CN1906182A - 抗高血压药物硝基氧基衍生物 - Google Patents

抗高血压药物硝基氧基衍生物 Download PDF

Info

Publication number
CN1906182A
CN1906182A CNA2004800409272A CN200480040927A CN1906182A CN 1906182 A CN1906182 A CN 1906182A CN A2004800409272 A CNA2004800409272 A CN A2004800409272A CN 200480040927 A CN200480040927 A CN 200480040927A CN 1906182 A CN1906182 A CN 1906182A
Authority
CN
China
Prior art keywords
compound
integer
pharmaceutically acceptable
enantiomers
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800409272A
Other languages
English (en)
Chinese (zh)
Inventor
P·德尔索尔达托
F·贝内迪尼
E·安吉尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of CN1906182A publication Critical patent/CN1906182A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CNA2004800409272A 2003-12-02 2004-12-01 抗高血压药物硝基氧基衍生物 Pending CN1906182A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03104485 2003-12-02
EP03104485.2 2003-12-02

Publications (1)

Publication Number Publication Date
CN1906182A true CN1906182A (zh) 2007-01-31

Family

ID=34639310

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800409272A Pending CN1906182A (zh) 2003-12-02 2004-12-01 抗高血压药物硝基氧基衍生物

Country Status (21)

Country Link
US (1) US20070060586A1 (es)
EP (1) EP1748994B1 (es)
JP (1) JP2007513113A (es)
KR (1) KR20060120164A (es)
CN (1) CN1906182A (es)
AP (1) AP2006003622A0 (es)
AR (1) AR047264A1 (es)
AT (1) ATE423107T1 (es)
AU (1) AU2004295105A1 (es)
BR (1) BRPI0417182A (es)
CA (1) CA2548127A1 (es)
DE (1) DE602004019579D1 (es)
EA (1) EA200600891A1 (es)
EC (1) ECSP066590A (es)
ES (1) ES2320002T3 (es)
IL (1) IL176061A0 (es)
MA (1) MA28224A1 (es)
NO (1) NO20062527L (es)
TN (1) TNSN06151A1 (es)
WO (1) WO2005054218A1 (es)
ZA (1) ZA200604463B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118146175A (zh) * 2024-02-07 2024-06-07 广州楷石生物科技有限公司 右旋噻吗洛尔衍生物及其制备方法和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60233140D1 (de) 2001-05-02 2009-09-10 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
WO2007090733A1 (en) * 2006-02-06 2007-08-16 Nicox S.A. Nitrooxy derivatives suitable as alpha2 adrenergic receptor agonists
JP2009525970A (ja) * 2006-02-06 2009-07-16 ニコックス エス エイ α２−アドレナリン受容体アゴニストとしてのアプラクロニジンおよびブリモドニジンのニトロオキシ含有誘導体
AU2021241591A1 (en) 2020-03-24 2022-10-20 Michael W. BURNET Anti-infective and anti-viral compounds and compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1311923B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118146175A (zh) * 2024-02-07 2024-06-07 广州楷石生物科技有限公司 右旋噻吗洛尔衍生物及其制备方法和应用

Also Published As

Publication number Publication date
EA200600891A1 (ru) 2006-10-27
ZA200604463B (en) 2007-04-25
AP2006003622A0 (en) 2006-06-30
BRPI0417182A (pt) 2007-03-06
NO20062527L (no) 2006-06-30
EP1748994A1 (en) 2007-02-07
MA28224A1 (fr) 2006-10-02
JP2007513113A (ja) 2007-05-24
ECSP066590A (es) 2006-10-17
DE602004019579D1 (de) 2009-04-02
IL176061A0 (en) 2006-10-05
US20070060586A1 (en) 2007-03-15
ATE423107T1 (de) 2009-03-15
KR20060120164A (ko) 2006-11-24
AR047264A1 (es) 2006-01-11
TNSN06151A1 (en) 2007-11-15
AU2004295105A1 (en) 2005-06-16
ES2320002T3 (es) 2009-05-18
WO2005054218A1 (en) 2005-06-16
CA2548127A1 (en) 2005-06-16
EP1748994B1 (en) 2009-02-18

Similar Documents

Publication Publication Date Title
CN1906159A (zh) 前列腺素硝基氧衍生物
CN1027068C (zh) α-取代的4-(喹啉-2-基-甲氧基)苯乙酸和酯的制备方法
CN1073166A (zh) 羟肟酸衍生物
CN1040986A (zh) 环烷基取代的戊二酰胺衍生物的制备
CN1015054B (zh) N-吲哚基乙基-磺酰胺类的制备方法
CN1150162C (zh) 联苯基脒衍生物
CN1097192A (zh) 逆转录酶病毒蛋白酶抑制剂
CN1492859A (zh) 嘧啶无环核苷衍生物、其制备方法及其用途
HK1044955A1 (en) Heterocyclic compounds, intermediates thereof and elastase inhibitors
CN1071665A (zh) 唑烷酮衍生物
CN1138583A (zh) 9-取代的2-(2-正烷氧基苯基)-嘌呤-6-酮类化合物
CN88101674A (zh) 色酮衍生物
CN1024790C (zh) 尿素衍生物及其盐的制备方法
CN1060769C (zh) 1，4-苯并嗪衍生物，含该化合物的药物组合物及其用途
CN1886132A (zh) 用作降压药的卡维地洛和其它β阻断剂的硝基氧基衍生物
HK1042094A1 (en) New benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
CN88100129A (zh) 甜味剂胍基乙酸和乙脒基乙酸衍生物的制备方法以及含有这类甜味剂的配方
CN1147491C (zh) 新的吖啶羧酸酯化合物、其制备方法及其药物组合物
CN1035876C (zh) 四氢噻吩衍生物及其药物组合物
CN1043133A (zh) 含咪唑肽及其制备方法
CN1074440A (zh) 胃酸分泌抑制及胃细胞保护性药物组合物，新的法莫替丁(famotidinc)盐及其制备方法
CN1021441C (zh) 新型苯甲酰胺的制备方法
HK1104032A (en) Nitrooxyderivatives of antihypertensive drugs
CN1747930A (zh) 具有脯氨酰基寡肽酶抑制活性的化合物
CN1097010A (zh) 新的呋喃基噻唑衍生物及其盐

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1104032

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1104032

Country of ref document: HK