CN1238806A - 甲醇毕赤酵母营养突变体的制备 - Google Patents

甲醇毕赤酵母营养突变体的制备 Download PDF

Info

Publication number
CN1238806A
CN1238806A CN97197503.5A CN97197503A CN1238806A CN 1238806 A CN1238806 A CN 1238806A CN 97197503 A CN97197503 A CN 97197503A CN 1238806 A CN1238806 A CN 1238806A
Authority
CN
China
Prior art keywords
cells
cell
dna
pichia methanolica
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97197503.5A
Other languages
English (en)
Chinese (zh)
Inventor
C·K·雷蒙德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/703,808 external-priority patent/US5736383A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of CN1238806A publication Critical patent/CN1238806A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN97197503.5A 1996-07-17 1997-07-14 甲醇毕赤酵母营养突变体的制备 Pending CN1238806A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68350096A 1996-07-17 1996-07-17
US08/683,500 1996-07-17
US08/703,808 US5736383A (en) 1996-08-26 1996-08-26 Preparation of Pichia methanolica auxotrophic mutants
US08/703,808 1996-08-26

Publications (1)

Publication Number Publication Date
CN1238806A true CN1238806A (zh) 1999-12-15

Family

ID=27103122

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97197503.5A Pending CN1238806A (zh) 1996-07-17 1997-07-14 甲醇毕赤酵母营养突变体的制备

Country Status (6)

Country Link
JP (1) JP2002514049A (fr)
CN (1) CN1238806A (fr)
AU (1) AU708572B2 (fr)
CA (1) CA2261020C (fr)
IL (1) IL128072A0 (fr)
WO (1) WO1998002536A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116064597B (zh) * 2023-01-17 2024-04-26 北京大学 通过自主复制rna实现哺乳动物细胞中的定向进化和达尔文适应

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69941126D1 (de) 1998-09-23 2009-08-27 Zymogenetics Inc Cytokinerezeptor zalpha11
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
SI1642972T1 (sl) 1999-01-07 2010-05-31 Zymogenetics Inc Terapevtske uporabe BR X topnih receptorjev
KR100743640B1 (ko) 1999-03-09 2007-07-27 지모제넥틱스, 인코포레이티드 신규한 사이토킨 zalpha 11 리간드
EP2241623A3 (fr) 1999-07-07 2010-12-01 ZymoGenetics, Inc. Anti-corps monoclonal contre un récepteur de cytokine humain
AU2292601A (en) 1999-12-23 2001-07-03 Zymogenetics Inc. Novel cytokine zcyto18
CA2412239C (fr) 2000-06-26 2013-05-28 Zymogenetics, Inc. Zcytor17, recepteur de la cytokine
WO2002066516A2 (fr) 2001-02-20 2002-08-29 Zymogenetics, Inc. Anticorps liant a la fois bcma et taci
BRPI0209933B8 (pt) 2001-05-24 2021-05-25 Zymogenetics Inc proteína de fusão, e, molécula de ácido nucleico
ES2411007T3 (es) 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
ES2334338T3 (es) 2001-11-05 2010-03-09 Zymogenetics, Inc. Antagonistas de il-21.
EP2840089A1 (fr) 2002-01-18 2015-02-25 ZymoGenetics, Inc. Multimères Zcytor17 du récepteur de la cytokine
DK1961811T3 (da) 2002-01-18 2010-11-08 Zymogenetics Inc Cytokinligand til behandling af asthma og luftvejs-hyper-responsivitet
CN1659274A (zh) 2002-04-19 2005-08-24 津莫吉尼蒂克斯公司 细胞因子受体
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
WO2006013072A2 (fr) 2004-08-02 2006-02-09 Basf Plant Science Gmbh Procede pour l'isolement de sequences de terminaison de transcription
CN100347287C (zh) * 2004-09-30 2007-11-07 汪和睦 一种重组多形汉逊酵母菌及其构建方法与应用
EP1856156A2 (fr) 2005-02-08 2007-11-21 ZymoGenetics, Inc. Anticorps et partenaires de liaison anti-il-20, anti-il-22 et anti-il-22ra, et methodes d'utilisation de ces anticorps et partenaires de liaison dans des processus inflammatoires
EP1891107B1 (fr) 2005-05-12 2011-07-06 ZymoGenetics, Inc. Compositions et procedes permettant de moduler des reponses immunitaires
EP1922080A2 (fr) 2005-08-09 2008-05-21 ZymoGenetics, Inc. Procedes destines au traitement des malignites des lymphocytes b au moyen d'une molecule de fusion taci-ig
WO2007019573A2 (fr) 2005-08-09 2007-02-15 Zymogenetics, Inc. Procedes pour le traitement et la prevention de proliferation cellulaire anormale par le biais de molecules de fusion taci
JP2009510093A (ja) 2005-09-28 2009-03-12 ザイモジェネティクス, インコーポレイテッド Il−17aおよびil−17fアンタゴニストならびにその使用方法
BRPI0711823A2 (pt) 2006-05-15 2012-01-17 Ares Trading Sa métodos para tratamento de doenças auto-imunes com uma molécula de fusão taci-ig
WO2009065415A1 (fr) 2007-11-21 2009-05-28 Roskilde Universitet Polypeptides comprenant une activité de liaison à la glace
KR101720760B1 (ko) 2008-01-25 2017-03-28 오르후스 우니베르시테트 Igfbp-4에 대한 papp-a 활성의 선택적 엑소사이트 억제
ES2410579T5 (es) 2008-12-16 2021-10-04 Novartis Ag Sistemas de despliegue de levaduras
EP3597764A3 (fr) 2012-02-01 2020-05-06 SGI-DNA, Inc. Matériau et procédés de synthèse de molécules d'acide nucléique à réduction d'erreurs
WO2014202089A2 (fr) 2013-06-18 2014-12-24 Roskilde Universitet Variants de polypeptides antigel
CN111157680B (zh) * 2019-12-31 2021-10-26 北京辰安科技股份有限公司 室内挥发性物质的泄漏溯源方法及装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965389A (en) * 1995-11-09 1999-10-12 Zymogenetics, Inc. Production of GAD65 in methylotrophic yeast

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116064597B (zh) * 2023-01-17 2024-04-26 北京大学 通过自主复制rna实现哺乳动物细胞中的定向进化和达尔文适应

Also Published As

Publication number Publication date
WO1998002536A2 (fr) 1998-01-22
IL128072A0 (en) 1999-11-30
AU3885697A (en) 1998-02-09
WO1998002536A3 (fr) 1998-02-26
CA2261020A1 (fr) 1998-01-22
JP2002514049A (ja) 2002-05-14
CA2261020C (fr) 2004-06-08
AU708572B2 (en) 1999-08-05

Similar Documents

Publication Publication Date Title
CN1238806A (zh) 甲醇毕赤酵母营养突变体的制备
CN1230997A (zh) 甲醇毕赤酵母的转化
AU712650B2 (en) Compositions and methods for producing heterologous polypeptides in pichia methanolica
US5955349A (en) Compositions and methods for producing heterologous polypeptides in Pichia methanolica
US5716808A (en) Genetic engineering of pichia methanolica
AU718510B2 (en) Transformation of pichia methanolica
CN1198924C (zh) 在丝状真菌中表达克隆
CN1367838A (zh) 用于在真菌细胞中表达基因的启动子
CN1192106C (zh) 分离突变体及克隆互补基因的新方法
CN1079831C (zh) 编码黑曲霉羧肽酶的基因
CN103097536B (zh) 具有粘度改变表型的丝状真菌
CN1253575C (zh) 用共有翻译起始区序列制备多肽的方法
CN1341149A (zh) 草酰乙酸水解酶缺陷型真菌宿主细胞
US6153424A (en) Protease-deficient strains of Pichia methanolica
Krasovska et al. Glucose‐induced production of recombinant proteins in Hansenulapolymorpha mutants deficient in catabolite repression
CN1139457A (zh) 曲霉表达系统
CN1342204A (zh) 用于在真菌细胞中生产多肽的方法
CN1237208A (zh) 用于产朊假丝酵母转化的方法和材料
KR20010023688A (ko) 효모에서 폴리펩티드를 생산하는 발현 벡터
US6001597A (en) Compositions and methods for producing heterologous polypeptides in Pichia methanolica
US8703444B2 (en) Pichia pastoris deficient in endogenous secreted protease
CN1303440A (zh) 适合生产蛋白质的表达系统
EP0946734B1 (fr) Preparation de mutants auxotrophes de pichia methanolica
JP3945866B2 (ja) メタノール酵母由来のプロテインジスルフィドイソメラーゼ遺伝子
US20030022280A1 (en) Compositions and methods for producing high yields of heterologous polypeptides in a pichia cell

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication