CN1262667C - 利用颗粒标记物检测分析物 - Google Patents

利用颗粒标记物检测分析物 Download PDF

Info

Publication number
CN1262667C
CN1262667C CNB971958688A CN97195868A CN1262667C CN 1262667 C CN1262667 C CN 1262667C CN B971958688 A CNB971958688 A CN B971958688A CN 97195868 A CN97195868 A CN 97195868A CN 1262667 C CN1262667 C CN 1262667C
Authority
CN
China
Prior art keywords
particles
light
particle
scattering
analytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB971958688A
Other languages
English (en)
Chinese (zh)
Other versions
CN1223692A (zh
Inventor
J·伊格拉比德
E·E·伊格拉比德
D·E·克纳
J·T·杰克森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GENECOM Inc
Original Assignee
GENECOM Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GENECOM Inc filed Critical GENECOM Inc
Publication of CN1223692A publication Critical patent/CN1223692A/zh
Application granted granted Critical
Publication of CN1262667C publication Critical patent/CN1262667C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB971958688A 1996-04-25 1997-04-17 利用颗粒标记物检测分析物 Expired - Fee Related CN1262667C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1638396P 1996-04-25 1996-04-25
US60/016,383 1996-04-25

Publications (2)

Publication Number Publication Date
CN1223692A CN1223692A (zh) 1999-07-21
CN1262667C true CN1262667C (zh) 2006-07-05

Family

ID=21776844

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971958688A Expired - Fee Related CN1262667C (zh) 1996-04-25 1997-04-17 利用颗粒标记物检测分析物

Country Status (12)

Country Link
US (1) US6214560B1 (2)
EP (1) EP1021554B1 (2)
JP (3) JP2000510582A (2)
CN (1) CN1262667C (2)
AT (1) ATE357663T1 (2)
AU (1) AU736340B2 (2)
BR (1) BR9710836A (2)
CA (1) CA2253710A1 (2)
DE (1) DE69737513T2 (2)
IL (1) IL126544A (2)
RU (1) RU2251572C2 (2)
WO (1) WO1997040181A1 (2)

Families Citing this family (327)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
ES2287956T3 (es) * 1996-07-29 2007-12-16 Nanosphere Inc. Nanoparticulas que tienen oligonucleotidos unidos a las mismas y usos de las mismas.
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
GB9618897D0 (en) 1996-09-10 1996-10-23 Bio Rad Micromeasurements Ltd Micro defects in silicon wafers
EP1562035B1 (en) 1997-01-31 2017-01-25 Xy, Llc Optical apparatus and method
US6180415B1 (en) 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
EP0985142A4 (en) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc SYSTEM AND APPARATUS FOR THE SEQUENTIAL TREATMENT OF ANALYTES
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
JP3650582B2 (ja) 1998-11-30 2005-05-18 ナノスフェアー インコーポレイテッド ポリマー−ナノ粒子ハイブリッド粒子
WO2000036450A1 (de) * 1998-12-17 2000-06-22 Leica Microsystems Heidelberg Gmbh Verfahren zur differenzierten untersuchung unterschiedlicher strukturen in vorzugsweise biologischen präparaten
EP1039291A1 (en) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemical sensor and method for its construction
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
WO2000063419A1 (en) * 1999-04-15 2000-10-26 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6868371B1 (en) * 1999-05-03 2005-03-15 General Electric Company System and method to quantify appearance defects in molded plastic parts
US6608716B1 (en) 1999-05-17 2003-08-19 New Mexico State University Technology Transfer Corporation Optical enhancement with nanoparticles and microcavities
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6606566B1 (en) * 1999-11-01 2003-08-12 Steven A. Sunshine Computer code for portable sensing
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
AU1476601A (en) 1999-11-09 2001-06-06 Sri International Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU774593C (en) 2000-01-13 2005-06-23 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2001096604A2 (en) * 2000-06-12 2001-12-20 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002219983A1 (en) 2000-12-06 2002-06-18 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US7811768B2 (en) * 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
WO2002068932A2 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20040166502A1 (en) * 2001-03-13 2004-08-26 Yaming Lai Microelectromagnetic dispenser heads and uses thereof
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
ATE431853T1 (de) * 2001-03-28 2009-06-15 Nanosphere Inc Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
CA2442282A1 (en) * 2001-03-29 2002-10-10 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
AU2002310343A1 (en) * 2001-06-07 2002-12-16 University Of Pennsylvania-Center For Technology Transfer Multiplexing method
US6714299B2 (en) 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
AU2002365247B2 (en) * 2001-08-03 2006-06-08 Nanosphere, Inc. Nanoparticle imaging system and method
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
US20030112432A1 (en) 2001-09-05 2003-06-19 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
EP2311934B1 (en) * 2001-09-06 2013-06-05 Rapid Micro Biosystems, Inc. Rapid detection of replicating cells
CA2460985C (en) 2001-09-20 2016-01-05 Anticancer, Inc. Nestin-expressing hair follicle stem cells
US6754414B2 (en) * 2001-09-27 2004-06-22 Bio-Rad Laboratories, Inc. Imaging of microarrays using fiber optic exciter
US8148171B2 (en) * 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
EP1478774A4 (en) * 2001-10-09 2006-11-29 Nanosphere Inc ELECTRONIC DETECTION OF DNA BASED ON AN ASSEMBLY AND IMPLEMENTING NANOPARTICLE-LIKE PROBES
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
AU2002367817B2 (en) * 2001-11-09 2008-05-29 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7029631B2 (en) * 2002-04-19 2006-04-18 Agilent Technologies, Inc. Apparatus for improved light collection
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
DE60326228D1 (de) * 2002-05-08 2009-04-02 Panasonic Corp Biomolekulares substrat und testvorrichtung
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
GB2389230A (en) 2002-05-28 2003-12-03 Univ Nat Taiwan Nanoparticle light emitting device (LED)
ATE420357T1 (de) * 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
WO2004009237A2 (en) * 2002-07-22 2004-01-29 Xy, Inc. Sperm cell process system
US20040018495A1 (en) * 2002-07-24 2004-01-29 Xing-Xiang Li Microparticle based signal amplification for the detection of analytes
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CN1674780A (zh) 2002-08-01 2005-09-28 Xy公司 低压精子分离系统
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7126755B2 (en) * 2002-09-12 2006-10-24 Moon John A Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
EP1535241A1 (en) * 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based optical identification element
JP4485949B2 (ja) * 2002-08-20 2010-06-23 シヴェラ コーポレイション マルチプレックス実験用の回折格子ベースのコード化マイクロパーティクル
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US20040043385A1 (en) * 2002-09-03 2004-03-04 Yo-Hsin Su Microarray biochip
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
AU2003270726A1 (en) * 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
CA2498933C (en) * 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
WO2004025561A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP1552025A4 (en) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc METHOD FOR IDENTIFYING ANTIVIRAL MOLECULES DETECTED BY A QUADRUPLEX STRUCTURE
WO2004042403A2 (en) * 2002-11-04 2004-05-21 Ludwig-Maximilian-Uni Versität München Methods, device and instrument for detection of analytes
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
WO2004059293A2 (en) * 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
EP1583473A2 (en) * 2003-01-16 2005-10-12 St. Johns University New York Nanoparticle based stabilization of ir fluorescent dyes
JP2007524347A (ja) * 2003-02-27 2007-08-30 ナノスフェアー　インコーポレイテッド マイクロアレイ形式のアッセイにおける、万能ナノ粒子プローブを用いた標識不要の遺伝子発現プロファイリング
JP4769580B2 (ja) * 2003-03-27 2011-09-07 ザ ジェネラル ホスピタル コーポレイション 皮膚科的処置及び部分的な皮膚の表面再形成のための装置
EP2305173B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Apparatus and methods for providing sorted particles
EP1610795A4 (en) * 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc HETEROCYCLIC SUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHPYRIDINE ANALOGUE
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
EP1610759A4 (en) * 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc SUBSTITUTED CHINOBENZOXAZINE ANALOGUE
GB0308182D0 (en) * 2003-04-09 2003-05-14 Aoti Operating Co Inc Detection method and apparatus
US7177487B2 (en) * 2003-04-21 2007-02-13 Baxter International Inc. Determination of particle size by image analysis
WO2004104178A2 (en) * 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US7641971B2 (en) * 2003-08-13 2010-01-05 Crane Company Metal-treated particles for remediation
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US7413868B2 (en) * 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
US7553625B2 (en) * 2003-12-22 2009-06-30 John Wayne Cancer Institute Method and apparatus for in vivo collection of circulating biological components
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
EP1711623A4 (en) 2003-12-22 2008-05-21 Wayne John Cancer Inst METHOD AND DEVICE FOR IN VIVO COLLECTION AND MONITORING OF CIRCULATING BIOLOGICAL COMPONENTS
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
US7736890B2 (en) 2003-12-31 2010-06-15 President And Fellows Of Harvard College Assay device and method
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
DE102004006470B4 (de) * 2004-02-06 2006-06-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse
US20060023310A1 (en) * 2004-02-19 2006-02-02 Putnam Martin A Optical identification element using separate or partially overlapped diffraction gratings
WO2005079545A2 (en) * 2004-02-19 2005-09-01 Illumina, Inc. Optical identification element using separate or partially overlapped diffraction gratings
US20050270603A1 (en) * 2004-02-19 2005-12-08 Cyuera Corporation Optical identification element using separate or partially overlapped diffraction gratings
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
JP2007537727A (ja) 2004-03-29 2007-12-27 モンサント テクノロジー エルエルシー 受精で用いられる精子分散液
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
US20060057613A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant S. aureus from methicillin sensitive S. aureus in a mixed culture
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7288134B2 (en) * 2004-09-10 2007-10-30 International Business Machines Corporation Dumbbell-like nanoparticles and a process of forming the same
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
EP2339342B1 (en) 2004-09-14 2014-11-12 LSI Medience Corporation Biomaterial structure, method of producing the same and uses thereof
SG155995A1 (en) * 2004-09-24 2009-10-29 Ingeneus Inc Genomic assay
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7602952B2 (en) * 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
ATE459933T1 (de) 2004-11-16 2010-03-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
CA2604323A1 (en) 2005-04-19 2006-10-26 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
TWI391645B (zh) * 2005-07-06 2013-04-01 Nanometrics Inc 晶圓或其他工作表面下污染物及缺陷非接觸測量之差分波長光致發光
TWI439684B (zh) * 2005-07-06 2014-06-01 Nanometrics Inc 具自晶圓或其他工件特定材料層所發射光致發光信號優先偵測之光致發光成像
ATE525655T1 (de) * 2005-08-02 2011-10-15 Univ Maryland Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen
EP1915466B1 (en) * 2005-08-19 2010-11-24 Nanosphere, Inc. Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
AU2006284832B2 (en) 2005-08-31 2011-06-02 T2 Biosystems Inc. NMR device for detection of analytes involving magnetic particles
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
CN101528912B (zh) 2005-09-26 2014-08-27 快速微型生物系统公司 包含生长培养基的盒
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
USD580285S1 (en) 2006-01-13 2008-11-11 Invitrogen Corporation Fluorometer
RU2298798C1 (ru) * 2006-01-17 2007-05-10 Общество с ограниченной ответственностью "Биочип-Аналитика" (ООО "Биочип-Аналитика") Способ контроля биологической пробы в реакции латекс-агглютинации и аналитическая система для его осуществления
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
RU2327170C2 (ru) * 2006-02-27 2008-06-20 Закрытое акционерное общество "ДиТест" Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
EP2027468B1 (en) * 2006-05-09 2011-06-22 Koninklijke Philips Electronics N.V. Detection of target molecules in a sample by using a magnetic field
EP2021766A2 (en) * 2006-05-17 2009-02-11 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
EP3260556B1 (en) 2006-05-31 2019-07-31 Sequenom, Inc. Methods for the extraction of nucleic acid from a sample
JP5151097B2 (ja) * 2006-09-01 2013-02-27 株式会社リコー 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
US8207509B2 (en) * 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8124598B2 (en) * 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
DK2064549T3 (da) * 2006-09-21 2013-02-04 Nestec Sa Antistof-baserede arrays til detektion af flere signaltransducere i sjældne cirkulerende celler
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US20120321759A1 (en) * 2007-01-05 2012-12-20 Myskin, Inc. Characterization of food materials by optomagnetic fingerprinting
JP2010516999A (ja) * 2007-01-19 2010-05-20 トゥドール・アービンテ 試料の特性を検出し自記する為の方法と装置
EP2152417B1 (en) * 2007-05-04 2018-07-11 Opko Diagnostics, LLC Device and method for analyses in microfluidic systems
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2009026164A1 (en) 2007-08-17 2009-02-26 The General Hospital Corporation Magnetic resonance-based viscometers and methods
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
JP4597175B2 (ja) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス
EP2208045B9 (en) * 2007-10-25 2012-01-04 Koninklijke Philips Electronics N.V. Sensor device for target particles in a sample
JP4975599B2 (ja) * 2007-12-17 2012-07-11 シスメックス株式会社 標本作製装置および標本作製方法
JP2009150799A (ja) * 2007-12-21 2009-07-09 Sysmex Corp 分析装置、コンピュータプログラムおよび分析方法
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
CA2717320A1 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
RU2472221C2 (ru) * 2008-03-21 2013-01-10 Закрытое акционерное общество "СЕЛЬМАШПРОЕКТ" Система для моделирования генетической и лингвистической информации
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
MY174816A (en) * 2008-06-10 2020-05-17 Xtralis Technologies Ltd Particle detection
TW201017149A (en) * 2008-08-06 2010-05-01 Invitrox Inc Use of focused light scattering techniques in biological applications
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CN102224260B (zh) 2008-09-24 2015-11-25 施特劳斯控股公司 用于检测分析物的试剂盒和装置
CN102165305B (zh) * 2008-09-25 2014-08-20 皇家飞利浦电子股份有限公司 检测系统与方法
WO2010051362A1 (en) 2008-10-29 2010-05-06 T2 Biosystems, Inc. Nmr detection of coagulation time
EP3181702B1 (en) 2008-11-24 2019-04-17 Sequenom, Inc. Improving nucleic acid quantitation by compressing the dynamic range of high-abundance molecules
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
CN102365543A (zh) 2009-01-16 2012-02-29 纽约大学 用全息视频显微术的自动实时粒子表征和三维速度计量
ES2695039T3 (es) 2009-02-02 2018-12-28 Opko Diagnostics, Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
US20100279295A1 (en) * 2009-03-18 2010-11-04 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
EP3514244B1 (en) 2009-04-03 2021-07-07 Sequenom, Inc. Nucleic acid preparation methods
JP2013503352A (ja) * 2009-08-31 2013-01-31 エムバイオ ダイアグノスティクス，インコーポレイティド 統合されたサンプル調製及び検体検出
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
ES2859481T3 (es) * 2009-11-24 2021-10-04 Opko Diagnostics Llc Mezcla y suministro de fluidos en sistemas microfluídicos
WO2011073867A1 (en) 2009-12-18 2011-06-23 Koninklijke Philips Electronics N.V. Substance determining apparatus
EP3088532B1 (en) 2009-12-22 2019-10-30 Sequenom, Inc. Processes and kits for identifying aneuploidy
BR112012026366B1 (pt) 2010-04-16 2020-05-05 Opko Diagnostics, Llc analisador de amostras microfluídicas e método para analisar uma amostra microfluídica
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
USD653981S1 (en) 2010-08-06 2012-02-14 Life Technologies Corporation Fluorometer
CA2812208C (en) * 2010-09-24 2019-10-22 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
EP3470526A3 (en) 2011-02-08 2019-07-17 Medimmune, LLC Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use
JP5681517B2 (ja) * 2011-02-15 2015-03-11 新日本空調株式会社 粒子導電性判別装置及び粒子導電性判別方法
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
EP3321373B1 (en) 2011-07-13 2020-01-15 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
JP5762225B2 (ja) * 2011-09-08 2015-08-12 新留　康郎 銀シェル金ナノロッドを用いる分析方法
EP2748651B1 (en) 2011-09-21 2017-08-30 T2 Biosystems, Inc. Nmr methods for endotoxin analysis
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
MX368123B (es) 2011-11-07 2019-09-19 Rapid Micro Biosystems Inc Cassette para pruebas de esterilidad.
DE102011087679B3 (de) * 2011-12-02 2013-04-18 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes
WO2013109981A1 (en) 2012-01-20 2013-07-25 Sequenom, Inc. Diagnostic processes that factor experimental conditions
HK1206055A1 (en) 2012-03-02 2015-12-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP2013181935A (ja) * 2012-03-05 2013-09-12 Fujifilm Corp クロマトグラフ方法
TWI596494B (zh) 2012-03-05 2017-08-21 Ｏｐｋｏ診斷法有限責任公司 預測前列腺癌風險及前列腺腺體體積之方法及裝置
KR102114734B1 (ko) 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
IN2014DN08564A (2) 2012-04-16 2015-05-22 Rapid Micro Biosystems Inc
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140146157A1 (en) * 2012-11-29 2014-05-29 Fluid Imaging Technologies, Inc. System and method for sample dilution and particle imaging
US9739733B2 (en) 2012-12-07 2017-08-22 T2 Biosystems, Inc. Methods for monitoring tight clot formation
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
HK1216655A1 (zh) 2013-03-13 2016-11-25 Sequenom, Inc. 用於dna甲基化分析的引物
ES2741001T3 (es) 2013-03-13 2020-02-07 Opko Diagnostics Llc Mezcla de fluidos en sistemas fluídicos
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
PL2981921T3 (pl) 2013-04-03 2023-05-08 Sequenom, Inc. Metody i procesy nieinwazyjnej oceny zmienności genetycznych
EP4604127A3 (en) 2013-05-24 2025-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
HUE042654T2 (hu) 2013-06-21 2019-07-29 Sequenom Inc Eljárás genetikai variációk nem-invazív megállapítására
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
IL304949B2 (en) 2013-10-04 2025-09-01 Sequenom Inc Methods and processes for non-invasive assessment of genetic variations
EP3495496B1 (en) 2013-10-07 2020-11-25 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
EP3105638B1 (en) 2014-02-12 2020-07-22 New York University Fast feature identification for holographic tracking and characterization of colloidal particles
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2016019042A1 (en) 2014-07-30 2016-02-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3218690B1 (en) 2014-11-12 2022-03-09 New York University Colloidal fingerprints for soft materials using total holographic characterization
US10279345B2 (en) 2014-12-12 2019-05-07 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3091347A1 (en) * 2015-05-04 2016-11-09 The European Union, represented by the European Commission Screening of nanoparticle properties
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
CN108351288B (zh) 2015-09-18 2021-04-27 纽约大学 精密浆料中大杂质颗粒的全息检测和表征
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
DK3414517T3 (da) 2016-02-08 2021-12-13 Univ New York Holografisk karakterisering af proteinaggregater
RU2631237C2 (ru) * 2016-02-26 2017-09-19 Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" Способ контроля структурного качества тонких плёнок для светопоглощающих слоёв солнечных элементов и устройство для его реализации
US10670677B2 (en) 2016-04-22 2020-06-02 New York University Multi-slice acceleration for magnetic resonance fingerprinting
CN109561890A (zh) 2016-06-09 2019-04-02 海马切克公司 用于检测和可逆地捕获活体内体液中的细胞的收集器
RU169521U1 (ru) * 2016-06-28 2017-03-21 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" Устройство для оценки интенсивности светорассеивающей способности биологической ткани
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
US11694768B2 (en) 2017-01-24 2023-07-04 Sequenom, Inc. Methods and processes for assessment of genetic variations
JP7370862B2 (ja) 2017-03-17 2023-10-30 セクエノム， インコーポレイテッド 遺伝子モザイク症のための方法およびプロセス
CA3097748A1 (en) 2018-04-19 2019-10-24 First Light Biosciences, Inc. Detection of targets
EP3820610A1 (en) 2018-07-12 2021-05-19 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
US11017520B2 (en) * 2018-09-04 2021-05-25 Kla Corporation Multi-wavelength interferometry for defect classification
WO2020073015A1 (en) 2018-10-04 2020-04-09 First Light Diagnostics, Inc. Analysis instrument
CN109254022B (zh) * 2018-10-24 2021-07-20 首钢智新迁安电磁材料有限公司 一种测量晶粒尺寸的方法
CN109540855B (zh) * 2018-11-07 2021-03-23 沈阳化工大学 一种荧光金壳磁性椭球的制备方法
FI129722B (en) * 2018-12-28 2022-07-29 Kemira Oyj Monitoring and regulation of hydrophobic components in a pulping process
MX2021009264A (es) * 2019-01-30 2021-08-24 Regeneron Pharma Metodo de caracterizacion de particulas visibles y/o subvisibles en agentes biologicos.
IL265914B (en) * 2019-04-08 2020-11-30 Convergent R N R Ltd System and method for optimization of radiotherapy treatments
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay
US12158430B2 (en) 2020-03-23 2024-12-03 Kenvue Brands Llc Disposable indicator component for measuring analyte concentration in bodily fluids
EP3941168A1 (de) * 2020-07-14 2022-01-19 ZKW Group GmbH Fahrzeugmodul mit einer manipulationserkennenden elektronischen steuereinheit
CN112014369B (zh) * 2020-08-25 2024-02-09 上海市皮肤病医院 超灵敏数字层析快速检测分析物的系统及方法
US12066368B2 (en) * 2020-10-15 2024-08-20 Robert R. Alfano Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence
CN112229769B (zh) * 2020-10-22 2023-03-14 山东长信化学科技股份有限公司 一种n-甲基吡咯烷酮颗粒度的检测系统及检测方法
TWI912371B (zh) * 2021-01-14 2026-01-21 瑞士商通用表面增強光譜學股份有限公司 用於判定顆粒尺寸之方法及用於該方法之總成
CN113340894B (zh) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 一种非透明微粒的检测方法
US20240272060A1 (en) * 2021-06-08 2024-08-15 Regents Of The University Of Minnesota Method and apparatus for particle detection
CN115482643B (zh) * 2022-08-24 2024-02-02 清华大学 火灾烟雾探测器及其探测方法
CN115452667B (zh) * 2022-08-31 2024-10-01 中南大学 一种颗粒物同步追踪装置和基于其的颗粒物同步追踪方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4157498A (en) * 1977-08-01 1979-06-05 Miles Laboratories, Inc. Flow-through type particle analyzing apparatus
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4420558A (en) * 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) * 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
US4752567A (en) * 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4983834A (en) * 1985-10-10 1991-01-08 Quantex Corporation Large area particle detector system
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4851329A (en) 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
AU7385387A (en) * 1986-06-09 1987-12-10 Ortho Diagnostic Systems Inc. Immunoassay using detection of colloidal gold
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8623072D0 (en) * 1986-09-25 1986-10-29 Amersham Int Plc Particle analysis
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
US4952517A (en) * 1988-02-08 1990-08-28 Hygeia Sciences, Inc. Positive step immunoassay
US5079172A (en) * 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5338353A (en) * 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US5120135A (en) * 1989-12-13 1992-06-09 Syntex (U.S.A.) Inc. Method and apparatus for keeping particles in suspension
JP2899360B2 (ja) 1990-05-21 1999-06-02 興和株式会社 流体中の粒子計測方法及びその装置
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
JP3115641B2 (ja) 1991-04-24 2000-12-11 シスメックス株式会社 粒子計数方法
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5516670A (en) * 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
RU2009505C1 (ru) * 1992-02-04 1994-03-15 Государственный научно-исследовательский институт биологического приборостроения Способ люминесцентного иммуноанализа
US5305073A (en) 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
US5357320A (en) * 1992-09-04 1994-10-18 Canon Kabushiki Kaisha Electrophotographic apparatus
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc., Deerfield Agglutinationstest unter Anwendung eines multivalenten Liganden
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
DE4414166C1 (de) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
JPH0881678A (ja) * 1994-09-14 1996-03-26 Toshiba Corp 無機蛍光体および特異的結合物質
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US6180415B1 (en) * 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus

Also Published As

Publication number Publication date
US6214560B1 (en) 2001-04-10
IL126544A0 (en) 1999-08-17
CN1223692A (zh) 1999-07-21
ATE357663T1 (de) 2007-04-15
EP1021554A4 (en) 2004-06-30
DE69737513D1 (de) 2007-05-03
IL126544A (en) 2004-08-31
CA2253710A1 (en) 1997-10-30
DE69737513T2 (de) 2007-12-13
AU736340B2 (en) 2001-07-26
EP1021554B1 (en) 2007-03-21
WO1997040181A1 (en) 1997-10-30
JP2009236921A (ja) 2009-10-15
EP1021554A1 (en) 2000-07-26
AU2805697A (en) 1997-11-12
JP2007263974A (ja) 2007-10-11
RU2251572C2 (ru) 2005-05-10
BR9710836A (pt) 2000-10-24
JP2000510582A (ja) 2000-08-15

Similar Documents

Publication Publication Date Title
CN1262667C (zh) 利用颗粒标记物检测分析物
CN1282378A (zh) 利用颗粒标记物检测分析物
AU2002245537B2 (en) Methods for providing extended dynamic range in analyte assays
WO1997040181A9 (en) Analyte assay using particulate labels
AU2002245537A1 (en) Methods for providing extended dynamic range in analyte assays
HK1020987A (en) Analyte assay using particulate labels
AU783941B2 (en) Analyte assay using particulate labels
HK1034291B (en) Analyte assay using particulate labels
AU2007200887A1 (en) Analyte Assay Using Particulate Labels

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: Genecom Inc.

Applicant before: Spectrametrix Inc.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: SPECTRAMETRIX INC. TO: RUNNICOM SCIENTIFIC CO., LTD.

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1020987

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060705

Termination date: 20140417