CN202497219U - Orthopaedics screw having meso pore biological coating - Google Patents
Orthopaedics screw having meso pore biological coating Download PDFInfo
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- CN202497219U CN202497219U CN2012200663595U CN201220066359U CN202497219U CN 202497219 U CN202497219 U CN 202497219U CN 2012200663595 U CN2012200663595 U CN 2012200663595U CN 201220066359 U CN201220066359 U CN 201220066359U CN 202497219 U CN202497219 U CN 202497219U
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- mesoporous
- nail body
- biological coating
- fracture
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- 239000011248 coating agent Substances 0.000 title claims abstract description 31
- 238000000576 coating method Methods 0.000 title claims abstract description 31
- 239000011148 porous material Substances 0.000 title description 9
- 239000004005 microsphere Substances 0.000 claims abstract description 23
- 206010017076 Fracture Diseases 0.000 abstract description 18
- 208000010392 Bone Fractures Diseases 0.000 abstract description 16
- 239000013543 active substance Substances 0.000 abstract description 11
- 230000000399 orthopedic effect Effects 0.000 abstract description 10
- 239000002077 nanosphere Substances 0.000 abstract description 7
- 229910052710 silicon Inorganic materials 0.000 abstract description 7
- 239000010703 silicon Substances 0.000 abstract description 7
- 230000004071 biological effect Effects 0.000 abstract description 6
- 230000035876 healing Effects 0.000 abstract description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract description 5
- 206010017081 Fracture delayed union Diseases 0.000 abstract description 4
- 206010017088 Fracture nonunion Diseases 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 abstract description 4
- 229960004276 zoledronic acid Drugs 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229920000592 inorganic polymer Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000005543 nano-size silicon particle Substances 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- -1 silicon ions Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910001868 water Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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Abstract
一种带有介孔生物涂层的骨科螺钉，包括钉体，钉体的前端呈锥形，钉体的表面覆盖有一层介孔纳米微球生物涂层。介孔纳米微球生物涂层包围钉体。钉体上设置有螺纹，介孔纳米微球生物涂层覆盖螺纹的表面。介孔纳米微球生物涂层由复数个介孔硅纳米微球排列组成。钉体的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。本实用新型提高了骨折救治的成功率，降低了骨折不愈合及延迟愈合的发生率。
An orthopedic screw with a mesoporous biological coating comprises a nail body, the front end of the nail body is conical, and the surface of the nail body is covered with a layer of mesoporous nano microsphere biological coating. A biocoating of mesoporous nanospheres surrounds the nail body. Threads are arranged on the nail body, and the mesoporous nano microsphere biological coating covers the surface of the threads. The mesoporous nano-microsphere biological coating is composed of a plurality of mesoporous silicon nano-microspheres. The surface of the nail body is covered with a layer of mesoporous nano-microsphere biological coating, which can create good conditions for carrying biologically active substances such as BMP and zoledronic acid. The biocoating of mesoporous nanospheres loaded with active substances can release active substances at the fracture end while completing fracture fixation, thereby producing a biological effect of promoting fracture healing. The utility model improves the success rate of fracture treatment and reduces the incidence rate of fracture nonunion and delayed union.
Description
技术领域: Technical field:
本实用新型涉及人类生活用品，尤其涉及医疗器械，特别涉及骨科手术材料，具体的是一种带有介孔生物涂层的骨科螺钉。 The utility model relates to articles for human life, in particular to medical instruments, in particular to orthopedic operation materials, in particular to an orthopedic screw with a mesoporous biological coating.
背景技术: Background technique:
骨折是人类常见的损伤，也是矫形外科治疗的重要方面。目前，切开复位加内固定已成为治疗骨折的重要方式。但是，依据骨折类型及受伤年龄不同，其愈后也各不相同，骨折不愈合或延迟愈合的病例仍然存在，骨折不愈合或延迟愈合可能造成患肢长期疼痛、无法负重及内固定失败等严重后果。 Fractures are common injuries in humans and represent an important aspect of orthopedic treatment. At present, open reduction and internal fixation have become an important way to treat fractures. However, depending on the type of fracture and the age of the injury, the healing process is also different. There are still cases of fracture nonunion or delayed union, which may cause long-term pain in the affected limb, inability to bear weight, and failure of internal fixation. as a result of.
发明内容： Invention content:
本实用新型的目的在于提供一种带有介孔生物涂层的骨科螺钉，所述的这种带有介孔生物涂层的骨科螺钉要解决现有技术中骨折不愈合或延迟愈合的技术问题。 The purpose of this utility model is to provide a kind of orthopedic screw with mesoporous bio-coating, said orthopedic screw with mesoporous bio-coating should solve the technical problem of fracture nonunion or delayed union in the prior art .
本实用新型的这种带有介孔生物涂层的骨科螺钉，包括钉体，所述的钉体的前端呈锥形，其中，所述的钉体的表面覆盖有一层介孔纳米微球生物涂层。 The orthopedic screw with mesoporous bio-coating of the present utility model includes a nail body, the front end of the nail body is conical, wherein the surface of the nail body is covered with a layer of mesoporous nano-microsphere biological coating.
进一步的，所述的介孔纳米微球生物涂层包围所述的钉体。 Further, the bio-coating of mesoporous nano-microspheres surrounds the nail body.
进一步的，所述的钉体上设置有螺纹，所述的介孔纳米微球生物涂层覆盖螺纹的表面。 Further, the nail body is provided with threads, and the mesoporous nano-microsphere biological coating covers the surface of the threads.
进一步的，所述的介孔纳米微球生物涂层由复数个介孔硅纳米微球（mesoporous silica nanoparticulate，MSN）排列组成。所述的介孔硅纳米微球由SiO2-CaO-P2O3组成的。与传统的无机及有机高分子药物载体材料相比，介孔硅纳米微球具有较大的比表面积，可以提高生物活性；介孔孔道直径可以进行调控，表面进行化学改性，有利于不同分子量药物的装载；介孔孔道具有均一大小的规则孔道，较大的比表面积，能够实现较大量的药物装载；介孔的孔表面有丰富的化学基团，可以和很多药物分子形成化学键合，结合较为牢固，药物的释放通过孔道扩散，从而实现缓慢的可持续释放；介孔二氧化硅微球降解产物为水、钙、磷和硅离子，无任何毒性。 Further, the mesoporous nanosphere bio-coating is composed of a plurality of mesoporous silicon nanoparticle (mesoporous silica nanoparticulate, MSN) arrays. The mesoporous silicon nanometer microsphere is composed of SiO2-CaO-P2O3. Compared with traditional inorganic and organic polymer drug carrier materials, mesoporous silicon nanospheres have a larger specific surface area, which can improve biological activity; the diameter of mesoporous channels can be adjusted, and the surface can be chemically modified, which is beneficial to different molecular weights. Drug loading; mesoporous pores have regular channels of uniform size and large specific surface area, which can realize a large amount of drug loading; the pore surface of mesoporous pores is rich in chemical groups, which can form chemical bonds with many drug molecules. It is relatively firm, and the release of drugs diffuses through the pores to achieve slow and sustainable release; the degradation products of mesoporous silica microspheres are water, calcium, phosphorus and silicon ions, without any toxicity.
本实用新型的工作原理是：钉体的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。 The working principle of the utility model is: the surface of the nail body is covered with a layer of mesoporous nano-microsphere biological coating, and the mesoporous nano-microsphere biological coating can create good conditions for carrying biologically active substances such as BMP, zoledronic acid, etc. . The biocoating of mesoporous nano-microspheres loaded with active substances can release active substances at the fracture end while completing fracture fixation, thereby producing a biological effect of promoting fracture healing.
本实用新型和已有技术相比较，其效果是积极和明显的。本实用新型在骨科螺钉的钉体表面覆盖一层介孔纳米微球生物涂层，利用该介孔纳米微球生物涂层，可携带生物活性物质如BMP、唑来膦酸等，在钉体植入体内并完成骨折固定时，介孔纳米微球生物涂层可在骨折端释放活性物质，产生促进骨折愈合的生物学作用，促进骨折愈合。本实用新型提高了骨折救治的成功率，降低了骨折不愈合及延迟愈合的发生率。 Compared with the prior art, the utility model has positive and obvious effects. The utility model covers a layer of mesoporous nano-microsphere bio-coating on the nail body surface of orthopedic screws, and the mesoporous nano-micro-sphere bio-coating can carry biologically active substances such as BMP, zoledronic acid, etc. on the nail body When implanted into the body and the fracture is fixed, the bio-coating of mesoporous nano-microspheres can release active substances at the fracture end to produce a biological effect of promoting fracture healing and promote fracture healing. The utility model improves the success rate of fracture treatment and reduces the incidence rate of fracture nonunion and delayed union. the
附图说明： Description of drawings:
图1是本实用新型的带有介孔生物涂层的骨科螺钉的结构示意图。 Fig. 1 is a schematic structural view of an orthopedic screw with a mesoporous bio-coating of the present invention.
具体实施方式： Detailed ways:
实施例1: Example 1:
如图1所示，本实用新型的带有介孔生物涂层的骨科螺钉，包括钉体1，所述的钉体1的前端呈锥形，其中，所述的钉体1的表面覆盖有一层介孔纳米微球生物涂层。
As shown in Figure 1, the orthopedic screw with mesoporous bio-coating of the present invention includes a
进一步的，所述的介孔纳米微球生物涂层包围所述的钉体1。
Further, the bio-coating of mesoporous nano-microspheres surrounds the
进一步的，所述的钉体1上设置有螺纹，所述的介孔纳米微球生物涂层覆盖螺纹的表面。
Further, the
进一步的，所述的介孔纳米微球生物涂层由复数个介孔硅纳米微球（mesoporous silica nanoparticulate，MSN）排列组成。所述的介孔硅纳米微球由SiO2-CaO-P2O3组成的。与传统的无机及有机高分子药物载体材料相比，介孔硅纳米微球具有较大的比表面积，可以提高生物活性；介孔孔道直径可以进行调控，表面进行化学改性，有利于不同分子量药物的装载；介孔孔道具有均一大小的规则孔道，较大的比表面积，能够实现较大量的药物装载；介孔的孔表面有丰富的化学基团，可以和很多药物分子形成化学键合，结合较为牢固，药物的释放通过孔道扩散，从而实现缓慢的可持续释放；介孔二氧化硅微球降解产物为水、钙、磷和硅离子，无任何毒性。 Further, the mesoporous nanosphere bio-coating is composed of a plurality of mesoporous silicon nanoparticle (mesoporous silica nanoparticulate, MSN) arrays. The mesoporous silicon nanometer microsphere is composed of SiO2-CaO-P2O3. Compared with traditional inorganic and organic polymer drug carrier materials, mesoporous silicon nanospheres have a larger specific surface area, which can improve biological activity; the diameter of mesoporous channels can be adjusted, and the surface can be chemically modified, which is beneficial to different molecular weights. Drug loading; mesoporous pores have regular channels of uniform size and large specific surface area, which can realize a large amount of drug loading; the pore surface of mesoporous pores is rich in chemical groups, which can form chemical bonds with many drug molecules. It is relatively firm, and the release of drugs diffuses through the pores to achieve slow and sustainable release; the degradation products of mesoporous silica microspheres are water, calcium, phosphorus and silicon ions, without any toxicity.
本实施例的工作原理是：钉体1的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。
The working principle of this embodiment is: the surface of the
上述实施例为本实用新型较佳的实施方式，但本实用新型的实施方式并不受上述实施例的限制，其它的任何未背离本实用新型的精神实质与原理下所作的改变，修饰，替代，组合，简化均应为等效的置换方式，都包含在本实用新型的保护范围之内。 The above-mentioned embodiment is a preferred embodiment of the present utility model, but the embodiment of the present utility model is not limited by the above-mentioned embodiment, and any other changes, modifications, and replacements made without departing from the spirit and principle of the present utility model , combination, and simplification should all be equivalent replacement methods, all of which are included in the protection scope of the present utility model.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505299C1 (en) * | 2012-11-20 | 2014-01-27 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Method of treating skeletal complications in patients with lytic long bone metastases |
| CN107412855A (en) * | 2017-08-03 | 2017-12-01 | 华东理工大学 | Has cated 3D printing support and its preparation method and application |
| CN107551329A (en) * | 2017-10-20 | 2018-01-09 | 上海交通大学医学院附属第九人民医院 | A kind of inner fixing device treated for osteoporotic fracture and preparation method thereof |
-
2012
- 2012-02-27 CN CN2012200663595U patent/CN202497219U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505299C1 (en) * | 2012-11-20 | 2014-01-27 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Method of treating skeletal complications in patients with lytic long bone metastases |
| CN107412855A (en) * | 2017-08-03 | 2017-12-01 | 华东理工大学 | Has cated 3D printing support and its preparation method and application |
| CN107551329A (en) * | 2017-10-20 | 2018-01-09 | 上海交通大学医学院附属第九人民医院 | A kind of inner fixing device treated for osteoporotic fracture and preparation method thereof |
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Granted publication date: 20121024 Termination date: 20150227 |
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