TR199902239A2 - Art�r�lm�� avermektin �retim i�in streptomyces avermitilis d�zenleyici genler. - Google Patents
Art�r�lm�� avermektin �retim i�in streptomyces avermitilis d�zenleyici genler.Info
- Publication number
- TR199902239A2 TR199902239A2 TR1999/02239A TR9902239A TR199902239A2 TR 199902239 A2 TR199902239 A2 TR 199902239A2 TR 1999/02239 A TR1999/02239 A TR 1999/02239A TR 9902239 A TR9902239 A TR 9902239A TR 199902239 A2 TR199902239 A2 TR 199902239A2
- Authority
- TR
- Turkey
- Prior art keywords
- avermectin
- increased
- genes
- regulatory genes
- streptomyces avermitilis
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 5
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 5
- 241001468227 Streptomyces avermitilis Species 0.000 title abstract 2
- 108700005075 Regulator Genes Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108010030975 Polyketide Synthases Proteins 0.000 abstract 2
- 241000187747 Streptomyces Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10013498P | 1998-09-14 | 1998-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199902239A2 true TR199902239A2 (xx) | 2000-04-21 |
Family
ID=22278261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02239A TR199902239A2 (xx) | 1998-09-14 | 1999-09-14 | Art�r�lm�� avermektin �retim i�in streptomyces avermitilis d�zenleyici genler. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6197591B1 (2) |
| EP (1) | EP0997528A1 (2) |
| JP (1) | JP3595210B2 (2) |
| KR (1) | KR100343357B1 (2) |
| CN (1) | CN1252440A (2) |
| AR (1) | AR021485A1 (2) |
| AU (1) | AU758329B2 (2) |
| BR (1) | BR9904109A (2) |
| CA (1) | CA2281935A1 (2) |
| HU (1) | HUP9903073A3 (2) |
| ID (1) | ID23542A (2) |
| IL (1) | IL131845A0 (2) |
| IN (1) | IN190976B (2) |
| PL (1) | PL335438A1 (2) |
| RU (1) | RU2221042C2 (2) |
| TR (1) | TR199902239A2 (2) |
| ZA (1) | ZA995872B (2) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326542B2 (en) * | 1998-12-02 | 2008-02-05 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
| US6720415B2 (en) * | 1998-12-02 | 2004-04-13 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
| WO2001062939A1 (fr) * | 2000-02-24 | 2001-08-30 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un derive d'avermectine |
| JP2003532698A (ja) * | 2000-05-10 | 2003-11-05 | プリンストン ユニバーシティ | 細菌の増殖および病理発生を調節するための化合物ならびに方法 |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| PT1476539E (pt) | 2002-02-12 | 2009-04-09 | Pfizer Prod Inc | Gene streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
| US7326782B2 (en) * | 2003-08-21 | 2008-02-05 | Wisconsin Alumni Research Foundation | Metabolic engineering of viomycin biosynthesis |
| US7645600B2 (en) * | 2004-07-23 | 2010-01-12 | Shin-Etsu Chemical Co., Ltd. | Compositions and methods for enhanced bacterial exopolysaccharide production |
| KR100564156B1 (ko) * | 2004-08-23 | 2006-03-24 | 주식회사 진켐 | 스트렙토마이세스 푸세티우스 유래 전사활성체 및 그 유전자 |
| JP2006296419A (ja) * | 2005-03-04 | 2006-11-02 | Hiroshima Univ | 遺伝子破壊による抗生物質産生微生物の生産方法およびこれを用いて得られる抗生物質産生微生物、並びに抗生物質代謝中間体の生産方法 |
| WO2008121324A2 (en) * | 2007-03-30 | 2008-10-09 | Abbott Laboratories | Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4362816A (en) | 1980-11-13 | 1982-12-07 | The Upjohn Company | Hybrid plasmid and process of making same |
| US4898828A (en) | 1985-08-07 | 1990-02-06 | Eli Lilly And Company | Ultrahigh copy number streptomycetes plasmids |
| US5242809A (en) | 1986-02-28 | 1993-09-07 | Smithkline Beecham Corporation | Gal operon of streptomyces |
| US5238848A (en) | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
| US5234831A (en) | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
| US5525506A (en) | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| DE3881147T2 (de) | 1987-10-23 | 1993-09-02 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
| US5240850A (en) | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
| DE3825615A1 (de) * | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
| US5264354A (en) | 1988-09-30 | 1993-11-23 | Eli Lilly And Company | Method for isolating transposable elements from streptomyces |
| ES2079436T3 (es) | 1989-03-31 | 1996-01-16 | Merck & Co Inc | Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso. |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| US5118617A (en) | 1989-05-19 | 1992-06-02 | Applied Research Systems Ars Holding N.V. | Saf polypeptide, gene coding therefor, saf promoter and expression methods for expressing foreign dna sequences in streptomyces |
| US5122595A (en) | 1989-05-19 | 1992-06-16 | Applied Research Systems Ars Holding N.V. | SAF polypeptide gene coding therefor, and SAF promoter |
| US5292647A (en) * | 1992-11-30 | 1994-03-08 | Eli Lilly And Company | Strain of streptomyces for producing avermectins and processes therewith |
| JP2807348B2 (ja) | 1993-07-30 | 1998-10-08 | ファイザー・インコーポレーテッド | ストレプトミセス・アベルミティリスからの分岐状鎖α−ケト酸デヒドロゲナーゼ複合体をコードする遺伝子 |
| FI942725L (fi) | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| US5474912A (en) | 1994-03-03 | 1995-12-12 | Sherman; David H. | Method for increasing production of microbial metabolites by genetic engineering |
| US5876987A (en) | 1996-02-07 | 1999-03-02 | Board Of Trustees Operating Michigan State University | Method, DNA and bacteria for hyperproduction of an antibiotic due to disruption of an AbsA gene |
-
1999
- 1999-09-07 US US09/390,721 patent/US6197591B1/en not_active Expired - Fee Related
- 1999-09-08 IN IN1203DE1999 patent/IN190976B/en unknown
- 1999-09-09 IL IL13184599A patent/IL131845A0/xx unknown
- 1999-09-13 HU HU9903073A patent/HUP9903073A3/hu unknown
- 1999-09-13 RU RU99119890/13A patent/RU2221042C2/ru not_active IP Right Cessation
- 1999-09-13 EP EP99307230A patent/EP0997528A1/en not_active Ceased
- 1999-09-13 AR ARP990104584A patent/AR021485A1/es not_active Application Discontinuation
- 1999-09-13 ID IDP990859A patent/ID23542A/id unknown
- 1999-09-13 KR KR1019990039097A patent/KR100343357B1/ko not_active Expired - Fee Related
- 1999-09-13 ZA ZA9905872A patent/ZA995872B/xx unknown
- 1999-09-14 CN CN99123897A patent/CN1252440A/zh active Pending
- 1999-09-14 BR BR9904109-0A patent/BR9904109A/pt not_active Application Discontinuation
- 1999-09-14 PL PL99335438A patent/PL335438A1/xx not_active Application Discontinuation
- 1999-09-14 JP JP26084299A patent/JP3595210B2/ja not_active Expired - Fee Related
- 1999-09-14 CA CA002281935A patent/CA2281935A1/en not_active Abandoned
- 1999-09-14 AU AU47575/99A patent/AU758329B2/en not_active Ceased
- 1999-09-14 TR TR1999/02239A patent/TR199902239A2/xx unknown
-
2000
- 2000-11-16 US US09/713,893 patent/US6689611B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2221042C2 (ru) | 2004-01-10 |
| HU9903073D0 (en) | 1999-11-29 |
| ZA995872B (en) | 2001-03-13 |
| KR100343357B1 (ko) | 2002-07-15 |
| EP0997528A1 (en) | 2000-05-03 |
| HUP9903073A3 (en) | 2005-05-30 |
| JP2000102394A (ja) | 2000-04-11 |
| JP3595210B2 (ja) | 2004-12-02 |
| AR021485A1 (es) | 2002-07-24 |
| HUP9903073A2 (en) | 2000-07-28 |
| CA2281935A1 (en) | 2000-03-14 |
| CN1252440A (zh) | 2000-05-10 |
| PL335438A1 (en) | 2000-03-27 |
| AU758329B2 (en) | 2003-03-20 |
| IN190976B (2) | 2003-09-06 |
| US6689611B1 (en) | 2004-02-10 |
| AU4757599A (en) | 2000-03-23 |
| BR9904109A (pt) | 2000-10-17 |
| US6197591B1 (en) | 2001-03-06 |
| IL131845A0 (en) | 2001-03-19 |
| KR20000023111A (ko) | 2000-04-25 |
| ID23542A (id) | 2000-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69934242D1 (de) | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen | |
| Irschik et al. | Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases | |
| BR9907736A (pt) | Agentes terapêuticos catalisados por enzima | |
| DE69008399D1 (de) | Avermectin-Ketal-Derivate, die als Antiparasitenmittel geeignet sind. | |
| EP1454897A4 (en) | PYRAZOLOPYRIMIDINONE DERIVATIVES WITH PDE7-HEMMENDER EFFECT | |
| ATE154029T1 (de) | 7-deazapurin modifizierte oligonukleotide | |
| NO20071843L (no) | Substituerte anilinderivater | |
| GEP20063937B (en) | Substituted pyridinones as modulators of p38 map kinase | |
| WO2002018405A3 (en) | Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives | |
| DE10190550D2 (de) | Kosmetische Zusammensetzung | |
| EP1603570A4 (en) | AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | |
| EP2241572A3 (en) | Modulation of survivin expression | |
| DE50104114D1 (de) | Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo f]chinolin-derivaten für eine selektive krebstherapie | |
| ATE432923T1 (de) | 5-aminoindenoä1,2-cüpyrazol-4-one als antitumor- und wachstumshemmende mittel | |
| MX2007007598A (es) | Macrolidos. | |
| NO20040354L (no) | Fremgangsmater og sammensetninger for kontroll av koksidose | |
| DE69533615D1 (de) | Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie | |
| CY1113368T1 (el) | Αλας π-τολουολο σουλφονικου οξεος της 5-αμινο-3-(2'-ο-ακετυλ-3'-δεοξυ-βητα-d-ριβοφουρανοζυλ)-3η-θειαζολο[4,5-d]πυριμιδινο-2-ονης και μεθοδοι παρασκευης | |
| BR0109809A (pt) | Derivados do carbamato de 2-hidroxi-mutilina para uso antibacteriano | |
| McNulty et al. | Transcriptional regulation of glyceraldehyde-3-phosphate dehydrogenase by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin | |
| DE602004018547D1 (de) | Herstellung von tacrolimus (fk-506) unter verwendung neuer streptomyces-spezies | |
| EA200100347A1 (ru) | Метод и композиция для лечения и профилактики туберкулеза | |
| ES515079A0 (es) | Un procedimiento para la preparacion de macrolidas c-076 | |
| KR950005306A (ko) | 매크롤라이드 및 그의 용도 | |
| BR0318521A (pt) | arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados |