CN1318103A - 肺炎链球菌的核酸和蛋白质 - Google Patents

肺炎链球菌的核酸和蛋白质 Download PDF

Info

Publication number
CN1318103A
CN1318103A CN99810978A CN99810978A CN1318103A CN 1318103 A CN1318103 A CN 1318103A CN 99810978 A CN99810978 A CN 99810978A CN 99810978 A CN99810978 A CN 99810978A CN 1318103 A CN1318103 A CN 1318103A
Authority
CN
China
Prior art keywords
protein
sequence
polypeptide
streptococcus pneumoniae
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99810978A
Other languages
English (en)
Chinese (zh)
Inventor
R·W·F·勒佩吉
J·M·威尔斯
S·B·汉尼福
P·M·汉斯布罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Technics Ltd
Original Assignee
Microbial Technics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9816336.3A external-priority patent/GB9816336D0/en
Application filed by Microbial Technics Ltd filed Critical Microbial Technics Ltd
Publication of CN1318103A publication Critical patent/CN1318103A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN99810978A 1998-07-27 1999-07-27 肺炎链球菌的核酸和蛋白质 Pending CN1318103A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9816336.3 1998-07-27
GBGB9816336.3A GB9816336D0 (en) 1998-07-27 1998-07-27 Proteins
US12532999P 1999-03-19 1999-03-19
US60/125,329 1999-03-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101283898A Division CN101108877A (zh) 1998-07-27 1999-07-27 肺炎链球菌的核酸和蛋白质

Publications (1)

Publication Number Publication Date
CN1318103A true CN1318103A (zh) 2001-10-17

Family

ID=26314124

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99810978A Pending CN1318103A (zh) 1998-07-27 1999-07-27 肺炎链球菌的核酸和蛋白质

Country Status (4)

Country Link
EP (1) EP1144640A3 (fr)
JP (2) JP2002521058A (fr)
CN (1) CN1318103A (fr)
WO (1) WO2000006738A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155833B (zh) * 2005-04-08 2011-04-20 惠氏公司 通过pH操作将污染物与肺炎链球菌多糖分离
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
CA2341268C (fr) 1998-07-22 2010-10-12 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Vaccins contre le streptococcus suis et tests diagnostiques
EP1950302B1 (fr) * 1998-12-23 2012-12-05 ID Biomedical Corporation of Quebec Nouveaux antigènes de streptocoque
KR100802198B1 (ko) * 1998-12-23 2008-02-11 샤이어 바이오켐 인코포레이티드 신규한 스트렙토코커스 항원
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
WO2000076540A2 (fr) * 1999-06-10 2000-12-21 Med Immune, Inc. Proteines et vaccins de streptococcus pneumoniae
US6887480B1 (en) 1999-06-10 2005-05-03 Medimmune, Inc. Streptococcus pneumoniae proteins and vaccines
DE10012370A1 (de) * 2000-03-14 2001-09-27 Chiron Behring Gmbh & Co Adjuvans für Vakzinen
US7074415B2 (en) 2000-06-20 2006-07-11 Id Biomedical Corporation Streptococcus antigens
EP1205552A1 (fr) * 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence de streptococci, avec ORFs de Streptococcus suis
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0108079D0 (en) * 2001-03-30 2001-05-23 Microbial Technics Ltd Protein
EP1456231A2 (fr) 2001-12-20 2004-09-15 Shire Biochem Inc. Antigenes de streptococcus
AU2003286056A1 (en) * 2002-11-26 2004-06-18 Id Biomedical Corporation Streptococcus pneumoniae surface polypeptides
EP2333114A1 (fr) * 2003-04-15 2011-06-15 Intercell AG S. pneumoniae antigènes
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
ES2546213T3 (es) 2008-03-03 2015-09-21 Novartis Ag Compuestos y composiciones como moduladores de la actividad de TLR
CN101977927A (zh) * 2008-03-17 2011-02-16 英特塞尔股份公司 针对肺炎链球菌保护的肽以及与其有关的组合物、方法和用途
EP2218457B1 (fr) * 2009-02-16 2011-09-07 Karlsruher Institut für Technologie Peptides CD44v6 en tant qu'inhibiteurs d'infections bactériennes
CA2765112A1 (fr) 2009-06-10 2010-12-16 Novartis Ag Vaccins contenant de la benzonaphtyridine
CN107126557A (zh) 2009-06-29 2017-09-05 健诺西生物科学公司 抗肺炎链球菌的疫苗和组合物
AU2010290896B2 (en) 2009-09-02 2014-07-03 Glaxosmithkline Biologicals S.A. Immunogenic compositions including TLR activity modulators
JO3257B1 (ar) 2009-09-02 2018-09-16 Novartis Ag مركبات وتركيبات كمعدلات لفاعلية tlr
WO2011030218A1 (fr) 2009-09-10 2011-03-17 Novartis Ag Vaccins combinés contre les maladies des voies respiratoires
WO2011057148A1 (fr) 2009-11-05 2011-05-12 Irm Llc Composés et compositions permettant de moduler l'activité des tlr-7
US9408907B2 (en) 2009-12-15 2016-08-09 Glaxosmithkline Biologicals Sa Homogenous suspension of immunopotentiating compounds and uses thereof
EP3165531B1 (fr) 2010-03-12 2020-11-25 Children's Medical Center Corporation Composition immunogène, vaccin et leurs utilisations
AU2011232421B2 (en) 2010-03-23 2015-08-13 Novartis Ag Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc.
WO2012072769A1 (fr) 2010-12-01 2012-06-07 Novartis Ag Epitopes rrgb de pneumocoque et combinaisons de variantes
WO2012100234A1 (fr) 2011-01-20 2012-07-26 Genocea Biosciences, Inc. Vaccins et compositions contre streptococcus pneumoniae
CN104519910B (zh) 2012-03-07 2017-05-03 诺华股份有限公司 肺炎链球菌抗原的含佐剂制剂
TR201807340T4 (tr) 2013-02-01 2018-06-21 Glaxosmithkline Biologicals Sa Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi.
CA2900008C (fr) 2013-02-07 2025-10-07 Children's Medical Center Corporation Antigenes de proteine qui conferent une protection contre une colonisation et/ou une maladie pneumococcique
PL3752182T3 (pl) 2018-02-12 2024-11-25 Inimmune Corporation Ligandy receptorów toll-podobnych
IL281204B2 (en) 2018-09-12 2025-07-01 Affinivax Inc Multivalent pneumococcal vaccines
TWI852943B (zh) * 2018-09-12 2024-08-21 美商兒童醫療中心公司 肺炎鏈球菌融合蛋白疫苗
CA3198876A1 (fr) 2020-11-04 2022-05-12 Eligo Bioscience Phages recombinants de cutibacterium acnes, leur procede de production et leurs utilisations
AU2022342080A1 (en) 2021-09-09 2024-03-28 Affinivax, Inc. Multivalent pneumococcal vaccines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928900A (en) * 1993-09-01 1999-07-27 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1997037026A1 (fr) * 1996-04-02 1997-10-09 Smithkline Beecham Corporation Nouveaux composes
WO1997043304A1 (fr) * 1996-05-14 1997-11-20 Smithkline Beecham Corporation Composes de type nouveau
CA2271720A1 (fr) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Polynucleotides et sequences de streptococcus pneumoniae
US6271000B1 (en) * 1996-12-13 2001-08-07 Eli Lilly And Company Streptococcus pneumoniae gene sequence mraY
GB9700939D0 (en) * 1997-01-17 1997-03-05 Microbial Technics Limited Therapy

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155833B (zh) * 2005-04-08 2011-04-20 惠氏公司 通过pH操作将污染物与肺炎链球菌多糖分离
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
CN103834667B (zh) * 2013-12-31 2016-08-17 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用

Also Published As

Publication number Publication date
JP2008022856A (ja) 2008-02-07
WO2000006738A3 (fr) 2001-08-23
EP1144640A2 (fr) 2001-10-17
JP2002521058A (ja) 2002-07-16
WO2000006738A2 (fr) 2000-02-10
EP1144640A3 (fr) 2001-11-28

Similar Documents

Publication Publication Date Title
US12599637B2 (en) Genetically modified Lactobacillus and uses thereof
JP2008022856A (ja) 肺炎連鎖球菌由来の核酸及びタンパク質
US8101187B2 (en) Secreted Streptococcus pneumoniae proteins
JP6262728B2 (ja) 弱毒化ストレプトコッカス・スイスワクチン並びにその製造方法及び使用
JP2009148283A (ja) 肺炎連鎖球菌のタンパク質及び核酸分子
JP2009077713A (ja) アイメリア・マキシマ（Ｅｉｍｅｒｉａｍａｘｉｍａ）の配偶子母細胞由来の組換え５６及び８２ｋＤａ各抗原をコードする核酸及びその使用
TWI224107B (en) Novel proteins from actinobacillus pleuropneumoniae
CN110582296B (zh) 通过减弱细菌叶酸转运来减弱细菌毒力
DK2450054T3 (en) New virulence factors of Streptococcus pneumoniae
AU2005203189B2 (en) Anti-bacterial vaccine compositions
Fatehi et al. Oral vaccination with novel Lactococcus lactis mucosal live vector-secreting Brucella lumazine synthase (BLS) protein induces humoral and cellular immune protection against Brucella abortus
CN1215729A (zh) 产气荚膜梭状芽孢杆菌疫苗
CN1345375A (zh) 肺炎链球菌抗原
Wong et al. Recombinant lactococcal-based oral vaccine for protection against Streptococcus agalactiae infections in tilapia (Oreochromis niloticus)
US9493519B2 (en) Toxin in type A Clostridium perfringens
CN1226414C (zh) 乳房链球菌的camp因子
KR101845571B1 (ko) 전통적 돼지열에 대한 마커 백신
US8632784B2 (en) Nucleic acids and proteins from Streptococcus pneumoniae
CN1367833B (zh) 肺炎链球菌的蛋白质和核酸分子
JP2002514657A (ja) モラクセラ・カタラリス蛋白質
CN101108877A (zh) 肺炎链球菌的核酸和蛋白质
EP1624064A2 (fr) Acides nucléiques et protéines de streptococcus pneumoniae
EP1801218A2 (fr) Acides nucléiques et protéines de la pneumonie à streptocoques
CN121219006A (zh) 用于马链球菌兽疫亚种的疫苗
AU2013201267B2 (en) Anti-bacterial vaccine compositions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication