CN1233169A - 一种粉末状制剂的制备工艺 - Google Patents

一种粉末状制剂的制备工艺 Download PDF

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Publication number
CN1233169A
CN1233169A CN97198781A CN97198781A CN1233169A CN 1233169 A CN1233169 A CN 1233169A CN 97198781 A CN97198781 A CN 97198781A CN 97198781 A CN97198781 A CN 97198781A CN 1233169 A CN1233169 A CN 1233169A
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CN
China
Prior art keywords
technology
pressure
carotene
active substance
dimethyl ether
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Pending
Application number
CN97198781A
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English (en)
Chinese (zh)
Inventor
A·鲍什
S·K·F·彼得
K·斯戴纳
H·施多勒
E·维德纳
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1233169A publication Critical patent/CN1233169A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN97198781A 1996-10-14 1997-10-13 一种粉末状制剂的制备工艺 Pending CN1233169A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP96116420.9 1996-10-14
EP96116420 1996-10-14
CH2895/96 1996-11-25
CH289596 1996-11-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN00131456A Division CN1394597A (zh) 1996-10-14 2000-10-17 一种粉末状制剂的制备工艺

Publications (1)

Publication Number Publication Date
CN1233169A true CN1233169A (zh) 1999-10-27

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ID=25691665

Family Applications (2)

Application Number Title Priority Date Filing Date
CN97198781A Pending CN1233169A (zh) 1996-10-14 1997-10-13 一种粉末状制剂的制备工艺
CN00131456A Pending CN1394597A (zh) 1996-10-14 2000-10-17 一种粉末状制剂的制备工艺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN00131456A Pending CN1394597A (zh) 1996-10-14 2000-10-17 一种粉末状制剂的制备工艺

Country Status (7)

Country Link
US (3) US20010031282A1 (fr)
EP (2) EP0952820A1 (fr)
JP (2) JP2001505190A (fr)
CN (2) CN1233169A (fr)
BR (1) BR9713258A (fr)
ID (1) ID21571A (fr)
WO (1) WO1998016204A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100366243C (zh) * 2001-06-19 2008-02-06 Dsmip资产有限公司 制备分散体的方法
CN101879428A (zh) * 2010-06-12 2010-11-10 宁波工程学院 异构体比例可控的类胡萝卜素微胶囊的制备方法
WO2015003536A1 (fr) 2013-07-09 2015-01-15 浙江新维普添加剂有限公司 Procédé de préparation d'une préparation de caroténoïde dispersible dans une huile
CN110115952A (zh) * 2018-02-05 2019-08-13 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE204787T1 (de) * 1997-10-06 2001-09-15 Adalbert Raps Stiftung Verfahren zur herstellung eines pulverförmigen produktes aus einem flüssigen stoff oder stoffgemisch
AU3705799A (en) * 1998-04-09 1999-11-01 F. Hoffmann-La Roche Ag Process for the manufacture of (sub)micron sized particles by dissolving in compressed gas and surfactants
DE19841930A1 (de) 1998-09-14 2000-03-16 Basf Ag Stabile, pulverförmige Lycopin-Formulierungen, enthaltend Lycopin mit einem Kristallinitätsgrad von größer 20%
WO2000015329A1 (fr) * 1998-09-15 2000-03-23 Henkel Kommanditgesellschaft Auf Aktien Procede de production de nanoparticules
DE19923730A1 (de) * 1999-05-22 2000-11-23 Fraunhofer Ges Forschung Verfahren zur Herstellung feinpartikulärer Explosivstoffe
DK1263413T3 (da) * 2000-03-09 2006-09-11 Univ Ohio State Res Found Fremgangsmåde til fremstilling af faste dispersioner
AU2001254995A1 (en) * 2000-05-15 2001-11-26 Vectura Limited Method of manufacturing particles
PL203804B1 (pl) 2000-06-27 2009-11-30 Hoffmann La Roche Sposób wytwarzania kompozycji farmaceutycznej w postaci spoistej, płytkowej, piankowej, gąbczastej lub ciastowatej struktury i kompozycja farmaceutyczna otrzymana tym sposobem
CA2435410A1 (fr) * 2001-01-26 2002-08-01 Steven Baranowitz Preparations systemiques contenant du beta-carotene et des derives correspondants
US7329789B1 (en) * 2001-10-25 2008-02-12 Phasex Corporation Method for extraction and concentration of carotenoids using supercritical fluids
IL146737A (en) 2001-11-26 2010-02-17 Lycored Natural Prod Ind Ltd Method for protecting lycopene dispersed in tomato fibers
CA2478475A1 (fr) 2002-02-25 2003-09-04 Phasex Corporation Procede de sechage de materiaux a base d'eau
DE10217356B4 (de) 2002-04-18 2012-03-29 Fresenius Medical Care Deutschland Gmbh Lösung für die Peritonealdialyse
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
AR045957A1 (es) * 2003-10-03 2005-11-16 Novartis Ag Composicion farmaceutica y combinacion
EP1670441A4 (fr) * 2003-10-07 2012-05-02 Andrx Pharmaceuticals Llc Formulation a desintegration rapide
FR2874836B1 (fr) * 2004-09-09 2007-04-27 Pierre Fabre Medicament Sa Procede d'enrobage de poudres
US8079838B2 (en) * 2005-03-16 2011-12-20 Horiba, Ltd. Pure particle generator
JP2007046015A (ja) * 2005-08-12 2007-02-22 Tohoku Univ カロテノイド色素の製造方法
US20130093111A1 (en) * 2010-06-14 2013-04-18 Xspray Microparticles Ab Apparatus and Method for the Production of Particles
JP5850576B2 (ja) * 2010-07-06 2016-02-03 富士化学工業株式会社 ボセンタン固体分散体
US9097678B2 (en) 2011-11-03 2015-08-04 Basf Se Method for removing sulfur-comprising compounds from a hydrocarbonaceous gas mixture
CN111214846B (zh) * 2019-11-29 2022-05-17 云南绿A生物产业园有限公司 一种雨生红球藻提取物及其制备方法
WO2025206390A1 (fr) * 2024-03-29 2025-10-02 三栄源エフ・エフ・アイ株式会社 Composition contenant du carotène et son procédé de production

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2943267A1 (de) * 1979-10-26 1981-05-07 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinstverteilten carotinoiden
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
US5170727A (en) * 1991-03-29 1992-12-15 Union Carbide Chemicals & Plastics Technology Corporation Supercritical fluids as diluents in combustion of liquid fuels and waste materials
CH685325A5 (de) * 1994-01-04 1995-06-15 Marigen Sa Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit schwer löslichen Carotinen.
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
DE4440831C1 (de) * 1994-11-15 1996-05-09 Peter Siegfried Verfahren zur Erzeugung von hochprozentigen, pulverförmigen Phosphatidylcholinen

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100366243C (zh) * 2001-06-19 2008-02-06 Dsmip资产有限公司 制备分散体的方法
CN101879428A (zh) * 2010-06-12 2010-11-10 宁波工程学院 异构体比例可控的类胡萝卜素微胶囊的制备方法
WO2015003536A1 (fr) 2013-07-09 2015-01-15 浙江新维普添加剂有限公司 Procédé de préparation d'une préparation de caroténoïde dispersible dans une huile
CN110115952A (zh) * 2018-02-05 2019-08-13 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法

Also Published As

Publication number Publication date
JP2001226262A (ja) 2001-08-21
US20010031282A1 (en) 2001-10-18
US20020086059A1 (en) 2002-07-04
EP1097705A2 (fr) 2001-05-09
EP0952820A1 (fr) 1999-11-03
JP2001505190A (ja) 2001-04-17
BR9713258A (pt) 2000-03-28
CN1394597A (zh) 2003-02-05
ID21571A (id) 1999-06-24
WO1998016204A1 (fr) 1998-04-23
US20010000143A1 (en) 2001-04-05

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