CN1299347A - 磷脂酶抑制剂 - Google Patents

磷脂酶抑制剂 Download PDF

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Publication number
CN1299347A
CN1299347A CN99805385A CN99805385A CN1299347A CN 1299347 A CN1299347 A CN 1299347A CN 99805385 A CN99805385 A CN 99805385A CN 99805385 A CN99805385 A CN 99805385A CN 1299347 A CN1299347 A CN 1299347A
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CN
China
Prior art keywords
alkyl
methyl
phenyl
compound
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99805385A
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English (en)
Chinese (zh)
Inventor
J·S·赛拉
N·凯拉
J·C·麦库
F·洛夫林
J·E·贝米斯
Y·B·向
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of CN1299347A publication Critical patent/CN1299347A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN99805385A 1998-02-25 1999-02-24 磷脂酶抑制剂 Pending CN1299347A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3006298A 1998-02-25 1998-02-25
US09/030062 1998-02-25

Publications (1)

Publication Number Publication Date
CN1299347A true CN1299347A (zh) 2001-06-13

Family

ID=21852314

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99805385A Pending CN1299347A (zh) 1998-02-25 1999-02-24 磷脂酶抑制剂

Country Status (19)

Country Link
EP (1) EP1056719A2 (id)
JP (1) JP2002504539A (id)
KR (1) KR20010041343A (id)
CN (1) CN1299347A (id)
AU (1) AU2782699A (id)
BG (1) BG104780A (id)
BR (1) BR9908280A (id)
CA (1) CA2322161A1 (id)
EA (1) EA200000868A1 (id)
EE (1) EE200000486A (id)
HR (1) HRP20000552A2 (id)
HU (1) HUP0100757A3 (id)
ID (1) ID27280A (id)
IL (1) IL137718A0 (id)
NO (1) NO20004220L (id)
PL (1) PL342995A1 (id)
SK (1) SK12742000A3 (id)
TR (1) TR200002446T2 (id)
WO (1) WO1999043651A2 (id)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100503566C (zh) * 2001-12-03 2009-06-24 惠氏公司 细胞溶质磷脂酶a2抑制剂
CN101628888B (zh) * 2001-12-03 2012-05-23 惠氏公司 细胞溶质磷脂酶a2抑制剂
CN102040550B (zh) * 2005-05-27 2012-10-03 惠氏公司 胞质磷脂酶a2抑制剂

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US7291639B2 (en) 2001-06-20 2007-11-06 Wyeth Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
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US7189751B2 (en) * 2001-06-25 2007-03-13 Nippon Soda Co., Ltd. Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
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US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
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CN1726190A (zh) 2002-12-10 2006-01-25 惠氏公司 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN100503566C (zh) * 2001-12-03 2009-06-24 惠氏公司 细胞溶质磷脂酶a2抑制剂
CN101628888B (zh) * 2001-12-03 2012-05-23 惠氏公司 细胞溶质磷脂酶a2抑制剂
CN102040550B (zh) * 2005-05-27 2012-10-03 惠氏公司 胞质磷脂酶a2抑制剂

Also Published As

Publication number Publication date
TR200002446T2 (tr) 2000-12-21
WO1999043651A2 (en) 1999-09-02
BR9908280A (pt) 2000-10-31
KR20010041343A (ko) 2001-05-15
CA2322161A1 (en) 1999-09-02
EA200000868A1 (ru) 2001-04-23
HUP0100757A3 (en) 2001-11-28
EP1056719A2 (en) 2000-12-06
SK12742000A3 (sk) 2001-05-10
BG104780A (en) 2001-10-31
NO20004220D0 (no) 2000-08-23
PL342995A1 (en) 2001-07-16
NO20004220L (no) 2000-10-05
IL137718A0 (en) 2001-10-31
JP2002504539A (ja) 2002-02-12
HRP20000552A2 (en) 2001-04-30
ID27280A (id) 2001-03-22
HUP0100757A1 (hu) 2001-08-28
AU2782699A (en) 1999-09-15
EE200000486A (et) 2002-02-15
WO1999043651A3 (en) 1999-12-16

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