DK1569899T3 - Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) - Google Patents

Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)

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Publication number
DK1569899T3
DK1569899T3 DK03796792T DK03796792T DK1569899T3 DK 1569899 T3 DK1569899 T3 DK 1569899T3 DK 03796792 T DK03796792 T DK 03796792T DK 03796792 T DK03796792 T DK 03796792T DK 1569899 T3 DK1569899 T3 DK 1569899T3
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Prior art keywords
sub
pai
indol
arylalkyl
inhibitors
Prior art date
Application number
DK03796792T
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English (en)
Inventor
Lee Dalton Jennings
Scott Lee Kincaid
Original Assignee
Wyeth Corp
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Publication of DK1569899T3 publication Critical patent/DK1569899T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
DK03796792T 2002-12-10 2003-12-09 Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) DK1569899T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43233002P 2002-12-10 2002-12-10

Publications (1)

Publication Number Publication Date
DK1569899T3 true DK1569899T3 (da) 2006-10-23

Family

ID=32507902

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03796792T DK1569899T3 (da) 2002-12-10 2003-12-09 Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)

Country Status (13)

Country Link
US (1) US7348351B2 (da)
EP (1) EP1569899B1 (da)
JP (1) JP2006514640A (da)
CN (1) CN1723197A (da)
AT (1) ATE331708T1 (da)
AU (1) AU2003297727A1 (da)
BR (1) BR0316583A (da)
CA (1) CA2509170A1 (da)
DE (1) DE60306547T2 (da)
DK (1) DK1569899T3 (da)
ES (1) ES2268480T3 (da)
MX (1) MXPA05006282A (da)
WO (1) WO2004052853A2 (da)

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CN1723197A (zh) 2006-01-18
MXPA05006282A (es) 2005-08-19
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WO2004052853A2 (en) 2004-06-24
DE60306547T2 (de) 2007-06-28
US7348351B2 (en) 2008-03-25
US20040116488A1 (en) 2004-06-17
ATE331708T1 (de) 2006-07-15
AU2003297727A1 (en) 2004-06-30
WO2004052853A3 (en) 2004-09-16
ES2268480T3 (es) 2007-03-16
BR0316583A (pt) 2005-10-04

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