ATE403751T1 - Biokonjugat-nanopartikelsonden - Google Patents
Biokonjugat-nanopartikelsondenInfo
- Publication number
- ATE403751T1 ATE403751T1 AT02806838T AT02806838T ATE403751T1 AT E403751 T1 ATE403751 T1 AT E403751T1 AT 02806838 T AT02806838 T AT 02806838T AT 02806838 T AT02806838 T AT 02806838T AT E403751 T1 ATE403751 T1 AT E403751T1
- Authority
- AT
- Austria
- Prior art keywords
- bioconjugate
- nanoparticle probe
- probes
- nanoparticle
- dithiothreitol
- Prior art date
Links
- 239000000523 sample Substances 0.000 title abstract 3
- 239000002105 nanoparticle Substances 0.000 title 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34823901P | 2001-11-09 | 2001-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE403751T1 true ATE403751T1 (de) | 2008-08-15 |
Family
ID=28454565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02806838T ATE403751T1 (de) | 2001-11-09 | 2002-11-08 | Biokonjugat-nanopartikelsonden |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7186814B2 (de) |
| EP (1) | EP1466015B1 (de) |
| JP (1) | JP4220397B2 (de) |
| AT (1) | ATE403751T1 (de) |
| AU (1) | AU2002367817B2 (de) |
| CA (1) | CA2466656C (de) |
| DE (1) | DE60228128D1 (de) |
| WO (1) | WO2003081202A2 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984491B2 (en) * | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| US7169556B2 (en) | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6506564B1 (en) * | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6750016B2 (en) * | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US20050037397A1 (en) * | 2001-03-28 | 2005-02-17 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| US6974669B2 (en) * | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| EP1135682B1 (de) | 1998-11-30 | 2007-07-11 | Nanosphere, Inc. | Nanopartikel mit polymerschalen |
| US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
| CA2396113C (en) * | 2000-01-13 | 2009-04-07 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| DE60119170T2 (de) * | 2000-07-11 | 2007-05-24 | Northwestern University, Evanston | Nachweismethode mittels verstärkter silberfärbung |
| US20060040286A1 (en) * | 2001-03-28 | 2006-02-23 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| US20030113740A1 (en) * | 2001-04-26 | 2003-06-19 | Mirkin Chad A. | Oligonucleotide-modified ROMP polymers and co-polymers |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| US7147687B2 (en) | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| AU2005241112B2 (en) | 2001-07-13 | 2009-07-30 | Nanosphere, Inc. | Method for preparing substrates having immobilized molecules and substrates |
| US20060177852A1 (en) * | 2001-12-12 | 2006-08-10 | Do-Coop Technologies Ltd. | Solid-fluid composition |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| EP1540006B1 (de) * | 2002-07-02 | 2009-01-07 | Nanosphere, Inc. | Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten |
| JP2007524347A (ja) * | 2003-02-27 | 2007-08-30 | ナノスフェアー インコーポレイテッド | マイクロアレイ形式のアッセイにおける、万能ナノ粒子プローブを用いた標識不要の遺伝子発現プロファイリング |
| US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
| US7226636B2 (en) * | 2003-07-31 | 2007-06-05 | Los Alamos National Security, Llc | Gold-coated nanoparticles for use in biotechnology applications |
| JP4207754B2 (ja) * | 2003-10-31 | 2009-01-14 | 和光純薬工業株式会社 | 磁性体を用いた免疫学的測定方法 |
| US7396677B2 (en) * | 2003-11-07 | 2008-07-08 | Nanosphere, Inc. | Method of preparing nucleic acids for detection |
| US7906345B2 (en) | 2003-11-12 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
| EP1731905A4 (de) * | 2004-03-31 | 2012-08-22 | Shionogi & Co | Massenanalyseverfahren mit feinenmetallteilchen |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
| JP2008507296A (ja) * | 2004-07-26 | 2008-03-13 | ナノスフェアー インコーポレイテッド | 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法 |
| US20060134694A1 (en) * | 2004-12-22 | 2006-06-22 | Intel Corporation | Methods of protein profiling by thiolation |
| JP4791867B2 (ja) * | 2005-03-31 | 2011-10-12 | 日立マクセル株式会社 | 貴金属コート磁性粒子を用いた被検物質の検出方法 |
| WO2007002567A2 (en) * | 2005-06-23 | 2007-01-04 | Nanosphere, Inc. | Selective isolation and concentration of nucleic acids from complex samples |
| JP2009505106A (ja) * | 2005-08-19 | 2009-02-05 | ナノスフェアー インコーポレイテッド | Dna及び抗体を含むハイブリッド基板を調製するための方法及びその使用 |
| US20090004296A1 (en) * | 2006-01-04 | 2009-01-01 | Do-Coop Technologies Ltd. | Antiseptic Compositions and Methods of Using Same |
| US20090253613A1 (en) * | 2006-01-04 | 2009-10-08 | Do-Coop Technologies Ltd. | Solid-Fluid Composition |
| KR20080087148A (ko) * | 2006-01-04 | 2008-09-30 | 두-쿱 테크놀로지스 리미티드 | 저온보호 조성물 및 그 이용방법 |
| WO2008091364A2 (en) * | 2006-06-30 | 2008-07-31 | Intel Corporation | Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance |
| KR100828936B1 (ko) | 2006-08-01 | 2008-05-20 | 김성천 | 단일가닥핵산 압타머와 금-나노입자를 이용한 생체분자분석방법 |
| EP2122350A4 (de) * | 2007-01-04 | 2010-10-27 | Do Coop Technologies Ltd | Nachweis von analyten |
| JP2010515432A (ja) * | 2007-01-04 | 2010-05-13 | ドゥ−コープ テクノロジーズ リミテッド | 細胞増殖および細胞融合を高めるための組成物および方法 |
| CN101678090B (zh) | 2007-03-07 | 2012-04-11 | 乌第有限合伙公司 | 用于预防和治疗自身免疫病的组合物和方法 |
| US8597959B2 (en) * | 2007-04-19 | 2013-12-03 | 3M Innovative Properties Company | Methods of use of solid support material for binding biomolecules |
| US20100209946A1 (en) * | 2007-04-19 | 2010-08-19 | Naiyong Jing | Uses of water-dispersible silica nanoparticles for attaching biomolecules |
| KR101532064B1 (ko) | 2007-07-26 | 2015-06-26 | 아가매트릭스, 인코포레이티드 | 전기화학적 분석물 검출 장치 및 방법 |
| CN101868286A (zh) | 2007-09-20 | 2010-10-20 | 马格雷股份有限公司 | 采用磁性传感器进行的分析物检测 |
| US20090185113A1 (en) * | 2008-01-22 | 2009-07-23 | Industrial Technology Research Institute | Color Filter Module and Device of Having the Same |
| EP2419733A4 (de) | 2009-04-13 | 2013-12-25 | Univ Leland Stanford Junior | Verfahren und vorrichtungen zur erkennung des vorhandenseins eines analyts in einer probe |
| CN102459298A (zh) * | 2009-05-05 | 2012-05-16 | 阿尔特姆恩科技责任有限公司 | 化学可编程免疫 |
| US20100291541A1 (en) * | 2009-05-14 | 2010-11-18 | Evoy Stephane | Bacteriophage immobilization for biosensors |
| JP5937019B2 (ja) | 2010-03-12 | 2016-06-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 磁気センサに基づく結合反応速度の定量的な分析 |
| KR20130124487A (ko) | 2010-09-29 | 2013-11-14 | 유티아이 리미티드 파트너쉽 | 생체적합성, 생흡수성 나노구를 사용하는 자가면역 질병의 치료방법 |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| US9851308B2 (en) * | 2010-11-19 | 2017-12-26 | Wisconsin Alumni Research Foundation (Warf) | Visible detection of microorganisms |
| US20120258870A1 (en) | 2010-11-22 | 2012-10-11 | The University Of Chicago | Methods, Systems, and/or Use of Oligonucleotide Conjugates to Develop Panels for Use in Assays and Detections |
| JP6101215B2 (ja) | 2011-03-09 | 2017-03-22 | マグアレイ,インコーポレイテッド | サンプル中の分析対象物に対するハイスループット検出を行うシステム及び方法 |
| US8946389B2 (en) * | 2011-04-25 | 2015-02-03 | University Of Washington | Compositions and methods for multiplex biomarker profiling |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| US9982292B2 (en) | 2012-09-28 | 2018-05-29 | Src, Inc. | Detecting chemical and biological agents using textile-based sensors |
| US9512468B2 (en) | 2012-11-06 | 2016-12-06 | Industrial Technology Research Institute | Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto |
| JP6422935B2 (ja) | 2013-03-15 | 2018-11-14 | マグアレイ,インコーポレイテッド | 磁気トンネル接合センサ及びその使用方法 |
| JP6463750B2 (ja) * | 2013-10-23 | 2019-02-06 | ケムジーンズ コーポレーション | 固体表面上に生体分子をより強力に固定化するためのジチオラン官能化ヌクレオシドアミダイトおよび担体 |
| KR101718867B1 (ko) * | 2014-06-02 | 2017-03-22 | 한국과학기술연구원 | 생체적합성 형광 나노입자 및 이의 용도 |
| CN104894097B (zh) * | 2015-05-09 | 2018-11-06 | 浙江省农业科学院 | 一种长效净水菌胶囊及其制备方法 |
| CN104909463A (zh) * | 2015-05-09 | 2015-09-16 | 浙江省农业科学院 | 一种核壳结构净水菌胶囊及其制备方法 |
| JP6752231B2 (ja) | 2015-06-01 | 2020-09-09 | カリフォルニア インスティテュート オブ テクノロジー | 抗原を用いて特異的集団に関してt細胞をスクリーニングするための組成物および方法 |
| WO2018165475A1 (en) | 2017-03-08 | 2018-09-13 | California Institute Of Technology | Pairing antigen specificity of a t cell with t cell receptor sequences |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| CN113311047B (zh) * | 2021-05-06 | 2022-06-21 | 复旦大学 | 一种纳米金颗粒修饰的伪mos生化分子传感器及其制备方法 |
| US20250188521A1 (en) | 2022-03-10 | 2025-06-12 | Singular Genomics Systems, Inc. | Nucleic acid delivery scaffolds |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4193983A (en) | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
| NL7807532A (nl) | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
| US4318707A (en) | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
| US4256834A (en) | 1979-04-09 | 1981-03-17 | Syva Company | Fluorescent scavenger particle immunoassay |
| US4261968A (en) | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4650770A (en) | 1981-04-27 | 1987-03-17 | Syntex (U.S.A.) Inc. | Energy absorbing particle quenching in light emitting competitive protein binding assays |
| US4713348A (en) | 1983-04-05 | 1987-12-15 | Syntex (U.S.A.) Inc. | Fluorescent multiparameter particle analysis |
| US5288609A (en) * | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US4868104A (en) | 1985-09-06 | 1989-09-19 | Syntex (U.S.A.) Inc. | Homogeneous assay for specific polynucleotides |
| US4996143A (en) * | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US5514602A (en) | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
| US5360895A (en) * | 1987-04-22 | 1994-11-01 | Associated Universities, Inc. | Derivatized gold clusters and antibody-gold cluster conjugates |
| US4853335A (en) | 1987-09-28 | 1989-08-01 | Olsen Duane A | Colloidal gold particle concentration immunoassay |
| GB8800702D0 (en) | 1988-01-13 | 1988-02-10 | Nycomed As | Test method & reagent kit therefor |
| WO1990002205A1 (en) | 1988-08-25 | 1990-03-08 | Angenics, Inc. | Detection of nucleic acid sequences using particle agglutination |
| US5460831A (en) | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Targeted transfection nanoparticles |
| GB9019512D0 (en) | 1990-09-06 | 1990-10-24 | Ici Plc | Assay method |
| JPH06510363A (ja) * | 1990-10-29 | 1994-11-17 | ディカルブ プラント ジェネティクス | 磁気性粒子を使用する生物学的材料の単離 |
| US5665582A (en) | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
| US5294369A (en) | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
| WO1993010564A1 (en) * | 1991-11-22 | 1993-05-27 | The Regents Of The University Of California | Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers |
| US5225064A (en) | 1992-01-15 | 1993-07-06 | Enzyme Technology Research Group, Inc. | Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination |
| GB9212164D0 (en) | 1992-06-09 | 1992-07-22 | Medical Res Council | Preparation of nucleic acids |
| US5472881A (en) * | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| US5637508A (en) * | 1993-03-26 | 1997-06-10 | Geo-Centers, Inc. | Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same |
| US5384265A (en) * | 1993-03-26 | 1995-01-24 | Geo-Centers, Inc. | Biomolecules bound to catalytic inorganic particles, immunoassays using the same |
| US5681943A (en) | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
| AU690124B2 (en) | 1993-06-09 | 1998-04-23 | Gamera Bioscience Corporation | Magnetic cycle reaction |
| EP0630974A3 (de) | 1993-06-25 | 1995-11-15 | Clinical Diagnostic Syst | Verfahren und Testkit zum Nachweis von anorganischen Orthophosphat bei der Amplifizierung von Zielnukleinsäuren. |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| JPH07227299A (ja) | 1994-02-14 | 1995-08-29 | Kyoto Daiichi Kagaku:Kk | Dnaの特定塩基配列の検出方法及びその装置 |
| US6121425A (en) * | 1994-07-29 | 2000-09-19 | Nanoprobes, Inc. | Metal-lipid molecules |
| US5521289A (en) * | 1994-07-29 | 1996-05-28 | Nanoprobes, Inc. | Small organometallic probes |
| US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
| US6025202A (en) | 1995-02-09 | 2000-02-15 | The Penn State Research Foundation | Self-assembled metal colloid monolayers and detection methods therewith |
| US5609907A (en) | 1995-02-09 | 1997-03-11 | The Penn State Research Foundation | Self-assembled metal colloid monolayers |
| US6586193B2 (en) | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
| JP2000510582A (ja) | 1996-04-25 | 2000-08-15 | ゼニコン・サイエンシーズ・コーポレーション | 微粒子標識を使用した分析物アッセイ |
| DE69737598T2 (de) | 1996-07-29 | 2007-12-27 | Nanosphere Inc., Skokie | Nanopartikel mit daran angehefteten oligonukleotiden sowie deren verwendungen |
| US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US20020172953A1 (en) | 1996-07-29 | 2002-11-21 | Mirkin Chad A. | Movement of biomolecule-coated nanoparticles in an electric field |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6242264B1 (en) | 1996-09-04 | 2001-06-05 | The Penn State Research Foundation | Self-assembled metal colloid monolayers having size and density gradients |
| WO1998017317A2 (de) | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten |
| US5830986A (en) | 1996-10-28 | 1998-11-03 | Massachusetts Institute Of Technology | Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US5922537A (en) * | 1996-11-08 | 1999-07-13 | N.o slashed.AB Immunoassay, Inc. | Nanoparticles biosensor |
| US5939021A (en) * | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
| US6149868A (en) | 1997-10-28 | 2000-11-21 | The Penn State Research Foundation | Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches |
| AUPP004497A0 (en) | 1997-10-28 | 1997-11-20 | University Of Melbourne, The | Stabilized particles |
| JP2002509443A (ja) | 1997-10-31 | 2002-03-26 | ジェン−プローブ・インコーポレーテッド | 核酸検出法 |
| US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US5972615A (en) * | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| US6287765B1 (en) | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
| US6290839B1 (en) * | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| US6251303B1 (en) | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
| US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| EP1135682B1 (de) | 1998-11-30 | 2007-07-11 | Nanosphere, Inc. | Nanopartikel mit polymerschalen |
| US6277489B1 (en) | 1998-12-04 | 2001-08-21 | The Regents Of The University Of California | Support for high performance affinity chromatography and other uses |
| WO2001000876A1 (en) | 1999-06-25 | 2001-01-04 | Mirkin Chad A | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| EP1208663A4 (de) | 1999-08-03 | 2005-07-27 | Polycom Inc | Vorrichtung und verfahren zur gesicherten datenübertragung in einem drahtlosen kommunikationssystem |
| CA2396113C (en) | 2000-01-13 | 2009-04-07 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| CA2402955C (en) | 2000-03-28 | 2010-03-09 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| AU5667901A (en) | 2000-05-11 | 2001-11-20 | Center For Advanced Science And Technology Incubation, Ltd. | Polymer composition for forming surface of biosensor |
| DE60119170T2 (de) | 2000-07-11 | 2007-05-24 | Northwestern University, Evanston | Nachweismethode mittels verstärkter silberfärbung |
| CA2418502A1 (en) | 2000-08-11 | 2002-03-07 | Nanosphere Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| CN1507357A (zh) | 2000-10-31 | 2004-06-23 | PRҩƷ����˾ | 提高生物活性分子传递的方法和组合物 |
| WO2002046483A2 (en) | 2000-12-06 | 2002-06-13 | Northwestern University | Silver stain removal from dna detection chips by cyanide etching or sonication |
| WO2002046472A2 (en) | 2000-12-08 | 2002-06-13 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| WO2002079514A1 (en) * | 2001-01-10 | 2002-10-10 | The Trustees Of Boston College | Dna-bridged carbon nanotube arrays |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| US7147687B2 (en) | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| ATE423975T1 (de) | 2001-08-03 | 2009-03-15 | Nanosphere Inc | Nanopartikelabbildungssystem und -verfahren |
| CA2508359A1 (en) | 2002-12-12 | 2004-06-24 | Nanosphere, Inc. | Direct snp detection with unamplified dna |
-
2002
- 2002-11-08 US US10/291,291 patent/US7186814B2/en not_active Expired - Lifetime
- 2002-11-08 EP EP02806838A patent/EP1466015B1/de not_active Expired - Lifetime
- 2002-11-08 DE DE60228128T patent/DE60228128D1/de not_active Expired - Lifetime
- 2002-11-08 JP JP2003578887A patent/JP4220397B2/ja not_active Expired - Lifetime
- 2002-11-08 AU AU2002367817A patent/AU2002367817B2/en not_active Ceased
- 2002-11-08 WO PCT/US2002/035888 patent/WO2003081202A2/en not_active Ceased
- 2002-11-08 CA CA2466656A patent/CA2466656C/en not_active Expired - Lifetime
- 2002-11-08 AT AT02806838T patent/ATE403751T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2466656A1 (en) | 2003-10-02 |
| EP1466015A4 (de) | 2007-02-28 |
| US7186814B2 (en) | 2007-03-06 |
| CA2466656C (en) | 2013-07-02 |
| EP1466015B1 (de) | 2008-08-06 |
| WO2003081202A2 (en) | 2003-10-02 |
| JP4220397B2 (ja) | 2009-02-04 |
| AU2002367817A1 (en) | 2003-10-08 |
| JP2005519627A (ja) | 2005-07-07 |
| DE60228128D1 (de) | 2008-09-18 |
| AU2002367817B2 (en) | 2008-05-29 |
| EP1466015A2 (de) | 2004-10-13 |
| US20030143598A1 (en) | 2003-07-31 |
| WO2003081202A3 (en) | 2004-07-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE403751T1 (de) | Biokonjugat-nanopartikelsonden | |
| Lee et al. | A simple and facile paper-based colorimetric assay for detection of free hydrogen sulfide in prostate cancer cells | |
| Jones et al. | Analogues of thiolactomycin as potential antimalarial agents | |
| WO2006128138A3 (en) | Biodetection by nucleic acid-templated chemistry | |
| ATE530911T1 (de) | Bindungsproteine als biosensoren | |
| WO2008054600A3 (en) | Compositions and methods for biodetection by nucleic acid-templated chemistry | |
| AR014835A1 (es) | Instrumento para medir las propiedades compresivas de un cuerpo | |
| WO2004022721A3 (en) | Quantification of gene expression | |
| BRPI0406715A (pt) | Inibidores seletivos de ciclooxigenase-2 antiinflamatórios | |
| Gratz et al. | A CE‐based assay for human protein kinase CK2 activity measurement and inhibitor screening | |
| EP1987166A4 (de) | Binäre deoxyribozym-sonden zur nukleinsäure-analyse | |
| Parveen et al. | Plumbagin as colorimetric and ratiometric sensor for arginine | |
| DK1381697T3 (da) | Cirkulær probe-amplifikation (CPA) af ringformede nukleinsyremolekyler | |
| CY1112553T1 (el) | Ανοσοπροσδιορισμοι υψηλης ευαισθησιας και κιτια για τον προσδιορισμο πεπτιδιων και πρωτεϊνων βιολογικου ενδιαφεροντος | |
| Hu et al. | A sensitive and selective fluorescent probe for detection of glutathione in the presence of Cu2+ and its application to biological imaging | |
| KR100711046B1 (ko) | 대장암에 대한 마커로서의 니코틴아미드n―메틸트랜스퍼라아제의 용도 | |
| Hamajima et al. | Site-selective synthetic acylation of a target protein in living cells promoted by a chemical catalyst/donor system | |
| EP1838867A4 (de) | Apolipoprotein-a-ii-isoform als biomarker für prostatakrebs | |
| Chen et al. | Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases | |
| Heal et al. | Getting a chemical handle on protein post-translational modification | |
| WO2003048732A3 (en) | Multiplexed methylation detection methods | |
| Liu et al. | A highly selective fluorescent chemodosimeter for imaging hydrogen sulfide in living cells | |
| WO2005124356A3 (en) | Use of protein cbp2 as a marker for colorectal cancer | |
| DE60113811D1 (de) | NACHWEIS DER BINDUNG VON Ladungsträgern mittels PH- ODER POTENTiaL-SENSITIVEr SONDEN | |
| BR0213997A (pt) | Métodos de detecção e identificação de bactérias entéricas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |