CN1575302A - 人组织因子抗体 - Google Patents

人组织因子抗体 Download PDF

Info

Publication number: CN1575302A
Authority: CN; China
Prior art keywords: antibody; value; rfviia; ffr; people
Prior art date: 2001-10-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CNA028208463A

Other languages

English (en)

Chinese (zh)

Inventor

P－O·弗瑞斯克加尔德

J·T·克劳森

B·B·瑟林森

M·克加尔克

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-02

Filing date

2002-09-30

Publication date

2005-02-02

2002-09-30 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2005-02-02 Publication of CN1575302A publication Critical patent/CN1575302A/zh

Status Pending legal-status Critical Current

Links

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Biophysics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CNA028208463A 2001-10-02 2002-09-30 人组织因子抗体 Pending CN1575302A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200101437		2001-10-02
DKPA200101437		2001-10-02

Publications (1)

Publication Number	Publication Date
CN1575302A true CN1575302A (zh)	2005-02-02

Family

ID=8160743

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNA028208463A Pending CN1575302A (zh)	2001-10-02	2002-09-30	人组织因子抗体

Country Status (15)

Country	Link
EP (1)	EP1434802A1 (cs)
JP (1)	JP2005512970A (cs)
KR (1)	KR20040045478A (cs)
CN (1)	CN1575302A (cs)
BR (1)	BR0213046A (cs)
CA (1)	CA2460917A1 (cs)
CZ (1)	CZ2004454A3 (cs)
HU (1)	HUP0401658A2 (cs)
IL (1)	IL160998A0 (cs)
MX (1)	MXPA04003051A (cs)
NO (1)	NO20041802L (cs)
PL (1)	PL368989A1 (cs)
RU (1)	RU2004113373A (cs)
WO (1)	WO2003029295A1 (cs)
ZA (1)	ZA200402303B (cs)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102317319A (zh) *	2008-12-09	2012-01-11	根马布股份公司	针对组织因子的人抗体
CN101423552B (zh) *	2008-02-29	2012-05-16	复旦大学	一种人源抗人组织因子Fab及其制备方法
CN106467574A (zh) *	2015-08-20	2017-03-01	复旦大学	靶向于组织因子的抗体、其制备方法和用途
WO2018036117A1 (zh) *	2016-08-22	2018-03-01	复旦大学	靶向于组织因子的抗体、其制备方法和用途
US12246025B2 (en)	2018-03-21	2025-03-11	Genmab A/S	Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate
US12290505B2 (en)	2016-08-22	2025-05-06	Fudan University	Tissue factor-targeted antibody-drug conjugate
US12324841B2 (en)	2018-05-07	2025-06-10	Genmab A/S	Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
US12453781B2 (en)	2018-10-30	2025-10-28	Genmab A/S	Methods of treating cancer with a combination of an anti-VEGF antibody and an anti-tissue factor antibody-drug conjugate

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5986065A (en)	1997-03-10	1999-11-16	Sunol Molecular Corporation	Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en)	2001-11-21	2003-06-12	Sunol Molecular Corporation	Antibodies for inhibiting blood coagulation and methods of use thereof
US7749498B2 (en)	1997-03-10	2010-07-06	Genentech, Inc.	Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en)	1997-03-10	2006-10-19	Jin-An Jiao	Use of anti-tissue factor antibodies for treating thromboses
US20040180051A1 (en) *	2001-03-26	2004-09-16	Koji Suzuki	Blood rheology improving agents
AU2003277832A1 (en) *	2002-10-31	2004-05-25	Novo Nordisk A/S	Humanized tissue factor antibodies
JP2006516564A (ja) *	2003-01-22	2006-07-06	ノボ　ノルディスク　アクティーゼルスカブ	Ｔｆ結合薬剤及びそれらの使用
US20050031615A1 (en) *	2003-05-30	2005-02-10	Anderson G. Mark	Method of inhibiting tumor growth with anti-tissue factor antibodies
US7605235B2 (en)	2003-05-30	2009-10-20	Centocor, Inc.	Anti-tissue factor antibodies and compositions
US9708410B2 (en)	2003-05-30	2017-07-18	Janssen Biotech, Inc.	Anti-tissue factor antibodies and compositions
CA2530980A1 (en) *	2003-06-19	2005-01-20	Tanox, Inc.	Tissue factor-specific antibodies for preventing or treating acute lung injury or acute respiratory distress syndrome
CA2542372A1 (en) *	2003-08-29	2005-03-10	Centocor, Inc.	Method of promoting graft survival with anti-tissue factor antibodies
JP2007523099A (ja) *	2004-02-20	2007-08-16	ノボ　ノルディスク　アクティーゼルスカブ	組み合わせ療法
JP2010502224A (ja) *	2006-09-08	2010-01-28	アボット・ラボラトリーズ	インターロイキン１３結合タンパク質
AU2016277670B2 (en) *	2008-12-09	2019-02-07	Genmab A/S	Human antibodies against tissue factor
AU2013203150B2 (en) *	2008-12-09	2016-09-22	Genmab A/S	Human antibodies against tissue factor
WO2010131235A1 (en) *	2009-05-15	2010-11-18	University Of The Free State	Inhibitory antibody fragments to human tissue factor
BR112012031727B1 (pt) *	2010-06-15	2022-03-29	Genmab A/S	Conjugado de droga-anticorpo, composição farmacêutica, e, uso do conjugado de droga- anticorpo
US8722044B2 (en)	2011-03-15	2014-05-13	Janssen Biotech, Inc.	Human tissue factor antibody and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001978A (en) *	1987-03-31	1999-12-14	The Scripps Research Institute	Human tissue factor related DNA segments polypeptides and antibodies
US5223427A (en) *	1987-03-31	1993-06-29	The Scripps Research Institute	Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
JP2779193B2 (ja) *	1989-02-02	1998-07-23	帝人株式会社	抗ヒト組織因子モノクローナル抗体
PT833911E (pt) *	1995-06-07	2004-09-30	Ortho Mcneil Pharm Inc	Anticorpos anti-factor tecidular enxertados com cdr e metodos para a sua utilizacao
DK1069185T3 (da) *	1998-04-03	2011-06-27	Chugai Pharmaceutical Co Ltd	Humaniseret antistof mod human vævsfaktor (TF) og fremgangsmåde til at konstruere humaniseret antistof
DK1222854T3 (da) *	1999-10-01	2011-03-14	Chugai Pharmaceutical Co Ltd	Forebyggelse og behandling af sygdomme forbundet med blodkoagulering
WO2001070984A2 (en) *	2000-03-16	2001-09-27	Genentech, Inc.	Anti-tissue factor antibodies with enhanced anticoagulant potency

2002
- 2002-09-30 KR KR10-2004-7004942A patent/KR20040045478A/ko not_active Withdrawn
- 2002-09-30 IL IL16099802A patent/IL160998A0/xx unknown
- 2002-09-30 HU HU0401658A patent/HUP0401658A2/hu unknown
- 2002-09-30 MX MXPA04003051A patent/MXPA04003051A/es unknown
- 2002-09-30 CN CNA028208463A patent/CN1575302A/zh active Pending
- 2002-09-30 RU RU2004113373/13A patent/RU2004113373A/ru not_active Application Discontinuation
- 2002-09-30 WO PCT/DK2002/000644 patent/WO2003029295A1/en not_active Ceased
- 2002-09-30 BR BR0213046-7A patent/BR0213046A/pt not_active IP Right Cessation
- 2002-09-30 EP EP02800043A patent/EP1434802A1/en not_active Withdrawn
- 2002-09-30 PL PL02368989A patent/PL368989A1/xx not_active Application Discontinuation
- 2002-09-30 JP JP2003532540A patent/JP2005512970A/ja not_active Withdrawn
- 2002-09-30 CA CA002460917A patent/CA2460917A1/en not_active Abandoned
- 2002-09-30 CZ CZ2004454A patent/CZ2004454A3/cs unknown
2004
- 2004-03-24 ZA ZA200402303A patent/ZA200402303B/en unknown
- 2004-04-30 NO NO20041802A patent/NO20041802L/no not_active Application Discontinuation

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101423552B (zh) *	2008-02-29	2012-05-16	复旦大学	一种人源抗人组织因子Fab及其制备方法
CN102317319A (zh) *	2008-12-09	2012-01-11	根马布股份公司	针对组织因子的人抗体
CN102317319B (zh) *	2008-12-09	2016-06-29	根马布股份公司	针对组织因子的人抗体
CN106632678B (zh) *	2008-12-09	2022-05-31	健玛保	针对组织因子的人抗体
CN106632678A (zh) *	2008-12-09	2017-05-10	根马布股份公司	针对组织因子的人抗体
CN106467574B (zh) *	2015-08-20	2019-09-20	复旦大学	靶向于组织因子的抗体、其制备方法和用途
CN106467574A (zh) *	2015-08-20	2017-03-01	复旦大学	靶向于组织因子的抗体、其制备方法和用途
WO2018036117A1 (zh) *	2016-08-22	2018-03-01	复旦大学	靶向于组织因子的抗体、其制备方法和用途
US10676537B2 (en)	2016-08-22	2020-06-09	Fudan University	Antibody targeted to tissue factor, preparation method therefor, and use thereof
US12290505B2 (en)	2016-08-22	2025-05-06	Fudan University	Tissue factor-targeted antibody-drug conjugate
US12246025B2 (en)	2018-03-21	2025-03-11	Genmab A/S	Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate
US12324841B2 (en)	2018-05-07	2025-06-10	Genmab A/S	Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
US12453781B2 (en)	2018-10-30	2025-10-28	Genmab A/S	Methods of treating cancer with a combination of an anti-VEGF antibody and an anti-tissue factor antibody-drug conjugate

Also Published As

Publication number	Publication date
JP2005512970A (ja)	2005-05-12
RU2004113373A (ru)	2005-03-27
KR20040045478A (ko)	2004-06-01
MXPA04003051A (es)	2004-07-05
EP1434802A1 (en)	2004-07-07
HUP0401658A2 (hu)	2004-11-29
IL160998A0 (en)	2004-08-31
ZA200402303B (en)	2004-11-25
PL368989A1 (en)	2005-04-04
BR0213046A (pt)	2005-06-28
WO2003029295A1 (en)	2003-04-10
NO20041802L (no)	2004-04-30
CA2460917A1 (en)	2003-04-10
CZ2004454A3 (cs)	2004-09-15

Legal Events

Date	Code	Title
2005-02-02	C06	Publication
2005-02-02	PB01	Publication
2005-04-06	C10	Entry into substantive examination
2005-04-06	SE01	Entry into force of request for substantive examination
2007-10-03	C02	Deemed withdrawal of patent application after publication (patent law 2001)
2007-10-03	WD01	Invention patent application deemed withdrawn after publication

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