CN1450896A - 用吲哚衍生物降低眼内压的方法 - Google Patents

用吲哚衍生物降低眼内压的方法 Download PDF

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Publication number
CN1450896A
CN1450896A CN01815096A CN01815096A CN1450896A CN 1450896 A CN1450896 A CN 1450896A CN 01815096 A CN01815096 A CN 01815096A CN 01815096 A CN01815096 A CN 01815096A CN 1450896 A CN1450896 A CN 1450896A
Authority
CN
China
Prior art keywords
indole
unsubstituted
ethyl
acetylaminohydroxyphenylarsonic acid
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01815096A
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English (en)
Chinese (zh)
Inventor
J·J·平特
M·A·佩拉尔
W·M·彼德森
R·小普罗德
E·G·布朗
B·R·耶扎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Complutense Madrid, University of
Inspire Pharmaceuticals Inc
Original Assignee
Complutense Madrid, University of
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200001916A external-priority patent/ES2172415B2/es
Application filed by Complutense Madrid, University of, Inspire Pharmaceuticals Inc filed Critical Complutense Madrid, University of
Publication of CN1450896A publication Critical patent/CN1450896A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN01815096A 2000-07-28 2001-07-27 用吲哚衍生物降低眼内压的方法 Pending CN1450896A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200001916 2000-07-28
ES200001916A ES2172415B2 (es) 2000-07-28 2000-07-28 Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina.
US27688501P 2001-03-16 2001-03-16
US60/276,885 2001-03-16

Publications (1)

Publication Number Publication Date
CN1450896A true CN1450896A (zh) 2003-10-22

Family

ID=26156193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01815096A Pending CN1450896A (zh) 2000-07-28 2001-07-27 用吲哚衍生物降低眼内压的方法

Country Status (9)

Country Link
EP (1) EP1307191A2 (fr)
JP (1) JP2004518612A (fr)
KR (1) KR20030046395A (fr)
CN (1) CN1450896A (fr)
AR (1) AR035651A1 (fr)
AU (1) AU2001280984A1 (fr)
CA (1) CA2417489A1 (fr)
MX (1) MXPA03000729A (fr)
WO (1) WO2002009702A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102712584A (zh) * 2009-11-23 2012-10-03 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法
CN116782896A (zh) * 2020-09-02 2023-09-19 恩维瑞克生物科学加拿大公司 硝化裸盖菇素衍生物及其用于调节5-ht2a受体和治疗精神障碍的用途
CN118575786A (zh) * 2024-05-08 2024-09-03 杭州环特优检生物科技有限公司 一种斑马鱼失眠的造模方法及其应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084128B2 (en) 2002-01-18 2006-08-01 Inspire Pharmaceuticals, Inc. Method for reducing intraocular pressure
JP4324480B2 (ja) 2002-03-26 2009-09-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物、及び使用
ES2397574T3 (es) 2002-07-30 2013-03-08 Omeros Corporation Procedimiento y soluciones de irrigación oftalmológica
NZ538932A (en) * 2002-08-29 2007-04-27 Boehringer Ingelheim Pharma 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative disease
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
WO2005107787A1 (fr) 2004-05-06 2005-11-17 Molichem Medicines, Inc. Traitement de maladies et troubles associes aux membranes au moyen de compositions contenant des lantibiotiques
CA2565545A1 (fr) 2004-05-06 2005-12-08 Molichem Medicines, Inc. Traitement de maladies et de troubles oculaires utilisant des compositions lantibiotiques
PE20060776A1 (es) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
MX2009005264A (es) 2006-12-06 2009-05-28 Boehringer Ingelheim Int Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
JP5535910B2 (ja) 2007-08-28 2014-07-02 バクスター・インターナショナル・インコーポレイテッド ウイルスワクチンを生産する方法
DK2300472T3 (da) 2008-06-06 2012-04-10 Boehringer Ingelheim Int Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf
JP2013516495A (ja) 2010-01-11 2013-05-13 イノテック ファーマシューティカルズ コーポレイション 眼圧を低下させる組合せ、キット、および方法
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
SMT201700377T1 (it) 2012-01-26 2017-09-07 Inotek Pharmaceuticals Corp Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
NZ630759A (en) 2013-03-15 2017-07-28 Inotek Pharmaceuticals Corp Ophthalmic formulations comprising an a1 agonist
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
LT3860998T (lt) 2018-10-05 2024-06-25 Annapurna Bio Inc. Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu
WO2023044556A1 (fr) 2021-09-24 2023-03-30 Enveric Biosciences Canada Inc. Dérivés de psilocybine aminés et procédés d'utilisation
SMT202500447T1 (it) 2021-11-02 2026-01-12 Flare Therapeutics Inc Agonisti inversi di pparg e loro usi

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654361A (en) * 1986-01-27 1987-03-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Method of lowering intraocular pressure using melatonin
WO1989001472A1 (fr) * 1987-08-17 1989-02-23 Nelson Research & Development Co. Composes analogues de la melatonine
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
FR2737725B1 (fr) * 1995-08-08 1997-10-31 Valentonine Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102712584A (zh) * 2009-11-23 2012-10-03 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法
CN102712584B (zh) * 2009-11-23 2014-10-29 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法
CN116782896A (zh) * 2020-09-02 2023-09-19 恩维瑞克生物科学加拿大公司 硝化裸盖菇素衍生物及其用于调节5-ht2a受体和治疗精神障碍的用途
CN118575786A (zh) * 2024-05-08 2024-09-03 杭州环特优检生物科技有限公司 一种斑马鱼失眠的造模方法及其应用

Also Published As

Publication number Publication date
KR20030046395A (ko) 2003-06-12
WO2002009702A3 (fr) 2002-12-27
WO2002009702A2 (fr) 2002-02-07
MXPA03000729A (es) 2004-11-01
EP1307191A2 (fr) 2003-05-07
AR035651A1 (es) 2004-06-23
JP2004518612A (ja) 2004-06-24
WO2002009702A8 (fr) 2003-05-08
CA2417489A1 (fr) 2002-02-07
AU2001280984A1 (en) 2002-02-13

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WD01 Invention patent application deemed withdrawn after publication