CN1252440A - 用于提高除虫菌素产量的阿维链霉菌调节基因 - Google Patents

用于提高除虫菌素产量的阿维链霉菌调节基因 Download PDF

Info

Publication number
CN1252440A
CN1252440A CN99123897A CN99123897A CN1252440A CN 1252440 A CN1252440 A CN 1252440A CN 99123897 A CN99123897 A CN 99123897A CN 99123897 A CN99123897 A CN 99123897A CN 1252440 A CN1252440 A CN 1252440A
Authority
CN
China
Prior art keywords
aver1
aver2
polynucleotide molecule
nucleotide sequence
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99123897A
Other languages
English (en)
Chinese (zh)
Inventor
K·J·斯图兹曼-恩格瓦尔
B·S·普里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1252440A publication Critical patent/CN1252440A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN99123897A 1998-09-14 1999-09-14 用于提高除虫菌素产量的阿维链霉菌调节基因 Pending CN1252440A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10013498P 1998-09-14 1998-09-14
US60/100134 1998-09-14

Publications (1)

Publication Number Publication Date
CN1252440A true CN1252440A (zh) 2000-05-10

Family

ID=22278261

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99123897A Pending CN1252440A (zh) 1998-09-14 1999-09-14 用于提高除虫菌素产量的阿维链霉菌调节基因

Country Status (17)

Country Link
US (2) US6197591B1 (2)
EP (1) EP0997528A1 (2)
JP (1) JP3595210B2 (2)
KR (1) KR100343357B1 (2)
CN (1) CN1252440A (2)
AR (1) AR021485A1 (2)
AU (1) AU758329B2 (2)
BR (1) BR9904109A (2)
CA (1) CA2281935A1 (2)
HU (1) HUP9903073A3 (2)
ID (1) ID23542A (2)
IL (1) IL131845A0 (2)
IN (1) IN190976B (2)
PL (1) PL335438A1 (2)
RU (1) RU2221042C2 (2)
TR (1) TR199902239A2 (2)
ZA (1) ZA995872B (2)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720415B2 (en) * 1998-12-02 2004-04-13 Princeton University Compositions and methods for regulating bacterial pathogenesis
US7326542B2 (en) * 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
US20040101936A1 (en) * 2000-02-24 2004-05-27 Hirofumi Endo Process for producing avermectin derivative
US6559176B1 (en) 2000-05-10 2003-05-06 Princeton University Compounds and methods for regulating bacterial growth and pathogenesis
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
RS50813B (sr) * 2002-02-12 2010-08-31 Pfizer Products Inc. Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
WO2005021586A2 (en) * 2003-08-21 2005-03-10 Wisconsin Alumni Research Foundation Metabolic engineering of viomycin biosynthesis
US7645600B2 (en) * 2004-07-23 2010-01-12 Shin-Etsu Chemical Co., Ltd. Compositions and methods for enhanced bacterial exopolysaccharide production
KR100564156B1 (ko) * 2004-08-23 2006-03-24 주식회사 진켐 스트렙토마이세스 푸세티우스 유래 전사활성체 및 그 유전자
JP2006296419A (ja) * 2005-03-04 2006-11-02 Hiroshima Univ 遺伝子破壊による抗生物質産生微生物の生産方法およびこれを用いて得られる抗生物質産生微生物、並びに抗生物質代謝中間体の生産方法
WO2008121324A2 (en) * 2007-03-30 2008-10-09 Abbott Laboratories Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362816A (en) 1980-11-13 1982-12-07 The Upjohn Company Hybrid plasmid and process of making same
US4898828A (en) 1985-08-07 1990-02-06 Eli Lilly And Company Ultrahigh copy number streptomycetes plasmids
US5242809A (en) 1986-02-28 1993-09-07 Smithkline Beecham Corporation Gal operon of streptomyces
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE89604T1 (de) 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
DE3825615A1 (de) * 1988-07-28 1990-02-01 Behringwerke Ag Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung
US5264354A (en) 1988-09-30 1993-11-23 Eli Lilly And Company Method for isolating transposable elements from streptomyces
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5122595A (en) 1989-05-19 1992-06-16 Applied Research Systems Ars Holding N.V. SAF polypeptide gene coding therefor, and SAF promoter
US5118617A (en) 1989-05-19 1992-06-02 Applied Research Systems Ars Holding N.V. Saf polypeptide, gene coding therefor, saf promoter and expression methods for expressing foreign dna sequences in streptomyces
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
KR100221385B1 (ko) 1993-07-30 1999-10-01 디. 제이. 우드 스트렙토마이세스 아베르미틸리스로 부터의 측쇄 알파-케토산 데하이드로게나제 복합체를 암호화하는 유전자
FI942725A7 (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5474912A (en) 1994-03-03 1995-12-12 Sherman; David H. Method for increasing production of microbial metabolites by genetic engineering
US5876987A (en) 1996-02-07 1999-03-02 Board Of Trustees Operating Michigan State University Method, DNA and bacteria for hyperproduction of an antibiotic due to disruption of an AbsA gene

Also Published As

Publication number Publication date
HUP9903073A3 (en) 2005-05-30
AU4757599A (en) 2000-03-23
RU2221042C2 (ru) 2004-01-10
JP2000102394A (ja) 2000-04-11
TR199902239A2 (xx) 2000-04-21
IN190976B (2) 2003-09-06
CA2281935A1 (en) 2000-03-14
JP3595210B2 (ja) 2004-12-02
HU9903073D0 (en) 1999-11-29
ZA995872B (en) 2001-03-13
PL335438A1 (en) 2000-03-27
EP0997528A1 (en) 2000-05-03
US6197591B1 (en) 2001-03-06
AU758329B2 (en) 2003-03-20
US6689611B1 (en) 2004-02-10
KR100343357B1 (ko) 2002-07-15
BR9904109A (pt) 2000-10-17
IL131845A0 (en) 2001-03-19
ID23542A (id) 2000-05-04
HUP9903073A2 (en) 2000-07-28
AR021485A1 (es) 2002-07-24
KR20000023111A (ko) 2000-04-25

Similar Documents

Publication Publication Date Title
CN102015756B (zh) Nrps-pks基因簇及其操纵和应用
CN1298447A (zh) 生产刺糖噻杀虫剂所用的生物合成基因
CN110218244B (zh) 化合物ilamycin F及其应用
Wang et al. Genome shuffling and ribosome engineering of Streptomyces actuosus for high-yield nosiheptide production
US6689611B1 (en) Modified Streptomyces host cells for increased avermectin production and methods of making the same
JP2023012549A (ja) 改変ストレプトマイセス・フンジシディカス分離株およびその使用
CN1186447C (zh) 介导除虫菌素b2:b1比例的除虫链霉菌基因
JP4011036B2 (ja) Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子
JP3884651B2 (ja) Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
HK1026456A (en) Streptomyces avermitilis regulatory genes for increased avermectin production
CN102392028B (zh) 指导b2:b1除虫菌素比例的除虫链霉菌基因
CN108753799A (zh) 一种米尔贝霉素合成正调控基因kelR、编码蛋白、基因工程菌及其制备方法和应用
RU2773311C2 (ru) Модифицированные изоляты streptomyces fungicidicus и их применение
Machado Studies of ergot alkaloid biosynthesis genes in clavicipitaceous fungi
HK1034282A (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
CN104164399A (zh) 环酯肽类抗生素黑莫他丁的高产菌株及其构建方法
HK1068894A (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
CZ323299A3 (cs) Regulační geny Streptomyces avermitilis a způsob zvýšené produkce avermektinů

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1026456

Country of ref document: HK