en) 2006-09-28
ES2264164T3 (es) 2006-12-16
IL127861A0 (en) 1999-10-28
EP0924199A1 (en) 1999-06-23
CN1637017A (zh) 2005-07-13

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